The DOI matches its Crossref record; 247 of the 247 references it cites were found in a registry or an index.
Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation
Open accessAbstract
Advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs) have a pathogenetic role in the development and progression of different oxidative-based diseases including diabetes, atherosclerosis, and neurological disorders. AGEs and ALEs represent a quite complex class of compounds that are formed by different mechanisms, by heterogeneous precursors and that can be formed either exogenously or endogenously. There is a wide interest in AGEs and ALEs involving different aspects of research which are essentially focused on set-up and application of analytical strategies (1) to identify, characterize, and quantify AGEs and ALEs in different pathophysiological conditions; (2) to elucidate the molecular basis of their biological effects; and (3) to discover compounds able to inhibit AGEs/ALEs damaging effects not only as biological tools aimed at validating AGEs/ALEs as drug target, but also as promising drugs. All the above-mentioned research stages require a clear picture of the chemical formation of AGEs/ALEs but this is not simple, due to the complex and heterogeneous pathways, involving different precursors and mechanisms. In view of this intricate scenario, the aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation.
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“This positive partial charge is attacked by nucleophiles such as cysteine and histidine and stable Michael adducts are formed (Fig. 4B) [50]. Nucleophilic attack of lysine forms unstable Michael adducts, which require reduction, e.g., by sodium borohydride prior to analysis [57].”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [50]
Citations
Cites
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672
Rio, D. D., Stewart, A. J., & Pellegrini, N. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.05.003 · Cited by 2,789
Advanced glycation end-products: A review
Singh, R., Barden, A., Mori, T., & Beilin, L. (2001) · Diabetologia · doi:10.1007/s001250051591 · Cited by 2,597
Isolation and characterization
Turksen, K. (2006) · Humana Press eBooks · Cited by 2,082
Dehydrated Foods, Chemistry of Browning Reactions in Model Systems
Hodge, J. E. (1953) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf60015a004 · Cited by 1,979
Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose
Thornalley, P. J., LANGBORG, A., & Minhas, H. S. (1999) · Biochemical Journal · doi:10.1042/bj3440109 · Cited by 1,209
Lipid peroxidation: Physiological levels and dual biological effects
Niki, E. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.05.032 · Cited by 1,032
The Role of Advanced Glycation End Products in Progression and Complications of Diabetes
Goh, S.-Y., & Cooper, M. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1817 · Cited by 987
Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., & Schmidt, A. M. (2005) · Glycobiology · doi:10.1093/glycob/cwi053 · Cited by 834
Fu, M.-X., Requena, J. R., Jenkins, A. J., Lyons, T. J., Baynes, J. W., & Thorpe, S. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.17.9982 · Cited by 822
Research works printed but not linked: 14
- Sugiyama S, 1998, Int J Mol Med, 2, 561
- Ciulla MM, 2011, Cardiovasc Hematol Disord Drug Targets
- Thornalley PJ, 1998, AGE receptors, receptor recognition factors and functional classification of AGEs Cell Mol Biol, 44, 1013
- Negre-Salvayre A, 2008, Potential role in diseases and therapeutic prospects for the inhibitors Br J Pharmacol, 153, 6
- Tessier FJ, 2010, The main discoveries and factors that affect glycation Pathol Biol, 58, 214
- Amadori M, 1929, Atti Reale Accad Nazl Lincei, 9, 68
- Laroque D, 2008, Consideration of sugar reactivity Food Chem, 111, 1032
- Kielhorn J, 2004, Glyoxal. Concise international chemical assessment
- Fu TM, 2008, J Geophys Res Atmos, 113
- Degenhardt TP, 1998, Cell Mol Biol (Noisy- le-grand), 44, 1139
- Sakai M, 2002, Kobe J Med Sci, 48, 125
- Skovsted IC, 1998, Cell Mol Biol, 44, 1159
- Requena JR, 2000, Methods Mol Med, 38, 209
- Seiler N, 2004, Amino Acids, 26, 217
Cited by
Sorted by citations
Items 801–828 of 828
Mazenc, A. (2022) · theses.fr (ABES) · doi:10.70675/993fac83z1efdz4dd2z8639z1373d18cf659
Junho, C. V. C., Dai, Y., Schieren, L., Hourtz, S., Rykova, T., Vondenhoff, S., Wessiepe, M., Zou, J., Jankowski, J., Goettsch, C., et al. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124467
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Qian, X., Cao, C., & Liu, L. (2026) · Metabolites · doi:10.3390/metabo16050346
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Mazur, K., & Smoleń, A. (2026) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2026.0011
Cavalloro, V., Moretto, G., Fossati, A., della Cuna, F. S. R., Collina, S., Martino, E., Colombo, R., & Papetti, A. (2026) · Foods · doi:10.3390/foods15111907
Effects of Site-Specific Glycation on α-Synuclein
Baldensperger, T., Hampel, A., & Becker, C. F. W. (2026) · ACS Chemical Biology · doi:10.1021/acschembio.6c00322
Sobczyńska, J., Federowicz, J., Galińska, Z., Ziomek, M., Stach, W., Bronowicka-Szydełko, A., & Madziarska, K. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12545-9
Iram, F., Aiman, A., Vijh, D., Choudhir, G., Hassan, M. I., & Islam, A. (2026) · Journal of Cellular Biochemistry · doi:10.1002/jcb.70117
Jiang, X., Li, J., Lu, Y., Ni, F., & Li, S. (2026) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-026-10862-y
Pérez-Linaza, A., Díaz, S. P., Serrano-García, I., Yi, W., Lores, Á. G., González, J. M. A., Garcia-Cozar, F. J., Fernandez-Ponce, C., & Fernández-Cisnal, R. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1876035
Saygılı, S. A., & Ayaz, A. (2026) · Molecules · doi:10.3390/molecules31162928
Wang, Y., Li, Y., Zhang, T., Yang, B., Zhang, Y., & Wu, Y. (2026) · Foods · doi:10.3390/foods15173023
Park, H.-J., & Kim, H.-M. (2026) · Biology · doi:10.3390/biology15171519
Adhikary, K., Godwin, T. S., Karunanithi, A., Sarkar, R., Abubakar, M., Nag, S., Barman, S., Datta, N., & Maiti, R. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18091191
Li, H., Wang, Z., Lv, Y., & Li, Y. (2026) · Food Research International · doi:10.1016/j.foodres.2026.120868
Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis
Khan, Z. N., Clement, C. C., Roßmüller, P., Antila, S., Sutherland, L., Kabarriti, R., Shafik, J., Smirnov, I., D’Alessandro, A., Dzieciątkowska, M., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.09.005
Fixing cells with light and DNA-binding fluorophoresPreprint
Duval, R. A., Carraz, M., Bosch, S., Mangeat, T., Cantaloube, S., & Amarh, V. (2026) · Research Square · doi:10.21203/rs.3.rs-11168287/v1
Li, M., Huang, S.-M., Wu, P.-Y., Huang, C.-W., Hung, W., & Hsu, K. (2026) · Current Research in Food Science · doi:10.1016/j.crfs.2026.101592
Role of the RAGE signaling pathway in myocardial ischemia/reperfusion injury
Sun, P., Zhang, C., & Shi, Z. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118538
Comparative exometabolomic insights into indigenous Philippine plant-derived lactic acid bacteria
Diez, K. J. T., Bucao, X. E. N., Rafael, C. A. R., Batuyong-Lista, M. A. R., Valerozo, J. A., Ong, J. P., Bucao, D. S., Agrupis, S. C., & Ramil, R. J. D. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.103367
Pastuszka, B., Nowak, A. J., & Damasiewicz-Bodzek, A. (2026) · Environmental Medicine · doi:10.26444/ms/241448
Intermediate-half-life metabolites as systemic relay nodes in metabolic disease
Lee, S.-S., Lee, B. S., Park, H., Kim, K. J., & Yoo, Y. C. (2026) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2026.101522
The effects of methylglyoxal on the mitochondria
Kalapos, M. P., & Lidia de, B. A. R. I. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00004-x
de Araujo, B. P., Silvares, R. R., Pereira, E. N. G. D. S., Rodrigues, K. L., van de Waarenburg, M. P. H., Scheijen, J. L. J. M., Fernandes‐Santos, C., Wouters, K., Schalkwijk, C. G., & Daliry, A. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.120013
Zhang, Q., Zhao, M., Su, M., Jing, F., Dong, J., & Jiang, M. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110713
Metadata
- Authors
- Vistoli, G., De Maddis, D., Cipak, A., Zarkovic, N., Carini, M., & Aldini, G.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Aldini, G.
- Venue
- Free Radical Research
- Publisher
- Informa UK Limited
- Published
- 2013-06-17
- Volume
- 47
- Issue
- sup1
- Pages
- 3-27
- ISSN
- 1029-2470 (ISSN-L)
- 1071-5762
- OpenAlex
- W2136497849
- Cited by
- 823
- References
- 247
- Citations by year
- 2026: 38 · 2025: 58 · 2024: 84 · 2023: 85 · 2022: 96 · 2021: 84 · 2020: 68 · 2019: 69 · 2018: 61 · 2017: 64 · 2016: 41 · 2015: 37 · 2014: 31 · 2013: 3
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Free Radical Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) (submittedVersion, other-oa)
- Funders
- Ministero dell'Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- advanced glycation end products, advanced lipoxidation end products, oxidative stress, diabetes mellitus, atherosclerosis, neurological disorders, AGE inhibitors
- MeSH terms
- Receptor for Advanced Glycation End Products, Humans, Pyruvaldehyde, Receptors, Immunologic, Lipid Peroxidation, Maillard Reaction, Glycation End Products, Advanced, Protein Carbonylation
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