Connecting the immune system, systemic chronic inflammation and the gut microbiome: the role of sex

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Hojsak, I., Benninga, M. A., Hauser, B., Kansu, A., Kelly, V. B., Stephen, A. M., López, A. M., Slavin, J. L., & Tuohy, K. M. (2022) · Archives of Disease in Childhood · doi:10.1136/archdischild-2021-323571 · Cited by 74 · see citing works

Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions

Tesei, D., Jewczynko, A., Lynch, A., & Urbaniak, C. (2022) · Life · doi:10.3390/life12040495 · Cited by 75 · see citing works

Gut microbiota in children with juvenile idiopathic arthritis: characteristics, biomarker identification, and usefulness in clinical prediction

Qian, X., Liu, Y., Ye, X., Zheng, W. J., Lv, S., Mo, M., Lin, J., Wang, W., Wang, W., Zhang, X., et al. (2020) · BMC Genomics · doi:10.1186/s12864-020-6703-0 · Cited by 75 · see citing works

Gut Microbiome in Retina Health: The Crucial Role of the Gut-Retina Axis

Scuderi, G., Troiani, E., & Minnella, A. M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.726792 · Cited by 70 · see citing works

Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice

Yang, G., Yuan, X., Jin, C., Wang, D., Wang, Y., Miao, W., & Jin, Y. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115290 · Cited by 71 · see citing works

Potential biological contributers to the sex difference in multiple sclerosis progression

Álvarez‐Sánchez, N., & Dunn, S. E. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1175874 · Cited by 71 · see citing works

Folic Acid Protects against Hyperuricemia in C57BL/6J Mice via Ameliorating Gut–Kidney Axis Dysfunction

Wang, P., Zhang, X., Zheng, X., Gao, J., Shang, M., Xu, J., & Liang, H. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c06297 · Cited by 68 · see citing works

Sex differences in the oral microbiome, host traits, and their causal relationships

Liu, X., Tong, X., Jie, Z., Zhu, J., Tian, L., Sun, Q., Ju, Y., Zou, L., Lu, H., Qiu, X., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105839 · Cited by 66 · see citing works

Neuroendocrine Mechanisms Governing Sex Differences in Hyperalgesic Priming Involve Prolactin Receptor Sensory Neuron Signaling

Paige, C. A., Barba-Escobedo, P. A., Mecklenburg, J. M., Patil, M. J., Goffin, V., Grattan, D. R., Dussor, G. O., Akopian, A. N., & Price, T. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1499-20.2020 · Cited by 66 · see citing works

Where Sex Meets Gender: How Sex and Gender Come Together to Cause Sex Differences in Mental Illness

Christiansen, D. M., McCarthy, M. M., & Seeman, M. V. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856436 · Cited by 65 · see citing works

HIV and cardiovascular disease: the role of inflammation

Dirajlal‐Fargo, S., & Funderburg, N. (2022) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000755 · Cited by 65 · see citing works

Di‐(2‐ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice

Fu, X., Han, H., Li, Y., Xu, B., Dai, W., Zhang, Y., Zhou, F., Ma, H., & Pei, X. (2021) · Environmental Toxicology · doi:10.1002/tox.23121 · Cited by 65 · see citing works

The urinary microbiome and biological therapeutics: Novel therapies for urinary tract infections

Kenneally, C., Murphy, C. P., Sleator, R. D., & Culligan, E. P. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127010 · Cited by 62 · see citing works

Effects of Bisphenol A on reproductive toxicity and gut microbiota dysbiosis in male rats

Liu, R., Cai, D., Li, X., Liu, B., Chen, J., Jiang, X., Li, H., Li, Z., Teerds, K. J., Sun, J., et al. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113623 · Cited by 63 · see citing works

High-throughput sequencing reveals the core gut microbiota of the mud crab (Scylla paramamosain) in different coastal regions of southern China

Wei, H., Wang, H., Tang, L., Mu, C., Ye, C., Chen, L., & Wang, C. (2019) · BMC Genomics · doi:10.1186/s12864-019-6219-7 · Cited by 61 · see citing works

Sex differences in rumen fermentation and microbiota of Tibetan goat

Guo, X., Sha, Y., Lv, W., Pu, X., Liu, X., Luo, Y., Hu, J., Wang, J., Li, S., & Zhao, Z. (2022) · Microbial Cell Factories · doi:10.1186/s12934-022-01783-8 · Cited by 58 · see citing works

Elevated Levels of Circulating Biomarkers Related to Leaky Gut Syndrome and Bacterial Translocation Are Associated With Graves’ Disease

Zheng, D., Liao, H., Chen, S., Liu, X., Mao, C., Zhang, C., Meng, M., Wang, Z., Wang, Y., Jiang, Q., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.796212 · Cited by 58 · see citing works

Gut Microbiota Composition Changes in Constipated Women of Reproductive Age

Li, H., Chen, J., Ren, X., Yang, C., Liu, S., Bai, X., Shan, S., & Dong, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.557515 · Cited by 58 · see citing works

Host Gender and Androgen Levels Regulate Gut Bacterial Taxa in Pigs Leading to Sex-Biased Serum Metabolite Profiles

He, M., Gao, J., Wu, J., Zhou, Y., Fu, H., Ke, S., Yang, H., Chen, C., & Huang, L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01359 · Cited by 53 · see citing works

Dynamic Changes in the Gut Microbiome at the Acute Stage of Ischemic Stroke in a Pig Model

Jeon, J. H., Lourenco, J. M., Kaiser, E. E., Waters, E. S., Scheulin, K. M., Fang, X., Kinder, H. A., Platt, S. R., Rothrock, M. J., Callaway, T. R., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.587986 · Cited by 54 · see citing works

Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish

Jia, P., Junaid, M., Wen, P.-P., Yang, Y., Li, W.-G., Yang, X., & Pei, D. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116925 · Cited by 54 · see citing works

17β‐estradiol reduces SARS‐CoV‐2 infection in vitro

Lemes, R. M. R., Costa, A. J., Bartolomeo, C. S., Bassani, T. B., Nishino, M. S., Pereira, G. J. S., Smaili, S. S., Maciel, R. M. B., Braconi, C. T., da Cruz, E. F., et al. (2021) · Physiological Reports · doi:10.14814/phy2.14707 · Cited by 51 · see citing works

Glyphosate-based herbicides: Evidence of immune-endocrine alteration

Maddalon, A., Galbiati, V., Colosio, C., Mandić‐Rajčević, S., & Corsini, E. (2021) · Toxicology · doi:10.1016/j.tox.2021.152851 · Cited by 52 · see citing works

The microbiome and immunodeficiencies: Lessons from rare diseases

Pellicciotta, M., Rigoni, R., Falcone, E. L., Holland, S. M., VILLA, A. M., & Cassani, B. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.01.008 · Cited by 52 · see citing works

Immunometabolic Links between Estrogen, Adipose Tissue and Female Reproductive Metabolism

Eaton, S. A., & Sethi, J. K. (2019) · Biology · doi:10.3390/biology8010008 · Cited by 51 · see citing works

Effects of High-Fat Diet During Childhood on Precocious Puberty and Gut Microbiota in Mice

Bo, T., Liu, M., Tang, L., Lv, J., Wen, J., & Wang, D. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.930747 · Cited by 51 · see citing works

Dysbiosis of the gut microbiome impairs mouse skeletal muscle adaptation to exercise

Valentino, T. R., Vechetti, I. J., Mobley, C. B., Dungan, C. M., Golden, L. R., Goh, J. Z., & McCarthy, J. J. (2021) · The Journal of Physiology · doi:10.1113/jp281788 · Cited by 50 · see citing works

Sex, puberty, and the gut microbiome

Sisk-Hackworth, L., Kelley, S. T., & Thackray, V. G. (2022) · Reproduction · doi:10.1530/rep-22-0303 · Cited by 51 · see citing works

Diet and Chronic Non-Cancer Pain: The State of the Art and Future Directions

Brain, K., Burrows, T. L., Bruggink, L., Malfliet, A., Hayes, C., Hodson, F. J., & Collins, C. E. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215203 · Cited by 47 · see citing works

Gut microbiota in ALS: possible role in pathogenesis?

McCombe, P. A., Henderson, R. D., Lee, A., Lee, J. D., Woodruff, T. M., Restuadi, R., McRae, A., Wray, N. R., Ngo, S., & Steyn, F. J. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1623026 · Cited by 46 · see citing works

A tale of two systems: Lessons learned from female mid-life aging with implications for Alzheimer’s prevention & treatment

Mishra, A., Wang, Y., Yin, F., Vitali, F., Rodgers, K. E., Soto, M., Mosconi, L., Wang, T., & Brinton, R. D. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101542 · Cited by 44 · see citing works

Short Chain Fatty Acids Taken at Time of Thrombectomy in Acute Ischemic Stroke Patients Are Independent of Stroke Severity But Associated With Inflammatory Markers and Worse Symptoms at Discharge

Henry, N., Frank, J. A., McLouth, C. J., Trout, A. L., Morris, A. J., Chen, J., Stowe, A. M., Fraser, J. F., & Pennypacker, K. R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.797302 · Cited by 49 · see citing works

Considerations for the design and conduct of human gut microbiota intervention studies relating to foods

Swann, J. R., Rajilić-Stojanović, M. D., Salonen, A., Sakwińska, O., Gill, C. M., Meynier, A., Fança‐Berthon, P., Schelkle, B., Segata, N., Shortt, C., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02232-1 · Cited by 45 · see citing works

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Jia, X., Yang, R., Li, J., Жао, Л., Zhou, X., & Xu, X. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.752708 · Cited by 43 · see citing works

Probiotics as a therapeutic strategy in obesity and overweight: a systematic review

Tomé-Castro, X. M., Rodríguez-Arrastia, M. J., Cardona, D., Rueda‐Ruzafa, L., Molina‐Torres, G., & Román, P. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0111 · Cited by 43 · see citing works

The gut-retina axis: a new perspective in the prevention and treatment of diabetic retinopathy

Zhang, H., & Mo, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1205846 · Cited by 42 · see citing works

Acute Effects of Butyrate on Induced Hyperpermeability and Tight Junction Protein Expression in Human Colonic Tissues

Scharf, M. W., Marques, T. M., Markgren, M., Löfvendahl, L., Brummer, R. J., & Wall, R. (2020) · Biomolecules · doi:10.3390/biom10050766 · Cited by 41 · see citing works

More than a gut feeling: What is the role of the gastrointestinal tract in female athlete health?

Pugh, J. N., Lydon, K. M., O’Donovan, C. M., O’Sullivan, Ó., & Madigan, S. M. (2021) · European Journal of Sport Science · doi:10.1080/17461391.2021.1921853 · Cited by 40 · see citing works

Interplay between Serotonin, Immune Response, and Intestinal Dysbiosis in Inflammatory Bowel Disease

Delgado, S. G., Veloz, I. G., Trejo-Vázquez, F., & Martínez‐Fierro, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415632 · Cited by 41 · see citing works

The immunobiology of female predominance in primary biliary cholangitis

Gerussi, A., Cristoferi, L., Carbone, M., Asselta, R., & Invernizzi, P. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.015 · Cited by 41 · see citing works

Gender-sex differences in autoimmune atrophic gastritis

Lahner, E., Dilaghi, E., Cingolani, S., Pivetta, G., Dottori, L., Esposito, G., Marzinotto, I., Lampasona, V., Buzzetti, R., & Annibale, B. (2022) · Translational research · doi:10.1016/j.trsl.2022.04.006 · Cited by 41 · see citing works

What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract

Fernández-Reina, A., Urdiales, J. L., & Sánchez‐Jiménez, F. (2018) · Foods · doi:10.3390/foods7090145 · Cited by 40 · see citing works

NLRP3 inflammasome deficiency attenuates metabolic disturbances involving alterations in the gut microbial profile in mice exposed to high fat diet

Sokolova, M., Yang, K., Hansen, S. H., Louwe, M. C., Kummen, M., Hov, J. R., Sjaastad, I., Berge, R. K., Halvorsen, B. L., Aukrust, P., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-76497-1 · Cited by 40 · see citing works

Lycium ruthenicum diet alters the gut microbiota and partially enhances gut barrier function in male C57BL/6 mice

Tian, B., Zhao, J., An, W., Zhang, J., Cao, X., Mi, J., Zhao, J., Zhang, Y., & Li, J. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.11.034 · Cited by 39 · see citing works

Gut Microbiome of Chinese Forest Musk Deer Examined across Gender and Age

Zhao, G., Ma, T., Tang, W., Li, D., Mishra, S. K., Xu, Z., Wang, Q., & Jie, H. (2019) · BioMed Research International · doi:10.1155/2019/9291216 · Cited by 39 · see citing works

Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism

Lobzhanidze, G., Japaridze, N. J., Lordkipanidze, T. G., Rzayev, F., MacFabe, D. F., & Zhvania, M. G. (2020) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10011 · Cited by 38 · see citing works

Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease

Maffei, S., Forini, F., Canale, P., Nicolini, G., & Guiducci, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137154 · Cited by 36 · see citing works

Immunology of pregnancy and reproductive health in autoimmune rheumatic diseases. Update from the 11th International Conference on Reproduction, Pregnancy and Rheumatic Diseases

Andréoli, L., Chighizola, C. B., Iaccarino, L., Botta, A., Gerosa, M., Ramoni, V. L., Tani, C., Bermas, B. L., Brucato, A. L., Buyon, J. P., et al. (2022) · Autoimmunity Reviews · doi:10.1016/j.autrev.2022.103259 · Cited by 37 · see citing works

The gut-eye axis: the retinal/ocular degenerative diseases and the emergent therapeutic strategies

Kammoun, S., Rekik, M., Dlensi, A., Aloulou, S., Smaoui, W., Sellami, S., Trigui, K., Rahma, G., Chaari, I., Sellami, H., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1468187 · Cited by 35 · see citing works

The potential influence and intervention measures of gut microbiota on sperm: it is time to focus on testis-gut microbiota axis

Chen, W., Zou, H., Xu, H., Cao, R., Zhang, H., Zhang, Y., & Zhao, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1478082 · Cited by 39 · see citing works

Intestinal Microbiota Dysbiosis Promotes Mucosal Barrier Damage and Immune Injury in HIV‐Infected Patients

Pan, Z., Wu, N., & Jin, C. (2023) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2023/3080969 · Cited by 34 · see citing works

Gut–Brain Axis: Focus on Sex Differences in Neuroinflammation

Caldarelli, M., Rio, P., Marrone, A., Ocarino, F., Chiantore, M., Candelli, M., Gasbarrini, A., Gambassi, G., & Cianci, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105377 · Cited by 36 · see citing works

Protective Effects of Probiotics on Cognitive and Motor Functions, Anxiety Level, Visceral Sensitivity, Oxidative Stress and Microbiota in Mice with Antibiotic-Induced Dysbiosis

Arslanova, A., Tarasova, A., Alexandrova, A. D., Novoselova, V., Shaidullov, I., Khusnutdinova, D., Grigoryeva, T., Yarullina, D., Yakovleva, O., & Sitdikova, G. (2021) · Life · doi:10.3390/life11080764 · Cited by 32 · see citing works

Integrating Autism Spectrum Disorder Pathophysiology: Mitochondria, Vitamin A, CD38, Oxytocin, Serotonin and Melatonergic Alterations in the Placenta and Gut

Maes, M. H. J., Anderson, G., Medina, S. R. B., Seo, M., & Ojala, J. O. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666191102165459 · Cited by 33 · see citing works

The gut-brain axis and beyond: Microbiome control of spinal cord injury pain in humans and rodents

Bannerman, C. A., Douchant, K., Sheth, P. M., & Ghasemlou, N. (2020) · Neurobiology of Pain · doi:10.1016/j.ynpai.2020.100059 · Cited by 33 · see citing works

Sex Differences in Non-AIDS Comorbidities Among People With Human Immunodeficiency Virus

Pond, R. A., Collins, L. F., & Lahiri, C. D. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab558 · Cited by 34 · see citing works

Gut microbiome-brain axis and inflammation in temperament, personality and psychopathology

Sumich, A. L., Heym, N., Lenzoni, S., & Hunter, K. A. (2022) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2022.101101 · Cited by 35 · see citing works

The trace aminergic system: a gender-sensitive therapeutic target for IBS?

Pretorius, L., & Smith, C. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00688-1 · Cited by 32 · see citing works

Connecting the mechanisms of tumor sex differences with cancer therapy

Li, H., Jiang, W., Liu, S., Yang, M., Chen, S., Pan, Y., & Cui, M. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04723-1 · Cited by 31 · see citing works

The sex-dependent response to psychosocial stress and ischaemic heart disease

Helman, T. J., Headrick, J. P., Stapelberg, N. J. C., & Braidy, N. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1072042 · Cited by 34 · see citing works

Microbiome

Taneja, V. (2017) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-12-803506-1.00027-9 · Cited by 16 · see citing works

Microbiome-orchestrated cross-organ immunity in autoimmunity: from metabolites to therapeutic targets

Rao, X., Zou, L., Cai, X., Yao, Y., & Zhong, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1761834 · Cited by 2 · see citing works

Relationship between gut microbiota and development of T cell associated disease

Kosiewicz, M. M., Dryden, G. W., Chhabra, A., & Alard, P. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.019 · Cited by 118 · see citing works

Molecular Mechanisms of Gut Microbiota–Immune System Crosstalk: From Mucosal Architecture to Adaptive Immunity Programming

Ciaușu-Sliwa, D., Capotă, R., Bostănaru, A.-C., Năstasă, V., & Mareș, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146246 · Cited by 2 · see citing works

The Microbiota and Immune System Crosstalk in Health and Disease

Cianci, R., Pagliari, D., Piccirillo, C. A., Fritz, J. H., & Gambassi, G. (2018) · Mediators of Inflammation · doi:10.1155/2018/2912539 · Cited by 61 · see citing works