The DOI matches its Crossref record; 226 of the 226 references it cites were found in a registry or an index.
AMPK inhibition in health and disease
Open accessAbstract
All living organisms depend on dynamic mechanisms that repeatedly reassess the status of amassed energy, in order to adapt energy supply to demand. The AMP-activated protein kinase (AMPK) alphabetagamma heterotrimer has emerged as an important integrator of signals managing energy balance. Control of AMPK activity involves allosteric AMP and ATP regulation, auto-inhibitory features and phosphorylation of its catalytic (alpha) and regulatory (beta and gamma) subunits. AMPK has a prominent role not only as a peripheral sensor but also in the central nervous system as a multifunctional metabolic regulator. AMPK represents an ideal second messenger for reporting cellular energy state. For this reason, activated AMPK acts as a protective response to energy stress in numerous systems. However, AMPK inhibition also actively participates in the control of whole body energy homeostasis. In this review, we discuss recent findings that support the role and function of AMPK inhibition under physiological and pathological states.
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“It comprises three sub-units, each of which have multiple isoforms and confer tissue specificity (549).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [549]
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AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
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Metadata
- Authors
- Viollet, B., Horman, S., Leclerc, J., Lantier, L., Foretz, M., Billaud, M., Giri, S., & Andreelli, F.
- Affiliations
- UCLouvain (BE)
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Mayo Clinic (US)
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2010-06-04
- Volume
- 45
- Issue
- 4
- Pages
- 276-295
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- PMC
- PMC3132561
- OpenAlex
- W2015171350
- Cited by
- 383
- References
- 226
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 11 · 2023: 18 · 2022: 22 · 2021: 23 · 2020: 39 · 2019: 22 · 2018: 34 · 2017: 33 · 2016: 38 · 2015: 30 · 2014: 27 · 2013: 25 · 2012: 19
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Funders
- European Commission
- Agence Nationale de la Recherche (ANR-06-PHYS-0026)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- AMPK, AMPK inhibition, energy homeostasis, allosteric regulation, protein phosphorylation, central nervous system metabolism
- MeSH terms
- Animals, Energy Metabolism, Enzyme Activation, Humans, Down-Regulation, AMP-Activated Protein Kinases
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