Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators
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The magnitude and duration of acute inflammation are controlled by active resolution programs involving specialized proresolving mediators (SPMs; resolvins and maresins) and microRNAs (miRNAs). Here, we report that miR-466l was temporally regulated in murine exudate-infiltrating leukocytes. Neutrophil miR-466l overexpression in vivo promoted initiation of inflammation that anteceded macrophage expression of this miRNA, which accelerated resolution when overexpressed. In macrophages, miR-466l overexpression increased prostanoids and SPMs (e.g., resolvin D1 [RvD1] and RvD5), which enhanced resolution. RvD1, RvD2, maresin 1 (MaR1), and apoptotic neutrophils reduced miR-466l expression within human macrophages, a feedback regulation that most likely prepares for homeostasis. miR-466l was upregulated in peripheral blood of sepsis patients, and its increase correlated with nonsurvival from sepsis. SPMs and miR-466l regulated transcription factors activator protein 1 and nuclear factor κB1 in miRNA biogenesis. These results demonstrate pivotal roles for SPMs and miR-466l in dynamic leukocyte plasticity during resolution of acute inflammatory responses.
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miR-466l is upregulated in peripheral blood of sepsis patients and its levels correlate with risk of death.
“MiR-466l is upregulated in the peripheral blood of patients with sepsis, and its levels correlate with risk of death.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [224]
In a murine model, during the inflammatory response, miR-466l is first overexpressed in neutrophils, acting proinflammatory, and then overexpressed in macrophages, leading to increase in prostanoids and specialized proresolving mediators (RvD1, RvD5).
“During the inflammatory response, miR-466l is first overexpressed in neutrophils, acting proinflammatory, and then it is overexpressed in macrophages, leading to increase in prostanoids and specialized proresolving mediators (e.g., resolvin D1 [RvD1] and RvD5).”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [224]
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Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
Circulating microRNAs as stable blood-based markers for cancer detection
Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R., Wyman, S. K., Pogosova-Agadjanyan, E. L., Peterson, A., Noteboom, J., O'Briant, K. C., Allen, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804549105 · Cited by 7,969 · see citing works
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335 · see citing works
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
Switching from Repression to Activation: MicroRNAs Can Up-Regulate Translation
Vasudevan, S., Tong, Y., & STEITZ, J. A. (2007) · Science · doi:10.1126/science.1149460 · Cited by 2,806 · see citing works
VISTA: computational tools for comparative genomics
Frazer, K. A., Pachter, L. S., Poliakov, A., Rubin, E. M., & Dubchak, I. L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh458 · Cited by 2,791 · see citing works
Resolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works
Self-citationNucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works
Lipid mediator class switching during acute inflammation: signals in resolution
Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works
Self-citationThe Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
Underhill, D. M., Ozinsky, A., Hajjar, A. M., Stevens, A. M., Wilson, C. B., Bassetti, M., & Aderem, A. A. (1999) · Nature · doi:10.1038/44605 · Cited by 1,369 · see citing works
Phagocytosis and clearance of apoptotic cells is mediated by MER
Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K. (2001) · Nature · doi:10.1038/35075603 · Cited by 1,215 · see citing works
Resolvin E1 and protectin D1 activate inflammation-resolution programmes
Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,188 · see citing works
Self-citationSerhan, C. N. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141647 · Cited by 997 · see citing works
Self-citationSavill, J., Hogg, N., Ren, Y., & Haslett, C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116019 · Cited by 813 · see citing works
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., Johnston, W. K., Russ, C., Luo, S., Babiarz, J. E., et al. (2010) · Genes & Development · doi:10.1101/gad.1884710 · Cited by 732 · see citing works
Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins
Bannenberg, G. L., Chiang, N., Ariel, A., Arita, M., Tjonahen, E., Gotlinger, K. H., Hong, S., & Serhan, C. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.7.4345 · Cited by 699 · see citing works
Self-citationInfection regulates pro-resolving mediators that lower antibiotic requirements
Chiang, N., Fredman, G., Bäckhed, F., Oh, S. F., Vickery, T., Schmidt, B. A., & Serhan, C. N. (2012) · Nature · doi:10.1038/nature11042 · Cited by 664 · see citing works
Self-citationAU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
Vasudevan, S., & Steitz, J. A. (2007) · Cell · doi:10.1016/j.cell.2007.01.038 · Cited by 656 · see citing works
The macrophage: Past, present and future
Gordon, S. (2007) · European Journal of Immunology · doi:10.1002/eji.200737638 · Cited by 625 · see citing works
Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain
Serhan, C. N., Dalli, J., Karamnov, S., Choi, A. J. S., Park, C., Xu, Z., Ji, R., Zhu, M., & Petasis, N. A. (2012) · The FASEB Journal · doi:10.1096/fj.11-201442 · Cited by 596 · see citing works
Self-citationInflammasome-regulated Cytokines Are Critical Mediators of Acute Lung Injury
Dolinay, T., Kim, Y. S., Howrylak, J. A., Hunninghake, G. M., An, C. H., Fredenburgh, L. E., Massaro, A. F., Rogers, A. J., Gazourian, L., Nakahira, K., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201201-0003oc · Cited by 562 · see citing works
Self-citationDalli, J., & Serhan, C. N. (2012) · Blood · doi:10.1182/blood-2012-04-423525 · Cited by 556 · see citing works
Self-citationAcute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain
Kyritsis, N., Kızıl, Ç., Zocher, S., Kroehne, V., Kaslin, J., Freudenreich, D., Iltzsche, A., & Brand, M. (2012) · Science · doi:10.1126/science.1228773 · Cited by 512 · see citing works
Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
Freire-de-Lima, C. G., Nascimento, D. O., Soares, M. B. P., Bozza, P. T., Castro-Faria-Neto, H. C., Mello, F. G. D., DosReis, G. A., & Lopes, M. F. (2000) · Nature · doi:10.1038/35003208 · Cited by 455 · see citing works
MicroRNA-181b regulates NF-κB–mediated vascular inflammation
Sun, X., Icli, B., Wara, A. K., Belkin, N., He, S., Kobzik, L., Hunninghake, G. M., Pinilla-Vera, M., Blackwell, T. S., Baron, R. M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61495 · Cited by 450 · see citing works
Self-citationTitos, E., Rius, B., González-Périz, A., López-Vicario, C., Morán-Salvador, E., Martínez-Clemente, M., Arroyo, V., & Clària, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100225 · Cited by 412 · see citing works
Inhibition of 15-lipoxygenases by flavonoids: structure–activity relations and mode of action
Sadik, C. D., Sies, H., & SCHEWE, T. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01621-0 · Cited by 339 · see citing works
Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP
Byström, J., Evans, I. M., Newson, J., Stables, M. J., Toor, I. S., van Rooijen, N., Crawford, M., Colville‐Nash, P., Farrow, S. N., & Gilroy, D. W. (2008) · Blood · doi:10.1182/blood-2007-12-129767 · Cited by 335 · see citing works
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
Calabrese, J. M., Seila, A. C., Yeo, G. W.-M., & Sharp, P. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709193104 · Cited by 319 · see citing works
MicroRNAs in resolution of acute inflammation: identification of novel resolvin Dl‐miRNA circuits
Recchiuti, A., Krishnamoorthy, S., Fredman, G., Chiang, N., & Serhan, C. N. (2011) · The FASEB Journal · doi:10.1096/fj.10-169599 · Cited by 292 · see citing works
Self-citationTranscriptomic analyses of murine resolution-phase macrophages
Stables, M. J., Shah, S. H., Camon, E. B., Lovering, R. C., Newson, J., Byström, J., Farrow, S. N., & Gilroy, D. W. (2011) · Blood · doi:10.1182/blood-2011-04-345330 · Cited by 291 · see citing works
El Kebir, D., Gjorstrup, P., & Filep, J. G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206641109 · Cited by 289 · see citing works
József, L., Zouki, C., Petasis, N. A., Serhan, C. N., & Filep, J. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202296999 · Cited by 254 · see citing works
Self-citationMa, F., Liu, X., Li, D., Wang, P., Li, N., Lu, L., & Cao, X. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902308 · Cited by 249 · see citing works
Schif‐Zuck, S., Gross, N., Assi, S., Rostoker, R., Serhan, C. N., & Ariel, A. (2010) · European Journal of Immunology · doi:10.1002/eji.201040801 · Cited by 236 · see citing works
Self-citationSonkoly, E., & Pivarcsi, A. (2009) · International Reviews of Immunology · doi:10.3109/08830180903208303 · Cited by 212 · see citing works
COX-2 in Inflammation and Resolution
Rajakariar, R. (2006) · Molecular Interventions · doi:10.1124/mi.6.4.6 · Cited by 178 · see citing works
Gallin, E. K., & Gallin, J. (1977) · The Journal of Cell Biology · doi:10.1083/jcb.75.1.277 · Cited by 174 · see citing works
Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.
McCusker, J. H., Clemons, K. V., Stevens, D. A., & Davis, R. W. (1994) · Genetics · doi:10.1093/genetics/136.4.1261 · Cited by 171 · see citing works
miRNA regulation of cytokine genes
Asirvatham, A. J., Magner, W. J., & Tomasi, T. B. (2009) · Cytokine · doi:10.1016/j.cyto.2008.11.010 · Cited by 161 · see citing works
Mortensen, R. D., Serra, M., STEITZ, J. A., & Vasudevan, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105401108 · Cited by 124 · see citing works
Fredman, G., Li, Y., Dalli, J., Chiang, N., & Serhan, C. N. (2012) · Scientific Reports · doi:10.1038/srep00639 · Cited by 122 · see citing works
Self-citationMorris, T., Stables, M. J., Colville‐Nash, P., Newson, J., Bellingan, G. J., de Souza, P. M., & Gilroy, D. W. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000373107 · Cited by 106 · see citing works
KSRP, many functions for a single protein
Briata, P. (2010) · Frontiers in bioscience · doi:10.2741/3821 · Cited by 56 · see citing works
Pillai, P. S., Leeson, S., Porter, T. F., Owens, C. D., Kim, J. M., Conte, M. S., Serhan, C. N., & Gelman, S. (2011) · Inflammation · doi:10.1007/s10753-011-9294-8 · Cited by 52 · see citing works
Self-citationPhagocyte-pathogen interactions : macrophages and the host response to infection
Russell, D. G., & Gordon, S. (2009) · Cited by 21 · see citing works
Yamada, A., & Suzuki, T. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.7.2457 · Cited by 12 · see citing works
Flagged first, then by citations
1 of the 48 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Pro-resolving lipid mediators are leads for resolution physiology
Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
Self-citationProresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation
Buckley, C. D., Gilroy, D. W., & Serhan, C. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.009 · Cited by 811 · see citing works
Self-citationHellenbrand, D. J., Quinn, C. M., Piper, Z. J., Morehouse, C. N., Fixel, J. A., & Hanna, A. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02337-2 · Cited by 663 · see citing works
The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution
Serhan, C. N., Chiang, N., & Dalli, J. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.03.004 · Cited by 583 · see citing works
Self-citationSerhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492 · see citing works
Self-citationSurviving sepsis campaign: research priorities for sepsis and septic shock
Coopersmith, C. M., Backer, D. D., Deutschman, C. S., Ferrer, R., Lat, I., Machado, F. R., Martin, G. S., Martín‐Loeches, I., Nunnally, M., Antonelli, M. M., et al. (2018) · Intensive Care Medicine · doi:10.1007/s00134-018-5175-z · Cited by 283 · see citing works
MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis
Cai, B., Thorp, E. B., Doran, A. C., Sansbury, B. E., Daemen, M. J. A. P., Dorweiler, B., Spite, M., Fredman, G., & Tabas, I. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90520 · Cited by 262 · see citing works
Circulating MicroRNAs as Biomarkers for Sepsis
Benz, F., Roy, S., Trautwein, C., Roderburg, C., & Luedde, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17010078 · Cited by 258 · see citing works
Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation
Perretti, M., Leroy, X., Bland, E. J., & Montero‐Melendez, T. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.07.007 · Cited by 227 · see citing works
Francos-Quijorna, I., Amo‐Aparicio, J., Martínez‐Muriana, A., & López‐Vales, R. (2016) · Glia · doi:10.1002/glia.23041 · Cited by 211 · see citing works
Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis
Zhu, M., Wang, X., Hjorth, E., Colas, R. A., Schroeder, L., Granholm, A.-C., Serhan, C. N., & Schultzberg, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9544-0 · Cited by 204 · see citing works
Self-citationMaresin 1 improves the Treg/Th17 imbalance in rheumatoid arthritis through miR-21
Jin, S., Chen, H., Li, Y., Zhong, H., Sun, W., Wang, J., Zhang, T., Ma, J., Yan, S.-F., Zhang, J., et al. (2018) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-213511 · Cited by 195 · see citing works
Self-citationMicroRNAs as Molecular Switches in Macrophage Activation
Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 182 · see citing works
Nutrimiromics: Role of microRNAs and Nutrition in Modulating Inflammation and Chronic Diseases
Quintanilha, B. J., Reis, B. Z., Duarte, G. B. D. S., Cozzolino, S. M. F., & Rogero, M. M. (2017) · Nutrients · doi:10.3390/nu9111168 · Cited by 155 · see citing works
Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis
Hashemian, S. M. R., Pourhanifeh, M. H., Fadaei, S., Velayati, A. A., Mirzaei, H., & Hamblin, M. R. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.05.012 · Cited by 148 · see citing works
Park, J., Langmead, C. J., & Riddy, D. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00075 · Cited by 133 · see citing works
Role of extracellular and intracellular microRNAs in sepsis
Essandoh, K., & Fan, G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.07.021 · Cited by 130 · see citing works
FPR2/ALXR Agonists and the Resolution of Inflammation
Corminboeuf, O., & Leroy, X. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501051x · Cited by 131 · see citing works
Caserta, S., Kern, F., Cohen, J., Drage, S. M., Newbury, S. F., & Llewelyn, M. (2016) · Scientific Reports · doi:10.1038/srep28006 · Cited by 121 · see citing works
A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell–Potentiated Colorectal Carcinogenesis
Yan, G., Zhao, H., Zhang, Q., Zhou, Y. J., Wu, L., Lei, J., Wang, X., Zhang, J., Zhang, X., Zheng, L., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3962 · Cited by 120 · see citing works
Self-citationSurviving Sepsis Campaign: Research Priorities for Sepsis and Septic Shock
Coopersmith, C. M., Backer, D. D., Deutschman, C. S., Ferrer, R., Lat, I., Machado, F. R., Martin, G. S., Martín‐Loeches, I., Nunnally, M., Antonelli, M. M., et al. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003225 · Cited by 117 · see citing works
Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders
Yang, T., Xu, G., Newton, P. T., Chagin, A. S., Mkrtchian, S., Carlström, M., Zhang, X., Harris, R. A., Cooter, M. L., Berger, M., et al. (2018) · British Journal of Anaesthesia · doi:10.1016/j.bja.2018.10.062 · Cited by 117 · see citing works
Kingsley, S. M. K., & Bhat, B. V. (2017) · Inflammation Research · doi:10.1007/s00011-017-1031-9 · Cited by 104 · see citing works
The involvement of regulatory non-coding RNAs in sepsis: a systematic review
Ho, J., Chan, H., Wong, S. H., Wang, M. H., Yu, J. Q., Xiao, Z., Liu, X., Choi, G. Y. S., Leung, C. C. H., Wong, W. T., et al. (2016) · Critical Care · doi:10.1186/s13054-016-1555-3 · Cited by 98 · see citing works
Bai, Y.-H., Wang, J., He, Z., Yang, M. H., Li, L., & Jiang, H. (2019) · Medical Science Monitor · doi:10.12659/msm.914860 · Cited by 96 · see citing works
DEL-1-Regulated Immune Plasticity and Inflammatory Disorders
Hajishengallis, G., & Chavakis, T. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.02.010 · Cited by 90 · see citing works
Resolving inflammation by TAM receptor activation
Vago, J. P., Amaral, F. A., & van de Loo, F. A. J. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107893 · Cited by 90 · see citing works
Tang, S. J., Wan, M., Huang, W. G., Stanton, R. C., & Xu, Y. (2018) · Mediators of Inflammation · doi:10.1155/2018/2380319 · Cited by 88 · see citing works
Development of an immunomodulatory biomaterial: Using resolvin D1 to modulate inflammation
Vasconcelos, D. P., Costa, M. M., Amaral, I. F., Barbosa, M. A., Águas, A. P., & Barbosa, J. N. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.120 · Cited by 86 · see citing works
Bai, X., Shao, J., Zhou, S., Zhao, Z., Li, F., Xiang, R., Zhao, A. Z., & Pan, J. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1478-3 · Cited by 85 · see citing works
Non-coding RNA: a potential biomarker and therapeutic target for sepsis
Zhang, T., Li, D., Xia, J., Wu, Q., Wen, R., Yang, N., & Liu, C. (2017) · Oncotarget · doi:10.18632/oncotarget.21766 · Cited by 81 · see citing works
Emerging role of circulating microRNA in the diagnosis of human infectious diseases
Ojha, R., Nandani, R., Pandey, R. K., Mishra, A., & Prajapati, V. K. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27127 · Cited by 79 · see citing works
Jin, S., Sun, S., Ling, H., Ma, J., Zhang, X., Xie, Z., Zhan, N., Zheng, W., Li, M., Yang, Q. Z., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03562-6 · Cited by 79 · see citing works
Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury
Lee, T. J., Yuan, X., Kerr, K. M., Yoo, J. Y., Kim, D., Kaur, B., & Eltzschig, H. K. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.019026 · Cited by 78 · see citing works
Luo, B., Wang, J., Liu, Z., Shen, Z., Shi, R., Liu, Y., Liu, Y., Jiang, M., Wu, Y., & Zhang, Z. (2016) · Nature Communications · doi:10.1038/ncomms12177 · Cited by 79 · see citing works
Weylandt, K. H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.11.002 · Cited by 74 · see citing works
Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications
Giza, D. E., Fuentes‐Mattei, E., Bullock, M. D., Tudor, Ș., Goblirsch, M. J., Fabbri, M., Lupu, F., Yeung, S. J., Vasilescu, C., & Călin, G. A. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.94 · Cited by 73 · see citing works
Halade, G. V., Kain, V., & Serhan, C. N. (2018) · The FASEB Journal · doi:10.1096/fj.201701173rr · Cited by 73 · see citing works
Self-citationResolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1
Mattè, A., Recchiuti, A., Federti, E., Koehl, B., Mintz, T., Nemer, W. E., Tharaux, P., Brousse, V. A. M., Andolfo, I., Lamolinara, A., et al. (2018) · Blood · doi:10.1182/blood-2018-07-865378 · Cited by 65 · see citing works
Self-citationInflammation, Lipid (Per)oxidation, and Redox Regulation
Dias, I. H. K., Milic, I., Heiß, C., Ademowo, O. S., Polidori, M. C., Devitt, A., & Griffiths, H. R. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8022 · Cited by 57 · see citing works
MicroRNAs and Sepsis-Induced Cardiac Dysfunction: A Systematic Review
Manetti, A. C., Maiese, A., Paolo, M. D., Matteis, A. D., Russa, R. L., Turillazzi, E., Frati, P., & Fineschi, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010321 · Cited by 58 · see citing works
Kotlyarov, S. N., & Котлярова, А. А. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312803 · Cited by 58 · see citing works
Tang, H., Liu, Y., Yan, C., Petasis, N. A., Serhan, C. N., & Gao, H. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400942 · Cited by 57 · see citing works
Self-citationThe Role of Maresins in Inflammatory Pain: Function of Macrophages in Wound Regeneration
Hwang, S.-M., Chung, G., Kim, Y. H., & Park, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235849 · Cited by 56 · see citing works
Modes of action and diagnostic value of miRNAs in sepsis
Antonakos, N., Gilbert, C., Théroude, C., Schrijver, I. T., & Roger, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.951798 · Cited by 56 · see citing works
Pro-resolving lipid mediators: Agents of anti-ageing?
Doyle, R., Sadlier, D. M., & Godson, C. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.002 · Cited by 50 · see citing works
Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammation
Peh, H. Y., & Chen, J. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108753 · Cited by 48 · see citing works
Johnson, B. L., Midura, E. F., Prakash, P. S., Rice, T. C., Kunz, N., Kalies, K., & Caldwell, C. C. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.012 · Cited by 46 · see citing works
Pierdomenico, A. M., Recchiuti, A., Simiele, F., Codagnone, M., Mari, V. C., Davı̀, G., & Romano, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.592352 · Cited by 45 · see citing works
Cuello, F., Shankar‐Hari, M., Mayr, U., Yin, X., Marshall, M. J., Suna, G., Willeit, P., Langley, S. R., Jayawardhana, T., Zeller, T., et al. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m114.039446 · Cited by 43 · see citing works
Role of MicroRNAs in the development and function of innate immune cells
Kingsley, S. M. K., & Bhat, B. V. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1284212 · Cited by 43 · see citing works
Livshits, G., & Kalinkovich, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102267 · Cited by 37 · see citing works
Luo, B., Wang, Z., Zhang, Z., Shen, Z., & Zhang, Z. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.005 · Cited by 42 · see citing works
Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster
Curtale, G., Renzi, T. A., Mirolo, M., Drufuca, L., Albanese, M., Luca, M. D., Rossato, M., Bazzoni, F., & Locati, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02037 · Cited by 40 · see citing works
Liu, W., Yang, Y.-H., Wang, Y.-C., Chang, W., & Wang, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311012 · Cited by 39 · see citing works
Dinu, A. R., Rogobete, A. F., Bratu, T., Popovici, S. E., Bedreag, O. H., Păpurică, M., Bratu, T., & Săndesc, D. (2020) · Cells · doi:10.3390/cells9020307 · Cited by 38 · see citing works
Wang, J. C.-F., & Strichartz, G. R. (2017) · Journal of Pain · doi:10.1016/j.jpain.2016.12.012 · Cited by 38 · see citing works
Micro RNA s in neutrophils: potential next generation therapeutics for inflammatory ailments
Gurol, T., Zhou, W., & Deng, Q. (2016) · Immunological Reviews · doi:10.1111/imr.12450 · Cited by 36 · see citing works
Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review
Maiese, A., Scatena, A., Costantino, A., Chiti, E., Occhipinti, C., Russa, R. L., Paolo, M. D., Turillazzi, E., Frati, P., & Fineschi, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169354 · Cited by 33 · see citing works
Specialized Pro-Resolving Lipid Mediators: Emerging Therapeutic Candidates for Multiple Sclerosis
Zahoor, I., & Giri, S. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08796-4 · Cited by 33 · see citing works
Roles of Specialized Pro-Resolving Lipid Mediators in Cerebral Ischemia Reperfusion Injury
Yin, P., Wei, Y., Wang, X., Zhu, M., & Feng, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00617 · Cited by 33 · see citing works
Pastore, M., Grimaudo, S., Pipitone, R. M., Lori, G., Raggi, C., Petta, S., & Marra, F. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00604 · Cited by 31 · see citing works
Duality of lipid mediators in host response against Mycobacterium tuberculosis: good cop, bad cop
Dietzold, J., Gopalakrishnan, A., & Salgame, P. R. (2015) · F1000Prime Reports · doi:10.12703/p7-29 · Cited by 27 · see citing works
Păpurică, M., Rogobete, A. F., Săndesc, D., Cradigati, C. A., Sărăndan, M., Crişan, D., Horhat, F. G., Borugă, O., Dumache, R., Kundnani, N. R., et al. (2016) · Biochemical Genetics · doi:10.1007/s10528-016-9727-z · Cited by 28 · see citing works
D‐series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution
Ganesan, R., Henkels, K. M., Shah, K. N., de la Rosa, X., Libreros, S., Cheemarla, N. R., Serhan, C. N., & Gómez-Cambronero, J. (2020) · The FASEB Journal · doi:10.1096/fj.201903025rr · Cited by 28 · see citing works
Self-citationBalta, M. G., Papathanasiou, E., & CHRISTOPOULOS, P. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.632238 · Cited by 28 · see citing works
Fibrinogen-like protein 2 controls sepsis catabasis by interacting with resolvin Dp5
Zhou, Y. J., Lei, J., Xie, Q., Wu, L., Jin, S., Guo, B., Wang, X., Yan, G., Zhang, Q., Zhao, H., et al. (2019) · Science Advances · doi:10.1126/sciadv.aax0629 · Cited by 27 · see citing works
Self-citationMolecular Pharmacology of Inflammation Resolution in Atherosclerosis
Kotlyarov, S. N., & Котлярова, А. А. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094808 · Cited by 30 · see citing works
The roles of special proresolving mediators in pain relief
Lan-yu, Z., Jia, M., & Sun, T. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0074 · Cited by 27 · see citing works
MicroRNAs as Regulators of Phagocytosis
Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25 · see citing works
Lastrucci, C., Baillif, V., Béhar, A., Saati, T. A., Dubourdeau, M., Maridonneau‐Parini, I., & Cougoule, C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259341 · Cited by 25 · see citing works
Molecular Pathways Linking Oxylipins to Nociception in Rats
Domenichiello, A. F., Sapio, M. R., Loydpierson, A. J., Maric, D., Goto, T., Horowitz, M. S., Keyes, G. S., Yuan, Z., Majchrzak‐Hong, S. F., Mannes, A. J., et al. (2020) · Journal of Pain · doi:10.1016/j.jpain.2020.09.001 · Cited by 24 · see citing works
Are miRNAs critical determinants in herpes simplex virus pathogenesis?
Bhela, S., & Rouse, B. T. (2017) · Microbes and Infection · doi:10.1016/j.micinf.2017.12.007 · Cited by 23 · see citing works
Zhou, S., Dong, X., Zhang, C., Chen, X., Zhu, J., Li, W., Song, X., Xu, Z., Zhang, W., Yang, X., et al. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.10.001 · Cited by 22 · see citing works
Self-citationClinical significance of polyunsaturated fatty acids in the prevention of cardiovascular diseases
Kotlyarov, S. N., & Котлярова, А. А. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.998291 · Cited by 21 · see citing works
Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression
Chen, J., Adamiak, W., Huang, G., Atasoy, U., Rostami, A. M., & Yu, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-17371-5 · Cited by 22 · see citing works
The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities*
Deutschman, C. S., Hellman, J., Ferrer, R., Backer, D. D., & Coopersmith, C. M. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004408 · Cited by 20 · see citing works
Kumar, V., Yasmeen, N., Chaudhary, A. A., Alawam, A. S., Al-Zharani, M. M., Basher, N. S., Harikrishnan, S., Goud, M. D., Pandey, A., Lakhawat, S. S., et al. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1104577 · Cited by 20 · see citing works
HIF-2α-dependent induction of miR-29a restrains TH1 activity during T cell dependent colitis
Czopik, A. K., McNamee, E. N., Vaughn, V., Huang, X., Bang, I. H., Clark, T., Wang, Y., Ruan, W., Nguyen, T. T., Masterson, J. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52113-y · Cited by 19 · see citing works
Synthesis of maresin 1 and (7S)-isomer
Ogawa, N., Tojo, T., & Kobayashi, Y. (2014) · Tetrahedron Letters · doi:10.1016/j.tetlet.2014.03.065 · Cited by 19 · see citing works
Feng, X., Maze, M., Koch, L. G., Britton, S. L., & Hellman, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126906 · Cited by 18 · see citing works
Mehrpouya‐Bahrami, P., Miranda, K., Singh, N. P., Zumbrun, E. E., Nagarkatti, M., & Nagarkatti, P. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005094 · Cited by 18 · see citing works
Ungaro, F., D’Alessio, S., & Danese, S. (2020) · Cancers · doi:10.3390/cancers12082060 · Cited by 18 · see citing works
Lei, J., Zhou, Y. J., Zhao, H., Chen, Y., Yan, G., Wu, L., Xu, Y., Zhang, J., Zhang, X., Wang, J., et al. (2021) · Theranostics · doi:10.7150/thno.50182 · Cited by 17 · see citing works
Self-citationParikh, M., Kura, B., O’Hara, K. A., Dibrov, E., Netticadan, T., Slezák, J., & Pierce, G. N. (2020) · Biomolecules · doi:10.3390/biom10091297 · Cited by 16 · see citing works
The surviving sepsis campaign: basic/translational science research priorities
Deutschman, C. S., Hellman, J., Ferrer, R., Backer, D. D., Coopersmith, C. M., Coopersmith, C. M., Backer, D. D., Antonelli, M. M., Deutschman, C. S., Evans, L., et al. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00312-4 · Cited by 13 · see citing works
Hellman, J. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005088 · Cited by 13 · see citing works
Luca, L., Rogobete, A. F., & Bedreag, O. H. (2015) · The Journal of Critical Care Medicine · doi:10.1515/jccm-2015-0014 · Cited by 12 · see citing works
Yan, C., Guan, F., Shen, Y., Tang, H., Yuan, D., Gao, H., & Xu, F. (2016) · Mediators of Inflammation · doi:10.1155/2016/9201604 · Cited by 12 · see citing works
Dexmedetomidine promotes inflammation resolving through TGF-β1 secreted by F4/80+Ly6G+ macrophage
Li, L.-C., Tian, Y., Xiao, J., Yang, Y., Wu, J.-N., Chen, Y., Zhang, P., Smith, F. G., Wang, J., & Jin, S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107480 · Cited by 11 · see citing works
Sun, Y., Xian, Y., Duan, Z., Wan, Z., Li, J., Liao, Y., Bi, X., Wu, Z., Wang, L., & Zhang, K. (2022) · Cells · doi:10.3390/cells11192961 · Cited by 10 · see citing works
Linking Lipid Metabolism and Immune Function: New Insights into Chronic Respiratory Diseases
Kotlyarov, S. N. (2025) · Pathophysiology · doi:10.3390/pathophysiology32020026 · Cited by 9 · see citing works
Use of circulating microRNAs as biomarkers in critically ill polytrauma patients
Bedreag, O. H., Rogobete, A. F., Dumache, R., Sărăndan, M., Cradigati, C. A., Păpurică, M., Crăciunescu, M., Popa, D. M., Luca, L., Nartiţă, R., et al. (2015) · Biomarkers and Genomic Medicine · doi:10.1016/j.bgm.2015.11.002 · Cited by 9 · see citing works
miR-31: a key player in CD8 T-cell exhaustion
Bhela, S., & Rouse, B. T. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.89 · Cited by 7 · see citing works
Hemin impairs resolution of inflammation via microRNA‐144‐3p‐dependent downregulation of ALX/FPR2
Sun, G., Lu, Y. W., Zhao, L., Xia, W., Zhang, H., Wang, L., Zhang, L., & Wen, A. (2018) · Transfusion · doi:10.1111/trf.14991 · Cited by 7 · see citing works
Serna, E., Llorca, A. P., Panadero, J., Vento, M., & Cernada, M. (2021) · Diagnostics · doi:10.3390/diagnostics11081389 · Cited by 7 · see citing works
Evaluation of Cancer Cell Growth Suppressibility of ω-3 Fatty Acids and Their Metabolites
Tojo, T., Tsuruoka, M., Kondo, T., & Yuasa, M. (2022) · Journal of Oleo Science · doi:10.5650/jos.ess22183 · Cited by 6 · see citing works
Shomali, N., Mahmoodpoor, A., Abad, A. N. A., Marofi, F., Akbari, M., Hua-xi, X., & Shotorbani, S. S. (2020) · Immunological Investigations · doi:10.1080/08820139.2020.1817067 · Cited by 6 · see citing works
Regulation of Histone Acetylation During Inflammation Resolution
Gong, L., Lei, J., Zhou, Y. J., Zhang, J., Wu, L., Chen, Y., Liu, X., & Li, Y. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s537242 · Cited by 5 · see citing works
Self-citationLipoxins, Resolvins, and the Resolution of Inflammation
Recchiuti, A., Cianci, E., Simiele, F., & Romano, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-27766-0_10 · Cited by 4 · see citing works
- Authors
- Li, Y., Dalli, J., Chiang, N., Baron, R. M., Quintana, C., & Serhan, C. N.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Serhan, Charles N.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 39
- Issue
- 5
- Pages
- 885-898
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC3888517
- OpenAlex
- W1971880637
- Cited by
- 126
- References
- 48
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 17 · 2019: 10 · 2018: 15 · 2017: 11 · 2016: 12 · 2015: 12 · 2014: 15 · 2013: 1
- FWCI
- 12.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (P01HL108801, R01HL112747)
- National Institute of General Medical Sciences (P01GM095467, R01GM038765)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- microRNA, specialized pro-resolving mediators, resolvin D1, resolvin D5, maresin 1, neutrophils, macrophages, prostanoids, apoptotic neutrophils, sepsis, activator protein-1, nuclear factor-kappaB, microRNA biogenesis
- MeSH terms
- Acute Disease, Animals, Chemotaxis, Docosahexaenoic Acids, Gene Expression Regulation, Humans, Macrophages, Male, Neutrophils, Peritonitis, Phagocytosis, Transcription, Genetic, Zymosan, NF-kappa B, Apoptosis, Sepsis, Transcription Factor AP-1, Inflammation Mediators, MicroRNAs, Mice
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