The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
The placenta and neurodevelopment: sex differences in prenatal vulnerability
Open accessAbstract
Prenatal insults, such as maternal stress, are associated with an increased neurodevelopmental disease risk and impact males significantly more than females, including increased rates of autism, mental retardation, stuttering, dyslexia, and attention deficit/hyperactivity disorder (ADHD). Sex differences in the placenta, which begin with sex chromosomes, are likely to produce sex-specific transplacental signals to the developing brain. Our studies and others have identified X-linked genes that are expressed at higher levels in the female placenta. Through a genome-wide screen after maternal stress in mice, we identified the X-linked gene O-linked N-acetylglucosamine transferase (OGT) and demonstrated its causality in neurodevelopmental programming producing a male-specific stress phenotype. Elucidating the sex-specific molecular mechanisms involved in transplacental signals that impact brain development is key to understanding the sex bias in neurodevelopmental disorders and is expected to yield novel insight into disease risk and resilience.
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“In many studies, male offspring appear to be the most strongly affected. Interestingly, they often present with what is known as a dysmasculinized phenotype (i.e., with behaviors and gene expression patterns most commonly seen in females) (Bale 2016).”
From Prenatal developmental origins of future psychopathology: mechanisms and pathways (2019) · cites this paper as Bale 2016
In the citing paper
“In one elegant model in mice based on the X-linked gene OGT (O-linked N-acetylglucosamine transferase), male placentas with typically lower levels of OGT are poised for epigenetic alterations that appear to produce robust transcriptional responses to maternal prenatal stress that result in increased stress sensitivity as adults (Bale 2016).”
From Prenatal developmental origins of future psychopathology: mechanisms and pathways (2019) · cites this paper as Bale 2016
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Additional file 12 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556830
Additional file 6 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556812
Additional file 9 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556821
Liu, H., Liu, Y., Huang, K., Yan, S., Hao, J., Zhu, P., Tao, F., & Shao, S. (2021) · Figshare · doi:10.6084/m9.figshare.16907518
Additional file 4 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556806
Additional file 7 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556815
Liu, H., Liu, Y., Huang, K., Yan, S., Hao, J., Zhu, P., Tao, F., & Shao, S. (2021) · Figshare · doi:10.6084/m9.figshare.16907503
Additional file 8 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556818
Additional file 10 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556824
Additional file 11 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556827
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Self-citationAdditional file 3 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556803
Additional file 13 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556833
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Liu, H., Liu, Y., Huang, K., Yan, S., Hao, J., Zhu, P., Tao, F., & Shao, S. (2021) · Figshare · doi:10.6084/m9.figshare.16907515
Additional file 1 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556797
Additional file 5 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556809
Additional file 2 of Sex differences in early and term placenta are conserved in adult tissues
Olney, K. C., Plaisier, S. B., Phung, T. N., Silasi, M., Perley, L. E., O’Bryan, J., Ramirez, L., Kliman, H. J., & Wilson, M. A. (2024) · Figshare · doi:10.6084/m9.figshare.26556800
Liu, H., Liu, Y., Huang, K., Yan, S., Hao, J., Zhu, P., Tao, F., & Shao, S. (2021) · Figshare · doi:10.6084/m9.figshare.16907506
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Terada, S., Isumi, A., & Fujiwara, T. (2026) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.70213
Metadata
- Authors
- Bale, T. L.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Bale, Tracy L.
- ORCID
- Bale, Tracy L.
- Venue
- Dialogues in Clinical Neuroscience
- Publisher
- Informa UK Limited
- Published
- 2016-12-31
- Volume
- 18
- Issue
- 4
- Pages
- 459-464
- ISSN
- 1294-8322 (ISSN-L)
- 1958-5969
- PMC
- PMC5286731
- OpenAlex
- W2988356887
- Cited by
- 236
- References
- 86
- Citations by year
- 2026: 23 · 2025: 29 · 2024: 23 · 2023: 35 · 2022: 30 · 2021: 32 · 2020: 20 · 2019: 17 · 2018: 20 · 2017: 7
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Dialogues in Clinical Neuroscience (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh091258-05)
- National Institute of Mental Health (P50MH099910, R37MH108286, R33MH104184, R01 MH-091258, R01MH087597)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- placenta, sex differences, brain development, prenatal stress, maternal stress, neurodevelopmental disorders, autism spectrum disorder, attention deficit hyperactivity disorder, X-linked genes, O-GlcNAc transferase, sex bias
- MeSH terms
- Animals, Female, Humans, Male, Placenta, Pregnancy, Prenatal Exposure Delayed Effects, Sex Characteristics, Stress, Physiological, Stress, Psychological, Neurodevelopmental Disorders
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