A longitudinal study on resting state functional connectivity in behavioral variant frontotemporal dementia and Alzheimer’s disease
Open accessAbstract
Background/Objective: Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are the most common types of early-onset dementia. We applied longitudinal resting state functional magnetic resonance imaging (fMRI) to delineate functional brain connections relevant for disease progression and diagnostic accuracy. Methods: We used two-center resting state fMRI data of 20 AD patients (65.1±8.0 years), 12 bvFTD patients (64.7±5.4 years), and 22 control subjects (63.8±5.0 years) at baseline and 1.8-year follow-up. We used whole-network and voxel-based network-to-region analyses to study group differences in functional connectivity at baseline and follow-up, and longitudinal changes in connectivity within and between groups. Results: At baseline, connectivity between paracingulate gyrus and executive control network, between cuneal cortex and medial visual network, and between paracingulate gyrus and salience network was higher in AD compared with controls. These differences were also present after 1.8 years. At follow-up, connectivity between angular gyrus and right frontoparietal network, and between paracingulate gyrus and default mode network was lower in bvFTD compared with controls, and lower compared with AD between anterior cingulate gyrus and executive control network, and between lateral occipital cortex and medial visual network. Over time, connectivity decreased in AD between precuneus and right frontoparietal network and in bvFTD between inferior frontal gyrus and left frontoparietal network. Longitudinal changes in connectivity between supramarginal gyrus and right frontoparietal network differ between both patient groups and controls. Conclusion: We found disease-specific brain regions with longitudinal connectivity changes. This suggests the potential of longitudinal resting state fMRI to delineate regions relevant for disease progression and for diagnostic accuracy, although no group differences in longitudinal changes in the direct comparison of AD and bvFTD were found.
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- Authors
- Hafkemeijer, A., Möller, C., Dopper, E. G. P., Jiskoot, L. C., van den Berg-Huysmans, A. A., van Swieten, J. C., van der Flier, W. M., Vrenken, H., Pijnenburg, Y. A. L., Barkhof, F., Scheltens, P., van der Grond, J., & Rombouts, S. A. R. B.
- Affiliations
- Leiden University (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Leiden University Medical Center (NL)
- Leiden University Medical Center
- Erasmus Medical Center
- VU University Medical Center
- Gemeente Amsterdam (NL)
- Corresponding author
- Hafkemeijer, Anne
- ORCID
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2016-09-23
- Volume
- 55
- Issue
- 2
- Pages
- 521-537
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2428662225
- Cited by
- 57
- References
- 66
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 11 · 2018: 5 · 2017: 8 · 2016: 1
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Pfizer
- Sanofi
- Biogen
- Danone
- Roche Nederland
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (016-130-677, 056-13-010, 05613014)
- H. Lundbeck A/S
- Genentech
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- behavioral variant frontotemporal dementia, Alzheimer's disease
- MeSH terms
- Aged, Alzheimer Disease, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Oxygen, Rest, Frontotemporal Dementia, White Matter, Gray Matter
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