Neurobiological phenotypes associated with a family history of alcoholism
Open accessAbstract
Background Individuals with a family history of alcoholism are at much greater risk for developing an alcohol use disorder (AUD) than youth or adults without such history. A large body of research suggests that there are premorbid differences in brain structure and function in family history positive (FHP) individuals relative to their family history negative (FHN) peers. Methods This review summarizes the existing literature on neurobiological phenotypes present in FHP youth and adults by describing findings across neurophysiological and neuroimaging studies. Results Neuroimaging studies have shown FHP individuals differ from their FHN peers in amygdalar, hippocampal, basal ganglia, and cerebellar volume. Both increased and decreased white matter integrity has been reported in FHP individuals compared with FHN controls. Functional magnetic resonance imaging studies have found altered inhibitory control and working memory-related brain response in FHP youth and adults, suggesting neural markers of executive functioning may be related to increased vulnerability for developing AUDs in this population. Additionally, brain activity differences in regions involved in bottom-up reward and emotional processing, such as the nucleus accumbens and amygdala, have been shown in FHP individuals relative to their FHN peers. Conclusions It is critical to understand premorbid neural characteristics that could be associated with cognitive, reward-related, or emotional risk factors that increase risk for AUDs in FHP individuals. This information may lead to the development of neurobiologically informed prevention and intervention studies focused on reducing the incidence of AUDs in high-risk youth and adults.
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Individuals with a family history of alcohol dependence showed alterations in insular function compared to controls.
“individuals with a family history of alcohol dependence showed alternations in insular function compared to controls (Cservenka, 2016).”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Cservenka, 2016
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Research Review: What have we learned about adolescent substance use?
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The Insula: A Brain Stimulation Target for the Treatment of Addiction
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- Authors
- Cservenka, A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Cservenka, Anita
- ORCID
- Cservenka, Anita
- Venue
- Drug and Alcohol Dependence
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 158
- Pages
- 8-21
- ISSN
- 0376-8716 (ISSN-L)
- PMC
- PMC4698007
- OpenAlex
- W1868158529
- Cited by
- 111
- References
- 133
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 17 · 2019: 12 · 2018: 9 · 2017: 15 · 2016: 8
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Drug and Alcohol Dependence (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (U01AA021691)
- National Institute on Drug Abuse (T32DA024635)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- family history of alcoholism, alcoholism, amygdala, hippocampus, basal ganglia, cerebellum, white matter integrity, inhibitory control, working memory, executive function, nucleus accumbens, reward processing, emotional processing, alcohol use disorder risk, prevention
- MeSH terms
- Alcoholism, Brain, Emotions, Family, Humans, Magnetic Resonance Imaging, Memory, Short-Term, Phenotype, Reward, Alcohol-Related Disorders, Executive Function
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