Waist circumference and dual-energy X-ray absorptiometry measures of overall and central obesity are similarly associated with systemic oxidative stress in women
Abstract
Growing evidence suggests that overall and abdominal obesity might lead to oxidative stress (OxS), which, in turn, plays a key role in the pathogenesis of a wide spectrum of diseases. In this study, for the first time, we compared the correlations of indirect, i.e. anthropometric, and direct, by dual energy X-ray absorptiometry (DXA), measures of body fat with circulatory OxS markers in women. To address this issue, we assessed central and total body fat mass (FM) by DXA, and serum levels of advanced oxidation protein products (AOPP), thiols and hydroperoxides in 275 healthy women (age 21-65 years; body mass index [BMI] 21.1-32.0 kg/m(2); waist circumference [WC] 60.1-109.9 cm). Among the markers considered in the study, only hydroperoxides levels, i.e. by-products of lipid peroxidation, were significantly (p < 0.05 for all) and positively correlated to body fat accumulation after controlling for confounding factors. In particular, this marker was found to be similarly associated with DXA-derived total FM, total FM % and trunk FM as well as with WC. Of note, hydroperoxides appeared to be correlated with abdominal but not with general obesity, as classified according to standard WC and BMI cut-offs, respectively. In conclusion, taken together our data demonstrated that, at least in women, the measurement of body FM by DXA has no advantage over the simpler and cheaper WC with regard to their associations with systemic OxS markers. Moreover, WC emerged as a superior potential predictor of OxS compared to the other most commonly used anthropometric measures (including BMI and waist to hip ratio).
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CMV reactivation might be more frequent in obesity because excess adiposity drives chronic systemic inflammation and oxidative stress, which can reactivate CMV directly.
“CMV reactivation might be even more frequent in obesity, because excess adiposity drives chronic systemic inflammation and oxidative stress (Aroor and DeMarco 2014; Cervellati et al. 2014; de Heredia et al. 2012; Kanneganti and Dixit 2012; Le Lay and Simard 2014), which in turn can reactivate CMV directly (Cinatl et al. 1999; Docke et al. 1994; Jaganjac et al. 2010; Prosch et al. 1995; Speir 2000;”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Cervellati et al. 2014
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“In obese subjects body mass index (BMI) showed a positive correlation with PCs [14]; waist circumference (WC) was directly correlated with hydroperoxide levels [15] and lipid peroxidation [16].”
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- Authors
- Cervellati, C., Bonaccorsi, G., Cremonini, E., Romani, A., Castaldini, C., Ferrazzini, S., Giganti, M., Fila, E., Massari, L., & Bergamini, C. M.
- Affiliations
- University of Ferrara (IT)
- Corresponding author
- Cervellati, Carlo
- ORCID
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 2013-12-04
- Volume
- 74
- Issue
- 2
- Pages
- 102-107
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2136195672
- Cited by
- 10
- References
- 32
- Citations by year
- 2021: 1 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Funders
- Università degli Studi di Ferrara
- Topics
- Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- waist circumference, abdominal obesity, oxidative stress, fat mass, dual-energy X-ray absorptiometry, advanced oxidation protein products, lipid peroxidation, hydroperoxides, thiols, anthropometric measures, women, body mass index, waist-to-hip ratio
- MeSH terms
- Adipose Tissue, Adult, Aged, Female, Humans, Lipid Peroxides, Middle Aged, Lipid Peroxidation, Biomarkers, Absorptiometry, Photon, Body Mass Index, Oxidative Stress, Waist Circumference, Obesity, Abdominal
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