Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

The pro- and anti-inflammatory properties of the cytokine interleukin-6

Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212

Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

Goedert, M., Spillantini, M. G., Cairns, N. J., & Crowther, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90117-v · Cited by 1,122

Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

Liu, B., & Hong, J.-S. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035048 · Cited by 1,095

Microglia and neuroinflammation: a pathological perspective

Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039

Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress

Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 1,013

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

Bell, R. D., & Zloković, B. V. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0522-3 · Cited by 883

Matrix metalloproteinases in neuroinflammation

Rosenberg, G. A. (2002) · Glia · doi:10.1002/glia.10108 · Cited by 868

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.

Tilg, H., Trehu, E., Atkins, M., Dinarello, C., & Mier, J. (1994) · Blood · doi:10.1182/blood.v83.1.113.113 · Cited by 817

Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways

Ji, Y.-J., Kim, S., Kim, J.-J., Jang, G. Y., Moon, M., & Kim, H. D. (2021) · Antioxidants · doi:10.3390/antiox10121968 · Cited by 20

Advances in Studies on Stroke-Induced Secondary Neurodegeneration (SND) and Its Treatment

Datta, A., Sarmah, D., Kalia, K., Borah, A., Wang, X., Dave, K. R., Yavagal, D. R., & Bhattacharya, P. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200416090820 · Cited by 18

MiR‐483‐3p improves learning and memory abilities via XPO1 in Alzheimer's disease

Luo, G., Wang, X., & Liu, C. (2022) · Brain and Behavior · doi:10.1002/brb3.2680 · Cited by 20

2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic receptor back into play

Infantino, R., Boccella, S., Scuteri, D., Perrone, M., Ricciardi, F., Vitale, R. M., Bonsale, R., Parente, A., Allocca, I., Virtuoso, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113844 · Cited by 19

An in situ-triggered and chemi-excited photooxygenation system for Aβ aggregates

Yang, J., Chi, W., Shi, W.-J., Zhang, L., & Yan, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.140998 · Cited by 20

Exploring the Potential of Aptamers in Targeting Neuroinflammation and Neurodegenerative Disorders: Opportunities and Challenges

Kong, A. H.-Y., Wu, A. J., Ho, O. K.-Y., Leung, M. M.-K., Huang, S., Yu, Y., Zhang, G., Lü, A., Li, M., & Cheung, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411780 · Cited by 22

Current Perspectives and Mechanisms of Relationship between Intestinal Microbiota Dysfunction and Dementia: A Review

Welcome, M. O. (2018) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000492491 · Cited by 22

Dementia and depression: Biological connections with amyloid β protein

dos Santos, H. M., Bertollo, A. G., Mingoti, M. E. D., Grolli, R. E., Kreuz, K. M., & Ignácio, Z. M. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13996 · Cited by 19

Intranasal MMI-0100 Attenuates Aβ1−42- and LPS-Induced Neuroinflammation and Memory Impairments via the MK2 Signaling Pathway

Jiang, J., Wang, Z., Liang, X., Nie, Y., Chang, X., Xue, H., Li, S., & Chang, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02707 · Cited by 19

Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases: a role of mitochondria targeted catalase and xanthophylls

Filippov, M. A., Tatarnikova, O. G., Pozdnyakova, N. V., & Vorobyov, V. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.290878 · Cited by 21

NEUROINFLAMAÇÃO NA DOENÇA DE ALZHEIMER

Machado, A. P. R., Carvalho, I. O., & Sobrinho, H. M. D. R. (2020) · Revista Brasileira Militar de Ciências · doi:10.36414/rbmc.v6i14.33 · Cited by 67

Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice

Gao, J., Wang, L., Zhao, C., Wu, Y., Lu, Z., Gu, Y., Ba, Z., Wang, X., Wang, J., & Xu, Y. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0821-639rr · Cited by 18

Epigenomic and Other Evidence for Cannabis-Induced Aging Contextualized in a Synthetic Epidemiologic Overview of Cannabinoid-Related Teratogenesis and Cannabinoid-Related Carcinogenesis

Reece, A. S., & Hulse, G. K. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192416721 · Cited by 19

Targeting Progranulin as an Immuno-Neurology Therapeutic Approach

Boylan, M. A., Pincetic, A., Romano, G. J., Tatton, N. A., Kenkare-Mitra, S., & Rosenthal, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115946 · Cited by 19

COVID-19 and Alzheimer’s Disease Share Common Neurological and Ophthalmological Manifestations: A Bidirectional Risk in the Post-Pandemic Future

Amadoro, G., Latina, V., Stigliano, E., & Micera, A. (2023) · Cells · doi:10.3390/cells12222601 · Cited by 20

Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology

Kaur, S., Sharma, K., Sharma, A., Sandha, K. K., Ali, S. M., Ahmed, R., Ramajayan, P., Singh, P. P., Ahmed, Z., & Kumar, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1418422 · Cited by 17

A domestic strain of Lactobacillus rhamnosus attenuates cognitive deficit and pro-inflammatory cytokine expression in an animal model of Alzheimer’s disease

Heydari, R., Khosravifar, M., Abiri, S., Dashtbin, S., Alvandi, A., Nedaei, S. E., Salimi, Z., Zarei, F., & Abiri, R. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115277 · Cited by 19

A Review of the Consequences of Gut Microbiota in Neurodegenerative Disorders and Aging

Menezes, A. A., & Shah, Z. A. (2024) · Brain Sciences · doi:10.3390/brainsci14121224 · Cited by 20

Investigating the Spatial Associations Between Amyloid-β Deposition, Grey Matter Volume, and Neuroinflammation in Alzheimer’s Disease

Jorge, L., Martins, R., Canário, N., Xavier, A. C., Abrunhosa, A., Santana, I. J., & Castelo-Branco, M. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200840 · Cited by 19

A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice

Abd‐Elrahman, K. S., Colson, T. L., Sarasija, S., & Ferguson, S. S. G. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116388 · Cited by 18

Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer’s-like Disease Rat Model

Sepúlveda, P., Ferreira, A. F. F., Sandoval, C., Bergoc, G. G., Moreno, A. C. R., Nunes, M. T., & Torrão, A. D. S. (2024) · Cells · doi:10.3390/cells13211793 · Cited by 22

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

Ahmadi, S., Khaledi, S., Ahmadi, K., & Hassanzadeh, K. (2025) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70688 · Cited by 20

Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease

Canário, N., Jorge, L., Martins, R., Santana, I. J., & Castelo-Branco, M. S. (2022) · Communications Biology · doi:10.1038/s42003-022-03761-7 · Cited by 21

Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia

Temviriyanukul, P., Chansawhang, A., Karinchai, J., Phochantachinda, S., Buranasinsup, S., Inthachat, W., Pitchakarn, P., & Chantong, B. (2023) · Nutrients · doi:10.3390/nu15051098 · Cited by 19

Residual microglia following short‐term PLX5622 treatment in 5xFAD mice exhibit diminished NLRP3 inflammasome and mTOR signaling, and enhanced autophagy

Kodali, M., Madhu, L. N., Somayaji, Y., Attaluri, S., Huard, C., Panda, P. K., Shankar, G., Rao, S., Shuai, B., Gonzalez, J. J., et al. (2024) · Aging Cell · doi:10.1111/acel.14398 · Cited by 18

The protective effect of betulinic acid on microvascular responsivity and protein expression in alzheimer disease induced by cerebral micro‐injection of beta‐amyloid and streptozotocin

Sarkaki, A., Farbood, Y., Badavi, M., Ghadiri, A., Dehcheshmeh, M. G., Mansouri, E., & Navabi, S. P. (2018) · Microcirculation · doi:10.1111/micc.12503 · Cited by 17

Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway

Qu, X., Guan, P., Han, L., Wang, Z., & Huang, X. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00943-1 · Cited by 18

Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease

Ilina, A., Khavinson, V., Linkova, N. S., & Petukhov, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084259 · Cited by 18

Glial Cells in the Early Stages of Neurodegeneration: Pathogenesis and Therapeutic Targets

Ahremenko, E. A., Andreev, A., Apushkin, D., & Korkotian, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262411995 · Cited by 20

Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer’s disease risk

Murcia, J. D. G., Weinert, A., Freitas, C. M. T., Arens, D. K., Ferrel, M., Grose, J. H., Ridge, P. G., Wilson, E., Kauwe, J. S. K., & Weber, K. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-64755-1 · Cited by 17

Complement protein levels in serum astrocyte-derived exosomes are associated with cognitive impairment in obstructive sleep apnea

Li, M., Sun, C., Xue, S., Leng, B., Sun, H., Shen, T., Liu, X., Li, Z., Shang, X., & Zhang, J. (2023) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10412 · Cited by 16

CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model

Ennerfelt, H. E., Holliday, C., Shapiro, D. A., Zengeler, K. E., Bolte, A. C., Ulland, T. K., & Lukens, J. R. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2303760120 · Cited by 16

Neurobiological role and therapeutic potential of exercise-induced irisin in Alzheimer's disease management

Ratne, N., Jari, S., Tadas, M., Katariya, R., Kale, M. B., Kotagale, N. R., Madia, D., Umekar, M. J., & Taksande, B. G. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102687 · Cited by 17

Potential new therapeutic target for Alzheimer's disease: Glucagon‐like peptide‐1

Liu, X., Zhang, N., Zhang, S., & Xu, P. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15502 · Cited by 16

Aberrant Cerebral Iron Trafficking Co-morbid With Chronic Inflammation: Molecular Mechanisms and Pharmacologic Intervention

Rosenblum, S. L., & Kosman, D. J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.855751 · Cited by 19

γ-Glutamylcysteine attenuates amyloid-β oligomers-induced neuroinflammation in microglia via blocking NF-κB signaling pathway

Bi, A., Wang, Y., Chen, L., Yin, Z., & Luo, L. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110019 · Cited by 17

Antagonism of cysteinyl leukotrienes and their receptors as a neuroinflammatory target in Alzheimer’s disease

Singh, R. K. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04369-7 · Cited by 16

Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice

Li, S., Sakurai, K., Ohgidani, M., Kato, T. A., & Hikida, T. (2023) · Molecular Brain · doi:10.1186/s13041-023-01047-5 · Cited by 16

Metformin Prevents NDEA-Induced Memory Impairments Associated with Attenuating Beta-Amyloid, Tumor Necrosis Factor-Alpha, and Interleukin-6 Levels in the Hippocampus of Rats

Ponce-López, T., Tostado, J. A. G. Á., Dias, F., & Maltez, K. H. M. (2023) · Biomolecules · doi:10.3390/biom13091289 · Cited by 16

Neuroinflammation in Alzheimer’s Disease: A Potential Role of Nose-Picking in Pathogen Entry via the Olfactory System?

Zhou, X., Kumar, P., Bhuyan, D. J., Jensen, S. O., Roberts, T. L., & Münch, G. W. (2023) · Biomolecules · doi:10.3390/biom13111568 · Cited by 17

Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomes

Lee, C.-Y., Riffle, D., Xiong, Y., Momtaz, N., Lei, Y., Pariser, J. M., Sikdar, D., Hwang, A., Duan, Z., & Zhang, J. (2024) · BMC Neuroscience · doi:10.1186/s12868-024-00867-y · Cited by 17

Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease

Hinteregger, B., Loeffler, T., Flunkert, S., Neddens, J., Bayer, T. A., Madl, T., & Hutter‐Paier, B. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201204 · Cited by 15

A State-of-Art Review of the Vicious Circle of Sleep Disorders, Diabetes and Neurodegeneration Involving Metabolism and Microbiota Alterations

Versace, S., Pellitteri, G., Sperotto, R., Tartaglia, S., Porto, A. D., Catena, C., Gigli, G. L., Cavarape, A., & Valente, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310615 · Cited by 17

Inflammation in the CNS: Understanding Various Aspects of the Pathogenesis of Alzheimer's Disease

Doroszkiewicz, J., Mroczko, P., & Kulczyńska‐Przybik, A. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211202143935 · Cited by 14

Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism

Abdel‐Aal, R. A., Hussein, O. A., Elsaady, R. G., & Abdelzaher, L. A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174695 · Cited by 17

Neuroprotective Effect of Stearidonic Acid on Amyloid β-Induced Neurotoxicity in Rat Hippocampal Cells

Li, Y., Lai, W., Chen, Z., Babu, J. R., Xue, C., Ai, Q., & Huggins, K. W. (2022) · Antioxidants · doi:10.3390/antiox11122357 · Cited by 14

Possible Implications of Obesity-Primed Microglia that Could Contribute to Stroke-Associated Damage

Carreto, R. J. R., Rodríguez-Cortés, Y. M., Guerrero, H. T., & Chavarría, A. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01329-5 · Cited by 15

Glaucocalyxin A as a natural product increases amyloid β clearance and decreases tau phosphorylation involving the mammalian target of rapamycin signaling pathway

Zhou, T., Zhuang, J., Wang, Z., Zhou, Y., Li, W., Wang, Z., & Zhu, Z. (2019) · Neuroreport · doi:10.1097/wnr.0000000000001202 · Cited by 14

Microglial responses after phagocytosis: Escherichia coli bioparticles, but not cell debris or amyloid beta, induce matrix metalloproteinase‐9 secretion in cultured rat primary microglial cells

Hamanaka, G., Kubo, T., Ohtomo, R., Takase, H., Reyes‐Bricio, E., Oribe, S., Osumi, N., Lok, J. M., Lo, E. H., & Arai, K. (2020) · Glia · doi:10.1002/glia.23791 · Cited by 14

A Preliminary Study of Cu Exposure Effects upon Alzheimer’s Amyloid Pathology

Pilozzi, A. R., Yu, Z., Carreras, I., Cormier, K., Hartley, D. M., Rogers, J. T., Dedeoglu, A., & Huang, X. (2020) · Biomolecules · doi:10.3390/biom10030408 · Cited by 14

Alzheimer's Disease Risk and Progression: The Role of Nutritional Supplements and their Effect on Drug Therapy Outcome

Giulietti, A., Vignini, A., Nanetti, L., Mazzanti, L., Primio, R. D., & Salvolini, E. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666150928155321 · Cited by 14

Microfluidic-Based Technologies for Crossing the Blood–Brain Barrier Against Alzheimer’s Disease: Novel Strategies and Challenges

Ferrari, I., Limiti, E., Giannitelli, S. M., Trombetta, M., Rainer, A., D’Amelio, M., Barbera, L. L., & Gori, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199478 · Cited by 15

Novel molecular mechanism driving neuroprotection after soluble epoxide hydrolase inhibition: Insights for Alzheimer's disease therapeutics

Griñán‐Ferré, C., Jarné‐Ferrer, J., Bellver‐Sanchís, A., Codony, S., Puigoriol‐Illamola, D., Sanfeliu, C., Oh, Y., Lee, S., Vázquez, S., & Pallàs, M. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14511 · Cited by 14

Ecklonia cava Ameliorates Cognitive Impairment on Amyloid β-Induced Neurotoxicity by Modulating Oxidative Stress and Synaptic Function in Institute of Cancer Research (ICR) Mice

Lee, H. L., Go, M. J., Lee, H. S., & Heo, H. J. (2024) · Antioxidants · doi:10.3390/antiox13080951 · Cited by 14

Neuroprotective and memory enhancing effects of Zataria multiflora in lipopolysaccharide-treated rats.

Arab, Z., Hosseini, M., Marefati, N., Beheshti, F., Anaeigoudari, A., Sadeghnia, H. R., & Boskabady, M. H. (2022) · PubMed Central · doi:10.30466/vrf.2020.117553.2786 · Cited by 14

Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

Wang, Y., Cui, Y., Liu, J., Qiao, S., Cao, M., Hou, Y., Zhang, X., & Wang, P. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01050-3 · Cited by 14

Electroacupuncture Improves Blood-Brain Barrier and Hippocampal Neuroinflammation in SAMP8 Mice by Inhibiting HMGB1/TLR4 and RAGE/NADPH Signaling Pathways

Wang, Y., Wang, Q., Luo, D., Zhao, P., Zhong, S.-S., Dai, B., Wang, J.-J., Wan, Y.-T., Liu, Z., & Yang, H. (2023) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-023-3592-5 · Cited by 14

Multifunctional Ligands Targeting Phosphodiesterase as the Future Strategy for the Symptomatic and Disease-Modifying Treatment of Alzheimer’s Disease

Jankowska, A., Wesołowska, A., Pawłowski, M., & Chłoń‐Rzepa, G. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190620095623 · Cited by 13

Intermittent Fasting and Brain Health: Efficacy and Potential Mechanisms of Action

Francis, N. (2020) · OBM Geriatrics · doi:10.21926/obm.geriatr.2002121 · Cited by 14

The Molecular Mechanism of Chronic High-Dose Corticosterone-Induced Aggravation of Cognitive Impairment in APP/PS1 Transgenic Mice

Zhang, S.-Q., Cao, L., Liang, Y.-Y., & Wang, P. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.613421 · Cited by 16

Porphyromonas gingivalis, neuroinflammation and Alzheimer’s disease

Owoyele, P. V., & Malekzadeh, S. (2022) · Nigerian Journal of Physiological Sciences · doi:10.54548/njps.v37i2.1 · Cited by 14

Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice

Yang, G., Tong, Y., Wang, X., Zhao, C., Ba, Z., Ahelijiang, R., Liu, X., Gao, W., Zhao, Y., Gu, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1185570 · Cited by 12

Modified TPP-MoS2 QD Blend as a Bio-Functional Model for Normalizing Microglial Dysfunction in Alzheimer’s Disease

Alomari, O. A., Qusti, S. Y., Balgoon, M. J., Aljoud, F., Alamry, K. A., & Hussein, M. A. (2023) · Neurology International · doi:10.3390/neurolint15030061 · Cited by 12

Asthma aggravates alzheimer's disease by up-regulating NF- κB signaling pathway through LTD4

Wang, X., Gan, W., Kang, M., Lv, C., Zhao, Z., Wu, Y., Zhang, X., & Wang, R. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148711 · Cited by 12

Exploring the Interplay between COVID-19 and Gut Health: The Potential Role of Prebiotics and Probiotics in Immune Support

Giovanetti, M., Pannella, G., Altomare, A., Rocchi, G., Guarino, M. P. L., Ciccozzi, M., Riva, E., & Gherardi, G. (2024) · Viruses · doi:10.3390/v16030370 · Cited by 13

The Gut Microbiota-Brain Axis: A New Frontier in Alzheimer's Disease Pathology

Dhanawat, M., Garima, G., Wilson, K., Gupta, S., Gupta, N., & Sardana, S. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273302508240613114103 · Cited by 13

Irisin and neuroinflammation: Challenges and opportunities

Sandoval, E. Y. H., & Gómez, Z. J. D. (2024) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2024.104941 · Cited by 13

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice

Shin, S. J., Jeong, Y.-O., Jeon, S. G., Kim, S., Lee, S.-K., Nam, Y., Park, Y., Kim, D., Lee, Y. S., Choi, H. S., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124026 · Cited by 12

Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease

Ma, W., Chen, A.-F., Xie, X., & Huang, Y. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108342 · Cited by 12

Somatostatin and Astroglial Involvement in the Human Limbic System in Alzheimer’s Disease

González-Rodríguez, M., Astillero‐Lopez, V., Villanueva‐Anguita, P., Paya-Rodriguez, M. E., Flores‐Cuadrado, A., Villar‐Conde, S., Úbeda‐Bañón, I., Martı́nez-Marcos, A., & Saiz‐Sánchez, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168434 · Cited by 12

Review of Current Strategies for Delivering Alzheimer's Disease Drugs Across the Blood-Brain Barrier

Wong, K. H., Riaz, M. K., Xie, Y., Zhang, X., Liu, Q., Chen, H., Bian, Z., Chen, X., Lü, A., & Yang, Z. (2022) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20106 · Cited by 12

Anti-inflammatory Action of BT75, a Novel RARα Agonist, in Cultured Microglia and in an Experimental Mouse Model of Alzheimer’s Disease

Zhang, X., Subbanna, S., Williams, C. R. O., Canals‐Baker, S., Smiley, J. F., Wilson, D. A., Das, B. C., & Saito, M. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03888-x · Cited by 12

Extract of Aster koraiensis Nakai Leaf Ameliorates Memory Dysfunction via Anti-inflammatory Action

Lee, S., Park, S., Jang, G. Y., Lee, J.-H., Moon, M., Ji, Y., Jung, J. W., Nam, Y., Shin, S. J., Lee, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065765 · Cited by 12

Upregulation of Prickle2 Ameliorates Alzheimer’s Disease-Like Pathology in a Transgenic Mouse Model of Alzheimer’s Disease

Sun, F.-X., Jiang, F., Zhang, N., Li, H., Tian, W., & Liu, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.565020 · Cited by 13

Hydrogen sulfide-induced post-translational modification as a potential drug target

Chen, H., Qian, L., Li, K., Qin, Y., Zhou, J., Ji, X., & Wu, D. (2022) · Genes & Diseases · doi:10.1016/j.gendis.2022.03.022 · Cited by 11

Ginsenoside Rg1 promotes β‑amyloid peptide degradation through inhibition of the ERK/PPARγ phosphorylation pathway in an Alzheimer's disease neuronal model

Quan, Q., Ma, X., Li, M., Li, X., & Yuan, H. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.12319 · Cited by 11

Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer’s Disease

Kang, J., Park, M., & Kim, T. (2024) · Journal of Alzheimer's Disease · doi:10.3233/jad-231033 · Cited by 5

Microglial ApoD ‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression

Yu, Y., Lv, J., Ma, D., Han, Y., Zhang, Y., Xu, P., Wang, Z., & Wang, Z. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12361 · Cited by 12

PKCδ serves as a potential biomarker and therapeutic target for microglia‐mediated neuroinflammation in Alzheimer's disease

Du, Y., Guo, T., Hao, Y., Li, C., Tang, L., Li, X., Zhang, X., Li, L., Yao, D., Xu, X., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14047 · Cited by 11

Intravenous chaperone treatment of late-stage Alzheimer´s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes

Zhang, R., Ohshima, M., Brodin, D., Wang, Y., Morancé, A., Schultzberg, M., Chen, G., & Johansson, J. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03161-x · Cited by 11

Microglial double stranded DNA accumulation induced by DNase II deficiency drives neuroinflammation and neurodegeneration

Li, L.-J., Liang, S., Sun, X., Zhu, J., Niu, X.-Y., Du, X.-Y., Huang, Y., & Liu, R. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03333-6 · Cited by 14

A simple methyl substitution of 3-acetylcoumarin thiosemicarbazone enhances cellular autophagy flux, reduces inflammation and ameliorates rough eye phenotype in the Drosophila model of Alzheimer's disease

Varma, M. E., Shravage, B. V., Tayade, S. B., Kumbhar, A. S., Butcher, R. J., Jani, V., Sonavane, U., Joshi, R., & Kulkarni, P. P. (2021) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2021.130265 · Cited by 11

REMOVED: Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta peptide

Sharma, H. S., Muresanu, D. F., Nozari, A., Lafuente, J. V., Buzoianu, A. D., Sahib, S., Tian, Z. R., Bryukhovetskiy, I., Manzhulo, I., Menon, P. K., et al. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.04.008 · Cited by 11

Failure of Alzheimer’s Mice Brain Resident Neural Precursor Cells in Supporting Microglia-Mediated Amyloid β Clearance

Lachish, M., Fainstein, N., Ganz, T., Sofer, L., & Ben‐Hur, T. (2022) · Cells · doi:10.3390/cells11050876 · Cited by 13

MicroRNA-511-3p regulates Aβ1–40 induced decreased cell viability and serves as a candidate biomarker in Alzheimer's disease

Wang, T., Zhao, W., Liu, Y., Yang, D., He, G., & Wang, Z. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112195 · Cited by 13

The comprehensive impact of exercise interventions on cognitive function and quality of life in alzheimer’s disease patients: a systematic review and meta-analysis

Li, P., He, Y., & He, M. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06454-y · Cited by 11

The Inhibition of Mitogen-Activated Protein Kinases (MAPKs) and NF-κB Underlies the Neuroprotective Capacity of a Cinnamon/Curcumin/Turmeric Spice Blend in Aβ-Exposed THP-1 Cells

Maugeri, A., Russo, C., Patanè, G. T., Barreca, D., Mandalari, G., & Navarra, M. (2023) · Molecules · doi:10.3390/molecules28247949 · Cited by 10

Pyrola incarnata demonstrates neuroprotective effects against β-amyloid-induced memory impairment in mice

Li, S.-J., Liu, Q., He, X., Liu, J., Liu, X., Hu, J., Tang, Z., Peng, Q., Cui, L.-J., Zhang, H.-N., et al. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.126858 · Cited by 9

Blockage of Fc Gamma Receptors Alleviates Neuronal and Microglial Toxicity Induced by Palmitic Acid

Phitthayaphong, P., Kumfu, S., Chattipakorn, N., & Chattipakorn, S. C. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210417 · Cited by 10

Triggering Innate Immune Receptors as New Therapies in Alzheimer’s Disease and Multiple Sclerosis

Piec, P.-A., Pons, V., & Rivest, S. (2021) · Cells · doi:10.3390/cells10082164 · Cited by 10

Safety, tolerability, pharmacokinetics and effects of diet on AD16, a novel neuroinflammatory inhibitor for Alzheimer’s disease: a randomized phase 1 study

Peng, D., Xu, S., Zou, T., Wang, Y., Ouyang, W., Zhang, Y., Dong, C., Li, D., Guo, J., Shen, Q., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-03126-9 · Cited by 9

Chemiexcitation-Triggered Photosensitizer Activation for Photooxidation of Aβ1–42 Aggregates

Liu, S., Yang, J., & Yan, J. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c06901 · Cited by 9

Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer’s Disease

Lu, J., Chen, J., Li, S., Pan, G.-J., Ou, Y., Yuan, L.-F., Jiang, J., Zeng, L., & Zhao, J. J. (2024) · Current Medical Science · doi:10.1007/s11596-024-2921-z · Cited by 9

Protein kinases as therapeutic targets for Alzheimer’s disease: a brief review

Silva, I. M. F., Franco, G. D. R. R., Gontijo, V. S., & Viegas, C. (2024) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2024.00092 · Cited by 9

The roles of natural triterpenoid saponins against Alzheimer's disease

Zhou, J., Li, H., Zhou, Y. J., Li, X., Yang, Z., Tohda, C., Komatsu, K., Piao, X., & Ge, Y. (2023) · Phytotherapy Research · doi:10.1002/ptr.7967 · Cited by 9

Ferulic Acid reduces amyloid beta mediated neuroinflammation through modulation of Nurr1 expression in microglial cells

Khorasgani, A. M., Moghadam, F. H., & Nasr‐Esfahani, M. H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0290249 · Cited by 9

ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17

Lin, C.-W., Fan, C.-H., Chang, Y., & Hsieh‐Li, H. M. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135337 · Cited by 10

Exploring the impact of miR-128 in inflammatory diseases: A comprehensive study on autoimmune diseases

Margiana, R., Kzar, H. H., Hussam, F., Hameed, N. M., Al‐qaim, Z. H., Al-Gazally, M. E., Kandee, M., Saleh, M. M., Toshbekov, B. B. U., Tursunbaev, F., et al. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154705 · Cited by 9

Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease

Lee, E., & Chang, Y. (2025) · Cells · doi:10.3390/cells14030168 · Cited by 39

The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targets

AmeliMojarad, M., & AmeliMojarad, M. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14856 · Cited by 73

Microglial interaction with β‐amyloid: Implications for the pathogenesis of Alzheimer's disease

Bamberger, M. E., & Landreth, G. E. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1121 · Cited by 74

Microglia as a Potential Bridge between the Amyloid β‐Peptide and Tau

Kitazawa, M., Yamasaki, T. R., & LaFerla, F. M. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.006 · Cited by 187

Manipulation of Microglial Activation as a Therapeutic Strategy in Alzheimers Disease

Shie, F., & Woltjer, R. L. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707782359981 · Cited by 30