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KSRP, many functions for a single protein
Abstract
KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of post-translational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.
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“Some ARE-BPs are decay-promoting factors, such as KH-type splicing regulatory proteins (KSRPs), that interact with AREs and recruit RNA degradation machinery to the mRNA.”
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Singh, A. B., Li, H., Kan, C. F. K., Dong, B., Nicolls, M. R., & Liu, J. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.112.301131 · Cited by 32
Metadata
- Authors
- Briata, P.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2011
- Volume
- 16
- Issue
- 1
- Pages
- 1787
- ISSN
- 1093-9946
- 1093-4715
- DOI
- 10.2741/3821
- Cited by
- 49
- References
- 55
- Language
- en
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