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Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

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Vistoli, G., De Maddis, D., Cipak, A., Zarkovic, N., Carini, M., Aldini, G.·2013·Free Radical Research

DOI 10.3109/10715762.2013.815348

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Abstract

Advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs) have a pathogenetic role in the development and progression of different oxidative-based diseases including diabetes, atherosclerosis, and neurological disorders. AGEs and ALEs represent a quite complex class of compounds that are formed by different mechanisms, by heterogeneous precursors and that can be formed either exogenously or endogenously. There is a wide interest in AGEs and ALEs involving different aspects of research which are essentially focused on set-up and application of analytical strategies (1) to identify, characterize, and quantify AGEs and ALEs in different pathophysiological conditions; (2) to elucidate the molecular basis of their biological effects; and (3) to discover compounds able to inhibit AGEs/ALEs damaging effects not only as biological tools aimed at validating AGEs/ALEs as drug target, but also as promising drugs. All the above-mentioned research stages require a clear picture of the chemical formation of AGEs/ALEs but this is not simple, due to the complex and heterogeneous pathways, involving different precursors and mechanisms. In view of this intricate scenario, the aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation.

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Authors: Vistoli, G., De Maddis, D., Cipak, A., Zarkovic, N., Carini, M., & Aldini, G.
Affiliations: University of Milan (IT)
Corresponding author: Aldini, G.
ORCID: Vistoli, G.
Carini, M.
Aldini, G.
Venue: Free Radical Research
Publisher: Informa UK Limited
Published: 2013-06-17
Volume: 47
Issue: sup1
Pages: 3-27
ISSN: 1029-2470 (ISSN-L)
1071-5762
DOI: 10.3109/10715762.2013.815348
OpenAlex: W2136497849
Cited by: 823
References: 247
Citations by year: 2026: 38 · 2025: 58 · 2024: 84 · 2023: 85 · 2022: 96 · 2021: 84 · 2020: 68 · 2019: 69 · 2018: 61 · 2017: 64 · 2016: 41 · 2015: 37 · 2014: 31 · 2013: 3
FWCI: 3.86
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Free Radical Research (publishedVersion)
PubMed (publishedVersion)
Institutional Repository of the Ruđer Bošković Institute (Ruđer Bošković Institute) (submittedVersion, other-oa)
Funders: Ministero dell'Università e della Ricerca
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Life Sciences › Agricultural and Biological Sciences › Food Science › Potato Plant Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: advanced glycation end products, advanced lipoxidation end products, oxidative stress, diabetes mellitus, atherosclerosis, neurological disorders, AGE inhibitors
MeSH terms: Receptor for Advanced Glycation End Products, Humans, Pyruvaldehyde, Receptors, Immunologic, Lipid Peroxidation, Maillard Reaction, Glycation End Products, Advanced, Protein Carbonylation

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Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation

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