Cited by 201RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

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Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

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Keppetipola, Niroshika, Sharma, Shalini, Li, Qin, Black, Douglas L.·2012·Critical Reviews in Biochemistry and Molecular Biology

DOI 10.3109/10409238.2012.691456PMC PMC3422667

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Abstract

Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.

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Authors: Keppetipola, N., Sharma, S., Li, Q., & Black, D. L.
Affiliations: University of California, Los Angeles (US)
Howard Hughes Medical Institute (US)
Corresponding author: Black, Douglas L.
ORCID: Keppetipola, Niroshika
Sharma, Shalini
Li, Qin
Black, Douglas L.
Venue: Critical Reviews in Biochemistry and Molecular Biology
Publisher: Informa UK Limited
Published: 2012-06-02
Volume: 47
Issue: 4
Pages: 360-378
ISSN: 0045-6411 (ISSN-L)
1040-9238
1549-7798
DOI: 10.3109/10409238.2012.691456
PMC: PMC3422667
OpenAlex: W2024593827
Cited by: 201
References: 165
Citations by year: 2026: 15 · 2025: 22 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 14 · 2018: 19 · 2017: 15 · 2016: 17 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 1
FWCI: 0.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of General Medical Sciences (R01 GM 49662, R24GM070857, R01GM049662)
National Institute of Neurological Disorders and Stroke (T32NS007449, 5T32 NS07449)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: pre-mRNA splicing, alternative splicing, polypyrimidine tract-binding protein, PTBP1, PTBP2, RNA-binding proteins, spliceosome assembly, protein-RNA complex, neuronal development
MeSH terms: Animals, Humans, RNA Precursors, RNA Splicing, RNA-Binding Proteins, Alternative Splicing, Polypyrimidine Tract-Binding Protein

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Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

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