Cited by 587Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

The DOI matches its Crossref record; 233 of the 234 references it cites were found in a registry or an index.

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

Cai, Zhiyou, Hussain, M. Delwar, Yan, Liang-Jun·2014·International Journal of Neuroscience

DOI 10.3109/00207454.2013.833510

Open this paper in CoChat — free account

Abstract

Compelling evidence from basic molecular biology has demonstrated the dual roles of microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are involved in AD pathogenesis by releasing inflammatory mediators such as inflammatory cytokines, complement components, chemokines, and free radicals that are all known to contribute to beta-amyloid (Aβ) production and accumulation. On the other hand, microglia are also known to play a beneficial role in generating anti-Aβ antibodies and stimulating clearance of amyloid plaques. Aβ itself, an inducer of microglia activation and neuroinflammation, has been considered as an underlying and unifying factor in the development of AD. A vicious cycle of inflammation has been formed between Aβ accumulation, activated microglia, and microglial inflammatory mediators, which enhance Aβ deposition and neuroinflammation. Thus, inhibiting the vicious cycle seems to be a promising treatment to restrain further development of AD. With increasing research efforts on microglia in AD, intervention of microglia activation and neuroinflammation in AD may provide a potential target for AD therapy in spite of the provisional failure of nonsteroidal antiinflammatory drugs in clinical trials.

Integrity signals

Registry

Crossref · 10.3109/00207454.2013.833510

Cites

233 of 233 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329
Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
Goedert, M., Spillantini, M. G., Cairns, N. J., & Crowther, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90117-v · Cited by 1,122
Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention
Liu, B., & Hong, J.-S. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035048 · Cited by 1,095
Microglia and neuroinflammation: a pathological perspective
Streit (2004) · Journal of Neuroinflammation · doi:10.1186/1742-2094-1-14 · Cited by 1,039
Lipid peroxidation and protein oxidation in Alzheimer’s disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical oxidative stress
Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 1,013
Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease
Bell, R. D., & Zloković, B. V. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0522-3 · Cited by 883
Matrix metalloproteinases in neuroinflammation
Rosenberg, G. A. (2002) · Glia · doi:10.1002/glia.10108 · Cited by 868
Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855
Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55.
Tilg, H., Trehu, E., Atkins, M., Dinarello, C., & Mier, J. (1994) · Blood · doi:10.1182/blood.v83.1.113.113 · Cited by 817

Show all 234 references

Research works printed but not linked: 24

Dubinina EE, 2007, Adv Gerontol, 20, 109
Weitz TM, 2012, Int J Alzheimer's Dis, 2012, 314185
Imamoto K, 1981, Prog Clin Biol Res, 59, 125
Wierzba-Bobrowicz T, 2002, Folia Neuropathol, 40, 125
Krause DL, 2010, Int J Alzheimer's Dis, 2010, doi: 10.4061/20 · DOI
Sochocka M, 2013, CNS Neurol Disord Drug Targets
Lampron A, 2013, J Comp Neurol
McLarnon JG, 2012, Am J Neurodegener Dis, 1, 199
Thanopoulou K, 2010, Proc Natl Acad Sci USA, 107, 20816, 10.1073/pnas.1005888107 · DOI · Paper page
Pflanzner T, 2010, Neurobiol Aging, 32, 2323
Lee KW, 2009, J Neurochem, 108, 165
10.1002/glia.10108 · DOI
Eckman EA, 2005, Biochem Soc Trans, 33, 1101, 10.1042/BST0331101 · DOI
10.1111/j.14714159.2010.06899.x · DOI
Zou K, 2008, Rev Neurosci, 19, 203
10.1523/JNEUROSCI.0616-08.2008 · DOI · Paper page
Chiarini A, 2006, Ital J Anat Embryol, 111, 221
Samuelsson M, 2005, Int J Mol Med, 16, 449
Yan SD, 1998, Restor Neurol Neurosci, 12, 167
Gan L, 2004, J Biol Chem, 279, 5565, 10.1074/jbc.M306183200 · DOI
Lee HS, 2007, Pharmazie, 62, 937
Wilkinson K, 2012, Int J Alzheimer's Dis, 2012, 489456
Nakamura K, 2006, J Neurosci Res, 84, 874, 10.1002/jnr.20992 · DOI
Christie RH, 1996, Am J Pathol, 148, 399

Sorted by citations

β-Amyloid accumulation in the human brain after one night of sleep deprivation
Shokri-Kojori, E., Wang, G.-J., Wiers, C. E., Demiral, S. B., Guo, M., Kim, S. W., Lindgren, E., Ramirez, V., Zehra, A., Freeman, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721694115 · Cited by 893
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis
Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1434-3 · Cited by 767
A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Esfehani, R. J., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 586
Chitosan oligosaccharide: Biological activities and potential therapeutic applications
Muanprasat, C., & Chatsudthipong, V. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.10.013 · Cited by 518
Chitosan oligosaccharide (COS): An overview
Naveed, M., Phil, L., Sohail, M., Hasnat, M., Baig, M. M. F. A., Ihsan, A. U., Shumzaid, M., Kakar, M. U., Khan, T. M., Akabar, M., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.01.192 · Cited by 524
LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease
Heckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503
“Aβ, especially the Aβ1-42 oligomer and fibril, is an established instigator of neuroinflammation (Cai et al., 2014).”
Alzheimer’s disease and its treatment by different approaches: A review
Srivastava, S., Ahmad, R., & Khare, S. K. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113320 · Cited by 506
Antibiotics, gut microbiota, and Alzheimer’s disease
Angelucci, F., Cechova, K., Amlerova, J., & Hort, J. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1494-4 · Cited by 454
An early and late peak in microglial activation in Alzheimer’s disease trajectory
Fan, Z., Brooks, D. J., Okello, A., & Edison, P. (2017) · Brain · doi:10.1093/brain/aww349 · Cited by 438
Fecal Microbiota Transplantation in Neurological Disorders
Vendrik, K. E. W., Ooijevaar, R. E., de Jong, P. R. C., Laman, J. D., van Oosten, B. W., van Hilten, J. J., Ducarmon, Q. R., Keller, J. J., Kuijper, E. J., & Contarino, M. F. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00098 · Cited by 413
Role of Blood-Brain Barrier in Alzheimer’s Disease
Cai, Z., Qiao, P.-F., Wan, C.-Q., Cai, M., Zhou, N.-K., & Li, Q. (2018) · Journal of Alzheimer's Disease · doi:10.3233/jad-180098 · Cited by 370
Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer’s disease
Dhapola, R., Hota, S. S., Sarma, P., Bhattacharyya, A., Medhi, B., & Reddy, D. H. (2021) · Inflammopharmacology · doi:10.1007/s10787-021-00889-6 · Cited by 383
RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease
Cui, G.-H., Guo, H.-D., Li, H., Zhai, Y., Gong, Z., Wu, J., Liu, J.-S., Dong, Y., Hou, S., & Liu, J. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0150-2 · Cited by 359
Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease
Lee, J. K., & Kim, N. (2017) · Molecules · doi:10.3390/molecules22081287 · Cited by 326
Dopamine, Immunity, and Disease
Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J. R., & Gaskill, P. J. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000618 · Cited by 328
The Mechanisms of Action of Curcumin in Alzheimer’s Disease
Tang, M., & Taghibiglou, C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170188 · Cited by 317
Effect of Clostridium butyricum against Microglia‐Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate
Sun, J., Xu, J., Yang, B., Chen, K., Kong, Y., Fang, N., Gong, T., Wang, F., Ling, Z., & Liu, J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900636 · Cited by 302
Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer’s Disease
Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Xiang, X., Wind, K., Wiedemann, T., Blume, T., Shi, Y., Briel, N., Beyer, L., Biechele, G., Eckenweber, F., Zatcepin, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe5640 · Cited by 268
Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis
Bagyinszky, E., Giau, V. V., Shim, K., Suk, K., An, S. S. A., & Kim, S. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.03.031 · Cited by 276
Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer’s disease
Thawkar, B. S., & Kaur, G. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.11.010 · Cited by 254
New Insights into the Role of Neuron-Specific Enolase in Neuro-Inflammation, Neurodegeneration, and Neuroprotection
Haque, A., Polcyn, R., Matzelle, D. D., & Banik, N. L. (2018) · Brain Sciences · doi:10.3390/brainsci8020033 · Cited by 249
Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview
Archie, S. R., Shoyaib, A. A., & Cucullo, L. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13111779 · Cited by 244
Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation
Kou, J., Shi, J.-Z., He, Y., Hao, J.-J., Zhang, H.-Y., Dong-mei, L., Song, J.-K., Yan, Y., Xie, X., Du, G., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00702-8 · Cited by 232
Review of Current Strategies for Delivering Alzheimer’s Disease Drugs across the Blood-Brain Barrier
Wong, K. H., Riaz, M. K., Xie, Y., Zhang, X., Liu, Q., Chen, H., Bian, Z., Chen, X., Lü, A., & Yang, Z. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020381 · Cited by 228
Microglia in multiple sclerosis: Friend or foe
Guerrero, B. L., & Sicotte, N. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00374 · Cited by 215
Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism
Pilozzi, A. R., Carro, C., & Huang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010338 · Cited by 261
Anti-neuroinflammatory Effect of Short-Chain Fatty Acid Acetate against Alzheimer’s Disease via Upregulating GPR41 and Inhibiting ERK/JNK/NF-κB
Liu, J., Li, H., Gong, T., Chen, W., Mao, S., Kong, Y., Yu, J., & Sun, J. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c02807 · Cited by 199
Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
Wu, A., Zhou, X., Qiao, G., Yu, L., Tang, Y., Yan, L., Qiu, W., Pan, R., Yu, C., Law, B. Y. K., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101202 · Cited by 196
Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration
Quick, J. D., Silva, C., Wong, J. H., Lim, K. L., Reynolds, R., Barron, A. M., Zeng, J., & Lo, C. H. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02866-y · Cited by 203
Influence of microglia and astrocyte activation in the neuroinflammatory pathogenesis of Alzheimer’s disease: Rational insights for the therapeutic approaches
Ahmad, M. H., Fatima, M., & Mondal, A. C. (2018) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2018.10.034 · Cited by 201
Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches
Sung, P.-S., Lin, P.-Y., Liu, C.-H., Su, H.-C., & Tsai, K.-J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030701 · Cited by 193
β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
Friker, L. L., Scheiblich, H., Hochheiser, I. V., Brinkschulte, R., Riedel, D., Latz, E., Geyer, M., & Heneka, M. T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.025 · Cited by 191
MFG‐E8 reverses microglial‐induced neurotoxic astrocyte (A1) via NF‐κB and PI3K‐Akt pathways
Xu, X., Zhang, A., Zhu, Y., He, W., Di, W., Fang, Y., & Shi, X. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26918 · Cited by 193
Understanding the Amyloid Hypothesis in Alzheimer’s Disease
Paroni, G., Bisceglia, P., & Seripa, D. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180802 · Cited by 194
Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease
Venigalla, M., Sonego, S., Gyengési, E., Sharman, M. J., & Münch, G. W. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.10.011 · Cited by 176
Alzheimer’s disease: Targeting the glutamatergic system
Conway, M. E. (2020) · Biogerontology · doi:10.1007/s10522-020-09860-4 · Cited by 180
Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability
Xiao, S., Zhou, D., Luan, P., Gu, B., Feng, L., Fan, S., Liao, W., Fang, W., Yang, L., Tao, E., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.021 · Cited by 169
Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model
Bourgade, K., Le Page, A., Bocti, C., Witkowski, J. M., Dupuis, G., Frost, E. H., & Fülöp, T. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150652 · Cited by 161
Role of berberine in Alzheimer’s disease
Cai, Z., Wang, C., & Yang, W. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s114846 · Cited by 165
Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling
Kim, J., Lee, H.-J., Park, S. K., Park, J.-H., Jeong, H.-R., Lee, S.-J., Lee, H., Seol, E., & Hoe, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910637 · Cited by 166
Short-chain fatty acids-producing probiotics: A novel source of psychobiotics
Cheng, Y., Liu, J., & Ling, Z. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1920884 · Cited by 156
Molecular Mechanisms for Herpes Simplex Virus Type 1 Pathogenesis in Alzheimer’s Disease
Harris, S. A., & Harris, E. A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00048 · Cited by 154
Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease
Pinheiro, L. M. V., & Faustino, C. M. C. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190321163438 · Cited by 144
Physiology and pharmacology of amyloid precursor protein
Cho, Y., Bae, H., Okun, E., Arumugam, T. V., & Jo, D. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108122 · Cited by 150
Oligodendrocytes and Alzheimer's disease
Cai, Z., & Xiao, M. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1025778 · Cited by 140
Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease
Sun, J., Wei, C., Liu, Y., Xie, W., Xu, M., Zhou, H., & Liu, J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.12.027 · Cited by 130
Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
Wilkaniec, A., Gąssowska-Dobrowolska, M., Strawski, M., Adamczyk, A., & Czapski, G. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1027-y · Cited by 133
Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer’s Disease Mice and Wild-Type Littermates
Zhang, F., Zhong, R., Li, S., Fu, Z., Cheng, C., Cai, H., & Le, W. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00282 · Cited by 128
TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease
Li, Y., Xu, H., Wang, H., Yang, K., Luan, J., & Wang, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115218 · Cited by 133
Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease
Heckmann, B. L., Teubner, B. J. W., Boada-Romero, E., Tummers, B., Guy, C., Fitzgerald, P., Mayer, U., Carding, S., Zakharenko, S. S., Wileman, T., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb9036 · Cited by 114
Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease
Uddin, M. S., Kabir, M. T., Mamun, A. A., Barreto, G. E., Rashid, M., Perveen, A., & Ashraf, G. M. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106479 · Cited by 121
New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer’s disease
Wu, J., Yu, Y., Wan, Y., Xia, J., Xu, J., Zhang, L., Liu, D., Chen, L., Tang, F., Ao, H., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113207 · Cited by 119
Bile acids as key modulators of the brain-Gut-Microbiota axis in alzheimer’s disease
Mulak, A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210608 · Cited by 114
A Review of the Brain-Gut-Microbiome Axis and the Potential Role of Microbiota in Alzheimer’s Disease
Sun, M., Ma, K., Wen, J., Wang, G., Zhang, C., Li, Q., Bao, X., & Wang, H. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190872 · Cited by 113
The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
Bajwa, E., Pointer, C. B., & Klegeris, A. (2019) · Mediators of Inflammation · doi:10.1155/2019/4050796 · Cited by 111
Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders
Caruso, G., Caraci, F., & Jolivet, R. B. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.004 · Cited by 110
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome
Kou, L., Chi, X., Sun, Y., Han, C., Wan, F., Hu, J., Yin, S., Wu, J., Li, Y., Zhou, Q., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02494-y · Cited by 109
Curcumin Inhibits Aβ-Induced Microglial Inflammatory Responses In Vitro: Involvement of ERK1/2 and P38 Signaling Pathways
Shi, X., Zheng, Z., Li, J., Xiao, Z., Qi, W., Zhang, A., Wu, Q., & Fang, Y. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.03.045 · Cited by 108
Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies
Sarker, M. R., & Franks, S. F. (2018) · GeroScience · doi:10.1007/s11357-018-0017-z · Cited by 110
Cannabidiol for neurodegenerative disorders: A comprehensive review
Bhunia, S., Kolishetti, N., Yndart, A., Vashist, A., & Nair, M. G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.989717 · Cited by 121
Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis
Li, H., Liu, C.-C., Zheng, H., & Huang, T. Y. (2018) · Translational Neurodegeneration · doi:10.1186/s40035-018-0139-3 · Cited by 103
Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease
Yang, L., Wang, Y., Li, Z., Wu, X., Mei, J., & Zheng, G. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120714 · Cited by 106
A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse
Gee, M. S., Son, S. H., Jeon, S. H., Do, J., Kim, N., Ju, Y., Lee, S. J., Chung, E. K., Inn, K., Kim, N., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00617-2 · Cited by 105
ABCB1 and ABCG2 Regulation at the Blood-Brain Barrier: Potential New Targets to Improve Brain Drug Delivery
Schulz, J., Hartz, A. M. S., & Bauer, B. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000025 · Cited by 118
The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome
Montagnani, M., Bottalico, L., Potenza, M. A., Charitos, I. A., Topi, S., Colella, M., & Santacroce, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210322 · Cited by 109
Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
Tan, Y., Zheng, Y., Xu, D., Sun, Z., Yang, H., & Yin, Q. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00592-7 · Cited by 100
Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study
Gupta, M., & Kaur, G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0650-3 · Cited by 102
New Promising Therapeutic Avenues of Curcumin in Brain Diseases
Benameur, T., Giacomucci, G., Panaro, M. A., Ruggiero, M., Trotta, T., Monda, V., Pizzolorusso, I., Lofrumento, D. D., Porro, C., & Messina, G. (2021) · Molecules · doi:10.3390/molecules27010236 · Cited by 108
Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease
Yang, R., Zheng, Y., Wang, Q., & Zhao, L. (2018) · Nanoscale Research Letters · doi:10.1186/s11671-018-2759-z · Cited by 99
Anti-Viral Properties of Amyloid-β Peptides
Bourgade, K., Dupuis, G., Frost, E. H., & Fülöp, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160517 · Cited by 97
Exosomes in neurologic and psychiatric disorders
Tsilioni, I., Panagiotidou, S., & Theoharides, T. C. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.05.005 · Cited by 93
Neuroprotective potential of berberine in modulating Alzheimer’s disease via multiple signaling pathways
Akbar, M., Shabbir, A., Rehman, K., Akash, M. S. H., & Shah, M. A. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13936 · Cited by 97
Resveratrol Suppresses Aβ-Induced Microglial Activation Through the TXNIP/TRX/NLRP3 Signaling Pathway
Feng, L., & Zhang, L. (2019) · DNA and Cell Biology · doi:10.1089/dna.2018.4308 · Cited by 90
Artemisinin Improved Neuronal Functions in Alzheimer's Disease Animal Model 3xtg Mice and Neuronal Cells via Stimulating the ERK/CREB Signaling Pathway
Zhao, X., Li, S., Gaur, U., & Zheng, W. (2020) · Aging and Disease · doi:10.14336/ad.2019.0813 · Cited by 91
Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery
Ege, D. (2021) · Materials · doi:10.3390/ma14123332 · Cited by 97
Neural sphingosine 1‐phosphate accumulation activates microglia and links impaired autophagy and inflammation
Indulekha, K., Alam, S., Surendar, J., Frohberger, S. J., Hansen, J. N., Kuehlwein, J. M., Hölbling, B. V., Schumak, B., Hübner, M. P., Gräler, M. H., et al. (2019) · Glia · doi:10.1002/glia.23663 · Cited by 89
Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review
Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 84
Neutrophils Return to Bloodstream Through the Brain Blood Vessel After Crosstalk With Microglia During LPS-Induced Neuroinflammation
Kim, Y. R., Kim, Y. M., Lee, J., Park, J., Lee, J. E., & Hyun, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.613733 · Cited by 85
RETRACTED: Liraglutide Has Anti-Inflammatory and Anti-Amyloid Properties in Streptozotocin-Induced and 5xFAD Mouse Models of Alzheimer’s Disease
Paladugu, L., Gharaibeh, A., Kolli, N., Learman, C. R., Hall, T. C., Li, L., Rossignol, J., Maiti, P., & Dunbar, G. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020860 · Cited by 79
Retracted
Berberine: A Plant-derived Alkaloid with Therapeutic Potential to Combat Alzheimer’s disease
Singh, A. K., Singh, S. K., Nandi, M. K., Mishra, G., Maurya, A., Rai, A., Rai, G. K., Awasthi, R., Sharma, B., & Kulkarni, G. T. (2019) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524919666190820160053 · Cited by 79
The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice
Li, J., Hu, T., Zhou, X.-N., Zhang, T., Guo, J., Wang, M.-Y., Wu, Y., Su, W., & Jiang, C. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02791-0 · Cited by 80
Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells
Debbabi, M., Nury, T., Zarrouk, A., Mekahli, N., Bezine, M., Sghaier, R., Gregoire, S., Martine, L., Durand, P., Prost-Camus, E., et al. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17121973 · Cited by 86
Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer’s Disease
Olsen, M., Aguilar, X., Sehlin, D., Fang, X. T., Antoni, G., Erlandsson, A., & Syvänen, S. (2018) · Molecular Imaging and Biology · doi:10.1007/s11307-017-1153-z · Cited by 80
Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ
Xie, Z., Zhao, J., Wang, H., Jiang, Y., Yang, Q., Fu, Y., Zeng, H., Hölscher, C., Xu, J., & Zhang, Z. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109886 · Cited by 78
Gut Microbiota Disorder, Gut Epithelial and Blood–Brain Barrier Dysfunctions in Etiopathogenesis of Dementia: Molecular Mechanisms and Signaling Pathways
Welcome, M. O. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08547-5 · Cited by 77
Nano-Honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer’s disease via inhibiting neuropathology and modulating gut microbiota
Qu, C. F., Li, Q., Su, Z., Ip, S., Yuan, Q., Xie, Y., Xu, Q., Yang, W., Huang, Y., Xian, Y., et al. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.03.012 · Cited by 76
Probiotics for Neurodegenerative Diseases: A Systemic Review
Ojha, S., Patil, N., Jain, M., Kole, C., & Kaushik, P. (2023) · Microorganisms · doi:10.3390/microorganisms11041083 · Cited by 80
Neuroprotective protein hydrolysates from hemp ( Cannabis sativa L.) seeds
Rodríguez-Martín, N. M., Toscano, R., Villanueva-Lazo, A., Pedroche, J., Millán, F., la Paz, S. M., & Millán-Linares, M. C. (2019) · Food & Function · doi:10.1039/c9fo01904a · Cited by 78
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro
Balleza‐Tapia, H., Crux, S., Andrade‐Talavera, Y., Dolz-Gaitón, P., Papadia, D., Chen, G., Johansson, J., & Fisahn, A. (2018) · eLife · doi:10.7554/elife.37703 · Cited by 72
Microbiota‐microglia connections in age‐related cognition decline
Zhou, R., Qian, S., Cho, W. C. S., Zhou, J., Jin, C., Zhong, Y., Wang, J., Zhang, X., Xu, Z., Tian, M., et al. (2022) · Aging Cell · doi:10.1111/acel.13599 · Cited by 71
The Periodontal Pathogen Fusobacterium nucleatum Exacerbates Alzheimer’s Pathogenesis via Specific Pathways
Wu, H., Qiu, W., Zhu, X., Li, X., Xie, Z., Carreras, I., Dedeoglu, A., Dyke, T. E. V., Han, Y. W., Karimbux, N. Y., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.912709 · Cited by 73
Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products
Phil, L., Naveed, M., Mohammad, I. S., Li, B., & Di, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.03.108 · Cited by 71
Anti-inflammatory and immunomodulatory effects of baicalin in cerebrovascular and neurological disorders
Li, Y., Song, K., Zhang, H., Yuan, M., An, N., Wei, Y., Wang, L., Sun, Y., Xing, Y., & Gao, Y. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.08.016 · Cited by 74
Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42through Nrf2-Related Inflammatory Response
Seo, J. Y., Pyo, E., An, J., Kim, J., Sung, S. H., & Oh, W. K. (2017) · Mediators of Inflammation · doi:10.1155/2017/5906189 · Cited by 70
In vivo PET imaging of neuroinflammation in Alzheimer’s disease
Lagarde, J., Sarazin, M., & Bottlaender, M. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1731-x · Cited by 79
Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway
Guo, M., Zhang, H., Li, Y., Gu, Q., Wei, W., Wang, Y.-Y., Zhang, X.-J., Liu, X.-Q., Song, L., Chai, Z., et al. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577284 · Cited by 67
Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression
Yang, Z., Kuboyama, T., & Tohda, C. (2019) · Phytotherapy Research · doi:10.1002/ptr.6305 · Cited by 69
Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease
Baker, S. K., Chen, Z.-L., Norris, E. H., Revenko, A. S., MacLeod, A. R., & Strickland, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811172115 · Cited by 68
The protective effects of activating Sirt1/NF-κB pathway for neurological disorders
Song, Y., Wu, Z., & Zhao, P. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2021-0118 · Cited by 68

Authors: Cai, Z., Hussain, M. D., & Yan, L.-J.
Affiliations: Anhui Medical University (CN)
Texas A&M Health Science Center (US)
University of North Texas Health Science Center (US)
Corresponding author: Cai, Zhiyou
ORCID: Cai, Zhiyou
Hussain, M. Delwar
Yan, Liang-Jun
Venue: International Journal of Neuroscience
Publisher: Informa UK Limited
Published: 2013-09-12
Volume: 124
Issue: 5
Pages: 307-321
ISSN: 0020-7454 (ISSN-L)
1543-5245
DOI: 10.3109/00207454.2013.833510
OpenAlex: W2096407545
Cited by: 583
References: 234
Citations by year: 2026: 17 · 2025: 45 · 2024: 72 · 2023: 86 · 2022: 67 · 2021: 82 · 2020: 72 · 2019: 54 · 2018: 45 · 2017: 13 · 2016: 14 · 2015: 12 · 2014: 3 · 2013: 1
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: microglia, neuroinflammation, amyloid-beta, Alzheimer's disease, microglial activation, inflammatory cytokines, complement system, chemokines, free radicals, amyloid plaque clearance, anti-amyloid antibodies, anti-inflammatory therapy
MeSH terms: Alzheimer Disease, Humans, Inflammation, Amyloid beta-Peptides, Microglia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer’s disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks