Opinion of the Scientific Committee on a request from EFSA related to a generic approach to the safety assessment by EFSA of microorganisms used in food/feed and the production of food/feed additives: Opinion of the Scientific Committee on a request from EFSA related to a generic approach to the safety assessment by EFSA of microorganisms used in fo

European Commission 2003 On a generic approach to the safety assessment of microorganisms used in feed/food and feed/food production europa.eu.int/comm/food/fs/sc/scf/out178_en.pdf

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Criteria to Qualify Microorganisms as “Probiotic” in Foods and Dietary Supplements

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Introduction of a Qualified Presumption of Safety (QPS) approach for assessment of selected microorganisms referred to EFSA - Opinion of the Scientific Committee: Introduction of a Qualified Presumption of Safety (QPS) approach for assessment of selected microorganisms referred to EFSA - Opinion of the Scientifi

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Biocontrol yeasts: mechanisms and applications

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Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA†

(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Gironés, R., Herman, L., Koutsoumanis, K. P., Lindqvist, R., et al. (2017) · EFSA Journal · doi:10.2903/j.efsa.2017.4664 · Cited by 460 · see citing works

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 13: suitability of taxonomic units notified to EFSA until September 2020

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6377 · Cited by 443 · see citing works

Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2013 update)

(BIOHAZ), E. P. O. B. H. (2013) · EFSA Journal · doi:10.2903/j.efsa.2013.3449 · Cited by 326 · see citing works

Scientific Opinion on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA (2017–2019)

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., De Cesare, A., Hilbert, F., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.5966 · Cited by 294 · see citing works

Secondary metabolite production and the safety of industrially important members of the Bacillus subtilis group

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Physiology of Acetic Acid Bacteria and Their Role in Vinegar and Fermented Beverages

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Beneficial lactobacilli in food and feed: long-term use, biodiversity and proposals for specific and realistic safety assessments

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Guidance of the Scientific Panel of Food Contact Material, Enzymes, Flavourings and Processing Aids (CEF) on the Submission of a Dossier on Food Enzymes for Safety Evaluation

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Probiotics and phytogenics for poultry: Myth or reality?

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Probiotics: From Isolation to Application

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Qualified presumption of safety (QPS): a generic risk assessment approach for biological agents notified to the European Food Safety Authority (EFSA)

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 12: suitability of taxonomic units notified to EFSA until March 2020

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., De Cesare, A., Hilbert, F., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.6174 · Cited by 169 · see citing works

Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2012 update)

(BIOHAZ), E. P. O. B. H. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.3020 · Cited by 163 · see citing works

Update of the list of qualified presumption of safety (QPS) recommended microorganisms intentionally added to food or feed as notified to EFSA

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K. P., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Cesare, A. D., Hilbert, F., Lindqvist, R., et al. (2023) · EFSA Journal · doi:10.2903/j.efsa.2023.7747 · Cited by 167 · see citing works

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 15: suitability of taxonomic units notified to EFSA until September 2021

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., De Cesare, A., Hilbert, F., et al. (2022) · EFSA Journal · doi:10.2903/j.efsa.2022.7045 · Cited by 143 · see citing works

The use of probiotic bacteria against Aeromonas infections in salmonid aquaculture

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Considerations for determining safety of probiotics: A USP perspective

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History of safe use as applied to the safety assessment of novel foods and foods derived from genetically modified organisms

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Diversity and safety hazards of bacteria involved in meat fermentations

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Regulatory and Safety Requirements for Food Cultures

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Comparative accounts of probiotic characteristics of Bacillus spp. isolated from food wastes

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Unlocking the Potential of Probiotics: A Comprehensive Review on Research, Production, and Regulation of Probiotics

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 5: suitability of taxonomic units notified to EFSA until September 2016

(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Gironés, R., Koutsoumanis, K., Herman, L., Lindqvist, R., et al. (2017) · EFSA Journal · doi:10.2903/j.efsa.2017.4663 · Cited by 115 · see citing works

Protection activity of a novel probiotic strain of Bacillus subtilis against Salmonella Enteritidis infection

Thirabunyanon, M., & Thongwittaya, N. (2012) · Research in Veterinary Science · doi:10.1016/j.rvsc.2011.08.008 · Cited by 99 · see citing works

Characterization of antimicrobial resistance in lactobacilli and bifidobacteria used as probiotics or starter cultures based on integration of phenotypic and in silico data

Rozman, V., Lorbeg, P. M., Accetto, T., & Matijašić, B. B. (2019) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2019.108388 · Cited by 93 · see citing works

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 7: suitability of taxonomic units notified to EFSA until September 2017

(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Gironés, R., Koutsoumanis, K. P., Lindqvist, R., Nørrung, B., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5131 · Cited by 90 · see citing works

Buffalo Milk as a Source of Probiotic Functional Products

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Statement on the update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 3: Suitability of taxonomic units notified to EFSA until September 2015

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Perspectives and advances in probiotics and the gut microbiome in companion animals

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 10: Suitability of taxonomic units notified to EFSA until March 2019

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2019) · EFSA Journal · doi:10.2903/j.efsa.2019.5753 · Cited by 90 · see citing works

Screening of Bacteriocinogenic Lactic Acid Bacteria and Their Characterization as Potential Probiotics

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Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 8: Suitability of taxonomic units notified to EFSA until March 2018

(BIOHAZ), E. P. O. B. H., Ricci, A., Allende, A., Bolton, D., Chemaly, M., Davies, R., Fernández Escámez, P. S., Girones, R., Koutsoumanis, K., Lindqvist, R., et al. (2018) · EFSA Journal · doi:10.2903/j.efsa.2018.5315 · Cited by 72 · see citing works

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 14: suitability of taxonomic units notified to EFSA until March 2021

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6689 · Cited by 60 · see citing works

Statement on how to interpret the QPS qualification on ‘acquired antimicrobial resistance genes’

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Microbial food cultures – opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG)

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 9: suitability of taxonomic units notified to EFSA until September 2018

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Hilbert, F., Lindqvist, R., et al. (2019) · EFSA Journal · doi:10.2903/j.efsa.2019.5555 · Cited by 59 · see citing works

Recent investigations and updated criteria for the assessment of antibiotic resistance in food lactic acid bacteria

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Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2011 update)

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Legal aspects of microalgae in the European food sector

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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 17: suitability of taxonomic units notified to EFSA until September 2022

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Alvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., De Cesare, A., Hilbert, F., Lindqvist, R., et al. (2023) · EFSA Journal · doi:10.2903/j.efsa.2023.7746 · Cited by 56 · see citing works

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 21: Suitability of taxonomic units notified to EFSA until September 2024

(BIOHAZ), E. P. O. B. H., Allende, A., Álvarez‐Ordóñez, A., Bortolaia, V., Bover‐Cid, S., Cesare, A. D., Dohmen, W., Guillier, L., Jacxsens, L., Nauta, M. J., et al. (2025) · EFSA Journal · doi:10.2903/j.efsa.2025.9169 · Cited by 55 · see citing works

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 11: suitability of taxonomic units notified to EFSA until September 2019

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2020) · EFSA Journal · doi:10.2903/j.efsa.2020.5965 · Cited by 80 · see citing works

A Bacillus subtilis strain as probiotic in poultry: selection based on in vitro functional properties and enzymatic potentialities

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Perfume Guns: Potential of Yeast Volatile Organic Compounds in the Biological Control of Mycotoxin-Producing Fungi

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Purification and characterization of mejucin, a new bacteriocin produced by Bacillus subtilis SN7

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 6: suitability of taxonomic units notified to EFSA until March 2017

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Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 4: suitability of taxonomic units notified to EFSA until March 2016

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Effect of glucose and incubation temperature on metabolically active Lactobacillus plantarum from dadih in removing microcystin-LR

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Safety Assessment Systems for Microbial Starters Derived from Fermented Foods

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The role of probiotics in personalized therapeutics: Advances in gut microbe-driven interventions

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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 19: Suitability of taxonomic units notified to EFSA until September 2023

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The Crosstalk between the Gut Microbiota Composition and the Clinical Course of Allergic Rhinitis: The Use of Probiotics, Prebiotics and Bacterial Lysates in the Treatment of Allergic Rhinitis

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The Age of Next-Generation Therapeutic-Microbe Discovery: Exploiting Microbe-Microbe and Host-Microbe Interactions for Disease Prevention

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Assessment of Bacillus subtilis SN7 as a starter culture for Cheonggukjang , a Korean traditional fermented soybean food, and its capability to control Bacillus cereus in Cheonggukjang

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Obesity as the 21st Century's major disease: The role of probiotics and prebiotics in prevention and treatment

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Update of the list of QPS‐recommended microbiological agents intentionally added to food or feed as notified to EFSA 16: suitability of taxonomic units notified to EFSA until March 2022

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Strategies for the Development of Bioprotective Cultures in Food Preservation

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Update of the list of QPS‐recommended biological agents intentionally added to food or feeds as notified to EFSA

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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 20: Suitability of taxonomic units notified to EFSA until March 2024

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Dietary Supplementation With a Bacillus Superoxide Dismutase Protects Against γ-Radiation-induced Oxidative Stress and Ameliorates Dextran Sulphate Sodium-induced Ulcerative Colitis in Mice

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Immunomodulation by genetically engineered lactic acid bacteria

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Comparative Effects of Using New Multi-Strain Synbiotics on Chicken Growth Performance, Hematology, Serum Biochemistry and Immunity

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Antibiotic Resistance Profile of Microbes From Traditional Fermented Foods

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DNA microarray based detection of genes involved in safety and technologically relevant properties of food associated coagulase-negative staphylococci

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Altered gut microbiota in hepatocellular carcinoma: Insights into the pathogenic mechanism and preclinical to clinical findings

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Safety and Protective Effectiveness of Two Strains of Lactobacillus with Probiotic Features in an Experimental Model of Salmonellosis

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Effects of synbiotics on the gut microbiota, blood and rearing parameters of chickens

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Probiotic Microorganisms

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Occurrence and carcinogenic risk assessment of N-nitrosamines in some dried aquatic products in China

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The probiotic supplementation role in improving the immune system among people with ulcerative colitis: a narrative review

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Study on the Potential Probiotics Isolated from Marine Aquaculture System and Evaluation for Aquaculture Application

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Overview on biotics development

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Use of Dietary Probiotics to Improve Laying Hen Performance

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Lactic Acid Bacteria and Bacillus subtilis as Potential Protective Cultures for Biopreservation in the Food Industry

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Enterococcus Species: Multifaceted Probiotic Potential and Safety Considerations

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Assessment of the safety of “probiotics” in food supplements

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Suggestion of a Safety Evaluation Procedure to Improve Probiotic Safety

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Механизмы действия пробиотиков на основе Bacillus subtilis

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Characterization of feline-originated probiotics Lactobacillus rhamnosus CACC612 and Bifidobacterium animalis subsp. lactis CACC789 and evaluation of their host response

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Synbiotics: safety and toxicity considerations

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Microbial Ecology and Nutritional Features in Liquid Sourdough Containing Hemp Flour Fermented by Lactic Acid Bacterial Strains

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Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 23: Suitability of taxonomic units notified to EFSA until September 2025

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Characterization and probiotic potential of thermotolerant lactic acid bacteria from silage for ensiling crop residues

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Knowledge, attitude, and practice of Chinese parents with infants (aged 0–3 years) toward immunity, gut microbiota and biotics: a comprehensive study

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Main achievements and challenges of the EFSA Scientific Committee since its inception

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Development of microencapsulated dried Bacillus sp. 63‐11 with enhanced shelf stability and bioactivity for use as a food supplement

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Phenotypic and genotypic characterization of probiotic strains in the context of antimicrobial resistance

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Biotechnological potential and genomic analysis of the Leuconostoc mesenteroides F17 and F18 strains isolated from camel milk

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Antibiotic Resistance Gene Expression in Veterinary Probiotics: Two Sides of the Coin

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Migration of phthalates from packaging and contact materials into foods: Review of models

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Scientific Opinion on the safety evaluation of the substance, titanium nitride, nanoparticles, for use in food contact materials

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Significance of Perfluoroalkyl Substances (PFAS) in Food Packaging

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Large-scale in silico screening of compounds contained in printing inks for food packaging materials

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