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Bacopa monniera extract reduces amyloid levels in PSAPP mice
Abstract
PSAPP mice expressing the "Swedish" amyloid precursor protein and M146L presenilin-1 mutations are a well-characterized model for spontaneous amyloid plaque formation. Bacopa monniera has a long history of use in India as an anti-aging and memory-enhancing ethnobotanical therapy. To evaluate the effect of Bacopa monniera extract (BME) on amyloid (Abeta) pathology in PSAPP mice, two doses of BME (40 or 160 mg/kg/day) were administered starting at 2 months of age for either 2 or 8 months. Our present data suggests that BME lowers Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes present in PSAPP mice. The areas encompassed by Congo Red-positive fibrillar amyloid deposits, however, were not altered by BME treatment. The data suggest that BME has potential application in Alzheimer's disease therapeutics.
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“Various CNS active Indian herbal medicines like Withania somnifera, Centella asiatica, Celastrus paniculatus and Bacopa monnieri have shown cognitive improvement in experimental models of AD when given as prophylactic treatment [43,44,45,46,47,48].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [43]
In the citing paper
“Holcomb et al. [43] reported that administration of ethanolic extract of Bacopa leaves at doses of 40 and 160 mg/kg for 2 and 8 months reduced Aβ 1–40 and 1–42 levels in the cortex of PSAPP mice.”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [43]
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Metadata
- Authors
- Holcomb, L. A., Dhanasekaran, M., Hitt, A. R., Young, K. A., Riggs, M., & Manyam, B. V.
- Affiliations
- Texas A&M University System (US)
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2006-07-24
- Volume
- 9
- Issue
- 3
- Pages
- 243-251
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W2403935232
- Cited by
- 156
- References
- 37
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 14 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 13 · 2019: 9 · 2018: 3 · 2017: 10 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 10
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- Bacopa monnieri, amyloid-beta
- MeSH terms
- Amyloid, Animals, Behavior, Animal, Body Weight, Brain Chemistry, Cognition, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Humans, Mice, Transgenic, Motor Activity, Neurofibrils, Plant Extracts, Amyloid beta-Protein Precursor, Maze Learning, Bacopa, Mice, Presenilin-1
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