Cited by 156Alzheimer's disease research and treatmentsMedicinal Plants and NeuroprotectionGinkgo biloba and Cashew Applications

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Bacopa monniera extract reduces amyloid levels in PSAPP mice

Holcomb, Leigh A., Dhanasekaran, Muralikrishnan, Hitt, Angie R., Young, Keith A., Riggs, Mark, Manyam, Bala V.·2006·Journal of Alzheimer's Disease

DOI 10.3233/jad-2006-9303

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Abstract

PSAPP mice expressing the "Swedish" amyloid precursor protein and M146L presenilin-1 mutations are a well-characterized model for spontaneous amyloid plaque formation. Bacopa monniera has a long history of use in India as an anti-aging and memory-enhancing ethnobotanical therapy. To evaluate the effect of Bacopa monniera extract (BME) on amyloid (Abeta) pathology in PSAPP mice, two doses of BME (40 or 160 mg/kg/day) were administered starting at 2 months of age for either 2 or 8 months. Our present data suggests that BME lowers Abeta 1-40 and 1-42 levels in cortex by as much as 60%, and reverses Y-maze performance and open field hyperlocomotion behavioral changes present in PSAPP mice. The areas encompassed by Congo Red-positive fibrillar amyloid deposits, however, were not altered by BME treatment. The data suggest that BME has potential application in Alzheimer's disease therapeutics.

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Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210
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Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160
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Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530
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Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,486
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Holcomb, L., Gordon, M. N., McGowan, E., Yu, X., Benkovic, S., Jantzen, P., Wright, K., Saad, I., Mueller, R., Morgan, D., et al. (1998) · Nature Medicine · doi:10.1038/nm0198-097 · Cited by 1,386
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Näslund, J. (2000) · JAMA · doi:10.1001/jama.283.12.1571 · Cited by 1,268
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Authors: Holcomb, L. A., Dhanasekaran, M., Hitt, A. R., Young, K. A., Riggs, M., & Manyam, B. V.
Affiliations: Texas A&M University System (US)
ORCID: Dhanasekaran, Muralikrishnan
Young, Keith A.
Venue: Journal of Alzheimer's Disease
Publisher: SAGE Publications
Published: 2006-07-24
Volume: 9
Issue: 3
Pages: 243-251
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-2006-9303
OpenAlex: W2403935232
Cited by: 156
References: 37
Citations by year: 2026: 5 · 2025: 6 · 2024: 14 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 13 · 2019: 9 · 2018: 3 · 2017: 10 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 9 · 2012: 10
FWCI: 2.86
Type: journal article
Language: en
Open access: closed
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
Keywords: Bacopa monnieri, amyloid-beta
MeSH terms: Amyloid, Animals, Behavior, Animal, Body Weight, Brain Chemistry, Cognition, Dose-Response Relationship, Drug, Enzyme-Linked Immunosorbent Assay, Humans, Mice, Transgenic, Motor Activity, Neurofibrils, Plant Extracts, Amyloid beta-Protein Precursor, Maze Learning, Bacopa, Mice, Presenilin-1

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Bacopa monniera extract reduces amyloid levels in PSAPP mice

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