Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men
Abstract
OBJECTIVE— The goal of this study was to examine the relationship between serum testosterone levels and insulin sensitivity and mitochondrial function in men. RESEARCH DESIGN AND METHODS—A total of 60 men (mean age 60.5 ± 1.2 years) had a detailed hormonal and metabolic evaluation. Insulin sensitivity was measured using a hyperinsulinemic-euglycemic clamp. Mitochondrial function was assessed by measuring maximal aerobic capacity (Vo2max) and expression of oxidative phosphorylation genes in skeletal muscle. RESULTS—A total of 45% of subjects had normal glucose tolerance, 20% had impaired glucose tolerance, and 35% had type 2 diabetes. Testosterone levels were positively correlated with insulin sensitivity (r = 0.4, P < 0.005). Subjects with hypogonadal testosterone levels (n = 10) had a BMI >25 kg/m2 and a threefold higher prevalence of the metabolic syndrome than their eugonadal counterparts (n = 50); this relationship held true after adjusting for age and sex hormone–binding globulin but not BMI. Testosterone levels also correlated with Vo2max (r = 0.43, P < 0.05) and oxidative phosphorylation gene expression (r = 0.57, P < 0.0001). CONCLUSIONS—These data indicate that low serum testosterone levels are associated with an adverse metabolic profile and suggest a novel unifying mechanism for the previously independent observations that low testosterone levels and impaired mitochondrial function promote insulin resistance in men.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Low serum testosterone levels are associated with an adverse metabolic profile.
“Low serum testosterone levels are associated with an adverse metabolic profile which may be explained by the observation that low testosterone levels and impaired mitochondrial function promote insulin resistance in men (48).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [48]
Cites
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197 · see citing works
Self-citationGlucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824 · see citing works
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,761 · see citing works
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760 · see citing works
Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works
Mitochondrial dysfunction in the elderly: possible role in insulin resistance
Petersen, K. F., Befroy, D., Dufour, S., Dziura, J., Ariyan, C., Rothman, D. L., DiPietro, L., Cline, G. W., & Shulman, G. I. (2003) · Science · doi:10.1126/science.1082889 · Cited by 2,107 · see citing works
The Influence of Finasteride on the Development of Prostate Cancer
Sathianathen, N. J. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780190655341.003.0002 · Cited by 2,083 · see citing works
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952 · see citing works
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861 · see citing works
Insulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/er.18.6.774 · Cited by 1,167 · see citing works
Laaksonen, D. E., Niskanen, L., Punnonen, K., Nyyssönen, K., Tuomainen, T.-P., Valkonen, V.-P., Salonen, R., & Salonen, J. T. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1036 · Cited by 920 · see citing works
Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830 · see citing works
PLYMATE, S. R., MATEJ, L. A., JONES, R. E., & FRIEDL, K. E. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-3-460 · Cited by 693 · see citing works
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.
Wisløff, U., Najjar, S. M., Ellingsen, Ø., Haram, P. M., Swoap, S., Al-Share, Q., Fernström, M., Rezaei, K., Lee, S. J., Koch, L. G., et al. (2005) · Science · doi:10.1126/science.1108177 · Cited by 657 · see citing works
Stellato, R. K., Feldman, H. A., Hamdy, O., Horton, E. S., & McKinlay, J. B. (2000) · Diabetes Care · doi:10.2337/diacare.23.4.490 · Cited by 618 · see citing works
Oh, J.-Y., Barrett-Connor, E., Wedick, N. M., & Wingard, D. L. (2002) · Diabetes Care · doi:10.2337/diacare.25.1.55 · Cited by 594 · see citing works
Wang, C., Catlin, D. H., Demers, L. M., Starcevic, B., & Swerdloff, R. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031287 · Cited by 580 · see citing works
Seidell, J. C., Björntorp, P., Sjöström, L., Kvist, H., & Sannerstedt, R. (1990) · Metabolism · doi:10.1016/0026-0495(90)90297-p · Cited by 567 · see citing works
Page, S. T., Amory, J. K., Bowman, F. D., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1933 · Cited by 566 · see citing works
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553 · see citing works
Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.
Boden, G., Jadali, F., White, J. V., Liang, Y. T., Mozzoli, M. A., Chen, X., Coleman, E., & Smith, C. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115399 · Cited by 500 · see citing works
Amory, J. K., Watts, N. B., Easley, K. A., Sutton, P. R., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031110 · Cited by 475 · see citing works
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7851 · Cited by 458 · see citing works
Mauras, N., Hayes, V. Y., Welch, S., Rini, A., Helgeson, K., Dokler, M. L., Veldhuis, J. D., & Urban, R. J. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4892 · Cited by 409 · see citing works
Boyanov, M. A., Boneva, Z., & Christov, V. G. (2003) · The Aging Male · doi:10.1080/tam.6.1.1.7 · Cited by 381 · see citing works
Androgen Treatment of Abdominally Obese Men
Mårin, P., Holmtäng, S., Gustafsson, C., Jönsson, ‡., Kvist, ‡., Elander, A., Eldh, J., Sjöström, L., Holm, G., & Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00618.x · Cited by 345 · see citing works
Effect of obesity and body fat distribution on sex hormones and insulin in men
Pasquali, R., Casimirri, F., Cantobelli, S., Melchionda, N., Labate, A. M. M., Fabbri, R., Capelli, M., & Bortoluzzi, L. (1991) · Metabolism · doi:10.1016/0026-0495(91)90199-7 · Cited by 337 · see citing works
Mårin, P., Odén, B., & Björntorp, P. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.1.7829619 · Cited by 332 · see citing works
Haffner, S. M., Shaten, J., Stem, M. P., Smith, G. D., Kuller, L., & MRFIT Research Group (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008832 · Cited by 320 · see citing works
Insulin Resistance, Body Fat Distribution, and Sex Hormones in Men
Haffner, S. M., Karhapää, P., Mykkänen, L. M., & Laakso, M. (1994) · Diabetes · doi:10.2337/diab.43.2.212 · Cited by 305 · see citing works
Miller, K. K., Rosner, W., Lee, H., Hier, J., Sesmilo, G., Schoenfeld, D., Neubauer, G., & Klibanski, A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030680 · Cited by 301 · see citing works
Self-citationDockery, F., Bulpitt, C. J., AGARWAL, S., Donaldson, M., & Rajkumar, C. (2003) · Clinical Science · doi:10.1042/cs20020209 · Cited by 294 · see citing works
Barrett-Connor, E. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-10-807 · Cited by 281 · see citing works
Testosterone concentrations in women and men with NIDDM
Andersson, B., Märin, P., Lissner, L., Vermeulen, A., & Björntorp, P. (1994) · Diabetes Care · doi:10.2337/diacare.17.5.405 · Cited by 268 · cited 1× · see citing works
“weight-matched nondiabetic control subjects (12,13).”
Lower endogenous androgens predict central adiposity in men
Khaw, K., & Barrett-Connor, E. L. (1992) · Annals of Epidemiology · doi:10.1016/1047-2797(92)90012-f · Cited by 247 · see citing works
Effect of testosterone on abdominal adipose tissue in men.
Rebuffé-Scrive, M., Mårin, P., & Björntorp, P. A. (1991) · PubMed · Cited by 227 · see citing works
Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men
Tsai, E., Boyko, E. J., Leonetti, D., & Fujimoto, W. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801183 · Cited by 221 · see citing works
Serum Testosterone Assays—Accuracy Matters
Matsumoto, A. M., & Bremner, W. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032175 · Cited by 217 · see citing works
Pathogenesis of the decreased androgen levels in obese men.
Giagulli, V. A., Kaufman, J. M., & Vermeulen, A. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962311 · Cited by 215 · see citing works
The Effects of Androgens on the Regulation of Lipolysis in Adipose Precursor Cells
Xu, X., Pergola, G. D., & Björntorp, P. A. (1990) · Endocrinology · doi:10.1210/endo-126-2-1229 · Cited by 202 · see citing works
Testosterone Increases Lipolysis and the Number of β-Adrenoceptors in Male Rat Adipocytes*
Xu, X., Pergola, G. D., & Björntorp, P. A. (1991) · Endocrinology · doi:10.1210/endo-128-1-379 · Cited by 190 · see citing works
The effects of testosterone on insulin sensitivity in male rats
Holmäng, A. B., & Björntorp, P. A. (1992) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1992.tb09452.x · Cited by 189 · see citing works
Sex Steroid Hormones, Upper Body Obesity, and Insulin Resistance
Abate, N., Haffner, S. M., Garg, A., Peshock, R. M., & Grundy, S. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020567 · Cited by 187 · see citing works
Birkeland, K. I., Hanssen, K. F., Torjesen, P. A., & Vaaler, S. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.76.2.8432768 · Cited by 161 · cited 2× · see citing works
“Two studies demonstrate a positive relationship between total testosterone levels and insulin sensitivity in normal (20) and diabetic men (21).”
BackgroundResultInterrelation between plasma testosterone and plasma insulin in healthy adult men: the Telecom Study
Simon, D., Preziosi, P., Barrett-Connor, E., Roger, M., Saint-Paul, M., Nahoul, K., & Papoz, L. (1992) · Diabetologia · doi:10.1007/bf00402551 · Cited by 157 · see citing works
Phillips, G. B. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.4.1729 · Cited by 142 · see citing works
SEX HORMONES, INSULIN, LIPIDS, AND PREVALENT ISCHEMIC HEART DISEASE
Lichtenstein, M. J., YARNELL, J. W. G., Elwood, P. C., Beswick, A. D., Sweetnam, P. M., Marks, V., Teale, D., & Riad-Fahmy, D. (1987) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114704 · Cited by 138 · see citing works
Simon, D., Charles, M.-A., Lahlou, N., Nahoul, K., Oppert, J.-M., Gouault-Heilmann, M., Lemort, N., Thibult, N., Joubert, E., Balkau, B., et al. (2001) · Diabetes Care · doi:10.2337/diacare.24.12.2149 · Cited by 136 · see citing works
Razak, F. A., & Anand, S. S. (2004) · Vascular Medicine · doi:10.1191/1358863x04vm568xx · Cited by 133 · see citing works
The Pituitary-Gonadal Axis and Health in Elderly Men: A Study of Men Born in 1913
Tibblin, G., Adlerberth, A., Lindstedt, G., & Björntorp, P. A. (1996) · Diabetes · doi:10.2337/diab.45.11.1605 · Cited by 119 · see citing works
Rosner, W. (1999) · Steroids · doi:10.1016/s0039-128x(98)00108-1 · Cited by 98 · see citing works
Partial androgen deficiency in aging type 2 diabetic men and its relationship to glycemic control
Corrales, J. J., Burgo, R. M., Garcı́a-Berrocal, B., Almeida, M., Alberca, I., González-Buitrago, J. M., Orfao, A., & Miralles, J. M. (2004) · Metabolism · doi:10.1016/j.metabol.2003.12.016 · Cited by 97 · see citing works
Eriksson, K., & Lindg�rde, F. (1990) · Diabetologia · doi:10.1007/bf00404139 · Cited by 86 · see citing works
Self-citationInsulin resistance, body fat distribution, and sex hormones in men
Haffner, S. M., Karhapää, P., Mykkänen, L., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.2.212 · Cited by 78 · see citing works
Svartberg, J. B., Jenssen, T. G., Sundsfjord, J., & Jorde, R. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70086-1 · Cited by 70 · see citing works
Liu, P. Y., Wishart, S. M., Celermajer, D., Jimenez, M., di Pierro, I., Conway, A., & Handelsman, D. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480055 · Cited by 69 · see citing works
DHEA administration increases brown fat uncoupling protein 1 levels in obese OLETF rats
Ryu, J., Kim, M., Kim, C., Song, K., Park, J., Lee, J.-D., Kim, J. B., & Lee, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00409-1 · Cited by 37 · see citing works
The pituitary-gonadal axis and health in elderly men: a study of men born in 1913
Tibblin, G., Adlerberth, A., Lindstedt, G. O. R., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.11.1605 · Cited by 35 · see citing works
Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men
Kaplan, S. A., & Crawford, E. D. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-2100 · Cited by 20 · see citing works
Determinants of insulin‐stimulated skeletal muscle glycogen metabolism in man
Schalin‐Jäntti, C., Laurila, E., Löfman, M., & Groop, L. (1995) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1995.tb01988.x · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials
Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., & Leeuwenburgh, C. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.06.024 · Cited by 627 · see citing works
Jones, T. H., Arver, S., Behre, H. M., Buvat, J., Meuleman, E., Moncada, I., Morales, A. M., Volterrani, M., Yellowlees, A., Howell, J. D., et al. (2011) · Diabetes Care · doi:10.2337/dc10-1233 · Cited by 548 · see citing works
Shift work and diabetes mellitus: a meta-analysis of observational studies
Gan, Y., Yang, C., Tong, X., Sun, H., Cong, Y., Yin, X., Li, L., Cao, S., Dong, X., Gong, Y., et al. (2015) · Occupational and Environmental Medicine · doi:10.1136/oemed-2014-102150 · Cited by 526 · see citing works
Pitteloud, N., Hardin, M., Dwyer, A. A., Valassi, E., Yialamas, M., Elahi, D., & Hayes, F. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2190 · Cited by 525 · see citing works
Self-citationKelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487 · see citing works
Gender differences in glucose homeostasis and diabetes
Mauvais-Jarvis, F. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.08.016 · Cited by 377 · see citing works
Type 2 diabetes mellitus and testosterone: a meta-analysis study: Type 2 diabetes and testosterone
Corona, G., Monami, M., Rastrelli, G., Aversa, A., Sforza, A., Lenzi, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01117.x · Cited by 370 · see citing works
Mitochondria: A central target for sex differences in pathologies
Ventura-Clapier, R., Moulin, M., Piquereau, J., Lemaire, C., Mericskay, M., Veksler, V., & Garnier, A. (2017) · Clinical Science · doi:10.1042/cs20160485 · Cited by 371 · see citing works
Low Testosterone in Men with Type 2 Diabetes: Significance and Treatment
Grossmann, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0118 · Cited by 350 · see citing works
Heufelder, A. E., Saad, F., Bunck, M. C., & Gooren, L. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.007005 · Cited by 349 · see citing works
Mauvais-Jarvis, F. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.10.002 · Cited by 335 · see citing works
Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
Rao, P. M., Kelly, D. M., & Jones, T. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.122 · Cited by 292 · see citing works
The role of androgens in metabolism, obesity, and diabetes in males and females
Navarro, G., Allard, C., Xu, W., & Mauvais‐Jarvis, F. (2015) · Obesity · doi:10.1002/oby.21033 · Cited by 289 · see citing works
Testosterone therapy for transgender men
Irwig, M. S. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)00036-x · Cited by 272 · see citing works
The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance
Traish, A. M., Saad, F., & Guay, A. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.005751 · Cited by 266 · see citing works
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232 · see citing works
Corona, G., Mannucci, E., Forti, G., & Maggi, M. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00951.x · Cited by 223 · see citing works
Yialamas, M. A., Dwyer, A. A., Hanley, E., Lee, H., Pitteloud, N., & Hayes, F. J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0454 · Cited by 220 · see citing works
Self-citationHormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications
Pataky, M. W., Young, W. F., & Nair, K. S. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.07.033 · Cited by 207 · see citing works
Longitudinal changes in testosterone over five years in community-dwelling men
Shi, Z., Araujo, A. B., Martin, S., O'Loughlin, P., & Wittert, G. A. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3842 · Cited by 165 · see citing works
Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2017) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417691136 · Cited by 130 · see citing works
Yeap, B. B., Chubb, S. A. P., Hyde, Z., Jamrozik, K., Hankey, G. J., Flicker, L., & Norman, P. E. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0348 · Cited by 128 · see citing works
Gheller, B. J. F., Riddle, E. S., Lem, M. R., & Thalacker-Mercer, A. E. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050901 · Cited by 98 · see citing works
Corona, G., Mannucci, E., Forti, G., & Maggi, M. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2009.00965.x · Cited by 96 · see citing works
Mitochondrial and sex steroid hormone crosstalk during aging
Velarde, M. C. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-2 · Cited by 96 · see citing works
Cardiopulmonary Impairment in Young Women with Polycystic Ovary Syndrome
Orio, F., Giallauria, F., Palomba, S., Cascella, T., Manguso, F., Vuolo, L., Russo, T., Tolino, A., Lombardi, G., Colao, A., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0216 · Cited by 84 · see citing works
Guo, W., Wong, S., Li, M., Liang, W., Liesa, M., Serra, C., Jasuja, R., Bartke, A., Kirkland, J. L., Shirihai, O., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051180 · Cited by 59 · see citing works
Dwyer, A. A., Hayes, F. J., Plummer, L., Pitteloud, N., & Crowley, W. F. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0245 · Cited by 58 · see citing works
Self-citationThe Emerging Link Between Hypogonadism and Metabolic Syndrome
Guay, A. T. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.006015 · Cited by 50 · see citing works
Is Obesity a Further Cardiovascular Risk Factor in Patients with Erectile Dysfunction?
Corona, G., Monami, M., Boddi, V., Balzi, D., Melani, C., Federico, N., Balzi, D., Sforza, A., Rotella, C. M., Forti, G., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01839.x · Cited by 35 · see citing works
Sex steroids enhance insulin receptors and glucose oxidation in Chang liver cells
Parthasarathy, C., Renuka, V. N., & Balasubramanian, K. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.09.011 · Cited by 27 · see citing works
Short-Term Estrogen Withdrawal Increases Adiposity in Healthy Men
Chao, J., Rubinow, K. B., Kratz, M., Amory, J. K., Matsumoto, A. M., & Page, S. T. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1482 · Cited by 25 · see citing works
Correlation of sex hormone and androgen receptor with diabetes mellitus in elderly men
Cao, J., Li, J., Hao, W., Li, X., Wang, H., Liu, L., Zhu, B., & Guo, Z. (2011) · The Aging Male · doi:10.3109/13685538.2011.575479 · Cited by 21 · see citing works
Prenatal Testosterone Exposure Disrupts Insulin Secretion and Promotes Insulin Resistance
Carrasco, A., Recabarren, M. P., Rojas-García, P. P., Gutiérrez, M., Morales, K., Sir-Petermann, T., & Recabarren, S. E. (2020) · Scientific Reports · doi:10.1038/s41598-019-57197-x · Cited by 10 · see citing works
- Authors
- Pitteloud, N., Mootha, V. K., Dwyer, A. A., Hardin, M., Lee, H., Eriksson, K.-F., Tripathy, D., Yialamas, M., Groop, L., Elahi, D., & Hayes, F. J.
- Affiliations
- Massachusetts General Hospital (US)
- Broad Institute (US)
- Harvard University (US)
- Lund University (SE)
- University of Massachusetts Chan Medical School (US)
- ORCID
- Venue
- Diabetes Care
- Publisher
- American Diabetes Association
- Published
- 2005-07-01
- Volume
- 28
- Issue
- 7
- Pages
- 1636-1642
- ISSN
- 0149-5992 (ISSN-L)
- 1935-5548
- OpenAlex
- W2125468251
- Semantic Scholar
- 73a3e3203fe419597f95d9ce80c8f008dcca106c
- Cited by
- 472
- References
- 62
- Citations by year
- 2026: 18 · 2025: 23 · 2024: 17 · 2023: 12 · 2022: 14 · 2021: 17 · 2020: 17 · 2019: 21 · 2018: 26 · 2017: 32 · 2016: 26 · 2015: 26 · 2014: 35 · 2013: 24 · 2012: 20
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diabetes Care (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (5k23dk002858-04, 5r03dk064276-02)
- National Institute of Diabetes and Digestive and Kidney Diseases (R03-DK064276-01, K23 DK 02858-04)
- National Center for Research Resources (M01RR001066, M01-RR01066)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone, insulin sensitivity, insulin resistance, mitochondrial function, oxidative phosphorylation, skeletal muscle, cardiorespiratory fitness, hypogonadism, metabolic syndrome, type 2 diabetes, impaired glucose tolerance, men, sex hormone-binding globulin
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Humans, Hyperinsulinism, Insulin, Male, Middle Aged, Mitochondria, Oxidative Phosphorylation, Oxygen, Oxygen Consumption, Partial Pressure, Sex Hormone-Binding Globulin, Testosterone, Glucose Clamp Technique, Glucose Intolerance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
