Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

The pro- and anti-inflammatory properties of the cytokine interleukin-6

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Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

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Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

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Microglia and neuroinflammation: a pathological perspective

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Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

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Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

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Matrix metalloproteinases in neuroinflammation

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Oxidative Stress and the Pathogenesis of Alzheimer's Disease

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Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.

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Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

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An 18-Year Follow-up of Overweight and Risk of Alzheimer Disease

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Does neuroinflammation fan the flame in neurodegenerative diseases?

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Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

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Mitochondrial Defects and Oxidative Stress in Alzheimer Disease and Parkinson Disease

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Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

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Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

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CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation

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β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587

RAGE, LRP-1, and amyloid-beta protein in Alzheimer’s disease

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Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme

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CD36 Mediates the Innate Host Response to β-Amyloid

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The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

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A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

Ryu, J. K., & McLarnon, J. G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00434.x · Cited by 406

Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia

Grathwohl, S. A., Kälin, R. E., Bolmont, T., Prokop, S., Winkelmann, G., Kaeser, S. A., Odenthal, J., Radde, R., Eldh, T., Gandy, S., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2432 · Cited by 401

CD36, a Class B Scavenger Receptor, Is Expressed on Microglia in Alzheimer's Disease Brains and Can Mediate Production of Reactive Oxygen Species in Response to β-Amyloid Fibrils

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SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ‐Degrading Enzymes in Alzheimer's Disease

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Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures

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Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease

Deane, R., & Zloković, B. V. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362245 · Cited by 365

Microglia Function in Alzheimer’s Disease

Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 361

Education and Alzheimer disease without dementia

Roe, C. M., Xiong, C., Miller, J. P., & Morris, J. C. (2007) · Neurology · doi:10.1212/01.wnl.0000251303.50459.8a · Cited by 354

Neuroinflammation in Alzheimer's Disease and Mild Cognitive Impairment: A Field in Its Infancy

McGeer, E. G., & McGeer, P. L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1219 · Cited by 353

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism

Akama, K. T., Albanese, C., Pestell, R. G., & Eldik, L. J. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5795 · Cited by 345

Stroke and the Risk of Alzheimer Disease

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Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

Kraft, A. D., & Harry, G. J. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8072980 · Cited by 340

Fibrillar Amyloid-β Peptides Activate Microglia via TLR2: Implications for Alzheimer’s Disease

Jana, M., Palencia, C. A., & Pahan, K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.7254 · Cited by 338

Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease

Patel, N. S., Paris, D., Mathura, V. S., Quadros, A., Crawford, F., & MULLAN, M. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-9 · Cited by 335

A CD36-initiated Signaling Cascade Mediates Inflammatory Effects of β-Amyloid

Moore, K. J., El Khoury, J., Medeiros, L. A., Terada, K., Geula, C., Luster, A. D., & Freeman, M. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208788200 · Cited by 327

Inflammatory Cytokines in Acute Ischemic Stroke

Tuttolomondo, A., Di Raimondo, D., di Sciacca, R., Pinto, A., & Licata, G. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786848739 · Cited by 325

β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils

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Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

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Enhanced Risk for Alzheimer Disease in Persons With Type 2 Diabetes and APOE ε4

Irie, F., Fitzpatrick, A. L., López, O. L., Kuller, L. H., Peila, R., Newman, A. B., & Launer, L. J. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.29 · Cited by 306

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

Harry, G. J., & Kraft, A. D. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.10.1265 · Cited by 304

The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival

Carson, M. J., Cameron Thrash, J., & Walter, B. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.004 · Cited by 299

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia

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Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

Maezawa, I., Zimin, P. I., Wulff, H., & Jin, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135244 · Cited by 293

Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy

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Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer’s disease

Pan, X.-D., Zhu, Y.-G., Lin, N., Zhang, J., Ye, Q.-Y., Huang, H.-P., & Chen, X.-C. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-45 · Cited by 292

Microglial and Astrocyte Chemokines Regulate Monocyte Migration through the Blood-Brain Barrier in Human Immunodeficiency Virus-1 Encephalitis

Persidsky, Y., Ghorpade, A., Rasmussen, J., Limoges, J., Liu, X. J., Stins, M. F., Fiala, M., Way, D., Kim, K. S., Witte, M. H., et al. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65476-4 · Cited by 284

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

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Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

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Oxidative stress and β-amyloid protein in Alzheimer’s disease

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Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia

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Immunological Findings in Autism

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Role of the β‐amyloid protein in Alzheimer's disease

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Neuroinflammation in Alzheimer's Disease and Parkinson's Disease: Are Microglia Pathogenic in Either Disorder?

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The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate

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β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors

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IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

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Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer’s disease.

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Inflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders

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Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients

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Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

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β-Amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1

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Aβ-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention

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RAGE: A Potential Target for Aβ-Mediated Cellular Perturbation in Alzheimers Disease

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Microglial Scavenger Receptors and Their Roles in the Pathogenesis of Alzheimer's Disease

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β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway

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The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

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Alzheimer's Disease: A General Introduction and Pathomechanism

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Gene expression changes by amyloid β peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes

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Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells

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3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors Attenuate β-Amyloid-Induced Microglial Inflammatory Responses

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Protective effects of an anti‐inflammatory cytokine, interleukin‐4, on motoneuron toxicity induced by activated microglia

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Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

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A Dual Role of Lipocalin 2 in the Apoptosis and Deramification of Activated Microglia

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MAPK-activated Protein Kinase 2 Deficiency in Microglia Inhibits Pro-inflammatory Mediator Release and Resultant Neurotoxicity

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Microglial secreted cathepsin B induces neuronal apoptosis

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Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer’s disease

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Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β

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Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor

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Soluble CCL5 Derived from Bone Marrow-Derived Mesenchymal Stem Cells and Activated by Amyloid β Ameliorates Alzheimer's Disease in Mice by Recruiting Bone Marrow-Induced Microglia Immune Responses

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Ginger Extract Inhibits β-Amyloid Peptide–Induced Cytokine and Chemokine Expression in Cultured THP-1 Monocytes

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Inhibition by Naloxone Stereoisomers of β-Amyloid Peptide (1–42)-induced Superoxide Production in Microglia and Degeneration of Cortical and Mesencephalic Neurons

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β-Amyloid Protein Structure Determines the Nature of Cytokine Release From Rat Microglia

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Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation.

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