The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans
Abstract
This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean±SD: 23±5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.
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“These peripheral oscillators are normally in sync with the master clock in the SCN, but altered sleep/wake schedules associated with shift work may desynchronize them [46].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [46]
Citations
Cites
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Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265
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ETHICS AND METHODS FOR BIOLOGICAL RHYTHM RESEARCH ON ANIMALS AND HUMAN BEINGS
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Timing to perfection: the biology of central and peripheral circadian clocks
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Harmonics of Circadian Gene Transcription in Mammals
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Niittymäki, E. (2021) · Työväentutkimus Vuosikirja
MELATONIN AND MONOAMINERGIC SYSTEM – BEHAVIOURAL ASPECTS
Voiculescu, S. E., Rosca, A., Zahiu, C. D. M., Badiu, C., & Zăgrean, A. (2016) · Romanian Journal of Neurology · doi:10.37897/rjn.2016.1.1
Physiological Sleep and Cardiovascular Disease
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FACTORS INFLUENCING PERIPHERAL SKIN TEMPERATURE CIRCADIAN RHYTHM IN YOUNG ADULT MALES
Tranel, H. R. (2014) · UKnowledge (University of Kentucky)
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Insomnia is a significant factor in cognitive impairment: Literature review and clinical observation
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Sochal, M., Wojtera, A., Ditmer, M., Gabryelska, A., Tarasiuk, A., Turkiewicz, S., Karuga, F. F., Fichna, J., & Białasiewicz, P. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125209
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Impact of sleep insufficiency and recovery on cancer development
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Metadata
- Authors
- Ackermann, K., Plomp, R., Lao, O., Middleton, B., Revell, V. L., Skene, D. J., & Kayser, M.
- Affiliations
- Erasmus MC (NL)
- University of Surrey (GB)
- Corresponding author
- Ackermann, Katrin
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2013-06-05
- Volume
- 30
- Issue
- 7
- Pages
- 901-909
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2033387947
- Cited by
- 116
- References
- 39
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 11
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/I019405/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, circadian clock, clock gene expression, melatonin rhythm, Bmal1, HSPA1B, heat shock response, NR1D1, cortisol, peripheral oscillators, leukocytes
- MeSH terms
- Adult, Circadian Rhythm, Gene Expression Regulation, Humans, Hydrocortisone, Leukocytes, Light, Male, Melatonin, Oscillometry, Radioimmunoassay, Sleep, Sleep Deprivation, Time Factors, Oxidative Stress, HSP70 Heat-Shock Proteins, Gene Expression Profiling, Young Adult, ARNTL Transcription Factors, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1
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