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Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans
Abstract
This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean±SD: 23±5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.
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“These peripheral oscillators are normally in sync with the master clock in the SCN, but altered sleep/wake schedules associated with shift work may desynchronize them [46].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [46]
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Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases
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“Sleep disturbances have been associated with altered CLOCK gene expression in humans, which vitally affects neurobiological response to stress (353, 354).”
BackgroundSleep deprivation and its association with diseases- a review
Liew, S. C., & Aung, T. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.07.048 · Cited by 341
Metadata
- Authors
- Ackermann, K., Plomp, R., Lao, O., Middleton, B., Revell, V. L., Skene, D. J., & Kayser, M.
- Affiliations
- Erasmus MC (NL)
- University of Surrey (GB)
- Corresponding author
- Ackermann, Katrin
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 2013-06-05
- Volume
- 30
- Issue
- 7
- Pages
- 901-909
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2033387947
- Cited by
- 116
- References
- 39
- Citations by year
- 2026: 6 · 2025: 15 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 11
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council (BB/I019405/1)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- sleep deprivation, circadian clock, clock gene expression, melatonin rhythm, Bmal1, HSPA1B, heat shock response, NR1D1, cortisol, peripheral oscillators, leukocytes
- MeSH terms
- Adult, Circadian Rhythm, Gene Expression Regulation, Humans, Hydrocortisone, Leukocytes, Light, Male, Melatonin, Oscillometry, Radioimmunoassay, Sleep, Sleep Deprivation, Time Factors, Oxidative Stress, HSP70 Heat-Shock Proteins, Gene Expression Profiling, Young Adult, ARNTL Transcription Factors, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1
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