The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Circulating miR-127-3p as a Potential Biomarker for Differential Diagnosis in Frontotemporal Dementia
Abstract
Given the heterogeneous nature of frontotemporal dementia (FTD), sensitive biomarkers are greatly needed for the accurate diagnosis of this neurodegenerative disorder. Circulating miRNAs have been reported as promising biomarkers for neurodegenerative disorders and processes affecting the central nervous system, especially in aging. The objective of the study was to evaluate if some circulating miRNAs linked with apoptosis (miR-29b-3p, miR-34a-5p, miR-16-5p, miR-17-5p, miR-107, miR-19b-3p, let-7b-5p, miR-26b-5p, and 127-3p) were able to distinguish between FTD patients and healthy controls. For this study, we enrolled 127 subjects, including 54 patients with FTD, 20 patients with Alzheimer’s disease (AD), and 53 healthy controls. The qRT-PCR analysis showed a downregulation of miR-127-3p in FTD compared to controls, while the levels of other miRNAs remained unchanged. Then, miR-127-3p expression was also analyzed in AD patients, finding a different expression between two patient groups. A receiver operating characteristic curve was then created for miR-127-3p to discriminate FTD versus AD (AUC: 0.8986), and versus healthy controls (AUC: 0.8057). In conclusion, miR-127-3p could help to diagnose FTD and to distinguish it from AD.
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In the citing paper
“decreased plasma levels of miR-127-3p and miR-502-3p were observed in FTD patients [89, 90].”
From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [89]
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“decreased plasma levels of miR-127-3p and miR-502-3p were observed in FTD patients [89, 90].”
From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [89]
In the citing paper
“The collection of plasma samples followed previously validated procedures [40, 41].”
From miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia (2025) · cites this paper as [41]
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Cited by
Sorted by citations
Fluid biomarkers in frontotemporal dementia: past, present and future
Swift, I. J., Sogorb-Esteve, A., Heller, C., Synofzik, M., Otto, M., Graff, C., Galimberti, D., Todd, E., Heslegrave, A. J., van der Ende, E. L., et al. (2021) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-323520 · Cited by 122
Manzini, V., Cappelletti, P., Orefice, N. S., Brentari, I., Rigby, M. J., Lo Giudice, M., Feligioni, M., Rivabene, R., Crestini, A., Manfredi, F., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-024-04386-z · Cited by 16
Self-citationA role for astrocytic miR-129-5p in frontotemporal dementia
Kaurani, L., Pradhan, R., Schröder, S., Burkhardt, S., Schuetz, A.-L., Krüger, D. M., Pena, T., Heutink, P., Sananbenesi, F., & Fischer, A. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03338-y · Cited by 10
Metadata
- Authors
- Piscopo, P., Grasso, M., Puopolo, M., D’Acunto, E., Talarico, G., Crestini, A., Gasparini, M., Campopiano, R., Gambardella, S., Castellano, A. E., Bruno, G., Denti, M. A., & Confaloni, A.
- Affiliations
- Department of Neuroscience, Istituto Superiore di Sanità, Rome, Italy
- Centre for Integrative Biology, University of Trento, Trento, Italy
- Department of Human Neuroscience, University of Rome “Sapienza”, Rome, Italy
- Department of Neurology, IRCCS Neuromed Institute, Pozzilli, IS, Italy
- Venue
- Journal of Alzheimer’s Disease
- Publisher
- SAGE Publications
- Published
- 2018-07-21
- Volume
- 65
- Issue
- 2
- Pages
- 455-464
- ISSN
- 1387-2877
- 1875-8908
- Cited by
- 58
- References
- 9
- Language
- en
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