Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
Open accessAbstract
OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. METHODS: The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice. The circadian rhythm recovery patterns were collected through motor activities measured by Mlog system. Depressive and manic proneness were examined by forced swim test and quinpirole-induced open field test respectively. Enzyme-linked immunosorbent assay was employed to measure PKC activities. RESULTS: The delayed recovery group presented greater locomotor activities than the early recovery group (p=0.033). The delayed recovery group had significantly lower frontal PKC activity than the other (p=0.041). The former showed lower frontal/cerebellar PKC activity ratio (p=0.047) but higher striatal/frontal (p=0.038) and hippocampal/frontal (p=0.007) PKC activities ratios than the latter. CONCLUSION: These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern.
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Studies on circadian disruption in ICR mice by inverting the light-dark cycle for 3 days reported that approximately half of the mice fail to recover normal sleep-wake cycles within 6 days after re-exposure to normal lighting conditions.
“Studies on circadian disruption in ICR mice, by inverting the LD cycle for 3 days, have reported that approximately half of the mice fail to recover normal sleep-wake cycles within 6 days after re-exposure to normal lighting conditions.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [138]
The Methods (Animals and Experimental procedure; page numbers unavailable) confirm that ICR mice underwent an inverted light–dark cycle. But the inversion lasted two weeks, not three days, and the recovery times were measured before the return to normal lighting. The Methods (Measurements) report that 85% recovered within six days, not that approximately half failed to recover by then. (LLM, conf=0.90)
Experimental — accuracy not yet measuredMice that took longer to re-entrain normal sleep-wake rhythms after circadian disruption also displayed greater quinpirole-induced hyperactivity, indicative of a more mania-like state, however depressive-like behavior (forced swim test) was not affected.
“The mice that took longer to re-entrain normal sleep-wake rhythms after circadian disruption also displayed greater quinpirole-induced hyperactivity, indicative of a more mania-like state, however depressive-like behavior (forced swim test) was not affected137,138.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [138]
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- Authors
- Moon, E., Choe, B.-M., Park, J.-M., Chung, Y. I., Lee, B. D., Park, J.-H., Lee, Y. M., Jeong, H. J., Cheon, Y., Choi, Y., & Park, J.
- Affiliations
- Pusan National University Hospital (KR)
- Dong-A University (KR)
- Pusan National University (KR)
- Corresponding author
- Park, Je-Min
- ORCID
- Venue
- Psychiatry Investigation
- Publisher
- Korean Neuropsychiatric Association
- Published
- 2018-09-25
- Volume
- 15
- Issue
- 9
- Pages
- 907-913
- ISSN
- 1738-3684 (ISSN-L)
- 1976-3026
- PMC
- PMC6166033
- OpenAlex
- W2890138246
- Cited by
- 8
- References
- 46
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Psychiatry Investigation (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- protein kinase C, circadian rhythm disruption, bipolar disorder, depression-like behavior, manic-like behavior, frontal cortex, striatum, hippocampus, cerebellum, mood regulation
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