Cited by 201RNA Research and SplicingRNA regulation and diseaseRNA and protein synthesis mechanisms

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Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

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Keppetipola, Niroshika, Sharma, Shalini, Li, Qin, Black, Douglas L.·2012·Critical Reviews in Biochemistry and Molecular Biology

DOI 10.3109/10409238.2012.691456PMC PMC3422667

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Abstract

Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.

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Ladd, A. N., Stenberg, M. G., Swanson, M. S., & Cooper, T. A. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20382 · Cited by 131
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA
Nowak, U. M., Matthews, A. J., Zheng, S., & Chaudhuri, J. (2010) · Nature Immunology · doi:10.1038/ni.1977 · Cited by 131
Regulation of alternative splicing by PTB and associated factors
Spellman, R., Rideau, A., Matlin, A., Gooding, C., Robinson, F., McGlincy, N., Grellscheid, S. N., Southby, J., Wollerton, M., & Smith, C. W. J. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330457 · Cited by 128
Splicing Regulation in Neurons: Tinkering with Cell-Specific Control
Grabowski, P. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81399-9 · Cited by 126
Sam68 Regulates a Set of Alternatively Spliced Exons during Neurogenesis
Chawla, G., Lin, C.-H., Han, A., Shiue, L., Ares, M., & Black, D. L. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01349-08 · Cited by 126
Self-citation
The Dynamic Organization of the Perinucleolar Compartment in the Cell Nucleus
Huang, S., Deerinck, T. J., Ellisman, M. H., & Spector, D. L. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.5.965 · Cited by 123
Exon repression by polypyrimidine tract binding protein
Amir-Ahmady, B., Boutz, P. L., Markovtsov, V. V., Phillips, M. L., & Black, D. L. (2005) · RNA · doi:10.1261/rna.2250405 · Cited by 118
Self-citation
Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro
He, X., Pool, M. D., Darcy, K. M., Lim, S. B., Auersperg, N., Coon, J. S., & Beck, W. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210307 · Cited by 117
RNA looping by PTB: Evidence using FRET and NMR spectroscopy for a role in splicing repression
Lamichhane, R., Daubner, G. M., Thomas-Crusells, J., Auweter, S., Manatschal, C., Austin, K. S., Valniuk, O., Allain, F. H. ‐., & Rueda, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907072107 · Cited by 115
Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs
Gorospe, M., Tominaga, K., Wu, X., Fähling, M., & Ivan, M. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00007 · Cited by 115
Cooperative-Binding and Splicing-Repressive Properties of hnRNP A1
Okunola, H. L., & Krainer, A. R. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01678-08 · Cited by 115
Drosophila PTB promotes formation of high-order RNP particles and represses oskar translationPreprint
Besse, F., de Quinto, S. L., Marchand, V., Trucco, A., & Ephrussi, A. (2009) · Genes & Development · doi:10.1101/gad.505709 · Cited by 114
Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins
Hüttelmaier, S., Illenberger, S., Grosheva, I., Rüdiger, M., Singer, R. H., & Jockusch, B. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200105044 · Cited by 113
Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1
Cobbold, L. C., Wilson, L. A., Sawicka, K., King, H. A., Kondrashov, A. V., Spriggs, K. A., Bushell, M., & Willis, A. E. (2010) · Oncogene · doi:10.1038/onc.2010.31 · Cited by 112
Isolation of a Mammalian Homologue of a Fission Yeast Differentiation Regulator
Yamamoto, H., Tsukahara, K., Kanaoka, Y., Jinno, S., & Okayama, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3829 · Cited by 112
Conserved Intron Elements Repress Splicing of a Neuron-Specific c-src Exon In Vitro
Chan, R. C., & Black, D. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.5.2970 · Cited by 111
Self-citation
The PTB interacting protein raver1 regulates α‐tropomyosin alternative splicing
Gromak, N., Rideau, A., Southby, J., Scadden, A. D. J., Gooding, C., Hüttelmaier, S., Singer, R. H., & Smith, C. W. J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg609 · Cited by 109
The Polypyrimidine Tract Binding Protein (PTB) Represses Splicing of Exon 6B from the β-Tropomyosin Pre-mRNA by Directly Interfering with the Binding of the U2AF65 Subunit
Saulière, J., Sureau, A., Expert-Bezançon, A., & Marie, J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00893-06 · Cited by 106
Structure and RNA Interactions of the N-Terminal RRM Domains of PTB
Simpson, P. J., Monie, T. P., Szendröi, A., Davydova, N., Tyzack, J. K., Conte, M. R., Read, C. M., Cary, P. D., Svergun, D. I., Konarev, P. V., et al. (2004) · Structure · doi:10.1016/j.str.2004.07.008 · Cited by 100
A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain
Rideau, A., Gooding, C., Simpson, P. J., Monie, T. P., Lorenz, M., Hüttelmaier, S., Singer, R. H., Matthews, S., Curry, S., & Smith, C. W. J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1137 · Cited by 100
U1 snRNA Directly Interacts with Polypyrimidine Tract-Binding Protein during Splicing Repression
Sharma, S., Maris, C., Allain, F. H. ‐., & Black, D. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.012 · Cited by 98
Self-citation
Structure of the two most C‐terminal RNA recognition motifs of PTB using segmental isotope labeling
Vitali, F., Henning, A., Oberstrass, F. C., Hargous, Y., Auweter, S., Erat, M. C., & Allain, F. H. ‐. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600911 · Cited by 96
Polypyrimidine Tract Binding Protein Stabilizes the Encephalomyocarditis Virus IRES Structure via Binding Multiple Sites in a Unique Orientation
Kafasla, P., Morgner, N., Pöyry, T. A. A., Curry, S., Robinson, C. V., & Jackson, R. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.015 · Cited by 94
Determination of functional domains in polypyrimidine-tract-binding protein
Oh, Y. L., Hahm, B., Kim, Y. K., Lee, H. K., Lee, J. W., Ok.-K., S. O. N. G., Tsukiyama–Kohara, K., Kohara, M., Nomoto, A., & Jang, S. K. (1998) · Biochemical Journal · doi:10.1042/bj3310169 · Cited by 90
Structure-function relationships of the polypyrimidine tract binding protein
Auweter, S., & Allain, F. H. ‐. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7378-2 · Cited by 89
Regulation of the Mutually Exclusive Exons 8a and 8 in the CaV1.2 Calcium Channel Transcript by Polypyrimidine Tract-binding Protein
Tang, Z. Z., Sharma, S., Zheng, S., Chawla, G., Nikolic, J. M., & Black, D. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208116 · Cited by 83
Self-citation
Conserved Intron Elements Repress Splicing of a Neuron-Specific c- src Exon In Vitro
Chan, R. C., & Black, D. L. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.11.6377 · Cited by 83
Self-citation
Polypyrimidine tract‐binding protein is essential for early mouse development and embryonic stem cell proliferation
Shibayama, M., Ohno, S., Osaka, T., Sakamoto, R., Tokunaga, A., Nakatake, Y., Sato, M., & Yoshida, N. (2009) · The FEBS Journal · doi:10.1111/j.1742-4658.2009.07380.x · Cited by 82
Delineation of a Novel Pathway That Regulates CD154 (CD40 Ligand) Expression
Hamilton, B. J., Genin, A., Cron, R. Q., & Rigby, W. F. C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.2.510-525.2003 · Cited by 82
選択的スプライシングレプレッサーhnRNP A1/A2とPTBはピルビン酸キナーゼアイソフォーム発現と細胞代謝に影響する
Cynthia, V. C., Deblina, C., Zhenxun, W., Cantley, L. C., Matthew, G. V. H., & Adrian, R. (2010) · Cited by 82
STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivoPreprint
Ohno, G., Hagiwara, M., & Kuroyanagi, H. (2008) · Genes & Development · doi:10.1101/gad.1620608 · Cited by 79
Global analysis of mRNA splicing
Moore, M. J., & Silver, P. A. (2007) · RNA · doi:10.1261/rna.868008 · Cited by 79
Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors
Gama‐Carvalho, M., Barbosa‐Morais, N. L., Brodsky, A. S., Silver, P. A., & Carmo‐Fonseca, M. (2006) · Genome biology · doi:10.1186/gb-2006-7-11-r113 · Cited by 79
Differentiation-induced Colocalization of the KH-type Splicing Regulatory Protein with Polypyrimidine Tract Binding Protein and the c-srcPre-mRNA
Hall, M. P., Huang, S., & Black, D. L. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0692 · Cited by 76
Self-citation
Nucleocytoplasmic Shuttling of Polypyrimidine Tract-binding Protein Is Uncoupled from RNA Export
Kamath, R. V., Leary, D. J., & Huang, S. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.12.3808 · Cited by 75
Combinatorial control of a neuron-specific exon
Modafferi, E. F., & Black, D. L. (1999) · RNA · doi:10.1017/s1355838299990155 · Cited by 71
Self-citation
Polypyrimidine tract-binding protein inhibits translation of bip mRNA
Kim, Y. K., Hahm, B., & Jang, S. K. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4179 · Cited by 68
Comparative expression analysis of the genes encoding polypyrimidine tract binding protein (PTB) and its neural homologue (brPTB) in prenatal and postnatal mouse brain
Lilleväli, K., Kulla, A., & Örd, T. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00566-9 · Cited by 66
Solving the Structure of PTB in Complex with Pyrimidine Tracts: An NMR Study of Protein–RNA Complexes of Weak Affinities†
Auweter, S., Oberstrass, F. C., & Allain, F. H. ‐. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.12.053 · Cited by 64
Hypoxia May Increase Rat Insulin mRNA Levels by Promoting Binding of the Polypyrimidine Tract-binding Protein (PTB) to the Pyrimidine-rich Insulin mRNA 3′-Untranslated Region
Tillmar, L., & Welsh, N. (2002) · Molecular Medicine · doi:10.1007/bf03402152 · Cited by 64
Conformation of Polypyrimidine Tract Binding Protein in Solution
Petoukhov, M. V., Monie, T. P., Allain, F. H. ‐., Matthews, S., Curry, S., & Svergun, D. I. (2006) · Structure · doi:10.1016/j.str.2006.04.005 · Cited by 62
Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein
Liu, H., Zhang, W., Reed, R., Liu, W., & Grabowski, P. J. (2002) · RNA · doi:10.1017/s1355838202015029 · Cited by 58
A single polypyrimidine tract binding protein (PTB) binding site mediates splicing inhibition at mouse IgM exons M1 and M2
Shen, H., Kan, J. L. C., Ghigna, C., Biamonti, G., & Green, M. R. (2004) · RNA · doi:10.1261/rna.5229704 · Cited by 58
The polypyrimidine tract binding protein is a monomer
Monie, T. P., Hernández, H., Robinson, C. V., Simpson, P. J., Matthews, S., & Curry, S. (2005) · RNA · doi:10.1261/rna.2214405 · Cited by 57
Relocalization of the polypyrimidine tract-binding protein during PKA-induced neurite growth
Ma, S., Liu, G., Sun, Y., & Xie, J. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.02.006 · Cited by 56
PTBP1 Is Required for Embryonic Development before Gastrulation
Suckale, J., Wendling, O., Masjkur, J., Jäger, M., Münster, C., Anastassiadis, K., Stewart, A. F., & Solimena, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016992 · Cited by 55 · cited 1×
“PTB null mutations cause embryonic lethality in mouse, whereas conditional knockout specifically in the brain has minimal phenotype (Shibayama et al., 2009; Suckale et al., 2011; Sika Zheng and DLB, unpublished).”
Background
Polypyrimidine Tract-binding Protein (PTB) Differentially Affects Malignancy in a Cell Line-dependent Manner
Wang, C., Norton, J. T., Ghosh, S., Kim, J. J., Fushimi, K., Wu, J. Y., Stack, M. S., & Huang, S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803682200 · Cited by 54
Expression of the splicing regulator polypyrimidine tract-binding protein in normal and neoplastic brain
McCutcheon, I. E., Hentschel, S. J., Fuller, G. N., Jin, W., & Cote, G. J. (2004) · Neuro-Oncology · doi:10.1215/s1152851703000279 · Cited by 54
Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma
Beird, H. C., Corley, L. J., Fuller, G. N., McCutcheon, I. E., & Cote, G. J. (2006) · Modern Pathology · doi:10.1038/modpathol.3800635 · Cited by 52
Polypyrimidine Tract Binding Protein 2 Stabilizes Phosphoglycerate Kinase 2 mRNA in Murine Male Germ Cells by Binding to Its 3′UTR1
Xu, M., & Hecht, N. B. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.060079 · Cited by 52
A Splicing Repressor Domain in Polypyrimidine Tract-binding Protein
Robinson, F., & Smith, C. W. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510578200 · Cited by 50
PTB/hnRNP I Is Required for RNP Remodeling during RNA Localization in Xenopus Oocytes
Lewis, R. A., Gagnon, J. A., & Mowry, K. L. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00999-07 · Cited by 49
Stoichiometry of a regulatory splicing complex revealed by single‐molecule analyses
Cherny, D., Gooding, C., Eperon, G. E., Coelho, M. B., Bagshaw, C. R., Smith, C. W. J., & Eperon, I. C. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.103 · Cited by 48
A Novel Polypyrimidine Tract-binding Protein Paralog Expressed in Smooth Muscle Cells
Gooding, C., Kemp, P. R., & Smith, C. W. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210131200 · Cited by 48
Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing
Joshi, A., Coelho, M. B., Kotik-Kogan, O., Simpson, P. J., Matthews, S., Smith, C. W. J., & Curry, S. (2011) · Structure · doi:10.1016/j.str.2011.09.020 · Cited by 45
The Domains of Polypyrimidine Tract Binding Protein Have Distinct RNA Structural Preferences
Clerté, C., & Hall, K. B. (2009) · Biochemistry · doi:10.1021/bi8016872 · Cited by 44
Characterization of the Nuclear Export Signal of Polypyrimidine Tract-binding Protein
Li, B., & Yen, T. S. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109686200 · Cited by 43
Alternative Splicing of Brain-Specific PTB Defines a Tissue-Specific Isoform Pattern That Predicts Distinct Functional Roles
Rahman, L., Bliskovski, V., Reinhold, W. C., & Zajac‐Kaye, M. (2002) · Genomics · doi:10.1006/geno.2002.6826 · Cited by 42
Drosophila polypyrimidine‐tract binding protein (PTB) functions specifically in the male germline
Robida, M. D., & Singh, R. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg301 · Cited by 38
Characterization of multimeric complexes formed by the human PTB1 protein on RNA
Clerté, C., & Hall, K. B. (2006) · RNA · doi:10.1261/rna.2178406 · Cited by 37
Pre‐mRNA splicing during transcription in the mammalian system
Pandya‐Jones, A. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.86 · Cited by 33
Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein
Yuan, X. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.2.456 · Cited by 33
Splicing of a Myosin Phosphatase Targeting Subunit 1 Alternative Exon Is Regulated by Intronic Cis-elements and a Novel Bipartite Exonic Enhancer/Silencer Element
Dirksen, W. P., Mohamed, S. A., & Fisher, S. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207969200 · Cited by 32
A Role for Polypyrimidine Tract Binding Protein in the Establishment of Focal Adhesions
Babić, I., Sharma, S., & Black, D. L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00590-09 · Cited by 32
Self-citation
Expression of Human nPTB Is Limited by Extreme Suboptimal Codon Content
Robinson, F., Jackson, R. J., & Smith, C. W. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001801 · Cited by 30
Molecular Cloning and Characterization of a New Neuron-Specific Homologue of Rat Polypyrimidine Tract Binding Protein
Kikuchi, T., Ichikawa, M., Arai, J., Tateiwa, H., Fu, L., Higuchi, K., & Yoshimura, N. (2000) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022819 · Cited by 30
Structure and Function of the Perinucleolar Compartment in Cancer CellsPreprint
Ślusarczyk, A., Kamath, R. V., Wang, C., Anchel, D., Pollock, C. B., Lewandowska, M. A., Fitzpatrick, T., Bazett‐Jones, D. P., & Huang, S. (2010) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2010.75.026 · Cited by 30
Repression of α-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract
Matlin, A. J., Southby, J., Gooding, C., & Smith, C. W. J. (2007) · RNA · doi:10.1261/rna.219607 · Cited by 29
Perinucleolar compartment and transformation
Kopp, K., & Huang, S. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20403 · Cited by 29
Polypyrimidine tract-binding protein down-regulates fibroblast growth factor receptor 1 alpha-exon inclusion.
Jin, W., Bruno, I., Xie, T., Sanger, L., & Cote, G. J. (2003) · PubMed · Cited by 29
Drosophila polypyrimidine tract-binding protein is necessary for spermatid individualization
Robida, M. D., Sridharan, V., Morgan, S., Rao, T., & Singh, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007935107 · Cited by 27
Evolutionary conservation of a 2-kb intronic sequence flanking a tissue-specific alternative exon in the PTBP2 gene
Rahman, L., Bliskovski, V., Kaye, F. J., & Zajac‐Kaye, M. (2003) · Genomics · doi:10.1016/s0888-7543(03)00207-6 · Cited by 24
Interactions between PTB RRMs Induce Slow Motions and Increase RNA Binding Affinity
Maynard, C., & Hall, K. B. (2010) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.12.051 · Cited by 23
A conserved peptide motif in Raver2 mediates its interaction with the polypyrimidine tract-binding protein
Henneberg, B. J. M., Swiniarski, S., Becke, S., & Illenberger, S. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.11.023 · Cited by 23
The Role of PTB in Insulin mRNA Stability Control
Fred, R. G., Tillmar, L., & Welsh, N. (2006) · Current Diabetes Reviews · doi:10.2174/157339906777950570 · Cited by 22
Polypyrimidine Tract-Binding Protein Is Critical for the Turnover and Subcellular Distribution of CD40 Ligand mRNA in CD4+ T Cells
Matus‐Nicodemos, R., Vavassori, S., Castro‐Faix, M., Valentín-Acevedo, A., Singh, K., Marcelli, V., & Covey, L. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003236 · Cited by 21
MSY2 and polypyrimidine tract binding protein 2 stabilize mRNAs in the mammalian testis
Xu, M., & Hecht, N. B. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00885.x · Cited by 16
Activation of p38 mitogen-activated protein kinase and mitochondrial Ca2+-mediated oxidative stress are essential for the enhanced expression ofgrp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A
Chen, K., Lai, M.-T., Cho, J., Chen, L., & Lai, Y. (2000) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(20000315)76:4
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Self-citation

See all 201

Authors: Keppetipola, N., Sharma, S., Li, Q., & Black, D. L.
Affiliations: University of California, Los Angeles (US)
Howard Hughes Medical Institute (US)
Corresponding author: Black, Douglas L.
ORCID: Keppetipola, Niroshika
Sharma, Shalini
Li, Qin
Black, Douglas L.
Venue: Critical Reviews in Biochemistry and Molecular Biology
Publisher: Informa UK Limited
Published: 2012-06-02
Volume: 47
Issue: 4
Pages: 360-378
ISSN: 0045-6411 (ISSN-L)
1040-9238
1549-7798
DOI: 10.3109/10409238.2012.691456
PMC: PMC3422667
OpenAlex: W2024593827
Cited by: 201
References: 165
Citations by year: 2026: 15 · 2025: 22 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 16 · 2020: 14 · 2018: 19 · 2017: 15 · 2016: 17 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 1
FWCI: 0.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute of General Medical Sciences (R01 GM 49662, R24GM070857, R01GM049662)
National Institute of Neurological Disorders and Stroke (T32NS007449, 5T32 NS07449)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: pre-mRNA splicing, alternative splicing, polypyrimidine tract-binding protein, PTBP1, PTBP2, RNA-binding proteins, spliceosome assembly, protein-RNA complex, neuronal development
MeSH terms: Animals, Humans, RNA Precursors, RNA Splicing, RNA-Binding Proteins, Alternative Splicing, Polypyrimidine Tract-Binding Protein

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Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

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