Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that shows cognitive deficits and memory impairment. Extract from the leaves of Gotu Kola (Centella Asiatica) have been used as an alternative medicine for memory improvement in Indian Ayurvedic system of medicine for a long time. Although several studies have revealed its effect in ameliorating the cognitive impairment in rat models of AD and stimulating property on neuronal dendrites of hippocampal region, the molecular mechanism of Gotu Kola on neuroprotection still remains to be elucidated. In this study, we report that phosphorylation of cyclic AMP response element binding protein (CREB) is enhanced in both a neuroblastoma cell line expressing amyloid beta 1-42 (Abeta) and in rat embryonic cortical primary cell culture. In addition, the contribution of two major single components to the enhanced CREB phosphorylatioin was examined. Furthermore, inhibitors were applied in this study revealing that ERK/RSK signaling pathway might mediate this effect of Gotu Kola extract. Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time.
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Centella asiatica may have a role in Alzheimer's disease treatment and prevention.
“In vitro research studies utilizing madasiatic acid, madecassoside, asiatic acid, and asiaticosides C. asiatica derivatives have elucidated that these compounds have the ability to block hydrogen peroxide and beta-amyloid-induced cellular death, as well as to reduce the concentration of free radicals, thereby proposing a possible role for C. asiatica in AD treatment and prevention [64,132,133].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [132]
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- Authors
- Xu, Y., Cao, Z., Khan, I., & Luo, Y.
- Affiliations
- University of Maryland, Baltimore (US)
- University of Mississippi (US)
- Corresponding author
- Luo, Yuan
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2008-04-14
- Volume
- 13
- Issue
- 3
- Pages
- 341-349
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- OpenAlex
- W61098746
- Cited by
- 62
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 2 · 2015: 4 · 2014: 1 · 2013: 3 · 2012: 5
- FWCI
- 5.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01at001928-05)
- National Center for Complementary and Integrative Health (R01AT001928-03A1)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Ginkgo biloba and Cashew Applications
- Keywords
- Centella asiatica
- MeSH terms
- Cyclic AMP, Alzheimer Disease, Binding Sites, Brain Neoplasms, Enzyme-Linked Immunosorbent Assay, Humans, Memory, Neuroblastoma, Phosphorylation, Plant Extracts, Triterpenes, Blotting, Western, Amyloid beta-Peptides, Cell Culture Techniques, Centella, Cell Line, Tumor
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