Cited by 116Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and Wakefulness Research

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Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans

Ackermann, Katrin, Plomp, Rosina, Lao, Oscar, Middleton, Benita, Revell, Victoria L., Skene, Debra J., Kayser, Manfred·2013·Chronobiology International

DOI 10.3109/07420528.2013.784773

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Abstract

This study investigated the impact of sleep deprivation on the human circadian system. Plasma melatonin and cortisol levels and leukocyte expression levels of 12 genes were examined over 48 h (sleep vs. no-sleep nights) in 12 young males (mean±SD: 23±5 yrs). During one night of total sleep deprivation, BMAL1 expression was suppressed, the heat shock gene HSPA1B expression was induced, and the amplitude of the melatonin rhythm increased, whereas other high-amplitude clock gene rhythms (e.g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation.

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Authors: Ackermann, K., Plomp, R., Lao, O., Middleton, B., Revell, V. L., Skene, D. J., & Kayser, M.
Affiliations: Erasmus MC (NL)
University of Surrey (GB)
Corresponding author: Ackermann, Katrin
ORCID: Ackermann, Katrin
Middleton, Benita
Revell, Victoria L.
Skene, Debra J.
Kayser, Manfred
Venue: Chronobiology International
Publisher: Informa UK Limited
Published: 2013-06-05
Volume: 30
Issue: 7
Pages: 901-909
ISSN: 0742-0528 (ISSN-L)
1525-6073
DOI: 10.3109/07420528.2013.784773
OpenAlex: W2033387947
Cited by: 116
References: 39
Citations by year: 2026: 6 · 2025: 15 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 11
FWCI: 6.28
Type: journal article
Language: en
Open access: closed
Locations: Chronobiology International (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council (BB/I019405/1)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: sleep deprivation, circadian clock, clock gene expression, melatonin rhythm, Bmal1, HSPA1B, heat shock response, NR1D1, cortisol, peripheral oscillators, leukocytes
MeSH terms: Adult, Circadian Rhythm, Gene Expression Regulation, Humans, Hydrocortisone, Leukocytes, Light, Male, Melatonin, Oscillometry, Radioimmunoassay, Sleep, Sleep Deprivation, Time Factors, Oxidative Stress, HSP70 Heat-Shock Proteins, Gene Expression Profiling, Young Adult, ARNTL Transcription Factors, Period Circadian Proteins, Nuclear Receptor Subfamily 1, Group D, Member 1

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Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans

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