Cited by 88Neuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Does Microglial Activation Influence Hippocampal Volume and Neuronal Function in Alzheimer’s Disease and Parkinson’s Disease Dementia?

Femminella, Grazia D., Ninan, Siddharth, Atkinson, Rebecca, Fan, Zhen, Brooks, David J., Edison, Paul·2016·Journal of Alzheimer’s Disease

Abstract

Background: The influence of neuroinflammation on neuronal function and hippocampal atrophy in Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD) is still unclear. Objectives: Here we investigated whether microglial activation measured by [ 11 C]PK11195 PET is associated with neuronal function measured by cerebral glucose metabolic rate (rCMRGlc) using FDG-PET and hippocampal volume measurements. Methods: We enrolled 25 subjects (9 PDD, 8 AD, and 8 controls) who underwent PET scans with [ 11 C](R)PK11195, [ 18 F]FDG, and volumetric MRI scanning. Results: SPM correlation analysis in AD and PDD showed a negative correlation between hippocampal volume and microglial activation within hippocampus or parahippocampus and with cortical and subcortical areas of projections from hippocampus, while there was a positive correlation between rCMRGlc in cortical and subcortical areas of projections from hippocampus and hippocampal volume. Hippocampal volume was significantly reduced in AD compared to controls but not in PDD. Conclusions: These findings indicate that microglial activation inversely correlated with hippocampal volume and hippocampal rCMRGlc in neurodegenerative diseases with dementia, providing further evidence for the central role of microglial activation in neurodegenerative diseases.

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Crossref · 10.3233/jad-150827

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Authors
Femminella, G. D., Ninan, S., Atkinson, R., Fan, Z., Brooks, D. J., & Edison, P.
Affiliations
  • Imperial College London (GB)
  • Aarhus University (DK)
Corresponding author
Edison, Paul
Venue
Journal of Alzheimer’s Disease
Published
2016-03-05
Volume
51
Issue
4
Pages
1275-1289
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W2300117615
Cited by
88
References
50
Citations by year
2026: 2 · 2025: 7 · 2024: 4 · 2023: 16 · 2022: 18 · 2021: 10 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 7 · 2016: 1
FWCI
4.38
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
Versus Arthritis
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
microglial activation, neuroinflammation
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Antineoplastic Agents, Brain Mapping, Cognition, Female, Hippocampus, Humans, Isoquinolines, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Neuropsychological Tests, Parkinson Disease, Psychiatric Status Rating Scales, Supranuclear Palsy, Progressive, Microglia, Fluorodeoxyglucose F18, Positron-Emission Tomography

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