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Resting-State Brain Function Alteration in Colorectal Cancer Patients

Xu, Yanan, Ma, Zihan, Chen, Jieyu, Zhang, Huiyan, Shen, Guo, Huang, Gang, Zhang, Wenwen, Zhao, Lianping·2024·Journal of Integrative Neuroscience
DOI 10.31083/j.jin2308151
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Abstract

Background and Purpose: To investigate the abnormal pattern of altered functional activity in the brain and the neuroimaging mechanisms underlying the cognitive impairment of patients with colorectal cancer (CRC) via resting-state functional magnetic resonance imaging (rs-fMRI). Materials and Methods: CRC patients (n = 56) and healthy controls (HCs) (n = 50) were studied. The participants underwent rs-fMRI scans and the Montreal Cognitive Assessment (MoCA). The amplitude of low-frequency fluctuations (ALFF), degree centrality (DC), regional homogeneity (ReHo), and MoCA scores, were calculated for participants. Results: The scores of executives, visuospatial, memory, language and attention were lower in CRC patients. ReHo and ALFF values in the left postcentral gyrus, ReHo values in the right postcentral gyrus, ALFF and DC values in the left middle occipital gyrus, ReHo and DC values in the right lingual gyrus, DC values in the right angular gyrus and precuneus, and ALFF values in the left middle temporal gyrus decreased conspicuously in the CRC patients. Conclusion: CRC patients have abnormal resting state function, mainly in the brain areas involved in cognitive function. The overlapping brain regions with abnormal functional indicators are in the middle occipital gyrus, postcentral gyrus, and lingual gyrus. This study reveals the potential biological pathways involved in brain impairment and neurocognitive decline in patients with CRC.

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Metadata

Authors
Xu, Y., Ma, Z., Chen, J., Zhang, H., Shen, G., Huang, G., Zhang, W., & Zhao, L.
Venue
Journal of Integrative Neuroscience
Publisher
IMR Press
Published
2024-08-19
Volume
23
Issue
8
ISSN
  • 0219-6352
  • 1757-448X
DOI
10.31083/j.jin2308151
Cited by
4
References
3
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)
Funders
Natural Science Foundation of Gansu Province (23JRRA1772)

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CoChat. (2026). Citation check: Resting-State Brain Function Alteration in Colorectal Cancer Patients. https://app.cochat.ai/papers/10.31083/j.jin2308151
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Xu, Y., Ma, Z., Chen, J., Zhang, H., Shen, G., Huang, G., Zhang, W., & Zhao, L. (2024). Resting-State Brain Function Alteration in Colorectal Cancer Patients. Journal of Integrative Neuroscience. https://doi.org/10.31083/j.jin2308151

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