Sleep loss and inflammation

Mullington, Janet M.; Simpson, Norah S.; Meier-Ewert, Hans K.; Haack, Monika

doi:10.1016/j.beem.2010.08.014

Cited by 519Sleep and Work-Related FatigueSleep and Wakefulness ResearchCircadian rhythm and melatonin

Sleep loss and inflammation

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Mullington, Janet M., Simpson, Norah S., Meier-Ewert, Hans K., Haack, Monika·2010·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1016/j.beem.2010.08.014PMC PMC3548567

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Abstract

Controlled, experimental studies on the effects of acute sleep loss in humans have shown that mediators of inflammation are altered by sleep loss. Elevations in these mediators have been found to occur in healthy, rigorously screened individuals undergoing experimental vigils of more than 24h, and have also been seen in response to various durations of sleep restricted to between 25 and 50% of a normal 8h sleep amount. While these altered profiles represent small changes, such sub-clinical shifts in basal inflammatory cytokines are known to be associated with the future development of metabolic syndrome disease in healthy, asymptomatic individuals. Although the mechanism of this altered inflammatory status in humans undergoing experimental sleep loss is unknown, it is likely that autonomic activation and metabolic changes play key roles.

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Previous studies indicate that the immune system is activated during experimental sleep restriction, and in persons who in epidemiological studies report short sleep duration.
“Previous studies indicate that the immune system is activated during experimental sleep restriction, and in persons who in epidemiological studies report short sleep duration (reviewed in6465).”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [65]

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Authors: Mullington, J. M., Simpson, N. S., Meier-Ewert, H. K., & Haack, M.
Affiliations: Beth Israel Deaconess Medical Center (US)
Boston University (US)
Corresponding author: Mullington, Janet M.
ORCID: Mullington, Janet M.
Meier-Ewert, Hans K.
Haack, Monika
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2010-10
Volume: 24
Issue: 5
Pages: 775-784
ISSN: 1521-690X (ISSN-L)
DOI: 10.1016/j.beem.2010.08.014
PMC: PMC3548567
OpenAlex: W2087726866
Cited by: 519
References: 101
Citations by year: 2026: 35 · 2025: 53 · 2024: 37 · 2023: 41 · 2022: 51 · 2021: 55 · 2020: 38 · 2019: 32 · 2018: 36 · 2017: 31 · 2016: 27 · 2015: 26 · 2014: 17 · 2013: 22 · 2012: 11
FWCI: 1.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG028324)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep deprivation, inflammation, inflammatory cytokines, metabolic syndrome, autonomic activation, metabolic changes, subclinical inflammation
MeSH terms: Acute-Phase Reaction, Animals, Humans, Inflammation, Insulin Resistance, Obesity, Sleep Deprivation, Signal Transduction

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