Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging
Abstract
Coffee, tea, or caffeine consumption may be protective against cognitive impairment and dementia. We estimated the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI). We evaluated 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging, a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. Cognitively normal older individuals who habitually consumed moderate amount of coffee (from 1 to 2 cups of coffee/day) had a lower rate of the incidence of MCI than those who never or rarely consumed coffee [1 cup/day: hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.211 to 1.02 or 1-2 cups/day: HR: 0.31 95% CI: 0.13 to 0.75]. For cognitively normal older subjects who changed their coffee consumption habits, those increasing coffee consumption (>1 cup of coffee/day) had higher rate of the incidence of MCI compared to those with constant habits (up to ±1 cup of coffee/day) (HR: 1.80, 95% CI: 1.11 to 2.92) or those with reduced consumption (<1 cup of coffee/day) (HR: 2.17, 95% CI: 1.16 to 4.08). Finally, there was no significant association between subjects with higher levels of coffee consumption (>2 cups of coffee/day) and the incidence of MCI in comparison with those who never or rarely consumed coffee (HR: 0.26, 95% CI: 0.03 to 2.11). In conclusion, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing MCI, while a constant in time moderate coffee consumption was associated to a reduced rate of the incidence of MCI.
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People who consumed more than 60 cups of coffee per year had a 20% lower volume of pineal parenchyma than those who consumed less.
“Finally, among 162 cognitively healthy Koreans aged 60–94 (85 men, 77 women), people who consumed more than 60 cups of coffee per year had a 20% lower volume of pineal parenchyma, a melatonin-producing region, than those who consumed less than 60 cups of coffee per year [101].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [101]
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- Authors
- Solfrizzi, V., and for the Italian Longitudinal Study on Aging Working Group 2, Panza, F., Imbimbo, B. P., D’Introno, A., Galluzzo, L., Gandin, C., Misciagna, G., Guerra, V., Osella, A., Baldereschi, M., Di Carlo, A., Inzitari, D., Seripa, D., Pilotto, A., Sabbá, C., Logroscino, G., & Scafato, E.
- Affiliations
- University of Bari Aldo Moro (IT)
- Casa Sollievo della Sofferenza (IT)
- Chiesi (Italy) (IT)
- Istituto Superiore di Sanità (IT)
- Gastroenterology Hospital "Saverio de Bellis" (IT)
- National Research Council (IT)
- Institute of Neuroscience, Italian National Research Council (CNR), Firenze, Italy
- Geriatric Medicine-Memory Unit, Rare Disease Centre, Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy
- Corresponding author
- Solfrizzi, Vincenzo
- Panza, Francesco
- ORCID
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2015-08-11
- Volume
- 47
- Issue
- 4
- Pages
- 889-899
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W1958264218
- Cited by
- 65
- References
- 59
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 9 · 2022: 5 · 2021: 9 · 2020: 5 · 2019: 3 · 2018: 6 · 2017: 12 · 2016: 4
- FWCI
- 5.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- coffee consumption, mild cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Aging, Caffeine, Coffee, Depression, Feeding Behavior, Follow-Up Studies, Humans, Italy, Longitudinal Studies, Men, Neuropsychological Tests, Risk, Sex Factors, Tea, Women, Cognitive Dysfunction
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