Cited by 139Trace Elements in HealthAluminum toxicity and tolerance in plants and animalsAnalytical chemistry methods development

Brain aluminum, magnesium and phosphorus contents of control and Alzheimer-diseased patients

Andrási, Erzsébet, Páli, Noémi, Molnár, Zsuzsa, Kösel, Siegfried·2005·Journal of Alzheimer's Disease

Abstract

A study was undertaken to determine Al, Mg and P concentrations in 5 different brain regions of 3 control and 3 Alzheimer-diseased patients. One of the aims of this work was to evaluate the performance of applied analytical techniques. The digested samples were analyzed by inductively coupled plasma atomic emission spectrometry for Al, Mg and P. The dried samples were measured by instrumental neutron activation analysis for Al and Mg. The determination of human brain Al levels is complicated by the interfering reaction of P. We have previously worked out an analytical method which can eliminate this interference. The accuracy of the measured data was investigated by the analysis of biological standard reference materials. Our second goal was to study the possible elemental concentration changes in Alzheimer-diseased patients. Significantly higher Al and lower Mg and P values were found in some AD brain regions compared to the controls.

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Crossref · 10.3233/jad-2005-7402

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Authors
Andrási, E., Páli, N., Molnár, Z., & Kösel, S.
Affiliations
  • Eötvös Loránd University (HU)
  • Budapest University of Technology and Economics (HU)
  • Institut für Neuropathologie (DE)
Venue
Journal of Alzheimer's Disease
Published
2005-08-23
Volume
7
Issue
4
Pages
273-284
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1626736233
Cited by
139
References
44
Citations by year
2026: 4 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 12 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 12 · 2013: 12 · 2012: 6
FWCI
3.05
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
Funders
Institut national de la recherche scientifique
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
Keywords
Alzheimer's disease
MeSH terms
Aged, Aged, 80 and over, Aluminum, Brain Chemistry, Frontal Lobe, Globus Pallidus, Hippocampus, Humans, Magnesium, Phosphorus, Neurofibrillary Tangles

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