Family history of alcohol use disorders and neuromaturation: A functional connectivity study with adolescents
Open accessAbstract
BACKGROUND: A positive family history (FHP) of alcohol use disorders (AUD) is linked to increased risk for personal AUD, but the mechanisms behind this risk are unclear. Previous research suggests that a subtle neurodevelopmental lag in FHP adolescents may contribute to risk for future AUD. METHODS: Functional magnetic resonance imaging (fMRI) response to a spatial working memory (SWM) task was examined for markers of neuromaturational delay in 85 youth with and without FHP. It was hypothesized that FHP adolescents (n = 24, ages 12-14 years), as compared to matched FHN youth (n = 26, ages 12-14 years), would show less similarity to brain connectivity observed in older adolescents (n = 35, ages 16-20 years) and that statistical comparison of SWM functional connectivity models would differentiate FHN and FHP youth. Structural equation modeling tested the fit of brain response connectivity between FH groups and against the older-adolescent model. RESULTS: Patterns of connectivity were more similar between older adolescent and FHN than FHP adolescents; FHP youth demonstrated higher association between right posterior and left frontal brain regions than FHN and older adolescent youth. Comparison of FH groups indicated a significant difference on the pathway from the right superior parietal lobule to the left middle frontal gyrus. CONCLUSIONS: These findings provide additional support for the notion of a neuromaturational lag in FHP youth. Protracted neuromaturation may be a mechanism by which FH increases risk for alcohol dependence, and this less mature neural connectivity pattern may provide a novel endophenotype for identifying youth at risk for drinking problems.
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Environmental, parental, and youth factors may compound effects on neuromaturation and potentially increase STB and NSSI vulnerability.
“This may be compounded by environment (e.g., poverty (118)), parent (e.g., mental disorders (119)), and youth (e.g., stress (120); psychiatric symptoms (121)) factors—each affecting neuromaturation—and potentially, increasing STB and NSSI vulnerability.”
From Neural correlates associated with suicide and nonsuicidal self-injury in youth (2021) · cites this paper as [119]
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- Authors
- Spadoni, A. D., Simmons, A. N., Yang, T. T., & Tapert, S. F.
- Affiliations
- University of California San Diego (US)
- University of California, San Francisco (US)
- Corresponding author
- Tapert, Susan F.
- Venue
- The American Journal of Drug and Alcohol Abuse
- Publisher
- Informa UK Limited
- Published
- 2013-11-01
- Volume
- 39
- Issue
- 6
- Pages
- 356-364
- ISSN
- 0095-2990 (ISSN-L)
- 1097-9891
- PMC
- PMC3959877
- OpenAlex
- W2161354707
- Cited by
- 30
- References
- 75
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 3 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 7 · 2014: 2
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The American Journal of Drug and Alcohol Abuse (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Public Health Service (F31 FAA016727A)
- National Institute on Alcohol Abuse and Alcoholism (F31AA016727, R01AA013419, 5R01AA13419-06A1)
- National Institute of Mental Health (R01MH085734, T32MH018399 28, T32MH018399)
- National Institute on Drug Abuse (R01DA021182)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- family history of alcoholism, alcoholism, neuromaturation, functional connectivity, adolescents, spatial working memory, endophenotypes, alcohol dependence risk, superior parietal lobule, middle frontal gyrus, brain maturation
- MeSH terms
- Adolescent, Age Factors, Brain, Child, Cross-Sectional Studies, Family Health, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Models, Theoretical, Risk, Alcohol-Related Disorders, Adolescent Development, Young Adult
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