The DOI matches its Crossref record; 164 of the 165 references it cites were found in a registry or an index.
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2
Open accessAbstract
Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Each PTBP contains four RNA recognition motif domains that together bind to extended CU-rich sequences13,14.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mechanisms of Alternative Pre-Messenger RNA Splicing
Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704
Self-citationUltraconserved Elements in the Human Genome
Bejerano, G., Pheasant, M., Makunin, I., Stephen, S., Kent, W. J., Mattick, J. S., & Haussler, D. (2004) · Science · doi:10.1126/science.1098119 · Cited by 1,732
CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism
Splawski, I., Timothy, K. W., Sharpe, L. M., Decher, N., Kumar, P., Bloise, R., Napolitano, C., Schwartz, P. J., Joseph, R. M., Condouris, K., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.011 · Cited by 1,586 · cited 1×
“Exon 8A is also interesting as the site of human mutations causing Timothy syndrome (TS) (Splawski et al., 2004; Splawski et al., 2005).”
BackgroundMessenger-RNA-binding proteins and the messages they carry
Dreyfuss, G., Kim, V. N., & Kataoka, N. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm760 · Cited by 1,457
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395
HITS-CLIP yields genome-wide insights into brain alternative RNA processing
Licatalosi, D. D., Mele, A., Fak, J. J., Ule, J., Kayikci, M., Chi, S. W., Clark, T. A., Schweitzer, A. C., Blume, J. E., Wang, X., et al. (2008) · Nature · doi:10.1038/nature07488 · Cited by 1,352 · cited 2×
“Within the nucleus, these proteins affect large programs of alternative processing events (Ule et al., 2006; Boutz et al., 2007b; Kalsotra et al., 2008; Licatalosi et al., 2008; Xue et al., 2009; Yeo et al., 2009; Kalsotra and Cooper, 2011).”
BackgroundUnderstanding alternative splicing: towards a cellular code
Matlin, A. J., Clark, F., & Smith, C. W. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1645 · Cited by 1,299
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Chen, M., & Manley, J. L. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2777 · Cited by 1,284
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
David, C. J., Chen, M., Assanah, M., Canoll, P., & Manley, J. L. (2010) · Nature · doi:10.1038/nature08697 · Cited by 1,179
Regulation of Alternative Splicing by Histone Modifications
Luco, R. F., Pan, Q., Tominaga, K., Blencowe, B. J., Pereira‐Smith, O. M., & Misteli, T. (2010) · Science · doi:10.1126/science.1184208 · Cited by 1,099
Flagged first, then by citations
1 of the 165 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Ashiya M, 1997, RNA, 3, 996
- Gooding C, 1998, RNA, 4, 85
- Jin W, 2003, Cancer Res, 63, 6154
- Lin CH, 1995, RNA, 1, 234
- Pérez I, 1997, RNA, 3, 764
Cited by
Sorted by citations
Items 101–200 of 200
Bąk, M., van Nimwegen, E., Kouzel, I. U., Gür, T., Schmidt, R. L. J., Zavolan, M., & Gruber, A. J. (2024) · Nature Communications · doi:10.1038/s41467-024-48046-1 · Cited by 17
RNA Pol II inhibition activates cell death independently from the loss of transcription
Harper, N. W., Birdsall, G. A., Honeywell, M. E., Ward, K. M., Pai, A. A., & Lee, M. J. (2025) · Cell · doi:10.1016/j.cell.2025.07.034 · Cited by 18
Alternative splicing of inner-ear-expressed genes
Wang, Y., Liu, Y., Nie, H., Ma, X., & Xu, Z. (2016) · Frontiers of Medicine · doi:10.1007/s11684-016-0454-y · Cited by 16
Han, W., Wang, L., Yin, B., & Peng, X. (2014) · BMB Reports · doi:10.5483/bmbrep.2014.47.4.140 · Cited by 16
Greșiță, A., Hermann, D. M., Boboc, I. K. Ş., Doeppner, T. R., Petcu, E. B., Ghinea, F. S., & Popa‐Wagner, A. (2025) · Translational Stroke Research · doi:10.1007/s12975-025-01331-7 · Cited by 15
The Regulatory Network of hnRNPs Underlying Regulating PKM Alternative Splicing in Tumor Progression
Li, Y., Zhang, S., Li, Y., Liu, J., Li, Q., Zang, W., & Pan, Y. (2024) · Biomolecules · doi:10.3390/biom14050566 · Cited by 14
Self-citationWang, Y., Chembazhi, U. V., Yee, D., Chen, S., Ji, J., Wang, Y., Nguyen, K. L., Lin, P.-C. P., Ratti, A., Hess, R. A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae862 · Cited by 14
Polypyrimidine tract binding protein 1 regulates the activation of mouse CD8 T cells
D’Angeli, V., Monzón‐Casanova, E., Matheson, L. S., Gizlenci, Ö., Petkau, G., Gooding, C., Berrens, R. V., Smith, C. W. J., & Turner, M. (2022) · European Journal of Immunology · doi:10.1002/eji.202149781 · Cited by 13
LncRNA SNHG3 Promotes Sevoflurane-Induced Neuronal Injury by Activating NLRP3 via NEK7
Liang, M., Wang, F.-F., Li, Q., Lei, X., Chen, Y., & Hu, N. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03939-3 · Cited by 13
Self-citationPost-transcriptional regulation of the transcriptional apparatus in neuronal development
Nazim, M. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1483901 · Cited by 12
Alternative splicing regulation of membrane trafficking genes during myogenesis
Hinkle, E. R., Wiedner, H. J., Torres, E. V., Jackson, M., Black, A. J., Blue, R. E., Harris, S. E., Guzmán, B. B., Gentile, G. M., Lee, E. Y., et al. (2022) · RNA · doi:10.1261/rna.078993.121 · Cited by 12
Alternative Splicing in the Heart: The Therapeutic Potential of Regulating the Regulators
Briganti, F., & Wang, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313023 · Cited by 11
DevelopmentalXistinduction is mediated by enhanced splicing
Stork, C., Li, Z., Lin, L., & Zheng, S. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1198 · Cited by 10
Brečević, L., Rinčić, M., Krsnik, Ž., Sedmak, G., Hamid, A. B., Kosyakova, N., Galić, I., Liehr, T., & Borovečki, F. (2015) · Translational Neuroscience · doi:10.1515/tnsci-2015-0007 · Cited by 11
RNA and Proteins: Mutual Respect
Hall, K. B. (2017) · F1000Research · doi:10.12688/f1000research.10572.1 · Cited by 9
A quantitative model of cellular decision making in direct neuronal reprogramming
Merlevede, A., Legault, E. M., Drugge, V., Barker, R. A., Drouin‐Ouellet, J., & Olariu, V. (2021) · Scientific Reports · doi:10.1038/s41598-021-81089-8 · Cited by 10
In Vitro and in Silico Analysis of miR-125a with rs12976445 Polymorphism in Breast Cancer Patients
Lehmann, T. P., Miskiewicz, J., Szóstak, N., Szachniuk, M., Grodecka-Gazdecka, S., & Jagodziński, P. P. (2020) · Applied Sciences · doi:10.3390/app10207275 · Cited by 9
Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective
de Barros, I. I., Leão, V., de Santis, J. O., Rosa, R. C. A., Brotto, D. B., Storti, C. B., Siena, Á. D. D., de Molfetta, G. A., & Silva, W. A. (2021) · Non-Coding RNA · doi:10.3390/ncrna7010022 · Cited by 9
Huang, Q., Gu, S., Fang, J., Li, X., & Lin, L. (2022) · Medicine · doi:10.1097/md.0000000000032428 · Cited by 9
Alternative splicing in autism spectrum disorder: Recent insights from mechanisms to therapy
Zheng, M., Bao, N., Wang, Z., Song, C., & Jin, Y. (2025) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2025.104501 · Cited by 8
RNA processing in neurological tissue: development, aging and disease
Szeto, R. A., Tran, T. H., Truong, J., Negraes, P. D., & Trujillo, C. A. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.09.004 · Cited by 8
Monzón‐Casanova, E., Bates, K. J., Smith, C. W. J., & Turner, M. (2021) · European Journal of Immunology · doi:10.1002/eji.202149257 · Cited by 8
The bidirectional interplay between RNA processing and mechanotransduction
Bais, G. B., & Giudice, J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116175 · Cited by 8
The splice of life: how alternative splicing shapes regulatory and phenotypic evolution
Hunter, C. E., & Xing, Y. (2026) · The EMBO Journal · doi:10.1038/s44318-025-00666-z · Cited by 9
Transcriptome, Proteome, and Protein Synthesis Within the Intracellular Cytomatrix
Shaiken, T. E., Grimm, S. L., Siam, M., Williams, A., Rezaeian, A.-H., Kraushaar, D. C., Ricco, E., Robertson, M. J., Coarfa, C., Jain, A., et al. (2022) · iScience · doi:10.1016/j.isci.2023.105965 · Cited by 7
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Mehlferber, M., Kuyumcu‐Martinez, M. N., Miller, C. L., & Sheynkman, G. (2023) · Current Stem Cell Reports · doi:10.1007/s40778-023-00227-2 · Cited by 7
PTBP1 and Cancer: From RNA Regulation to Therapeutic Potential
Ji, C., Zhu, J., Hou, X., Zhou, C., Zhao, J., Zheng, X., & Tang, Y. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70675 · Cited by 13
Yang, Z., Jiang, Y., Ma, J., Wang, L., Han, S., Huda, N., Kusumanchi, P., Gao, H., Thoudam, T., Sun, Z., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000001078 · Cited by 6
Sullivan, M. E., Edberg, J. A., Nunez, C. I., Axelrod, H. L., & Keppetipola, N. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325143 · Cited by 8
Self-citationWaithaka, A., Maiakovska, O., Grimm, D., do Nascimento, L. M., & CLAYTON, C. E. (2022) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010876 · Cited by 6
Liu, G., Lei, L., Yu, J., Kung, S. K. P., & Xie, J. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.002 · Cited by 6
Reprogramming of mouse fibroblasts into neural lineage cells using biomaterials
Kantawong, F., Saksiriwisitkul, C., Riyapa, C., Limpakdee, S., Wanachantararak, P., & Kuboki, T. (2018) · Bioimpacts · doi:10.15171/bi.2018.15 · Cited by 7
Rawcliffe, D. F. R., Österman, L., Nordin, A., & Holmberg, M. (2018) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.413 · Cited by 5
Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1
Ontiveros, R. J., Hernandez, L. C., Nguyen, H., Lopez, A. L. H., Shankar, A., Kim, E., & Keppetipola, N. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00664 · Cited by 7
Self-citationNishanth, M. J., & Jha, S. (2022) · Biochemical Genetics · doi:10.1007/s10528-022-10230-7 · Cited by 6
Bourret, J., Borvető, F., & Bravo, I. G. (2023) · Journal of Evolutionary Biology · doi:10.1111/jeb.14212 · Cited by 5
Zhang, B., Ørning, P., Lehman, J. W., Dinis, A., Torres-Ulloa, L., Elling, R., Kelliher, M. A., Bertin, J., Proulx, M. K., Goguen, J. D., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2420802122 · Cited by 5
Xu, G. B., Cai, M., Kadayıfçı, F. Z., Dong, J., Zheng, S., Mei, W., Zhao, W., Pan, Y., & Chen, H. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109406 · Cited by 5
Re-Activation of Neurogenic Niches in Aging BrainPreprint
Maimon, R., Chillón-Marinas, C., Vazquez‐Sanchez, S., Kern, C., Jenie, I., Malukhina, K., Moore, S. R., Cui, J., Goginashvili, A., Moghadami, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.27.575940 · Cited by 6
Zhang, J., Gao, C., Li, H., Chen, Y., Yang, L., Jin, Q., Feng, L., Wang, X., Liu, X., Chen, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202507676 · Cited by 4
Yang, J., Feng, J. H., Lv, J. G., Chu, X., Wei, Y., Zhang, Y., Li, J., Sun, Y., Li, G., Jiang, T., et al. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01412-0 · Cited by 5
Li, Y., Yao, Y.-N., Zhou, S.-A., & Wang, Y. (2025) · World Journal of Stem Cells · doi:10.4252/wjsc.v17.i7.107688 · Cited by 4
Drops in the cell ocean: new roles for non-coding RNAs in liquid–liquid phase separation
Li, M., Thorne, R. F., Zhang, X. D., Wu, M., & Chen, S. (2022) · Genome Instability & Disease · doi:10.1007/s42764-022-00091-0 · Cited by 4
PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors
Göder, A., Quinlan, A., Rainey, M. D., Bennett, D., Shamavu, D., Corso, J., & Santocanale, C. (2023) · iScience · doi:10.1016/j.isci.2023.106951 · Cited by 5
Screening for small molecule inhibitors of HIV-1 Gag expression
Balachandran, A., & Cochrane, A. (2017) · Methods · doi:10.1016/j.ymeth.2017.06.007 · Cited by 4
Long Noncoding RNAs: Critical Regulators for Cell Lineage Commitment in the Central Nervous System
Dong, X., Muppani, N. R., & Wu, J. (2015) · Translational bioinformatics · doi:10.1007/978-94-017-7450-5_3 · Cited by 4
PTBP1 : A candidate gene for intellectual disability
Alkhateeb, A. M., Habbab, W., Aburahma, S. K., & Thompson, I. R. (2017) · Meta Gene · doi:10.1016/j.mgene.2017.05.002 · Cited by 3
Liu, B.-Y., Chen, X.-D., Liu, H.-L., Wang, S.-W., Song, Q. Y., Cheng, H., Li, S., Wang, H.-Y., Lu, X.-M., & Yong-tang, W. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01629-4 · Cited by 3
Truong, A., Barton, M., Tran, U. C., Mellody, M. M., Berger, D., Madory, D., Hitch, E., Jibrael, B., Nikolaidis, N., Luchko, T., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105733 · Cited by 5
Self-citationMartin, R. A., Zhang, X., Viggars, M. R., Sanford, J. A., Taylor, Z. W., Hansen, J., Clair, G., Douglas, C. M., Hesketh, S. J., Adkins, J., et al. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00575.2024 · Cited by 3
Jiang, H., Qi, H., Tang, A., Hu, S., & Lai, J. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102808 · Cited by 2
Yap, K., Ramakumar, S., Hamid, F., & Makeyev, E. V. (2026) · Journal of Molecular Biology · doi:10.1016/j.jmb.2026.169764 · Cited by 2
TDP-43: [GU]-ardian of the transcriptome
Sinha, I. R., Atkinson, A. L., Irwin, K. E., Ling, J. P., & Wong, P. C. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00944-2 · Cited by 2
KIS counteracts PTBP2 and regulates alternative exon usage in neurons
Moreno-Aguilera, M., Mendoza, M. B., Neher, A. M., Dodel, M., Mardakheh, F. K., Ortiz, R., & Gallego, C. (2024) · eLife · doi:10.7554/elife.96048 · Cited by 1
Profiling genetically driven alternative splicing across the Indonesian archipelago
Ibeh, N., Kusuma, P., Darusallam, C. C., Malik, S. G., Sudoyo, H., McCarthy, D. J., & Romero, I. G. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.09.004 · Cited by 2
Ismail, R., Najar, I. A., Rahamathulla, M., Hussain, M.-U., Banday, M. S., Devi, S., Arora, P., Kumar, M., Shivanandappa, T. B., Ahmed, M. M., et al. (2025) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2025.2480601 · Cited by 2
Nucleolar Proteomics Revealed the Regulation of RNA Exosome Localization by MTR4
Zhang, Y., Jiang, G., Wang, K., Hong, M., Huang, X., Chen, X., Feng, X., & Guang, S. (2025) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2025.101031 · Cited by 2
Associations between Gene‐Gene Interaction and Overweight/Obesity of 12‐Month‐Old Chinese Infants
Mei, H., Yin, B., Yang, W., Zhang, J., Lu, H., Qi, X., Mei, W., Zhang, H., & Zhang, J. (2022) · BioMed Research International · doi:10.1155/2022/1499454 · Cited by 2
Mehrjardi, E. Z., Tezerjani, M. D., Ghad, F. S., & Seifati, S. M. (2022) · Gene Reports · doi:10.1016/j.genrep.2022.101687 · Cited by 2
Nava, A. A., Jops, C. T., Vuong, C. K., Niles-Jensen, S. L., Bondhus, L., Ong, C. J., de la Torre-Ubieta, L., Gandal, M. J., & Arboleda, V. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.17.545322 · Cited by 2
Yang, X., & Domiński, Z. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.19.553944 · Cited by 2
Ye, Z., Gu, H., Wang, Y., Liu, Y., Huang, Y., Mao, M., Sun, L. Y., & Huang, M. (2025) · Protein Expression and Purification · doi:10.1016/j.pep.2025.106755 · Cited by 1
Yang, X., & Domiński, Z. (2025) · RNA · doi:10.1261/rna.080491.125 · Cited by 1
DRBD3 regulates long non-coding RNA abundance and cryptic splice site selection in trypanosomes
Ceballos-Pérez, G., Gómez-Liñán, C., Sanchez-Luque, F. J., Pérez-Victoria, J. M., & Estévez, A. M. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05929-w · Cited by 1
PTBP1 depletion in mature astrocytes reveals distinct splicing alterations without neuronal features
Zhang, M., Kubota, N., Nikom, D., Arient, A., & Zheng, S. (2025) · eLife · doi:10.7554/elife.107683.3 · Cited by 1
Nguyen, T. N. G., Kamal, M. M., Lin, C., & Leu, J. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag063 · Cited by 1
PTBP1: A master regulator of neural development and transdifferentiation—promise and pitfalls
Liu, Y., Huang, Y., Wang, Y., Mao, M., & Huang, M. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153948 · Cited by 1
Ma, Q., Zhang, S., & Zhang, S.-Y. (2022) · Methods · doi:10.1016/j.ymeth.2022.04.002 · Cited by 1
Yeom, K., Mitchell, S. A., Linares, A. J., Zheng, S., Lin, C.-H., Wang, X., Hoffmann, A., & Black, D. L. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/297515 · Cited by 1
Self-citationWeißbach, S., Todorov, H., Soliman, A., Schlichtholz, L., Mühlbauer, S., Zografidou, L., Lor-Zade, S., Wierczeiko, A., Strand, D. J., Strand, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.20.614071 · Cited by 1
Identification of novel signaling pathways for cardiomyocyte differentiation and growth
Ye, J. (2012) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
NEUROSPECIFIC LSD1 SPLICING ISOFORM LINKS EPIGENETICS TO MAMMALIAN BRAIN PHYSIOLOGY
Paganini, L. (2013) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/paganini-leda_phd2013-01-31
Comunicação exossomal na transdiferenciação de células-tronco em cocultivo com células neuronais
Roballo, K. C. S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.74.2017.tde-23112017-104437
Caracterização de um novo RNA longo não codificador e seu provável papel no desenvolvimento neuronal
de Barros, I. I. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2021.tde-11062021-080115
Tung, W., Chembazhi, U. V., Yang, J., Nguyen, K. L., Lalwani, A., Bangru, S., Yee, D., Chin, K., Kalsotra, A., & Mei, W. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.03.466345
Роль этноэтики в подготовке кадров сферы культуры
Николаевна, Л. Е. (2006) · Интеграция образования
Polypyrimidine Tract-binding Protein 2 is a Potential Treated Target in Tg(SOD1*G93A)1Gur MicePreprint
Xiong, Z., Li, X., Yang, D., Xiong, C., & Zhou, Q. (2022) · Research Square · doi:10.21203/rs.3.rs-1470191/v1
Ptbp1-Activateded Co-Transcriptional Splicing Controls Epigenetic Status of Pluripotent Stem CellsPreprint
Iannone, C., Kainov, Y. A., Zhuravskaya, A., Hamid, F., Nojima, T., & Makeyev, E. V. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4058691
The role of novel antisense long non-coding RNA, GHRLOS, in prostate and endometrial cancer
Shah, E. T. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.213106
Kelly, S. M., Paschack, A., Mishra, G., Ahn, J., Smith, E., Haynes, K., Shelmidine, K., Lee, K., Yazhbin, A., & Ji, Y. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.17.594635
Pol II degradation activates cell death independently from the loss of transcriptionPreprint
Harper, N. W., Birdsall, G. A., Honeywell, M. E., Pai, A. A., & Lee, M. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.09.627542
Lysine acetylation plays a role in RNA binding protein-regulated alternative pre-mRNA splicingPreprint
Nunez, C., Salgado, G., Tran, U., Horani, A., Dreyer, S., Luchko, T., & Keppetipola, N. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.11.664476
Self-citationPTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal FeaturesPreprint
Zhang, M., Kubota, N., Nikom, D., Arient, A., & Zheng, S. (2025) · eLife · doi:10.7554/elife.107683.1
Sinnassamy, S., Massiani-Beaudoin, O., Lombard, B., Loew, D., Bonnifet, T., Fradet, M., Monnet, H., Caille, T., Servant, N., Joshi, R. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.05.674414
PTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal FeaturesPreprint
Zhang, M., Kubota, N., Nikom, D., Arient, A., & Zheng, S. (2025) · eLife · doi:10.7554/elife.107683.2
Di Matteo, A., Belloni, E., Pradella, D., Cappelletto, A., Volf, N., Zacchigna, S., & Ghigna, C. (2020) · Figshare · doi:10.6084/m9.figshare.13346728
Intercellular Transfer of PTBP1 Drives Human Neural Stem Cell FatePreprint
Capobianco, D. L., Palma, F. D., Filomena, E., Lasconi, C., Pousis, C., Simeone, L., Proto, F., Profico, D. C., Gelati, M., Picardi, E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.706765
Michielsen, L., Hsu, J., Joglekar, A., Belchikov, N., Reinders, M. J. T., Tilgner, H., & Mahfouz, A. E. (2026) · Genome biology · doi:10.1186/s13059-026-04015-z · Cited by 3
Yang, X., & Xiang, X. (2026) · Nature Communications · doi:10.1038/s41467-026-77627-5
Endothelial Adgrl2 Expression and Alternative Splicing Controls the Cerebrovasculature
King, A., Garcia, C., Blanton, C., Chen, A., Ahmad, A., Lukacsovich, D., Földy, C., Makita, T., & Anderson, G. R. (2026) · Journal of Neuroscience · doi:10.1523/jneurosci.0019-26.2026
Évolution des préférences d'usage de codons et manipulation de la fidelité de la traduction
Borvető, F. (2021) · theses.fr (ABES) · doi:10.70675/8c3497aazfaf6z45cfz8cfazd5bc634cfd17
Pareek, A., Wardhan, V., Mishra, D., Rathi, D., Khan, I. N., Subba, P., Saxena, H., Jeevaraj, T., Chakraborty, S., & Chakraborty, N. (2026) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2026.111307
Dix, T. C., McQuarrie, D. W. J., Bräuer, U., Tian, Y. W., Haussmann, I. U., Li, M., Fütterer, K., & Soller, M. (2026) · Genes & Development · doi:10.1101/gad.353688.126
Nonsense-mediated mRNA decay and associated splicing patterns in neurodevelopmental disorders
Anisimova, P. E., Filat’eva, A. E., Tarabykin, V. S., & Kondakova, E. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1914793
Interactions of LINE-1 ORF1p with proteins and chromatin suggest a role in neuronal physiology
Sinnassamy, S., Massiani-Beaudoin, O., Lombard, B., Loew, D., Bonnifet, T., Fradet, M., Monnet, H., Caille, T., Servant, N., Joshi, R. L., et al. (2026) · Life Science Alliance · doi:10.26508/lsa.202503546
ALS-Associated Exitron Splicing Produces UBQLN2 Isoforms with Distinct PropertiesPreprint
Koo, A. S.-H., Zhou, J., Méndez-Albelo, N. M., Wei, Y., Xu, W., Zhao, X., Dewey, C. N., & Tibbetts, R. S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.2139/ssrn.7435655
Metadata
- Authors
- Keppetipola, N., Sharma, S., Li, Q., & Black, D. L.
- Affiliations
- University of California, Los Angeles (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Black, Douglas L.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2012-06-02
- Volume
- 47
- Issue
- 4
- Pages
- 360-378
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- PMC
- PMC3422667
- OpenAlex
- W2024593827
- Cited by
- 201
- References
- 165
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 14 · 2018: 19 · 2017: 15 · 2016: 17 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of General Medical Sciences (R01 GM 49662, R24GM070857, R01GM049662)
- National Institute of Neurological Disorders and Stroke (T32NS007449, 5T32 NS07449)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- pre-mRNA splicing, alternative splicing, polypyrimidine tract-binding protein, PTBP1, PTBP2, RNA-binding proteins, spliceosome assembly, protein-RNA complex, neuronal development
- MeSH terms
- Animals, Humans, RNA Precursors, RNA Splicing, RNA-Binding Proteins, Alternative Splicing, Polypyrimidine Tract-Binding Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
