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Cited by 160Hormonal and reproductive studiesNutrition and Health in AgingMenopause: Health Impacts and Treatments

Testosterone treatment in elderly men with subnormal testosterone levels improves body composition and BMD in the hip

Svartberg, J, Agledahl, I, Figenschau, Y, Sildnes, T, Waterloo, K, Jorde, R·2008·International Journal of Impotence Research
DOI 10.1038/ijir.2008.19
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Abstract

Our intention was to examine if subnormal testosterone levels in older men were associated with a reduction in quality of life and physical and mental health, and secondly to examine if testosterone treatment could improve these conditions. We performed a nested case-control study and a 1-year testosterone intervention study. Men with subnormal testosterone had significantly higher weight, fat mass and abdominal adipose tissue. They also had significantly higher glucose and insulin levels, and they had higher triglyceride levels. Testosterone treatment had a large impact on body composition with reduced fat mass and abdominal adipose tissue and increased fat-free mass, but it did not affect weight and glucose and lipid metabolism. Bone mineral density in the hip was significantly higher after the testosterone treatment. Older men with subnormal testosterone levels had an unfavorable metabolic profile. Testosterone treatment improved body composition, but it did not reverse the unfavorable metabolic profile.

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Crossref · 10.1038/ijir.2008.19

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  • Elderly men aged 60-80 with subnormal testosterone levels have elevated subcutaneous and visceral fat mass compared with elderly men with normal testosterone levels.

    “For example, it has been observed in elderly (60-80 year-old) men with subnormal T levels that subcutaneous and visceral fat mass are elevated when compared to elderly men with normal T levels.71”

    From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [71]

  • In elderly men, lower testosterone levels are associated with reduced insulin sensitivity as indicated by higher glucose during an oral glucose tolerance test, reduced QUICKI score, and lower HOMA-IR values.

    “In elderly men, lower T levels are associated with reduced insulin sensitivity as indicated by higher glucose levels during an oral glucose tolerance test,71 reduced quantitative insulin sensitivity check index score,93, 94 and lower HOMA-IR values.95”

    From Hormonal and Metabolic Changes of Aging and the Influence of Lifestyle Modifications (2021) · cites this paper as [71]

  • In studies using intramuscular testosterone undecanoate, reductions in fat mass ranged from 3.4 kg to 4.2 kg.

    “In studies using intramuscular testosterone undecanoate, reductions in fat mass ranged from 3.4 kg 81 to 4.2 kg, 93”

    From The role of the androgen receptor in the pathogenesis of obesity and its utility as a target for obesity treatments (2022) · cites this paper as [93]

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Authors
Svartberg, J., Agledahl, I., Figenschau, Y., Sildnes, T., Waterloo, K., & Jorde, R.
Affiliations
University Hospital of North Norway (NO)
Corresponding author
Svartberg, J
ORCID
Venue
International Journal of Impotence Research
Publisher
Springer Science and Business Media LLC
Published
2008-05-15
Volume
20
Issue
4
Pages
378-387
ISSN
  • 0955-9930 (ISSN-L)
  • 1476-5489
DOI
10.1038/ijir.2008.19
OpenAlex
W2023325491
Cited by
160
References
33
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 13 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 15 · 2012: 9
FWCI
6.77
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • International Journal of Impotence Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
testosterone replacement therapy, hypogonadism, older men, body composition, bone mineral density, hip bone, fat mass, abdominal fat, fat-free mass, insulin, glucose, triglycerides, lipid metabolism, quality of life, metabolic profile
MeSH terms
Aged, Aged, 80 and over, Body Composition, Disease, Glucose, Hip, Humans, Male, Middle Aged, Muscles, Quality of Life, Testosterone, Bone Density, Case-Control Studies, Lipid Metabolism

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