Effect of flaxseed supplementation on markers of inflammation and endothelial function: A systematic review and meta-analysis

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.

(2009) · PubMed Central · Cited by 44,859 · see citing works

Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement

Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554 · see citing works

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

Higgins, J. P. T., Altman, D. G., Gotzsche, P. C., Juni, P., Moher, D., Oxman, A. D., Savovic, J., Schulz, K. F., Weeks, L., Sterne, J. A. C., et al. (2011) · BMJ · doi:10.1136/bmj.d5928 · Cited by 33,817 · see citing works

Variance imputation for overviews of clinical trials with continuous response

Follmann, D. A., Elliott, P., Suh, I., & Cutler, J. A. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90054-q · Cited by 1,391 · see citing works

Inflammatory cytokines in vascular dysfunction and vascular disease

Sprague, A. H., & Khalil, R. A. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.04.029 · Cited by 1,347 · see citing works

The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil

Caughey, G. E., Mantzioris, E., Gibson, R. A., Cleland, L., & James, M. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.1.116 · Cited by 860 · see citing works

Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms

Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762 · see citing works

Flaxseed as a functional food source

Oomah, B. D. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.898 · Cited by 594 · see citing works

The effect of propolis and its components on eicosanoid production during the inflammatory response

Mirzoeva, O. K., & Calder, P. C. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90129-5 · Cited by 295 · see citing works

Food, immunity, and the microbiome

Tilg, H., & Moschen, A. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.036 · Cited by 292 · see citing works

Dietary α-linolenic acid decreases C-reactive protein, serum amyloid A and interleukin-6 in dyslipidaemic patients

Rallidis, L. S., Paschos, G., Liakos, G. K., Velissaridou, A. H., Anastasiadis, G., & Zampelas, A. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(02)00427-6 · Cited by 288 · see citing works

Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults.

Thies, F., Miles, E. A., Nebe‐von‐Caron, G., Powell, J. R., Hurst, T. L., Newsholme, E. A., & Calder, P. C. (2001) · Lipids · doi:10.1007/s11745-001-0831-4 · Cited by 279 · see citing works

Meta-analysis of the effects of flaxseed interventions on blood lipids

Pan, A., Yu, D., Demark-Wahnefried, W., Franco, O. H., & Lin, X. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27469 · Cited by 264 · see citing works

Endothelial function, inflammation, and prognosis in cardiovascular disease

Gonzalez, M. A., & Selwyn, A. P. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.09.016 · Cited by 258 · see citing works

Flaxseed and Cardiovascular Risk Factors: Results from a Double Blind, Randomized, Controlled Clinical Trial

Bloedon, L. T., Balikai, S., Chittams, J. L., Cunnane, S. C., Berlin, J. A., Rader, D. J., & Szapary, P. O. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719676 · Cited by 253 · see citing works

Flaxseed and Cardiovascular Risk

Bloedon, L. T., & Szapary, P. O. (2004) · Nutrition Reviews · doi:10.1111/j.1753-4887.2004.tb00002.x · Cited by 217 · see citing works

Flaxseed Supplementation (Not Dietary Fat Restriction) Reduces Prostate Cancer Proliferation Rates in Men Presurgery

Demark‐Wahnefried, W., Polascik, T. J., George, S. L., Switzer, B. R., Madden, J. F., Ruffin, M. T., Snyder, D. C., Owzar, K., Hárs, V., Albala, D. M., et al. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0008 · Cited by 209 · see citing works

Effects of a Flaxseed-Derived Lignan Supplement in Type 2 Diabetic Patients: A Randomized, Double-Blind, Cross-Over Trial

Pan, A., Sun, J., Chen, Y., Ye, X., Li, H., Yu, Z., Wang, Y., Gu, W., Zhang, X., Chen, X., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001148 · Cited by 195 · see citing works

Flaxseed: its bioactive components and their cardiovascular benefits

Parikh, M., Netticadan, T., & Pierce, G. N. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00400.2017 · Cited by 194 · see citing works

Flaxseed Improves Lipid Profile without Altering Biomarkers of Bone Metabolism in Postmenopausal Women

Lucas, E. A., Wild, R. D., Hammond, L. J., Khalil, D. A., Juma, S., Daggy, B. P., Stoecker, B. J., & Arjmandi, B. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8374 · Cited by 193 · see citing works

Flaxseed and Cardiovascular Health

Prasad, K. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181af04e5 · Cited by 187 · see citing works

Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study

Hutchins, A. M., Brown, B. D., Cunnane, S. C., Domitrovich, S. G., Adams, E. R., & Bobowiec, C. E. (2013) · Nutrition Research · doi:10.1016/j.nutres.2013.02.012 · Cited by 166 · see citing works

Flaxseed Reduces Total and LDL Cholesterol Concentrations in Native American Postmenopausal Women

Patade, A., Devareddy, L., Lucas, E. A., Korlagunta, K., Daggy, B. P., & Arjmandi, B. H. (2008) · Journal of Women's Health · doi:10.1089/jwh.2007.0359 · Cited by 164 · see citing works

A Comparison of Fish Oil, Flaxseed Oil and Hempseed Oil Supplementation on Selected Parameters of Cardiovascular Health in Healthy Volunteers

Kaul, N., Kreml, R., Austria, J. A., Richard, M. N., Edel, A. L., Dibrov, E., Hirono, S., Zettler, M. E., & Pierce, G. N. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719674 · Cited by 161 · see citing works

Flaxseed Consumption Reduces Blood Pressure in Patients With Hypertension by Altering Circulating Oxylipins via an α-Linolenic Acid–Induced Inhibition of Soluble Epoxide Hydrolase

Caligiuri, S. P. B., Aukema, H. M., Ravandi, A., Guzman, R., Dibrov, E., & Pierce, G. N. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03179 · Cited by 144 · see citing works

High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects

Gillingham, L. G., Gustafson, J. A., Han, S.-Y., Jassal, D. S., & Jones, P. J. H. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510003697 · Cited by 143 · see citing works

Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial

Dodin, S., Cunnane, S. C., Mâsse, B., Lemay, A., Jacques, H., Asselin, G., Tremblay-Mercier, J., Marc, I., Lamarche, B., Légaré, F., et al. (2008) · Nutrition · doi:10.1016/j.nut.2007.09.003 · Cited by 142 · see citing works

Natural approaches in metabolic syndrome management

Patti, A. M., Al‐Rasadi, K., Giglio, R. V., Nikolić, D., Mannina, C. M., Castellino, G., Chianetta, R., Banach, M., Cicero, A. F. G., Lippi, G., et al. (2017) · Archives of Medical Science · doi:10.5114/aoms.2017.68717 · Cited by 139 · see citing works

Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design

Rhee, Y. S., & Brunt, A. R. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-44 · Cited by 126 · see citing works

Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study

Yari, Z., Rahimlou, M., Eslamparast, T., Ebrahimi-Daryani, N., Poustchi, H., & Hekmatdoost, A. (2016) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2016.1161011 · Cited by 118 · see citing works

Oxidative stability of flaxseed lipids during baking

Chen, Z., Ratnayake, W. M. N., & Cunnane, S. C. (1994) · Journal of the American Oil Chemists Society · doi:10.1007/bf02540591 · Cited by 116 · see citing works

Effects of flaxseed supplements on blood pressure: A systematic review and meta-analysis of controlled clinical trial

Ursoniu, S., Sahebkar, A., Andrica, F., Șerban, M.-C., & Banach, M. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.05.012 · Cited by 113 · see citing works

Alpha-linolenic acid supplementation and resistance training in older adults

Cornish, S. M., & Chilibeck, P. D. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-136 · Cited by 112 · see citing works

Effects of Olive Oil Phenolic Compounds on Inflammation in the Prevention and Treatment of Coronary Artery Disease

de Souza, P. A. L., Marcadenti, A., & Portal, V. L. (2017) · Nutrients · doi:10.3390/nu9101087 · Cited by 109 · see citing works

The effect of a lignan complex isolated from flaxseed on inflammation markers in healthy postmenopausal women

Hallund, J., Tetens, I., Bügel, S., Tholstrup, T., & Bruun, J. M. (2008) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.05.007 · Cited by 108 · see citing works

Clinical and metabolic response to flaxseed oil omega-3 fatty acids supplementation in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial

Soleimani, Z., Hashemdokht, F., Bahmani, F., Taghizadeh, M., Memarzadeh, M. R., & Asemi, Z. (2017) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2017.06.010 · Cited by 107 · see citing works

Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed

Nordström, D., Friman, C., Konttinen, Y. T., Honkanen, V., Nasu, Y., & Antila, E. (1995) · Rheumatology International · doi:10.1007/bf00262088 · Cited by 105 · see citing works

C-reactive protein, inflammation, and cardiovascular disease: clinical update.

Ridker, P. M. (2005) · PubMed · Cited by 102 · see citing works

Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome

Dewell, A., Marvasti, F. F., Harris, W. S., Tsao, P., & Gardner, C. D. (2011) · The Journal of Nutrition · doi:10.3945/jn.111.142240 · Cited by 98 · see citing works

Flaxseed and Human Health: Reviewing Benefits and Adverse Effects

Carraro, J. C. C., Dantas, M. I. D. S., Espeschit, A. C. R., Martino, H. S. D., & Ribeiro, S. M. R. (2011) · Food Reviews International · doi:10.1080/87559129.2011.595025 · Cited by 95 · see citing works

Efficacy of synbiotic supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials: Synbiotic supplementation and NAFLD

Hadi, A., Mohammadi, H., Miraghajani, M. S., & Ghaedi, E. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1458021 · Cited by 94 · see citing works

Systemic Inflammation in Morbidly Obese Subjects: Response to Oral Supplementation with Alpha-Linolenic Acid

Faintuch, J., Horie, L. M., Barbeiro, H. V., Barbeiro, D. F., Soriano, F. G., Ishida, R. K., & Cecconello, I. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9062-x · Cited by 92 · see citing works

Flax Seed: A Potential Medicinal Food

Katare, C., Saxena, S., Agrawal, S., & Prasad, G. (2012) · Journal of Nutrition & Food Sciences · doi:10.4172/2155-9600.1000120 · Cited by 91 · see citing works

Effect of Flaxseed Intervention on Inflammatory Marker C-Reactive Protein: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ren, G.-Y., Chen, C.-Y., Chen, G.-C., Chen, W.-G., Pan, A., Pan, C.-W., Zhang, Y.-H., Qin, L.-Q., & Chen, L.-H. (2016) · Nutrients · doi:10.3390/nu8030136 · Cited by 88 · see citing works

Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients

Pan, A., Demark‐Wahnefried, W., Ye, X., Yu, Z., Li, H., Qi, Q., Sun, J., Chen, Y., Chen, X., Liu, Y., et al. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508061527 · Cited by 86 · see citing works

Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome

Vargas, M. L., Almario, R. U., Buchan, W., Kim, K., & Karakas, S. E. (2011) · Metabolism · doi:10.1016/j.metabol.2011.04.007 · Cited by 86 · see citing works

Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men

Paschos, G. K., Zampelas, A., Panagiotakos, D. B., Katsiougiannis, S., Griffin, B. A., Votteas, V., & Skopouli, F. N. (2007) · European Journal of Nutrition · doi:10.1007/s00394-007-0668-5 · Cited by 85 · see citing works

Benefits of foods supplemented with vegetable oils rich in α-linolenic, stearidonic or docosahexaenoic acid in hypertriglyceridemic subjects: a double-blind, randomized, controlled trail

Dittrich, M., Jahreis, G., Bothor, K., Drechsel, C., Kiehntopf, M., Blüher, M., & Dawczynski, C. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0764-2 · Cited by 81 · see citing works

Efficacy of synbiotic supplementation in obesity treatment: A systematic review and meta-analysis of clinical trials

Hadi, A., Alizadeh, K., Hajianfar, H., Mohammadi, H., & Miraghajani, M. S. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1545218 · Cited by 79 · see citing works

Flaxseed oil does not affect inflammatory markers and lipid profile compared to olive oil, in young, healthy, normal weight adults

Kontogianni, M. D., Vlassopoulos, A., Gatzieva, A., Farmaki, A., Katsiougiannis, S., Panagiotakos, D. B., Kalogeropoulos, N., & Skopouli, F. N. (2013) · Metabolism · doi:10.1016/j.metabol.2012.11.007 · Cited by 75 · see citing works

Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities

Khalatbari Soltani, S., Jamaluddin, R., Tabibi, H., Mohd Yusof, B. N., Atabak, S., Loh, S., & Rahmani, L. (2013) · Hemodialysis International · doi:10.1111/j.1542-4758.2012.00754.x · Cited by 72 · see citing works

Flaxseed Lignan Complex Administration in Older Human Type 2 Diabetics Manages Central Obesity and Prothrombosis—An Invitation to Further Investigation into Polypharmacy Reduction

Barre, D. E., Mizier-Barre, K. A., Stelmach, E., Hobson, J., Griscti, O., Rudiuk, A., & Muthuthevar, D. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/585170 · Cited by 68 · see citing works

Flaxseed oil supplementation decreases C-reactive protein levels in chronic hemodialysis patients

Lemos, J. R. N., Alencastro, M. G., Konrath, A. V., Cargnin, M., & Manfro, R. C. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.08.007 · Cited by 66 · see citing works

The Effects of Flaxseed Oil Omega-3 Fatty Acids Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Mirmasoumi, G., Fazilati, M., Foroozanfard, F., Vahedpoor, Z., Mahmoodi, S., Taghizadeh, M., Esfeh, N. K., Mohseni, M., Karbassizadeh, H., & Asemi, Z. (2017) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-119751 · Cited by 64 · see citing works

Supplementation of α-linolenic acid improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes

Gomes, P. M., Miranda, W. R. D. H., Beraldo, R. A., Castro, A. V., Geloneze, B., Foss, M. C., & Foss‐Freitas, M. C. (2015) · Nutrition · doi:10.1016/j.nut.2014.12.028 · Cited by 59 · see citing works

Low-Grade, Systemic Inflammation in Adolescents: Association With Early-Life Factors, Gender, and Lifestyle

Pirkola, J., Vääräsmäki, M., Ala‐Korpela, M., Bloigu, A. H., Canoy, D., Hartikainen, A., Leinonen, M., Miettola, S., Paldanius, M., Tammelin, T., et al. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp320 · Cited by 58 · see citing works

Unsaturated Fatty Acids Improve Atherosclerosis Markers in Obese and Overweight Non-diabetic Elderly Patients

de Oliveira, P. A., Kovacs, C., Moreira, P., Magnoni, D., Saleh, M. H., & Faintuch, J. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2704-8 · Cited by 58 · see citing works

The risk of plasma vitamin A, C, E and D deficiency in patients with metabolic syndrome: a case-control study

Godala, M. M., Materek-Kuśmierkiewicz, I., Moczulski, D. K., Rutkowski, M., Szatko, F., Gaszyńska, E., Tokarski, S., & Kowalski, J. (2017) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/62453 · Cited by 58 · see citing works

Effect of flaxseed oil on serum systemic and vascular inflammation markers and oxidative stress in hemodialysis patients: a randomized controlled trial

Mirfatahi, M., Tabibi, H., Nasrollahi, A., Hedayati, M., & Taghizadeh, M. (2016) · International Urology and Nephrology · doi:10.1007/s11255-016-1300-5 · Cited by 53 · see citing works

Cell and molecular mechanisms behind diet‐induced hypothalamic inflammation and obesity

Ávalos, Y., Kerr, B., Maliqueo, M. A., & Dorfman, M. D. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12598 · Cited by 53 · see citing works

Inflammation markers predict zinc transporter gene expression in women with type 2 diabetes mellitus

Foster, M. J., Petocz, P., & Samman, S. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.02.006 · Cited by 47 · see citing works

Inflammatory markers are not altered by an eight week dietary α-linolenic acid intervention in healthy abdominally obese adult males and females

Nelson, T. L., Stevens, J. R., & Hickey, M. S. (2007) · Cytokine · doi:10.1016/j.cyto.2007.05.010 · Cited by 47 · see citing works

Oxidative and endoplasmic reticulum stress is impaired in leukocytes from metabolically unhealthy vs healthy obese individuals

Bañuls, C., Rovira-Llopis, S., Lopez-Domenech, S., Diaz-Morales, N., Blas-Garcia, A., Veses, S., Morillas, C., Victor, V. M., Rocha, M., & Hernandez-Mijares, A. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.147 · Cited by 47 · see citing works

Lignan Content of the Flaxseed Influences Its Biological Effects in Healthy Men and Women

Almario, R. U., & Karakas, S. E. (2013) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.791147 · Cited by 46 · see citing works

Possible anti‐obesity effects of phytosterols and phytostanols supplementation in humans: A systematic review and dose–response meta‐analysis of randomized controlled trials

Ghaedi, E., Kord‐Varkaneh, H., Rahmani, J., Mousavi, S. M., Mohammadi, H., Fatahi, S., Pantović, A., Mofrad, M. D., & Zhang, Y. (2019) · Phytotherapy Research · doi:10.1002/ptr.6319 · Cited by 43 · see citing works

Effect of flaxseed consumption on flow-mediated dilation and inflammatory biomarkers in patients with coronary artery disease: a randomized controlled trial

Khandouzi, N., Zahedmehr, A., Mohammadzadeh, A., Sanati, H. R., & Nasrollahzadeh, J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0268-x · Cited by 40 · see citing works

Dietary flaxseed: what we know and don’t know about its effects on cardiovascular disease

Parikh, M., & Pierce, G. N. (2018) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2018-0547 · Cited by 40 · see citing works

Gene Polymorphism Association Studies in Dialysis: The Nutrition‐Inflammation Axis

Jaber, B. L., Balakrishnan, V. S., Stenvinkel, P., Pecoits‐Filho, R., & Lindholm, B. (2005) · Seminars in Dialysis · doi:10.1111/j.1525-139x.2005.18317.x · Cited by 35 · see citing works

Systemic inflammation and carotid diameter in obese patients: pilot comparative study with flaxseed powder and cassava powder.

Faintuch, J., Bortolotto, L. A., Marques, P. C. D. O. C., Faintuch, J., França, J. Í. D., & Cecconello, I. (2011) · PubMed · Cited by 35 · see citing works

High Prevalence of Vitamin D Deficiency and Correlation of Serum Vitamin D with Cardiovascular Risk in Patients with Metabolic Syndrome

Alkhatatbeh, M. J., Abdul‐Razzak, K. K., Khasawneh, L. Q., & Saadeh, N. A. (2017) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2017.0003 · Cited by 33 · see citing works

The effect of isolated soy protein adjunctive with flaxseed oil on markers of inflammation, oxidative stress, acute phase proteins, and wound healing of burn patients; a randomized clinical trial

Babajafari, S., Akhlaghi, M., Mazloomi, S. M., Ayaz, M., Noorafshan, A., Jafari, P., & Hojhabrimanesh, A. (2017) · Burns · doi:10.1016/j.burns.2017.05.014 · Cited by 28 · see citing works

Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome

Zong, G., Demark‐Wahnefried, W., Wu, H., & Xu, L. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0461-y · Cited by 23 · see citing works

Effects of ginseng supplementation on selected markers of inflammation: A systematic review and meta‐analysis

Mohammadi, H., Hadi, A., Kord‐Varkaneh, H., Arab, A., Afshari, M., Ferguson, A. J. R., & Ghaedi, E. (2019) · Phytotherapy Research · doi:10.1002/ptr.6399 · Cited by 23 · see citing works

Effects of Omega-3 Fatty Acid Supplementation on Inflammatory Cytokines and Advanced Glycation End Products in Patients With Diabetic Nephropathy: a Randomized Controlled Trial.

Mirhashemi, S. M., Rahimi, F., Soleimani, A., & Asemi, Z. (2016) · Iranian Journal of Kidney Diseases · Cited by 22 · see citing works

Brazilian oral herbal medication for osteoarthritis: a systematic review protocol

Moura, M. D. G., Lopes, L. C., Biavatti, M. W., Busse, J. W., Wang, L., Kennedy, S. A., Bhatnaga, N., & Bergamaschi, C. D. C. (2016) · Systematic Reviews · doi:10.1186/s13643-016-0261-1 · Cited by 16 · see citing works

The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-Analysis

Nikpayam, O., Rouhani, M. H., Pourmasoumi, M., Roshanravan, N., Ghaedi, E., & Mohammadi, H. (2018) · Clinical Nutrition Research · doi:10.7762/cnr.2018.7.2.117 · Cited by 13 · see citing works

The value of N-terminal pro-B-type natriuretic peptide (NT Pro-BNP) to predict sudden cardiac death in chronic heart failure patients with normal renal function; a systematic review and meta-analysis

Sheikhvatan, M., Ataei, Z., Heydari, A., & Zahergivar, A. (2018) · Journal of Nephropharmacology · doi:10.15171/npj.2018.32 · Cited by 5 · see citing works

The association between G\A455 and C\A148 polymorphisms with beta fibrinogen gene and presence of coronary artery disease among Iranian population

Motavas, M., Shojaee, M., & Aldavood, D. (2018) · Journal of Preventive Epidemiology · Cited by 2 · see citing works

Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition

Sala‐Vila, A., Fleming, J. A., Kris‐Etherton, P. M., & Ros, E. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac016 · Cited by 158 · see citing works

Consumption of Nuts and Seeds and Health Outcomes Including Cardiovascular Disease, Diabetes and Metabolic Disease, Cancer, and Mortality: An Umbrella Review

Balakrishna, R., Bjørnerud, T., Bemanian, M., Aune, D., & Fadnes, L. T. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac077 · Cited by 103 · see citing works

Lignan Intake and Risk of Coronary Heart Disease

Hu, Y., Li, Y., Sampson, L., Wang, M., Manson, J. E., Rimm, E. B., & Sun, Q. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.05.049 · Cited by 59 · see citing works

Impact of Dietary Fiber on Inflammation in Humans

Kabisch, S., Hajir, J., Sukhobaevskaia, V., Weickert, M. O., & Pfeiffer, A. F. H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052000 · Cited by 50 · see citing works

Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Nutrition & Metabolism · doi:10.1186/s12986-021-00619-3 · Cited by 40 · see citing works

Effect of flaxseed (Linum usitatissimum) supplementation on glycemic control and insulin resistance in prediabetes and type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials

Villarreal-Renteria, A. I., Herrera-Echauri, D. D., Rodríguez-Rocha, N. P., Zúñiga, L. Y., Muñóz-Valle, J. F., García‐Arellano, S., Bernal-Orozco, M. F., & Ojeda, G. M. (2022) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2022.102852 · Cited by 35 · see citing works

Natural remedies medicine derived from flaxseed (secoisolariciresinol diglucoside, lignans, and α‐linolenic acid) improve network targeting efficiency of diabetic heart conditions based on computational chemistry techniques and pharmacophore modeling

Hajibabaie, F., Abedpoor, N., Safavi, K., & Taghian, F. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14480 · Cited by 34 · see citing works

Effects of low-carbohydrate diets, with and without caloric restriction, on inflammatory markers in adults: a systematic review and meta-analysis of randomized clinical trials

Kazeminasab, F., Miraghajani, M. S., Khalafi, M., Sakhaei, M. H., Rosenkranz, S. K., & Santos, H. O. (2024) · European Journal of Clinical Nutrition · doi:10.1038/s41430-024-01431-x · Cited by 28 · see citing works

Effects of Flaxseed on Blood Lipids in Healthy and Dyslipidemic Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Masjedi, M. S., Pour, P. M., Shokoohinia, Y., & Asgary, S. (2021) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2021.100931 · Cited by 29 · see citing works

Dietary flaxseed: Cardiometabolic benefits and its role in promoting healthy aging

Kunutsor, S. K., Jassal, D. S., Ravandi, A., & Lehoczki, A. (2025) · GeroScience · doi:10.1007/s11357-025-01512-0 · Cited by 32 · see citing works

Increased circulating CD31+/CD42b-EMPs in Perthes disease and inhibit HUVECs angiogenesis via endothelial dysfunction

Li, B., Huang, Q., Lin, C., Lu, R., Wang, T., Chen, X., Liu, Z., Liu, Y., Wu, J., Wu, Y., et al. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118749 · Cited by 26 · see citing works

A narrative review on nutraceutical, food and industrial applications of flaxseed ( Linum usitatissimum. L)

Shahada, C., Morya, S., & Awuchi, C. G. (2024) · Cogent Food & Agriculture · doi:10.1080/23311932.2024.2306017 · Cited by 23 · see citing works

Impact of flaxseed supplementation on plasma lipoprotein(a) concentrations: A systematic review and meta‐analysis of randomized controlled trials

Hadi, A., Askarpour, M., Ziaei, R., Venkatakrishnan, K., Ghaedi, E., & Ghavami, A. (2020) · Phytotherapy Research · doi:10.1002/ptr.6640 · Cited by 20 · see citing works

Flaxseed (Linum Usitatissimum L.) Supplementation in Patients Undergoing Lipoprotein Apheresis for Severe Hyperlipidemia—A Pilot Study

Kanikowska, D., Korybalska, K., Mickiewicz, A., Rutkowski, R., Kuchta, A., Sato, M., Kreft, E., Fijałkowski, M., Gruchała, M., Jankowski, M., et al. (2020) · Nutrients · doi:10.3390/nu12041137 · Cited by 17 · see citing works

Influence of enhanced external counterpulsation on endothelial function: a meta-analysis of randomized controlled trials

Yin, Q., Jiang, H., Zhang, Z., Zhang, L., Wu, Z., Huang, L., & Chen, X. (2023) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2023.2273223 · Cited by 16 · see citing works

A descriptive review on nutraceutical constituents, detoxification methods and potential health benefits of flaxseed

Rizvi, Q. U. E. H., Shams, R., Pandey, V. K., Dar, A. H., Tripathi, A., & Singh, R. (2022) · Applied Food Research · doi:10.1016/j.afres.2022.100239 · Cited by 19 · see citing works

Whole Flaxseed-based Products and Their Health Benefits

Tang, Z., Shi, L., Wang, X., Dai, G.-W., Cheng, L.-A., Wan, Z.-X., He, H., Wu, Q., Wang, Y.-B., Xiao-yang, J., et al. (2020) · Food Science and Technology Research · doi:10.3136/fstr.26.561 · Cited by 15 · see citing works

The Effect of Oral Magnesium Supplementation on Inflammatory Biomarkers in Adults: A Comprehensive Systematic Review and Dose–response Meta-analysis of Randomized Clinical Trials

Talebi, S., Miraghajani, M. S., Hosseini, R., & Mohammadi, H. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02783-2 · Cited by 15 · see citing works

Effects of flaxseed supplementation on weight loss, lipid profiles, glucose, and high‐sensitivity C‐reactive protein in patients with coronary artery disease: A systematic review and meta‐analysis of randomized controlled trials

Sabet, H. R., Ahmadi, M., Akrami, M., Motamed, M., Keshavarzian, O., Abdollahi, M., Rezaei, M., & Akbari, H. (2024) · Clinical Cardiology · doi:10.1002/clc.24211 · Cited by 14 · see citing works

The Effect of Flaxseed Oil Supplementation on Body Composition and Inflammation Indices in Overweight Adults With Pre-Diabetes

Shareghfarid, E., Nadjarzadeh, A., Heidarzadeh‐Esfahani, N., Azamian, Y., & Hajiahmadi, S. (2022) · Nutrition and Metabolic Insights · doi:10.1177/11786388221090083 · Cited by 15 · see citing works

Effects of flaxseed supplementation on inflammatory biomarkers: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials

Musazadeh, V., Morovatshoar, R., Kavyani, Z., Vajdi, M., & Askari, G. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106868 · Cited by 12 · see citing works

The effects of flaxseed supplementation on metabolic syndrome risk factors; A comprehensive review

Nattagh‐Eshtivani, E., Barghchi, H., Hatami, A., Barati, M., Heydari, A., Abdi-Moghadam, Z., Fard, M. V., Mohammadhasani, K., Miri, H., Talebi, S., et al. (2025) · Clinical Nutrition Open Science · doi:10.1016/j.nutos.2025.02.010 · Cited by 12 · see citing works

Slower Pace of Epigenetic Aging and Lower Inflammatory Indicators in Females Following a Nutrient-Dense, Plant-Rich Diet Than Those in Females Following the Standard American Diet

Ferreri, D. M., Sutliffe, J. T., Lopez, N. V., Sutliffe, C. A., Smith, R. S., Carreras-Gallo, N., Dwaraka, V. B., Prestrud, A. A., & Fuhrman, J. (2024) · Current Developments in Nutrition · doi:10.1016/j.cdnut.2024.104497 · Cited by 7 · see citing works

Roles of foods and related components: an overview on cancer causatives, and plausible preventions

Mohammed, H. A., Sulaiman, G. M., Al‐Saffar, A. Z., Abomughaid, M. M., Hussein, N. N., Salih, Z. T., Hadi, N. A., Mohsin, M. H., Al-Kuraishy, H. M., Khan, R. A., et al. (2025) · Applied Food Research · doi:10.1016/j.afres.2025.101132 · Cited by 7 · see citing works

Effect of Flaxseed (Linum usitatissimum L.) Supplementation on Vascular Endothelial Cell Morphology and Function in Patients with Dyslipidaemia—A Preliminary Observation

Kanikowska, D., Malińska, A., Mickiewicz, A., Zawada, A. E., Rutkowski, R., Pawlaczyk, K., Sato, M., Bręborowicz, A., Witowski, J., & Korybalska, K. (2022) · Nutrients · doi:10.3390/nu14142879 · Cited by 6 · see citing works

Nuts and seeds – a scoping review for Nordic Nutrition Recommendations 2023

Fadnes, L. T., & Balakrishna, R. (2024) · Food & Nutrition Research · doi:10.29219/fnr.v68.10483 · Cited by 6 · see citing works

The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin‐6 and tumour necrosis factor‐α among post‐menopausal women? A systematic review and meta‐analysis of randomized controlled trials

Gholami, A., Mollanoroozy, E., Baradaran, H. R., & Hariri, M. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13586 · Cited by 6 · see citing works

Fatty Acid Release and Gastrointestinal Oxidation Status: Different Methods of Processing Flaxseed

Zhang, M., Chen, Y., Chen, H., & Deng, Q. (2024) · Foods · doi:10.3390/foods13050784 · Cited by 6 · see citing works

Flaxseed Lowers Blood Pressure in Hypertensive Subjects: A Meta-Analysis of Randomized Controlled Trials

Moghadam, E. F., Khaghani, L., & Shekarchizadeh, P. (2024) · Clinical Nutrition Research · doi:10.7762/cnr.2024.13.4.295 · Cited by 5 · see citing works

The Impact of Flaxseed (Linum usitatissimum L.) Oil Supplementation on Human Health: A Human-Centric Evidence-Graded Approach

Nie, Y., Wang, Y., Hui, J., Shao, D., Chen, R., Deng, Q., Chen, Y., Wang, X., & Zhu, D. (2025) · Nutrients · doi:10.3390/nu17111791 · Cited by 4 · see citing works

Inflammatory Biomarkers in Nutrition

Abreu, S., & Sousa‐Pimenta, M. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-07389-2_44 · Cited by 4 · see citing works

The Impact of Hempseed Consumption on Bone Parameters and Body Composition in Growing Female C57BL/6 Mice

Blanton, C. A., Barrott, J. J., Kunz, K. M., Bunde, E., Streff, H. M., Sparks, C. A., Williams, D. W., & Gabaldón, A. M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19105839 · Cited by 4 · see citing works

The impact of flaxseed oil on lipid profiles, weight loss, and inflammatory markers in hemodialysis patients: A systematic review and meta‐analysis of randomized controlled trials

Tabrizi, R., Azizi, Z., Bazmi, S., Keshavarzian, O., Akbari, M., Karimimoghadam, Z., & Haghpanah, A. (2024) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.14140 · Cited by 4 · see citing works

Perspective Chapter: Flaxseed (Linumusitatissimum L) – Chemical Structure and Health-Related Functions

Rahimlou, M., & Hejazi, J. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.108259 · Cited by 3 · see citing works

Application of flaxseed as an effective approach for improving lipid profile parameters: An updated systematic review and meta-analysis of randomized controlled trials

Moridpour, A. H., Goodarzi, M., Kavyani, Z., Nademi, N., Daneshvar, M., Musazadeh, V., & Faghfouri, A. H. (2023) · PharmaNutrition · doi:10.1016/j.phanu.2023.100366 · Cited by 3 · see citing works

Effects of Almond Consumption on Selected Markers of Inflammation and Oxidative Stress: A Systematic Review and Meta-Analysis

Eslami, M., Khaghani, L., & Moghadam, E. F. (2025) · Clinical Nutrition Research · doi:10.7762/cnr.2025.14.1.78 · Cited by 3 · see citing works

Inflammatory Biomarkers in Nutrition

Abreu, S., & Sousa‐Pimenta, M. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81304-8_44-1 · Cited by 1 · see citing works

EXPERIÊNCIAS COM O CULTIVO DE LINHAÇA EM SANTA CATARINA: ASPECTOS EDAFOCLIMÁTICOS E GENÉTICOS

Bosco, L. C., Carducci, C. E., Fioreze, A. C. D. C. L., Kohn, L. S., Becker, D., & Konkol, A. C. B. (2021) · doi:10.22533/at.ed.0572121062 · Cited by 1 · see citing works

HISTÓRICO, USOS E IMPORTÂNCIA ECONÔMICA DA LINHAÇA

Lúcio, A. D., Follmann, D. N., Emanuelli, T., Marchioro, V. S., & Velho, J. P. (2021) · doi:10.22533/at.ed.0572121061

: THE EFFICACY OF SOME HERBAL THERAPIES PREFERRED BY TURKISH MS PATIENTS

Demirci, S., & Ünlü, M. D. (2024) · SDÜ Tıp Fakültesi Dergisi · doi:10.17343/sdutfd.1330810

Bioinformatics and Chemoinformatics Analysis Explored the Role of Linum usitatissimum in Diabetic Heart Conditions: Experimental Analysis in H9c2 Rat Embryonic Cardiomyocytes Cell Lines

Safavi, K., Hajibabaie, F., & Abedpoor, N. (2024) · Journal of Medical Signals & Sensors · doi:10.4103/jmss.jmss_4_24

Biochemical, Mineral, and Vitamin Composition of Belarusian Linseed Cultivars

Лобанов, В. Г., Roslyakov, Y. F., Maslinskaya, M. E., Pochitskaya, I. M., & Komarova, N. (2024) · Food Processing Techniques and Technology · doi:10.21603/2074-9414-2023-3-2526

Additional file 1 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786917

Additional file 6 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786932

Additional file 2 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786920

Additional file 4 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786926

Additional file 5 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786929

Additional file 3 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786923

Effect of Flaxseed Supplementation on Headache Characteristics and Quality of Life in Patients with Migraine: A Randomized Controlled Trial

Jafarpour, A., Ostovan, V. R., & Akhlaghi, M. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.101312

The effect of lignan supplementation on lipid profile in adults: A systematic review and meta-analysis of randomized controlled trials

Ebrahimi, Z., Pourrajab, B., Shojaeian, Z., & Gholizadeh, M. (2026) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1177/1973798x261437685

Comparative Efficacy of Nutraceuticals on Endothelial Function: A Systematic Review and Network Meta-Analysis

Norouzzadeh, M., Rashedi, M. H., Mahdavi-Mazdeh, G., Kosari, A., & Shahinfar, H. (2026) · Current Atherosclerosis Reports · doi:10.1007/s11883-026-01436-w

Is Higher α-Linolenic Acid Content Preferable? Assessing Digestive Fate of Flaxseed Oil in In Vitro Digestion Models of Infants, Adults and the Elderly

Mu, L., Chu, B., Zhang, J., Hui, J., & Wang, X. (2026) · Foods · doi:10.3390/foods15162891

From morphology to metabolites: diversity and functional traits of flax (Linum spp.)

Rodrigues, A. I., Santos, M., Ferreira, H. F., Malheiro, A. C., & Bacelar, E. L. V. A. (2026) · Phytochemistry Reviews · doi:10.1007/s11101-026-10300-3

Mechanisms of biological effects of flaxseed components on human health

Zharkova, I., Kiselev, A. R., & Efremov, D. P. (2026) · Studies in natural products chemistry · doi:10.1016/b978-0-443-51072-4.00015-6

Effects of flaxseed supplementation on inflammatory biomarkers: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials

Musazadeh, V., Morovatshoar, R., Kavyani, Z., Vajdi, M., & Askari, G. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106868 · Cited by 12 · see citing works

Effects of Flaxseed Interventions on Circulating Inflammatory Biomarkers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Rahimlou, M., Jahromi, N. B., Hasanyani, N., & Ahmadi, A. R. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz048 · Cited by 52 · see citing works

Effect of Flaxseed Intervention on Inflammatory Marker C-Reactive Protein: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Ren, G.-Y., Chen, C.-Y., Chen, G.-C., Chen, W.-G., Pan, A., Pan, C.-W., Zhang, Y.-H., Qin, L.-Q., & Chen, L.-H. (2016) · Nutrients · doi:10.3390/nu8030136 · Cited by 88 · see citing works

Additional file 1 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786917

Additional file 2 of Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose–response meta-analysis of randomized controlled trials

Yang, C., Xia, H., Wan, M., Lu, Y., Xu, D., Yang, X., Yang, L., & Sun, G. (2021) · Figshare · doi:10.6084/m9.figshare.16786920