The DOI matches its Crossref record; 164 of the 165 references it cites were found in a registry or an index.
Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2
Open accessAbstract
Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.
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“Each PTBP contains four RNA recognition motif domains that together bind to extended CU-rich sequences13,14.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [13]
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Citations
Cites
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Cited by
Sorted by citations
Context-dependent control of alternative splicing by RNA-binding proteins
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A new view of transcriptome complexity and regulation through the lens of local splicing variations
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Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex
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Metadata
- Authors
- Keppetipola, N., Sharma, S., Li, Q., & Black, D. L.
- Affiliations
- University of California, Los Angeles (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Black, Douglas L.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2012-06-02
- Volume
- 47
- Issue
- 4
- Pages
- 360-378
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- PMC
- PMC3422667
- OpenAlex
- W2024593827
- Cited by
- 201
- References
- 165
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 14 · 2018: 19 · 2017: 15 · 2016: 17 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of General Medical Sciences (R01 GM 49662, R24GM070857, R01GM049662)
- National Institute of Neurological Disorders and Stroke (T32NS007449, 5T32 NS07449)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- pre-mRNA splicing, alternative splicing, polypyrimidine tract-binding protein, PTBP1, PTBP2, RNA-binding proteins, spliceosome assembly, protein-RNA complex, neuronal development
- MeSH terms
- Animals, Humans, RNA Precursors, RNA Splicing, RNA-Binding Proteins, Alternative Splicing, Polypyrimidine Tract-Binding Protein
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