Long-term impact of diabetes in patients hospitalized with ischemic and non-ischemic heart failure
Open accessAbstract
OBJECTIVES: Diabetes mellitus (DM) in combination with heart failure (HF) is associated with a high risk of death, but it is uncertain whether the prognosis differs in ischemic and non-ischemic HF groups. DESIGN: One thousand, three hundred and six patients with ischemic HF and 1315 patients with non-ischemic HF were followed for 6.8 years. Risk of all caue mortality was analyzed using Cox proportional hazard models. RESULTS: Mean age was 73 (+/- standard deviation 11) years. Two hundred and forty eight of 1306 (19%) patients with ischemic HF and 172/1315 (13%) patients with non-ischemic HF had DM (p for difference < 0.0001). Overall, 939/1306 (72%) patients in the ischemic HF group, and 835/1315 (64%) patients in the non-ischemic HF group died, respectively. Totally 191/248 (77%) DM patients with ischemic HF, and 127/172 (74%) DM patients with non-ischemic HF died. DM was associated with adjusted hazard ratios (HR) of 1.45 (1.22-1.73, p < 0.0001) if ischemic HF, and 1.50 (1.22-1.84, p < 0.0001) if non-ischemic HF (p for interaction = 0.4), compared to non-DM non-ischemic HF patients. CONCLUSION: The long-term prognosis of DM is equally adverse in ischemic and non-ischemic HF patients.
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In two population-based studies from Scotland and Sweden, the increased mortality risk of T2DM was seen in both women and men, but the effect was slightly greater in women.
“In two population-based studies from Scotland and Sweden, the increased mortality risk of T2DM was seen in both women and men, but the effect was slightly greater in women.87,96”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [96]
In a population-based Danish study which followed patients for 6.8 years, patients with T2DM and HF had higher mortality whether or not they had CAD.
“In a population-based Danish study, which followed patients for 6.8 years, patients with T2DM and HF had higher mortality whether or not they had CAD.96”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [96]
The majority of the available data suggests that T2DM is associated with higher risk of mortality in both patients of ischaemic and non-ischaemic aetiology.
“The majority of the available data suggests that T2DM is associated with higher risk of mortality in both patients of ischaemic and non-ischaemic aetiology (Table 6).29,88,94,96 -99”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [96]
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- Authors
- Andersson, C., Weeke, P., Pecini, R., Kjaergaard, J., Hassager, C., Køber, L., Torp-Pedersen, C., & On Behalf of the Echos Investigators
- Affiliations
- Gentofte Hospital (DK)
- Copenhagen University Hospital (DK)
- Corresponding author
- Andersson, Charlotte
- Venue
- Scandinavian Cardiovascular Journal
- Publisher
- Informa UK Limited
- Published
- 2009-11-02
- Volume
- 44
- Issue
- 1
- Pages
- 37-44
- ISSN
- 1401-7431 (ISSN-L)
- 1651-2006
- OpenAlex
- W2109472509
- Cited by
- 21
- References
- 20
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Cardiovascular Journal (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, heart failure, ischemic heart failure, non-ischemic heart failure, mortality, prognosis, long-term follow-up, comorbidities
- MeSH terms
- Aged, Aged, 80 and over, Denmark, Diabetes Mellitus, Female, Heart Failure, Hospitalization, Humans, Inpatients, Male, Middle Aged, Risk Factors, Time Factors, Multicenter Studies as Topic, Chi-Square Distribution, Proportional Hazards Models, Randomized Controlled Trials as Topic, Treatment Outcome, Myocardial Ischemia, Risk Assessment, Diabetes Complications, Kaplan-Meier Estimate
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