fMRI reveals alteration of spatial working memory networks across adolescence
Open accessAbstract
Recent studies have described neuromaturation and cognitive development across the lifespan, yet few neuroimaging studies have investigated task-related alterations in brain activity during adolescence. We used functional magnetic resonance imaging (fMRI) to examine brain response to a spatial working memory (SWM) task in 49 typically developing adolescents (25 females and 24 males; ages 12-17). No gender or age differences were found for task performance during SWM. However, age was positively associated with SWM brain response in left prefrontal and bilateral inferior posterior parietal regions. Age was negatively associated with SWM activation in bilateral superior parietal cortex. Gender was significantly associated with SWM response; females demonstrated diminished anterior cingulate activation and males demonstrated greater response in frontopolar cortex than females. Our findings indicate that the frontal and parietal neural networks involved in spatial working memory change over the adolescent age range and are further influenced by gender. These changes may represent evolving mnemonic strategies subserved by ongoing adolescent brain development.
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In an fMRI study of adolescents, age-related increases in spatial working memory-related brain activation were observed in left prefrontal and bilateral posterior parietal areas.
“Interestingly, in one fMRI study of adolescents, age-related increases in SWM-related brain activation were observed in left prefrontal areas as well as in bilateral posterior parietal areas (Schweinsburg, Nagel, & Tapert, 2005).”
From White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children (2011) · cites this paper as Schweinsburg et al., 2005
The results are consistent with prior functional magnetic resonance imaging studies that implicate the left hemisphere in spatial working memory functions in children and adolescents.
“These results are also consistent with prior fMRI studies that implicate the left hemisphere in SWM functions in children and adolescents (Schweinsburg et al. 2005;Olesen et al., 2003;Klingberg et al., 2002).”
From White Matter Microstructure in Superior Longitudinal Fasciculus Associated with Spatial Working Memory Performance in Children (2011) · cites this paper as Schweinsburg et al. 2005
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- Authors
- SCHWEINSBURG, A. D., NAGEL, B. J., & TAPERT, S. F.
- Affiliations
- University of California San Diego (US)
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-08-26
- Volume
- 11
- Issue
- 5
- Pages
- 631-644
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- PMC
- PMC2270702
- OpenAlex
- W2147887010
- Cited by
- 123
- References
- 11
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 1 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 10
- FWCI
- 3.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01 AA13419, R21 AA12519, R01AA013419, R21AA012519)
- National Institute on Drug Abuse (R21DA015228, DA15228)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- spatial working memory, adolescence, brain development, neuronal maturation, gender differences, prefrontal cortex, parietal cortex, anterior cingulate cortex, frontopolar cortex, cognitive development
- MeSH terms
- Adolescent, Adult, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Nerve Net, Neuropsychological Tests, Parietal Lobe, Puberty, Sex Characteristics, Space Perception
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