Histological assessment of nerve lesions caused by epineurial electrode application in rat sciatic nerve
Abstract
✓ The left sciatic nerve of 36 rats was exposed and four ring-shaped stainless steel wire electrodes were sutured to the epineurium of each nerve in the same manner as performed clinically for “carousel stimulation” in man. The rats were sacrificed 10 days (Group 1), 3 weeks (Group 2), or 3 months (Group 3) after implantation. The electrodes were excised, the nerves were embedded in Epon, and semithin sections were obtained for histological and planimetric assessment of lesions caused by the epineurially sutured electrodes. The right sciatic nerves served as controls. The total area of neural tissue within the perineurium was determined at three levels: at the site of the electrodes, 8 mm proximal, and 8 mm distal. The area of neural tissue damaged by the surgical procedure was expressed as a percentage of the total area. In Group 1, nine of 12 nerves showed lesions ranging from 0.39% to 25.39% of the total area of neural tissue, in Group 2 eight of 11 sciatic nerves showed lesions ranging from 0.24% to 13.03% of the total area, and in Group 3 five of 12 nerves showed lesions ranging from 0.21% to 4.96% of the total area. The pathologically altered areas in Groups 2 and 3 exhibited distinct signs of nerve fiber regeneration. The reasons for the decrease in damage from Group 1 to Group 3 and the clinical implications of the results for long-term electrical stimulation are discussed.
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In rat sciatic nerve, altered fascicular area after cuff electrode implantation gradually recovered from 4.74% at 10 days to 0.57% at 3 months.
“Girsch et al. assessed nerve lesions in the rat sciatic nerve 10 days, 3 weeks, and 3 months after cuff electrode implantation, and noted a gradual recovery from 4.74 to 0.57% of altered fascicular area.”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [53]
Neural damage induced by implantation and presence of an extraneural electrode is reversible.
“Girsch et al. and Larsen et al. showed that neural damage induced by the implantation and presence of an extraneural electrode is reversible [53, 54].”
From Safety of long-term electrical peripheral nerve stimulation: review of the state of the art (2019) · cites this paper as [53]
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- Authors
- Girsch, W., Koller, R., Gruber, H., Holle, J., Liegl, C., Losert, U., Mayr, W., & Thoma, H.
- Affiliations
- University of Vienna (AT)
- Venue
- Journal of Neurosurgery
- Published
- 1991-04
- Volume
- 74
- Issue
- 4
- Pages
- 636-642
- ISSN
- 0022-3085 (ISSN-L)
- OpenAlex
- W2130809133
- Cited by
- 18
- References
- 20
- Citations by year
- 2022: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2014: 1
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- sciatic nerve, nerve injury, perineurium, nerve fiber regeneration, nerve histology, rat model
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Implanted, Female, Rats, Inbred Strains, Sciatic Nerve, Time Factors, Rats
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