Flaxseed Reduces Total and LDL Cholesterol Concentrations in Native American Postmenopausal Women
Abstract
OBJECTIVE: The objective of the study was to investigate the extent to which the daily incorporation of approximately 30 g of flaxseed, a rich source of lignans, omega-3 fatty acids, and fiber, for a period of 3 months into the diet of Native American postmenopausal women positively affects their lipid profiles. METHODS: Fifty-five mild to moderately hypercholesterolemic (> or =5.1 to < or =9.8 mmol/L) Native American postmenopausal women were randomly assigned to control (A), flaxseed (B) or flaxseed + additional oat bran fiber (C) groups. Overnight fasting venous blood was collected at baseline and at the end of the treatment period to analyze lipid parameters. RESULTS: Dietary flaxseed supplementation lowered total cholesterol and low-density lipoprotein cholesterol (LDL-C) by approximately 7% and 10%, respectively. However, the levels of high-density lipoprotein (HDL) and triglyceride remained unaltered. No changes were observed in other clinical and hematological parameters. CONCLUSIONS: The results of the present study indicate that Native American postmenopausal women benefit from regular consumption of flaxseed by reducing their risk of cardiovascular disease as seen from lowered LDL-C and total cholesterol levels.
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The cholesterol-lowering effects of flaxseed may be enhanced by baking, perhaps because of the effect of high temperature on the bioavailability of some flaxseed phytochemicals.
“Another reason was that the cholesterol-lowering effects of flaxseed may be enhanced by baking, perhaps because of the effect of high temperature on the bioavailability of some of the flaxseed phytochemicals [30].”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [30]
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- Authors
- Patade, A., Devareddy, L., Lucas, E. A., Korlagunta, K., Daggy, B. P., & Arjmandi, B. H.
- Affiliations
- Oklahoma State University (US)
- University of Arkansas at Fayetteville (US)
- Florida State University (US)
- Venue
- Journal of Women's Health
- Publisher
- SAGE Publications
- Published
- 2008-04
- Volume
- 17
- Issue
- 3
- Pages
- 355-366
- ISSN
- 1059-7115 (ISSN-L)
- 1540-9996
- 1931-843X
- OpenAlex
- W1979600141
- Cited by
- 164
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 18 · 2020: 67 · 2019: 7 · 2018: 6 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 4
- FWCI
- 8.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Women s Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Keywords
- flaxseed, LDL cholesterol, total cholesterol, hypercholesterolemia, postmenopausal women, Native American women, dietary supplementation, lipid profile, cardiovascular risk, lignans, omega-3 fatty acids, dietary fiber
- MeSH terms
- Female, Humans, Hypercholesterolemia, Indians, North American, Cholesterol, HDL, Cholesterol, LDL, Phytotherapy, Middle Aged, Seeds, Triglycerides, Treatment Outcome, Postmenopause, Flax
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