Physical activity and cardiorespiratory fitness are beneficial for white matter in low-fit older adults
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Physical activity (PA) and cardiorespiratory fitness (CRF) are associated with better cognitive function in late life, but the neural correlates for these relationships are unclear. To study these correlates, we examined the association of both PA and CRF with measures of white matter (WM) integrity in 88 healthy low-fit adults (age 60-78). Using accelerometry, we objectively measured sedentary behavior, light PA, and moderate to vigorous PA (MV-PA) over a week. We showed that greater MV-PA was related to lower volume of WM lesions. The association between PA and WM microstructural integrity (measured with diffusion tensor imaging) was region-specific: light PA was related to temporal WM, while sedentary behavior was associated with lower integrity in the parahippocampal WM. Our findings highlight that engaging in PA of various intensity in parallel with avoiding sedentariness are important in maintaining WM health in older age, supporting public health recommendations that emphasize the importance of active lifestyle.
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Cardiorespiratory fitness and aerobic exercise have been positively associated with fronto-parietal and medial temporal lobe white matter tracts including the fornix, cingulum bundle, and superior longitudinal fasciculus.
“Cardiorespiratory fitness and aerobic exercise have been positively associated with fronto-parietal and medial temporal lobe white matter tracts including the fornix, cingulum bundle and superior longitudinal fasciculus”
From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [99]
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“However, some studies have found AE to be associated with greater white-matter volume in the temporal lobes that surround the hippocampus in older adults (Colcombe et al., 2003, 2006; Tseng et al., 2013; Burzynska et al., 2014).”
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“A study in rodents has demonstrated that aerobic exercise attenuates age-dependent alterations in a protein marker of myelin (myelin basic protein) as well as in astrocytes, which promote myelination via oligiodendrogial cells.17 In humans, CRF has been positively associated with enhanced white matter integrity in fib…”
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- Authors
- Burzynska, A. Z., Chaddock-Heyman, L., Voss, M. W., Wong, C. N., Gothe, N. P., Olson, E. A., Knecht, A., Lewis, A., Monti, J. M., Cooke, G. E., Wojcicki, T. R., Fanning, J., Chung, H. D., Awick, E., McAuley, E., & Kramer, A. F.
- Affiliations
- University of Illinois Urbana-Champaign (US)
- University of Iowa (US)
- Corresponding author
- Burzynska, Agnieszka Zofia
- Voss, Michelle W.
- Wong, Chelsea N.
- Gothe, Neha P.
- Olson, Erin A.
- Knecht, Anya
- Lewis, Andrew
- Monti, Jim M.
- Cooke, Gillian E.
- Fanning, Jason
- Chung, Hyondo David
- Awick, Elisabeth
- McAuley, Edward
- Kramer, Arthur F.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-09-17
- Volume
- 9
- Issue
- 9
- Pages
- e107413
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4167864
- OpenAlex
- W2074572113
- Cited by
- 161
- References
- 92
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 18 · 2020: 18 · 2019: 20 · 2018: 10 · 2017: 14 · 2016: 12 · 2015: 19 · 2014: 1
- FWCI
- 10.19
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Robert Bosch Stiftung
- University of Illinois at Urbana-Champaign
- National Institute on Aging (AG025667, R37AG025667)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- physical activity, cardiorespiratory fitness, white matter integrity, older adults, sedentary behavior, moderate-to-vigorous physical activity, white matter lesions, diffusion tensor imaging
- MeSH terms
- Age Factors, Aged, Cognition, Female, Humans, Life Style, Male, Middle Aged, Motor Activity, Physical Fitness, Sex Factors, Diffusion Tensor Imaging, Sedentary Behavior, White Matter
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