Cited by 587Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 233 of the 234 references it cites were found in a registry or an index.

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

Cai, Zhiyou, Hussain, M. Delwar, Yan, Liang-Jun·2014·International Journal of Neuroscience

DOI 10.3109/00207454.2013.833510

Open this paper in CoChat — free account

Abstract

Compelling evidence from basic molecular biology has demonstrated the dual roles of microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are involved in AD pathogenesis by releasing inflammatory mediators such as inflammatory cytokines, complement components, chemokines, and free radicals that are all known to contribute to beta-amyloid (Aβ) production and accumulation. On the other hand, microglia are also known to play a beneficial role in generating anti-Aβ antibodies and stimulating clearance of amyloid plaques. Aβ itself, an inducer of microglia activation and neuroinflammation, has been considered as an underlying and unifying factor in the development of AD. A vicious cycle of inflammation has been formed between Aβ accumulation, activated microglia, and microglial inflammatory mediators, which enhance Aβ deposition and neuroinflammation. Thus, inhibiting the vicious cycle seems to be a promising treatment to restrain further development of AD. With increasing research efforts on microglia in AD, intervention of microglia activation and neuroinflammation in AD may provide a potential target for AD therapy in spite of the provisional failure of nonsteroidal antiinflammatory drugs in clinical trials.

Integrity signals

Registry

Crossref · 10.3109/00207454.2013.833510

Cites

233 of 233 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329
Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
Goedert, M., Spillantini, M. G., Cairns, N. J., & Crowther, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90117-v · Cited by 1,122
Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention
Liu, B., & Hong, J.-S. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035048 · Cited by 1,095
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039
Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress
Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 1,013
Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease
Bell, R. D., & Zloković, B. V. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0522-3 · Cited by 883
Matrix metalloproteinases in neuroinflammation
Rosenberg, G. A. (2002) · Glia · doi:10.1002/glia.10108 · Cited by 868
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855
Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.
Tilg, H., Trehu, E., Atkins, M., Dinarello, C., & Mier, J. (1994) · Blood · doi:10.1182/blood.v83.1.113.113 · Cited by 817

Show all 234 references

Research works printed but not linked: 24

Dubinina EE, 2007, Adv Gerontol, 20, 109
Weitz TM, 2012, Int J Alzheimer's Dis, 2012, 314185
Imamoto K, 1981, Prog Clin Biol Res, 59, 125
Wierzba-Bobrowicz T, 2002, Folia Neuropathol, 40, 125
Krause DL, 2010, Int J Alzheimer's Dis, 2010, doi: 10.4061/20 · DOI
Sochocka M, 2013, CNS Neurol Disord Drug Targets
Lampron A, 2013, J Comp Neurol
McLarnon JG, 2012, Am J Neurodegener Dis, 1, 199
Thanopoulou K, 2010, Proc Natl Acad Sci USA, 107, 20816, 10.1073/pnas.1005888107 · DOI · Paper page
Pflanzner T, 2010, Neurobiol Aging, 32, 2323
Lee KW, 2009, J Neurochem, 108, 165
10.1002/glia.10108 · DOI
Eckman EA, 2005, Biochem Soc Trans, 33, 1101, 10.1042/BST0331101 · DOI
10.1111/j.14714159.2010.06899.x · DOI
Zou K, 2008, Rev Neurosci, 19, 203
10.1523/JNEUROSCI.0616-08.2008 · DOI · Paper page
Chiarini A, 2006, Ital J Anat Embryol, 111, 221
Samuelsson M, 2005, Int J Mol Med, 16, 449
Yan SD, 1998, Restor Neurol Neurosci, 12, 167
Gan L, 2004, J Biol Chem, 279, 5565, 10.1074/jbc.M306183200 · DOI
Lee HS, 2007, Pharmazie, 62, 937
Wilkinson K, 2012, Int J Alzheimer's Dis, 2012, 489456
Nakamura K, 2006, J Neurosci Res, 84, 874, 10.1002/jnr.20992 · DOI
Christie RH, 1996, Am J Pathol, 148, 399

Sorted by citations

Items 201–300 of 587

Amyloid Proteins and Peripheral Neuropathy
Albariqi, M. M. H., Engelsman, S., Eijkelkamp, N., & Höppener, J. W. M. (2020) · Cells · doi:10.3390/cells9061553 · Cited by 41
Betaine Mitigates Amyloid-β-Associated Neuroinflammation by Suppressing the NLRP3 and NF-κB Signaling Pathways in Microglial Cells
Zhang, Y., & Jia, J. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230064 · Cited by 35
Multiple Metabolites Derived from Mushrooms and Their Beneficial Effect on Alzheimer’s Diseases
Tong, Z., Chu, G., Wan, C., Wang, Q., Yang, J., Meng, Z., Du, L., Yang, J., & Ma, H. (2023) · Nutrients · doi:10.3390/nu15122758 · Cited by 37
Dihydro‐resveratrol ameliorates NLRP3 inflammasome‐mediated neuroinflammation via Bnip3‐dependent mitophagy in Alzheimer's disease
Tao, G., Wang, X., Wang, J., Ye, Y., Zhang, M., Yan, L., & Ding, S. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17373 · Cited by 36
A novel therapeutic potential of cysteinyl leukotrienes and their receptors modulation in the neurological complications associated with Alzheimer's disease
Rahman, S. O., Singh, R. K., Hussain, S., Akhtar, M., & Najmi, A. K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.10.040 · Cited by 35
Protective effects of curcumin against neuroinflammation induced by Aβ25-35 in primary rat microglia: modulation of high-mobility group box 1, toll-like receptor 4 and receptor for advanced glycation end products expression
He, W., Yuan, K., Ji, B., Han, Y., & Li, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2019.12.147 · Cited by 34
Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer’s Disease
Wan, T., Fu, M., Jiang, Y., Jiang, W., Li, P., & Zhou, S. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03448-1 · Cited by 38
Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer’s disease pathology in mouse models
Manchanda, S., Galán-Acosta, L., Abelein, A., Tambaro, S., Chen, G., Nilsson, P., & Johansson, J. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.08.010 · Cited by 34
The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons
Sharma, M., Pal, P., & Gupta, S. K. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148797 · Cited by 34
The role of estrogen in Alzheimer’s disease pathogenesis and therapeutic potential in women
Wang, X., Feng, S., Deng, Q., Wu, C., Duan, R., & Yang, L. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05071-4 · Cited by 40
REMOVED: Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease
Sharma, H. S., Muresanu, D. F., Nozari, A., Lafuente, J. V., Tian, Z. R., Ozkızılcık, A., Manzhulo, I., Mössler, H., & Sharma, A. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.03.009 · Cited by 33
Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease
Li, P., Wu, Y., Hamlett, E. D., Goodwin, A. J., Halushka, P. V., Carroll, S. L., Liu, M., & Fan, H. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.023 · Cited by 33
Microglia and Cholesterol Handling: Implications for Alzheimer’s Disease
Herrera, O. M. M., & Zivkovic, A. M. (2022) · Biomedicines · doi:10.3390/biomedicines10123105 · Cited by 38
Recent Trends in the Management of Alzheimer’s Disease: Current Therapeutic Options and Drug Repurposing Approaches
Singh, R. K. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200128121920 · Cited by 32
MicroRNA-132-3p alleviates neuron apoptosis and impairments of learning and memory abilities in Alzheimer’s disease by downregulation of HNRNPU stabilized BACE1
Qu, J., Xiong, X., Hujie, G., Ren, J., Yan, L., & Ma, L. (2021) · Cell Cycle · doi:10.1080/15384101.2021.1982507 · Cited by 30
Inhibition of GPR17 with cangrelor improves cognitive impairment and synaptic deficits induced by Aβ1–42 through Nrf2/HO-1 and NF-κB signaling pathway in mice
Jin, S., Wang, X., Xiang, X., Wu, Y., Hu, J., Li, Y., Dong, Y. L., Tan, Y., & Wu, X. G. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108335 · Cited by 33
Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.
Daulatzai, M. A. (2016) · Europe PMC (PubMed Central) · Cited by 31
Microglia in Alzheimer's Disease: The Role of Stem Cell-Microglia Interaction in Brain Homeostasis
Bagheri‐Mohammadi, S. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03162-4 · Cited by 30
Phytohormone Abscisic Acid Improves Memory Impairment and Reduces Neuroinflammation in 5xFAD Mice by Upregulation of LanC-Like Protein 2
Jeon, S. H., Kim, N., Ju, Y., Gee, M. S., Lee, D., & Lee, J. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228425 · Cited by 32
Disrupting Neurons and Glial Cells Oneness in the Brain—The Possible Causal Role of Herpes Simplex Virus Type 1 (HSV-1) in Alzheimer’s Disease
Mielcarska, M. B., Skowrońska, K., Wyżewski, Z., & Toka, F. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010242 · Cited by 32
The Neuroprotective Effect of Byu d Mar 25 in LPS-Induced Alzheimer's Disease Mice Model
Liu, L., Zhang, Y., Tang, L., Zhong, H., Danzeng, D., Liang, C., & Liu, S. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/8879014 · Cited by 30
A 4.7-kDa polysaccharide from Panax ginseng suppresses Aβ pathology via mitophagy activation in cross-species Alzheimer’s disease models
Zhang, S., Liu, F., Li, J., Jing, C., Lü, J., Chen, X., Wang, D., Cao, D., Zhao, D., & Sun, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115442 · Cited by 32
Principles for central nervous system inflammation research: A call for a consortium approach
Rogers, J. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.01.008 · Cited by 30
GPETAFLR, a peptide from Lupinus angustifolius L. prevents inflammation in microglial cells and confers neuroprotection in brain
Lemus‐Conejo, A., Millán-Linares, M. C., Toscano, R., Millán, F., Pedroche, J., Muriana, F. J. G., & la Paz, S. M. (2020) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1763058 · Cited by 30
Extracellular Vesicles Released from Neprilysin Gene-Modified Human Umbilical Cord-Derived Mesenchymal Stem Cell Enhance Therapeutic Effects in an Alzheimer’s Disease Animal Model
Jeong, H., Kim, O. J., Oh, S., Lee, S., Lee, H. A. R., Lee, K. O., Lee, B.-Y., & Kim, N. K. (2021) · Stem Cells International · doi:10.1155/2021/5548630 · Cited by 33
Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer’s Disease
Ma, X., Zhang, Y., Gou, D., Ma, J., Du, J., Wang, C., Li, S., & Cui, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220227 · Cited by 30
Protection of Radial Glial-Like Cells in the Hippocampus of APP/PS1 Mice: a Novel Mechanism of Memantine in the Treatment of Alzheimer’s Disease
Sun, D., Chen, J., Bao, X., Cai, Y., Zhao, J., Huang, J., Huang, W. Y., Fan, X., & Xu, H. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8875-6 · Cited by 30
Fundamental role of pan-inflammation and oxidative-nitrosative pathways in neuropathogenesis of Alzheimer's disease in focal cerebral ischemic rats.
Daulatzai, M. A. (2016) · Europe PMC (PubMed Central) · Cited by 60
Retracted
Amyloid beta deposition related retinal pigment epithelium cell impairment and subretinal microglia activation in aged APPswePS1 transgenic mice
Dong, Z., Li, J., Gan, Y., Sun, X., Leng, Y., & Ge, J. (2018) · International Journal of Ophthalmology · doi:10.18240/ijo.2018.05.06 · Cited by 27
Dysfunctional proteins in neuropsychiatric disorders: From neurodegeneration to autism spectrum disorders
Jęśko, H. M., Cieślik, M., Gromadzka, G., & Adamczyk, A. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104853 · Cited by 30
Activated microglia–induced neuroinflammatory cytokines lead to photoreceptor apoptosis in Aβ-injected mice
Wu, J., Gao, G., Shi, F., Xie, H., Yang, Q., Liu, D., Qu, S., Qin, H., Zhang, C., Xu, G., et al. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02046-6 · Cited by 28
Propofol Mediated Protection of the Brain From Ischemia/Reperfusion Injury Through the Regulation of Microglial Connexin 43
Zhang, T., Wang, Y., Qin, X., Tu, Z., Sun, J.-J., Jing, Q., Chen, P., & Zhao, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637233 · Cited by 29
Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations
Mijailović, N. R., Vesić, K., Arsenijević, D., Milojević‐Rakić, M., & Borovčanin, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.923811 · Cited by 29
Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake
Marcos, J. L., Olivares-Barraza, R., Ceballo, K., Wastavino, M., Ortiz, V., Riquelme, J., Martínez-Pinto, J., Muñoz, P., Cruz, G., & Sotomayor‐Zárate, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021468 · Cited by 33
Anti-Neuroinflammatory Effects of Ginkgo biloba Extract EGb 761 in LPS-Activated BV2 Microglial Cells
Sun, L., Apweiler, M., Tirkey, A., Klett, D., Normann, C., Dietz, G. P. H., Lehner, M. D., & Fiebich, B. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158108 · Cited by 30
Cannabinoid Receptor 2 (CB2R) as potential target for the pharmacological treatment of neurodegenerative diseases
Meanti, R., Bresciani, E., Rizzi, L., Molteni, L., Coco, S., Omeljaniuk, R. J., & Torsello, A. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118044 · Cited by 30
IgM response against amyloid-beta in aging: a potential peripheral protective mechanism
Agrawal, S., Abud, E. M., Snigdha, S., & Agrawal, A. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0412-9 · Cited by 29
The β‐secretase (BACE) inhibitor NB‐360 in preclinical models: From amyloid‐β reduction to downstream disease‐relevant effects
Neumann, U., Machauer, R., & Shimshek, D. R. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14582 · Cited by 27
Inflammatory and Pro-resolving Mediators in Frontotemporal Dementia and Alzheimer’s Disease
Fraga, V. G., Magalhaes, C. A., Loures, C. D. M. G., de Souza, L. C., Guimarães, H. C., Zauli, D. A. G., Ferriani, M. D. G. C., Ferreira, C. N., Caramelli, P., Sousa, L. P., et al. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.008 · Cited by 28
Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice
Li, X., Zhang, H., Liu, Y., Dong, X., Han, Y., Su, Y., Li, W., & Li, W. (2023) · Behavioral and Brain Functions · doi:10.1186/s12993-023-00209-8 · Cited by 28
Potential Retinal Biomarkers in Alzheimer’s Disease
García-Bermúdez, M. Y., Vohra, R., Freude, K., van Wijngaarden, P., Martin, K. R. G., Thomsen, M. S., Aldana, B. I., & Kolko, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115834 · Cited by 30
The Role of Reactive Oxygen Species in Alzheimer's Disease: From Mechanism to Biomaterials Therapy
Yu, Z., & Luo, F. H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304373 · Cited by 30
Alzheimer’s Disease Etiology Hypotheses and Therapeutic Strategies: A Perspective
Scarano, N., Musumeci, F., Casini, B., Brullo, C., D’Ursi, P., Fossa, P., Schenone, S., & Cichero, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146980 · Cited by 32
Usnic acid enantiomers restore cognitive deficits and neurochemical alterations induced by Aβ1–42 in mice
Cazarin, C. A., Dalmagro, A. P., Gonçalves, A. E., Boeing, T., da Silva, L. M., Corrêa, R., Klein‐Júnior, L. C., Pinto, B. C., Lorenzett, T. S., Sobrinho, T. U. D. C., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112945 · Cited by 28
Fish, n-3 fatty acids, cognition and dementia risk: not just a fishy tale
Saleh, R. N. M., & Minihane, A. M. (2021) · Proceedings of The Nutrition Society · doi:10.1017/s0029665121003700 · Cited by 28
Animal Models for Neuroinflammation and Potential Treatment Methods
Tamura, Y., Yamato, M., & Kataoka, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.890217 · Cited by 30
Exosomes: A missing link between chronic systemic inflammation and Alzheimer’s disease?
Ozansoy, M., Mikati, H., Velioğlu, H. A., & Yuluğ, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114161 · Cited by 30
Personalized Biochemistry and Biophysics
Kroncke, B. M., Vanoye, C. G., Meiler, J., George, A. L., & Sanders, C. R. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00189 · Cited by 27
Activation of the IL-17/TRAF6/NF-κB pathway is implicated in Aβ-induced neurotoxicity
Liu, Y., Meng, Y., Zhou, C., Yan, J., Guo, C., & Dong, W. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00782-8 · Cited by 28
Clathrin mediated endocytosis in Alzheimer’s disease: cell type specific involvement in amyloid beta pathology
Jaye, S., Sandau, U. S., & Saugstad, J. A. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1378576 · Cited by 26
Ambroxol attenuates detrimental effect of LPS-induced glia-mediated neuroinflammation, oxidative stress, and cognitive dysfunction in mice brain
Ullah, S., Park, T. J., Park, J. S., Atiq, A., Ali, J., Kang, M. H., Ali, W., Choe, K., & Kim, M. O. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1494114 · Cited by 27
Parametric mapping using spectral analysis for 11C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects
Fan, Z., Dani, M., Femminella, G. D., Wood, M., Calsolaro, V., Veronese, M., Turkheimer, F., Gentleman, S., Brooks, D. J., Hinz, R., et al. (2018) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-018-3984-5 · Cited by 28
MFG-E8 inhibits Aβ-induced microglial production of cathelicidin-related antimicrobial peptide: A suitable target against Alzheimer’s disease
Xu, X., Cai, X., Zhu, Y., He, W., Wu, Q., Shi, X., Fang, Y., & Pei, Z. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.05.008 · Cited by 26
Challenges in the treatment of Alzheimer’s disease: recent progress and treatment strategies of pharmaceuticals targeting notable pathological factors
Kuo, Y., & Rajesh, R. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1621750 · Cited by 27
The Perfect Cytokine Storm: How Peripheral Immune Challenges Impact Brain Plasticity & Memory Function in Aging
Muscat, S. M., & Barrientos, R. M. (2021) · Brain Plasticity · doi:10.3233/bpl-210127 · Cited by 26
Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
Kim, B., Lee, K. Y., & Park, B. (2021) · Molecules · doi:10.3390/molecules26227056 · Cited by 26
Neuroprotective Effect of α-Lipoic Acid against Aβ25–35-Induced Damage in BV2 Cells
Pei, X., Hu, F., Hu, Z., Luo, F., Li, X., Xing, S., Sun, L., & Long, D. (2023) · Molecules · doi:10.3390/molecules28031168 · Cited by 26
Nitric Oxide Influences HSV-1-Induced Neuroinflammation
Cymerys, J., Kowalczyk, A., Mikołajewicz, K., Słońska, A., & Krzyżowska, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/2302835 · Cited by 26
Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion
Ortega‐Martínez, S., Palla, N., Zhang, X., Lipman, E., & Sisodia, S. S. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0884-19.2019 · Cited by 27
Anti-Inflammatory Anthranilate Analogue Enhances Autophagy through mTOR and Promotes ER-Turnover through TEX264 during Alzheimer-Associated Neuroinflammation.
Wang, Z.-Y., Huang, J.-B., Yang, S.-P., & Weaver, D. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00818 · Cited by 25
Modulation of MAPK- and PI3/AKT-Dependent Autophagy Signaling by Stavudine (D4T) in PBMC of Alzheimer’s Disease Patients
Rosa, F. L., Zoia, C., Bazzini, C., Bolognini, A., Saresella, M., Conti, E., Ferrarese, C., Piancone, F., Marventano, I., Fenoglio, C., et al. (2022) · Cells · doi:10.3390/cells11142180 · Cited by 25
Impaired autophagy in amyloid-beta pathology: A traditional review of recent Alzheimer's research
Yuan, M., Wang, Y., Huang, Z., Jing, F., Qiao, P., Zou, Q., Li, J., & Cai, Z. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220145 · Cited by 26
Interleukin 22 and its association with neurodegenerative disease activity
Chen, W., Wang, J., Yang, H., Sun, Y., Chen, B., Liu, Y., Han, Y., Shan, M., & Zhan, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.958022 · Cited by 27
Levels of Soluble Interleukin 6 Receptor and Asp358Ala Are Associated With Cognitive Performance and Alzheimer Disease Biomarkers
Quillen, D., Hughes, T. M., Craft, S., Howard, T. D., Register, T. C., Suerken, C. K., Hawkins, G. A., & Milligan, C. (2023) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000200095 · Cited by 24
Antioxidants and Dementia Risk: Consideration through a Cerebrovascular Perspective
Lam, V., Hackett, M. J., & Takechi, R. (2016) · Nutrients · doi:10.3390/nu8120828 · Cited by 26
Targeting Microglial Population Dynamics in Alzheimer’s Disease: Are We Ready for a Potential Impact on Immune Function?
Martin-Estebane, M., & Gomez-Nicola, D. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00149 · Cited by 25
RETRACTED: 5-HT1AR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice
Wang, M., Zong, H.-F., Chang, K.-W., Han, H., Rizvi, M. Y., Neha, S. I., Li, Z., Yang, W., & Qian, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106354 · Cited by 24
Retracted
PC12 and THP-1 Cell Lines as Neuronal and Microglia Model in Neurobiological Research
Balon, K., & Wiatrak, B. (2021) · Applied Sciences · doi:10.3390/app11093729 · Cited by 23
Bridging Cyanobacteria to Neurodegenerative Diseases: A New Potential Source of Bioactive Compounds against Alzheimer’s Disease
Castañeda, A., Ferraz, R., Vieira, M., Cardoso, I., Vasconcelos, V. M., & Martins, R. F. (2021) · Marine Drugs · doi:10.3390/md19060343 · Cited by 25
Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice
Xu, X., Du, L., Jiang, J., Yang, M., Wang, Z., Wang, Y., Tang, T., Fu, X., & Hao, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.716917 · Cited by 25
MiR-191-5p alleviates microglial cell injury by targeting Map3k12 (mitogen-activated protein kinase kinase kinase 12) to inhibit the MAPK (mitogen-activated protein kinase) signaling pathway in Alzheimer’s disease
Wan, W., Liu, G., Li, X., Liu, Y., Wang, Y., Pan, H., & Hu, J. (2021) · Bioengineered · doi:10.1080/21655979.2021.2008638 · Cited by 25
Microglia and microglial-based receptors in the pathogenesis and treatment of Alzheimer’s disease
Wang, Z., & Weaver, D. F. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109070 · Cited by 26
Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer’s disease via inhibiting NF-κB signaling pathway
Li, H., Sun, J., Miao, Z., Chen, S., & Yang, G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13411 · Cited by 24
The elusive role of herpesviruses in Alzheimer’s disease: current evidence and future directions
Piotrowski, S. L., Tucker, A., & Jacobson, S. (2023) · NeuroImmune Pharmacology and Therapeutics · doi:10.1515/nipt-2023-0011 · Cited by 24
Resveratrol targeting tau proteins, amyloid‐beta aggregations, and their adverse effects: An updated review
Ashrafizadeh, M., Zarrabi, A., Najafi, M., Samarghandian, S., Mohammadinejad, R., & Ahn, K. S. (2020) · Phytotherapy Research · doi:10.1002/ptr.6732 · Cited by 24
Chemerin-9 Peptide Enhances Memory and Ameliorates Aβ1–42-Induced Object Memory Impairment in Mice
Lei, Z., Lu, Y., Bai, X., Jiang, Z., & Yu, Q. (2020) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00510 · Cited by 23
Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses
Solomon, S., Sampathkumar, N. K., Carre, I., Mondal, M., Chennell, G., Vernon, A. C., Ruepp, M.-D., & Mitchell, J. C. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04473-1 · Cited by 23
“In addition, BV2 cells generally display a small round body with no obvious extensions, similar to the amoeboidlike state reported in vivo [22]; however, when transfected with PLCγ2 construct these cells displayed a bigger, elongated phenotype with several cytoplasmic extensions, possibly indicating a more ramified st…”
Background
Evaluation of Anticonvulsant Activity of Dual COX-2/5-LOX Inhibitor Darbufelon and Its Novel Analogues
Mishchenko, M., Shtrygol’, S., Lozynskyi, A., Khomyak, S., Novikov, V. P., Karpenko, O., Holota, S. M., & Lesyk, R. (2021) · Scientia Pharmaceutica · doi:10.3390/scipharm89020022 · Cited by 23
Isorhamnetin Attenuated the Release of Interleukin‐6 from β‐Amyloid‐Activated Microglia and Mitigated Interleukin‐6‐Mediated Neurotoxicity
Wei, P., Lee‐Chen, G., Chen, C., Chen, Y., Lo, Y., & Chang, K. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3652402 · Cited by 26
Gardenia jasminoides J.Ellis extract GJ-4 alleviated cognitive deficits of APP/PS1 transgenic mice
Zang, C., Liu, H., Shang, J., Yang, H., Wang, L., Sheng, C., Zhang, Z., Bao, X., Yu, Y., Yao, X., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153780 · Cited by 22
The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
Tian, Y., Milic, J., Monasor, L. S., Chakraborty, R., Wang, S., Yuan, Y., Asare, Y., Behrends, C., Tahirović, S., & Bernhagen, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04911-8 · Cited by 22
Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities
Olajide, T. S., Oyerinde, T. O., Omotosho, O. I., Okeowo, O. M., Olajide, O. J., & Ijomone, O. M. (2024) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.56 · Cited by 24
Neuroinflammation and Alzheimer's disease: Unravelling the molecular mechanisms
Kakkar, A., Singh, H., Singh, B. K., Kumar, A., Mishra, A. K., & Chopra, H. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251374353 · Cited by 26
Design, synthesis, and biological evaluation of furosemide analogs as therapeutics for the proteopathy and immunopathy of Alzheimer's disease
Wang, Z., Wang, Y., Pasangulapati, J. P., Stover, K. R., Liu, X., Schier, S., & Weaver, D. F. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113565 · Cited by 22
Anti-inflammatory Activity of a Polypeptide Fraction From Achyranthes bidentate in Amyloid β Oligomers Induced Model of Alzheimer’s Disease
Ge, X., Wang, Y., Yu, S., Cao, X., Chen, Y., Cheng, Q., & Ding, F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.716177 · Cited by 22
PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk
Lindman, K. L., Jonsson, C., Weidung, B., Olsson, J., Pandey, J. P., Prokopenko, D., Tanzi, R. E., Hallmans, G., Eriksson, S., Elgh, F., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-17058-6 · Cited by 24
Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases
Wei, R., Wei, P., Yuan, H., Yi, X., Aschner, M., Jiang, Y., & Li, S. (2024) · Biological Trace Element Research · doi:10.1007/s12011-023-04041-z · Cited by 24
Trajectory of brain-derived amyloid beta in Alzheimer’s disease: where is it coming from and where is it going?
Liu, N., Haziyihan, A., Zhao, W. G., Chen, Y., & Chao, H. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00434-9 · Cited by 21
Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa
Zhang, L., Cui, X., Jauregui, R., Park, K. S., Justus, S., Tsai, Y.-T., Duong, J., Hsu, C., Wu, W.-H., Xu, C. L., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.06.014 · Cited by 22
A multifunctional bis-(−)-nor-meptazinol-oxalamide hybrid with metal-chelating property ameliorates Cu(II)-induced spatial learning and memory deficits via preventing neuroinflammation and oxido-nitrosative stress in mice
Tan, X., Zhou, Y., Gong, P., Guan, H., Wu, B., Hou, L., Feng, X., Zheng, W., & Li, J. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.12.014 · Cited by 22
Recent Updates in the Alzheimer’s Disease Etiopathology and Possible Treatment Approaches: A Narrative Review of Current Clinical Trials
Zarini-Gakiye, E., Amini, J., Sanadgol, N., Vaezi, G., & Kazem, P. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200422090135 · Cited by 22
The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors
Vermersch, P., Airas, L., Berger, T., Deisenhammer, F., Grigoriadis, N., Hartung, H.-P., Magyari, M., Popescu, V., Pozzilli, C., Pugliatti, M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1495529 · Cited by 21
Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice
Bao, J., Liang, Z., Gong, X., Zhao, Y., Wu, M., Liu, W., Tu, C., Wang, X., & Shu, X. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c07241 · Cited by 21
Targeting the liver in dementia and cognitive impairment: Dietary macronutrients and diabetic therapeutics
Hunt, N. J., Wahl, D., Westwood, L. J., Lockwood, G. P., Couteur, D. G. L., & Cogger, V. C. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114537 · Cited by 21
Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective
Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 25
Long‐Term High‐Fat Diet Consumption Aggravates β‐Amyloid Deposition and Tau Pathology Accompanied by Microglial Activation in an Alzheimer's Disease Model
Liang, Z., Gong, X., Zhao, Y., Zhao, Y., Yu, J., Huang, T., Yang, C., Wu, L., Huang, M., Wang, X., et al. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300669 · Cited by 22
Chlamydia pneumoniae in Alzheimer's disease pathology
Subedi, L., Gaire, B. P., Koronyo, Y., Koronyo‐Hamaoui, M., & Crother, T. R. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1393293 · Cited by 24
The prokineticin receptor antagonist PC1 rescues memory impairment induced by β amyloid administration through the modulation of prokineticin system
Maftei, D., Ratano, P., Fusco, I., Marconi, V., Squillace, S., Negri, L., Severini, C., Balboni, G., Steardo, L., Bronzuoli, M. R., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107739 · Cited by 24
Characterizing the Molecular Architecture of Cortical Regions Associated with High Educational Attainment in Older Individuals
Bartrés‐Faz, D., González‐Escamilla, G., Vaqué‐Alcázar, L., Abellaneda‐Pérez, K., Valls‐Pedret, C., Ros, E., & Grothe, M. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2370-18.2019 · Cited by 22
Association of cholinergic basal forebrain volume and functional connectivity with markers of inflammatory response in the Alzheimer’s disease spectrum
Teipel, S. J., Dyrba, M., Ballarini, T., Brosseron, F., Bruno, D., Buerger, K., Cosma, N.-C., Dechent, P., Dobisch, L., Düzel, E., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215196 · Cited by 20

Authors: Cai, Z., Hussain, M. D., & Yan, L.-J.
Affiliations: Anhui Medical University (CN)
Texas A&M Health Science Center (US)
University of North Texas Health Science Center (US)
Corresponding author: Cai, Zhiyou
ORCID: Cai, Zhiyou
Hussain, M. Delwar
Yan, Liang-Jun
Venue: International Journal of Neuroscience
Publisher: Informa UK Limited
Published: 2013-09-12
Volume: 124
Issue: 5
Pages: 307-321
ISSN: 0020-7454 (ISSN-L)
1543-5245
DOI: 10.3109/00207454.2013.833510
OpenAlex: W2096407545
Cited by: 583
References: 234
Citations by year: 2026: 17 · 2025: 45 · 2024: 72 · 2023: 86 · 2022: 67 · 2021: 82 · 2020: 72 · 2019: 54 · 2018: 45 · 2017: 13 · 2016: 14 · 2015: 12 · 2014: 3 · 2013: 1
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: microglia, neuroinflammation, amyloid-beta, Alzheimer's disease, microglial activation, inflammatory cytokines, complement system, chemokines, free radicals, amyloid plaque clearance, anti-amyloid antibodies, anti-inflammatory therapy
MeSH terms: Alzheimer Disease, Humans, Inflammation, Amyloid beta-Peptides, Microglia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks