Effects of Endurance Exercise Training on The Motor and Non-Motor Features of Parkinson’s Disease: A Review
Open accessAbstract
BACKGROUND: Despite the benefits of medications and surgical interventions for Parkinson's disease (PD), these treatments are not without complications and neuroprotective strategies are still lacking. Therefore, there is a need for effective alternative approaches to treat motor and non-motor symptoms in PD. During the last decade, several studies have investigated endurance exercise training as a potential treatment for individuals with PD. OBJECTIVE: This paper reviews the therapeutically beneficial effects of endurance exercise training on motor and non-motor symptoms in PD. METHODS: First, we performed a systematic review of the literature on the effects of endurance exercise training on motor and non-motor signs of parkinsonism, functional outcomes including gait, balance and mobility, depression and fatigue, quality of life and perceived patient improvement, cardiorespiratory function, neurophysiological measures, and motor control measures in PD. Second we performed a meta-analysis on the motor section of the UPDRS. Then, we focused on several important factors to consider when prescribing endurance exercise training in PD such as intensity, duration, frequency, specificity and type of exercise. In addition, we identified current knowledge gaps regarding endurance exercise training in PD and made suggestions for future research. RESULTS: A total of eight randomized controlled trials met the inclusion criteria and were reviewed. This systematic review synthesizes evidence that endurance exercise training at a sufficiently high level enhances cardiorespiratory capacity and endurance by improving VO2 max and gait in moderately to mildly affected individuals with PD. However, there is not yet a proven effect of endurance exercise training on specific features of PD such as motor signs of parkinsonism. CONCLUSION: Endurance exercise training improves physical conditioning in PD patients; however, to date, there is insufficient evidence to include endurance exercise training as a specific treatment for PD. There is a need for well-designed large-scale randomized controlled trials to confirm benefits and safety of endurance exercise training in PD and to explore potential benefits on the motor and non-motor signs of PD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Exercise therapy in the form of endurance training, resistance training, intensive mixed training, or high-intensity interval training resulted in a reduction of clinical symptoms in Parkinson's disease.
“In addition, exercise therapy in the form of endurance training, resistance training, intensive mixed training, or high-intensity interval training (HIIT) resulted in a reduction of clinical symptoms in PD [145,146,147,148,149,150,151,152].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [148]
Cites
Hughes, A. J., Daniel, S. E., Kilford, L., & Lees, A. J. (1992) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.3.181 · Cited by 10,378 · see citing works
Interventions for preventing falls in older people living in the community
Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Sherrington, C., Gates, S., Clemson, L., & Lamb, S. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007146.pub3 · Cited by 3,966 · see citing works
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563 · see citing works
The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works
Larson, E. B., Wang, L., Bowen, J. D., McCormick, W. C., Teri, L., Crane, P., & Kukull, W. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-2-200601170-00004 · Cited by 1,463 · see citing works
Genetics of Parkinson's DiseasePreprint
Klein, C., & Westenberger, A. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a008888 · Cited by 1,370 · see citing works
Effective Exercise for the Prevention of Falls: A Systematic Review and Meta‐Analysis
Sherrington, C., Whitney, J. C., Lord, S. R., Herbert, R. D., Cumming, R. G., & Close, J. C. T. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02014.x · Cited by 1,309 · see citing works
Church, T. S., Thomas, D. M., Tudor-Locke, C., Katzmarzyk, P. T., Earnest, C. P., Rodarte, R. Q., Martin, C. K., Blair, S. N., & Bouchard, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019657 · Cited by 1,294 · see citing works
Heyn, P., Abreu, B. C., & Ottenbacher, K. J. (2004) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.03.019 · Cited by 1,223 · see citing works
Bridging animal and human models of exercise-induced brain plasticity
Voss, M. W., Vivar, C., Kramer, A. F., & van Praag, H. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.08.001 · Cited by 1,030 · see citing works
Tai chi and postural stability in patients with Parkinson's disease
Li, F., Harmer, P., Fitzgerald, K., Eckstrom, E., Stock, R., Galver, J., Maddalozzo, G., & Batya, S. S. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107911 · Cited by 890 · see citing works
Meta‐analysis of early nonmotor features and risk factors for Parkinson disease
Noyce, A. J., Bestwick, J. P., Silveira‐Moriyama, L., Hawkes, C. H., Giovannoni, G., Lees, A. J., & Schrag, A. E. (2012) · Annals of Neurology · doi:10.1002/ana.23687 · Cited by 772 · see citing works
Exercise programs for people with dementia
Forbes, D. A., Forbes, S. C., Blake, C. M., Thiessen, E., & Forbes, S. C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006489.pub4 · Cited by 693 · see citing works
Lewis, S. J. G., Dove, A., Robbins, T. W., Barker, R. A., & Owen, A. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06351.2003 · Cited by 532 · see citing works
Sport and exercise as contributors to the health of nations
Khan, K. M., Thompson, A. M., Blair, S. N., Sallis, J. F., Powell, K. E., Bull, F., & Bauman, A. E. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60865-4 · Cited by 477 · see citing works
The biomechanics and motor control of gait in Parkinson disease
Morris, M. E., Huxham, F. E., McGinley, J. L., Dodd, K., & Iansek, R. (2001) · Clinical Biomechanics · doi:10.1016/s0268-0033(01)00035-3 · Cited by 438 · see citing works
King, A. C. (1997) · JAMA · doi:10.1001/jama.1997.03540250040029 · Cited by 412 · see citing works
Randomized Clinical Trial of 3 Types of Physical Exercise for Patients With Parkinson Disease
Shulman, L. M., Katzel, L. I., Ivey, F. M., Sorkin, J. D., Favors, K., Anderson, K. E., Smith, B. A., Reich, S. G., Weiner, W. J., & Macko, R. F. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.646 · Cited by 410 · see citing works
Prescribing exercise as preventive therapy
Warburton, D. E. R. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.1040750 · Cited by 375 · see citing works
Physical activity and the risk of Parkinson disease
Chen, H., Zhang, S. M., Schwarzschild, M. A., Hernán, M. A., & Ascherio, A. (2005) · Neurology · doi:10.1212/01.wnl.0000151960.28687.93 · Cited by 371 · see citing works
Motor cortical inhibition and the dopaminergic system
Priori, A., Berardelli, A., Inghilleri, M., Accornero, N., & Manfredi, M. (1994) · Brain · doi:10.1093/brain/117.2.317 · Cited by 347 · see citing works
A two‐year randomized controlled trial of progressive resistance exercise for Parkinson's disease
Corcos, D. M., Robichaud, J. A., David, F. J., Leurgans, S. E., Vaillancourt, D. E., Poon, C., Rafferty, M. R., Kohrt, W. M., & Comella, C. L. (2013) · Movement Disorders · doi:10.1002/mds.25380 · Cited by 328 · see citing works
Self-citationPhysical activities and future risk of Parkinson disease
Xu, Q., Park, Y., Huang, X., Hollenbeck, A., Blair, A., Schatzkin, A., & Chen, H. (2010) · Neurology · doi:10.1212/wnl.0b013e3181ea1597 · Cited by 328 · see citing works
Dysautonomia in Parkinson's disease: neurocardiological abnormalities
Goldstein, D. S. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00555-6 · Cited by 328 · see citing works
Allen, N. E., Sherrington, C., Paul, S. S., & Canning, C. G. (2011) · Movement Disorders · doi:10.1002/mds.23790 · Cited by 311 · see citing works
Physical activity in relation to cognitive decline in elderly men: The FINE Study
van Gelder, B. M., Tijhuis, M. A. R., Kalmijn, S., Giampaoli, S., Nissinen, A., & Kromhout, D. (2004) · Neurology · doi:10.1212/01.wnl.0000147474.29994.35 · Cited by 311 · see citing works
Qutubuddin, A. A., Pegg, P. O., Cifu, D. X., Brown, R., McNamee, S., & Carne, W. F. (2005) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.11.005 · Cited by 304 · see citing works
The effects of aerobic activity on brain structure.
Thomas, A. G., Dennis, A., Bandettini, P. A., & Johansen-Berg, H. (2012) · Frontiers in Psychology · doi:10.3389/fpsyg.2012.00086 · Cited by 303 · see citing works
Leddy, A. L., Crowner, B. E., & Earhart, G. M. (2011) · Neurology Report · doi:10.1097/npt.0b013e31821a620c · Cited by 298 · see citing works
Blake, H., Mo, P., Malik, S., & Thomas, S. (2009) · Clinical Rehabilitation · doi:10.1177/0269215509337449 · Cited by 297 · see citing works
Prevalence, Clinical Manifestations, Etiology, and Treatment of Depression in Parkinson's Disease
Slaughter, J. R., Slaughter, K. A., Nichols, D., Holmes, S. E., & Martens, M. P. (2001) · Journal of Neuropsychiatry · doi:10.1176/jnp.13.2.187 · Cited by 284 · see citing works
Forced, not voluntary, exercise improves motor function in Parkinson's disease patients
Ridgel, A. L., Vitek, J. L., & Alberts, J. L. (2009) · Neurorehabilitation and neural repair · doi:10.1177/1545968308328726 · Cited by 284 · see citing works
Orimo, S., Suzuki, M., Inaba, A., & Mizusawa, H. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.01.009 · Cited by 279 · see citing works
Lau, Y.-S., Patki, G., Das-Panja, K., Le, W.-D., & Ahmad, S. O. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07626.x · Cited by 275 · see citing works
Gait disorders and balance disturbances in Parkinsonʼs disease: clinical update and pathophysiology
Boonstra, T. A., van der Kooij, H., Munneke, M., & Bloem, B. R. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328305bdaf · Cited by 272 · see citing works
Physical activity and cognitive decline, the role of the apolipoprotein e4 allele
SCHUIT, A. J., M. FESKENS, E. J., LAUNER, L. J., & KROMHOUT, D. (2001) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200105000-00015 · Cited by 261 · see citing works
Fatigue in patients with Parkinson's disease
Karlsen, K., Larsen, J. O., Tandberg, E., & J�rgensen, K. (1999) · Movement Disorders · doi:10.1002/1531-8257(199903)14:2 · Cited by 235 · see citing works
Phase I/II randomized trial of aerobic exercise in Parkinson disease in a community setting
Uc, E. Y., Doerschug, K. C., Magnotta, V., Dawson, J. D., Thomsen, T. R., Kline, J. N., Rizzo, M., Newman, S. R., Mehta, S., Grabowski, T. J., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000644 · Cited by 230 · see citing works
The Burden of Parkinson's Disease on Society, Family, and the Individual
Whetten‐Goldstein, K., Sloan, F. A., Kulas, E., Cutson, T. M., & Schenkman, M. L. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb01512.x · Cited by 229 · see citing works
Gastrointestinal dysfunction in Parkinson's disease
Edwards, L., Quigley, E., & Pfeiffer, R. (1992) · Neurology · doi:10.1212/wnl.42.4.726 · Cited by 226 · see citing works
Dance as therapy for individuals with Parkinson disease.
Earhart, G. M. (2009) · PubMed · Cited by 207 · see citing works
Balance and fear of falling in Parkinson's disease
Franchignoni, F. P., Martignoni, E., Ferriero, G., & Pasetti, C. (2005) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2005.05.005 · Cited by 147 · see citing works
Clinical and Research Methods for Evaluating Cortical Excitability
Abbruzzese, G., & Trompetto, C. (2002) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200208000-00005 · Cited by 144 · see citing works
Sage, M. D., & Almeida, Q. J. (2009) · Movement Disorders · doi:10.1002/mds.22469 · Cited by 144 · see citing works
Lima, L. A. O., Scianni, A. A., & Rodrigues-de-Paula, F. (2013) · Journal of physiotherapy · doi:10.1016/s1836-9553(13)70141-3 · Cited by 139 · see citing works
Derkinderen, P., Rouaud, T., Lebouvier, T., Varannes, S. B. D., Neunlist, M., & GIORGIO, R. D. (2011) · Neurology · doi:10.1212/wnl.0b013e318236ef60 · Cited by 125 · see citing works
Antihypertensive Effects of Aerobic Exercise
Kelley, G. A., & McClellan, P. D. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.2.115 · Cited by 123 · see citing works
Autonomic disorders predicting Parkinson's disease
Palma, J., & Kaufmann, H. (2013) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(13)70024-5 · Cited by 123 · see citing works
Effects of Long-Term Exercise Training on Autonomic Control in Myocardial Infarction Patients
Martinêz, D. G., Nicolau, J. C., Lage, R. L., Toschi‐Dias, E., de Matos, L. D. N. J., Alves, M. J. D. N. N., Trombetta, I. C., da Silva, V. J. D., Middlekauff, H. R., Negrão, C. E., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.176644 · Cited by 118 · see citing works
Exercise protects against MPTP-induced neurotoxicity in mice
Gerecke, K. M., Jiao, Y., Pani, A. K., Pagala, V., & Smeyne, R. J. (2010) · Brain Research · doi:10.1016/j.brainres.2010.01.053 · Cited by 112 · see citing works
Canning, C. G., Allen, N. E., Dean, C. M., Goh, L., & Fung, V. S. (2012) · Clinical Rehabilitation · doi:10.1177/0269215511432652 · Cited by 108 · see citing works
Walking economy in people with Parkinson's disease
Christiansen, C. L., Schenkman, M. L., McFann, K., Wolfe, P., & Kohrt, W. M. (2009) · Movement Disorders · doi:10.1002/mds.22621 · Cited by 107 · see citing works
Self-citationAutonomic dysfunction in Parkinson disease
Kaufmann, H., & Goldstein, D. S. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53491-0.00021-3 · Cited by 105 · see citing works
Stroth, S., Reinhardt, R. K., Thöne, J., Hille, K., Schneider, M., Härtel, S., Weidemann, W. M., Bös, K., & Spitzer, M. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.08.003 · Cited by 102 · see citing works
Kurtaiş, Y., Kutlay, Ş., Tur, B. S., Gök, H., & Akbostancı, C. (2008) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0b013e318170626d · Cited by 98 · see citing works
Exercise and cognition: Results from the National Long Term Care Survey
Jedrziewski, M. K., Ewbank, D. C., Wang, H., & Trojanowski, J. Q. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.02.004 · Cited by 81 · see citing works
Is cardiac function impaired in premotor Parkinson's disease? A retrospective cohort study
Palma, J., Carmona‐Abellan, M., Barriobero, N., Trevino-Peinado, C., Garcia‐Lopez, M., Fernandez‐Jarne, E., & Luquin, M. R. (2013) · Movement Disorders · doi:10.1002/mds.25431 · Cited by 77 · see citing works
Linking clinical variables to health-related quality of life in Parkinson's disease
Chrischilles, E. A., Rubenstein, L. M., Voelker, M. D., Wallace, R. B., & Rodnitzky, R. L. (2002) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(01)00044-x · Cited by 77 · see citing works
Parkinson disease and comorbid cerebrovascular disease
Nanhoe-Mahabier, W., de Laat, K. F., Visser, J. E., Zijlmans, J. C. M., de Leeuw, F., & Bloem, B. R. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.136 · Cited by 72 · see citing works
Park, A., Zid, D., Russell, J., Malone, A., Rendon, A., Wehr, A. M., & Li, X. (2013) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2013.10.003 · Cited by 66 · see citing works
Billman, G. E., & Kukielka, M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01328.2005 · Cited by 62 · see citing works
Exercise performance in those having Parkinson's disease and healthy normals
Stanley, R. K., Protas, E. J., & Jankovic, J. J. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199906000-00001 · Cited by 57 · see citing works
Sleep disorders in Parkinson’s disease: a narrative review of the literature
Raggi, A., Bella, R., Pennisi, G., Neri, W., & Ferri, R. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0002 · Cited by 57 · see citing works
Exercise alleviates Parkinsonism: clinical and laboratory evidence
Archer, T., Fredriksson, A., & Johansson, B. B. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01360.x · Cited by 53 · see citing works
Aerobic Exercise and Early Parkinson's Disease
Bridgewater, K. J., & Sharpe, M. H. (1996) · Neurorehabilitation and neural repair · doi:10.1177/154596839601000403 · Cited by 52 · see citing works
Aerobic Exercise to Improve Executive Function in Parkinson Disease
Tabak, R. G., Aquije, G., & Fisher, B. E. (2013) · Neurology Report · doi:10.1097/npt.0b013e31829219bc · Cited by 49 · see citing works
Can exercise improve language and cognition in Parkinson's disease? A case report
Nocera, J. R., Altmann, L. J. P., Sapienza, C. M., Okun, M. S., & Hass, C. J. (2010) · Neurocase · doi:10.1080/13554790903559663 · Cited by 39 · see citing works
Moore, C. G., Schenkman, M. L., Kohrt, W. M., Delitto, A., Hall, D. A., & Corcos, D. M. (2013) · Contemporary Clinical Trials · doi:10.1016/j.cct.2013.06.002 · Cited by 38 · see citing works
Self-citationDecreased cardiac uptake of MIBG is a potential biomarker for the presence of Lewy bodies
Orimo, S., Amino, T., Uchihara, T., Mori, F., Kakita, A., Wakabayashi, K., & Takahashi, H. (2007) · Journal of Neurology · doi:10.1007/s00415-007-4005-y · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
van der Kolk, N. M., de Vries, N. M., Kessels, R. P. C., Joosten, H., Zwinderman, A. H., Post, B., & Bloem, B. R. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30285-6 · Cited by 565 · see citing works
Long-term effects of exercise and physical therapy in people with Parkinson disease
Mak, K. Y., Wong-Yu, I. S. K., Shen, X., & Chung, C. L. H. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.128 · Cited by 553 · see citing works
Schenkman, M., Moore, C. G., Kohrt, W. M., Hall, D. A., Delitto, A., Comella, C. L., Josbeno, D. A., Christiansen, C. L., Berman, B. D., Kluger, B. M., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3517 · Cited by 515 · see citing works
Self-citationBDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease
Church, F. (2021) · Biomolecules · doi:10.3390/biom11040612 · Cited by 303 · see citing works
Osborne, J. A., Botkin, R., Colón-Semenza, C., DeAngelis, T. R., Gallardo, O. G., Kosakowski, H., Martello, J. P., Pradhan, S. D., Rafferty, M. R., Readinger, J. L., et al. (2021) · Physical Therapy · doi:10.1093/ptj/pzab302 · Cited by 249 · see citing works
Self-citationBarriers and Motivators to Engage in Exercise for Persons with Parkinson’s Disease
Schootemeijer, S., van der Kolk, N. M., Ellis, T. D., Mirelman, A., Nieuwboer, A., Nieuwhof, F., Schwarzschild, M. A., de Vries, N. M., & Bloem, B. R. (2020) · Journal of Parkinson s Disease · doi:10.3233/jpd-202247 · Cited by 199 · see citing works
Ferraz, D. D., Trippo, K. V., Duarte, G. P., Neto, M. G., Santos, K. O. B., & Filho, J. O. (2018) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2017.12.014 · Cited by 154 · see citing works
Current Perspectives on Aerobic Exercise in People with Parkinson's Disease
Schootemeijer, S., van der Kolk, N. M., Bloem, B. R., & de Vries, N. M. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00904-8 · Cited by 153 · see citing works
Reynolds, G., Otto, M. W., Ellis, T. D., & Cronin‐Golomb, A. (2015) · Movement Disorders · doi:10.1002/mds.26484 · Cited by 132 · see citing works
Exercise-induced neuroplasticity in human Parkinson's disease: What is the evidence telling us?
Hirsch, M. A., Iyer, S. S., & Sanjak, M. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.09.030 · Cited by 130 · see citing works
Fatigue in Parkinson’s disease: report from a multidisciplinary symposium
Friedman, J. H., Beck, J. C., Chou, K. L., Clark, G., Fagundes, C. P., Goetz, C. G., Herlofson, K., Kluger, B. M., Krupp, L., Lang, A. E., et al. (2016) · npj Parkinson s Disease · doi:10.1038/npjparkd.2015.25 · Cited by 99 · see citing works
Goldman, J. G., Volpe, D., Ellis, T. D., Hirsch, M. A., Johnson, J. A., Wood, J., Vinagre‐Aragón, A., Biundo, R., Rocco, A. D., Kasman, G. S., et al. (2024) · Journal of Parkinson s Disease · doi:10.3233/jpd-230117 · Cited by 93 · see citing works
Filho, A. V. D. M., Chaves, S. N., Martins, W. R., Tolentino, G. P., Homem, R., Landim, G., Fischer, B. L., Oliveira, J. A., Pereira, S., Vidal, S. E., et al. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s231359 · Cited by 91 · see citing works
Parkinson’s disease and intensive exercise therapy — An updated systematic review and meta‐analysis
Gamborg, M., Hvid, L. G., Dalgas, U., & Langeskov‐Christensen, M. (2022) · Acta Neurologica Scandinavica · doi:10.1111/ane.13579 · Cited by 90 · see citing works
Maranesi, E., Casoni, E., Baldoni, R., Barboni, I., Rinaldi, N., Tramontana, B., Amabili, G., Benadduci, M., Barbarossa, F., Luzi, R., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192214818 · Cited by 82 · see citing works
Advances in the treatment of cognitive impairment in P arkinson's disease
Goldman, J. G., & Weintraub, D. A. (2015) · Movement Disorders · doi:10.1002/mds.26352 · Cited by 80 · see citing works
Systematic review on strength training in Parkinson’s disease: an unsolved question
Ramazzina, I., Bernazzoli, B., & Costantino, C. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s131903 · Cited by 80 · see citing works
Gelaw, A. Y., & Teshome, A. (2016) · BMC Sports Science Medicine and Rehabilitation · doi:10.1186/s13102-016-0042-0 · Cited by 73 · see citing works
Qian, Y., Fu, X., Zhang, H., Yang, Y., & Wang, G. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04239-9 · Cited by 69 · see citing works
Chasing Protection in Parkinson’s Disease: Does Exercise Reduce Risk and Progression?
Crotty, G. F., & Schwarzschild, M. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00186 · Cited by 63 · see citing works
Lifestyle Interventions for the Prevention of Parkinson Disease
Daalen, J. M. J., Schootemeijer, S., Richard, E., Darweesh, S. K. L., & Bloem, B. R. (2022) · Neurology · doi:10.1212/wnl.0000000000200787 · Cited by 61 · see citing works
Collett, J., Franssen, M., Meaney, A., Wade, D. T., Izadi, H., Tims, M., Winward, C. E., Bogdanovic, M. D., Farmer, A. A., & Dawes, H. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314508 · Cited by 48 · see citing works
Endurance exercise improves function in individuals with Parkinson’s disease: A meta-analysis
Flach, A., Jaegers, L. A., Krieger, M., Bixler, E. A., Kelly, P., Weiss, E. P., & Ahmad, S. O. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.08.076 · Cited by 47 · see citing works
Physical exercise and its effects on people with Parkinson’s disease: Umbrella review
Padilha, C., Souza, R., Grossl, F. S., Gauer, A. P. M., Sá, C. A. D., & Rodrigues, S. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293826 · Cited by 45 · see citing works
Stuckenschneider, T., Askew, C. D., Menêses, A. L., Baake, R., Weber, J., & Schneider, S. (2019) · Journal of Parkinson s Disease · doi:10.3233/jpd-181484 · Cited by 45 · see citing works
An exercise regimen prevents development paclitaxel induced peripheral neuropathy in a mouse model
Park, J. S., Kim, S., & Höke, A. (2015) · Journal of the Peripheral Nervous System · doi:10.1111/jns.12109 · Cited by 42 · see citing works
Factors Associated With Ambulatory Activity in De Novo Parkinson Disease
Christiansen, C. L., Moore, C. G., Schenkman, M. L., Kluger, B. M., Kohrt, W. M., Delitto, A., Berman, B. D., Hall, D. A., Josbeno, D. A., Poon, C., et al. (2017) · Neurology Report · doi:10.1097/npt.0000000000000169 · Cited by 41 · see citing works
Self-citationEffects of Postnatal Enriched Environment in a Model of Parkinson’s Disease in Adult Rats
Jüngling, A., Reglődi, D., Karádi, Z. N., Horváth, G., Farkas, J. I., Gaszner, B., & Tamás, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020406 · Cited by 40 · see citing works
de Almeida, F. O., Santana, V. P., Corcos, D. M., Ugrinowitsch, C., & Silva‐Batista, C. (2022) · Sports Medicine · doi:10.1007/s40279-022-01650-x · Cited by 38 · see citing works
Self-citationGoikoetxea-Sotelo, G., & van Hedel, H. J. A. (2023) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2023.1139251 · Cited by 37 · see citing works
da Silva, K. G., de Freitas, T. B., Doná, F., Ganança, F. F., Ferraz, H. B., Torriani‐Pasin, C., & Pompeu, J. E. (2017) · Pilot and Feasibility Studies · doi:10.1186/s40814-017-0210-3 · Cited by 37 · see citing works
Coe, S., Franssen, M., Collett, J., Boyle, D., Meaney, A., Chantry, R., Esser, P., Izadi, H., & Dawes, H. (2018) · Parkinson s Disease · doi:10.1155/2018/1517807 · Cited by 37 · see citing works
Perry, S. I. B., Nelissen, P., Siemonsma, P. C., & Lucas, C. (2018) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2018.12.008 · Cited by 32 · see citing works
Sabino‐Carvalho, J. L., & Vianna, L. C. (2020) · SAGE Open Medicine · doi:10.1177/2050312120921603 · Cited by 32 · see citing works
Mrówczyński, W. (2019) · Neural Plasticity · doi:10.1155/2019/5413067 · Cited by 32 · see citing works
A Review of Recent Advances in Cognitive-Motor Dual-Tasking for Parkinson’s Disease Rehabilitation
Tan, X., Wang, K., Sun, W., Li, X., Wang, W., & Tian, F. (2024) · Sensors · doi:10.3390/s24196353 · Cited by 31 · see citing works
Zhou, X., Zhao, P., Guo, X., Wang, J., & Wang, R. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.935176 · Cited by 30 · see citing works
From Brain to Muscle: The Role of Muscle Tissue in Neurodegenerative Disorders
Duranti, E., & Villa, C. (2024) · Biology · doi:10.3390/biology13090719 · Cited by 29 · see citing works
Kathia, M. M., Duplea, S., Bommarito, J. C., Hinks, A., Leake, E., Shannon, J., Pitman, J., Khangura, P. K., Coates, A. M., Slysz, J. T., et al. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00219.2024 · Cited by 25 · see citing works
Cui, W., Li, D., Yue, L., & Xie, J. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11887-9 · Cited by 24 · see citing works
Hwang, D.-J., Koo, J., Kwon, K.-C., Choi, D.-H., Shin, S.-D., Jeong, J., Um, H.-S., & Cho, J. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0586-0 · Cited by 21 · see citing works
de Albuquerque, L. L., Pantović, M., Clingo, M., Fischer, K., Jalene, S., Landers, M. R., Mari, Z. K., & Poston, B. (2020) · Brain Sciences · doi:10.3390/brainsci10100735 · Cited by 20 · see citing works
Li, Y., Song, H., Shen, L., & Wang, Y. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-20-1661 · Cited by 20 · see citing works
Hall, M.-F. E., & Church, F. (2020) · Brain Sciences · doi:10.3390/brainsci10090612 · Cited by 17 · see citing works
A meta-analysis of exercise intervention and the effect on Parkinson’s Disease symptoms
Ahmad, S. O., Longhurst, J. K., Stiles, D., Downard, L., & Martin, S. L. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137162 · Cited by 15 · see citing works
Bosch‐Barceló, P., Climent‐Sanz, C., Martínez-Navarro, O., Masbernat, M. A., Pakarinen, A., Ghosh, P. K., & Fernández‐Lago, H. (2024) · PLoS ONE · doi:10.1371/journal.pone.0307304 · Cited by 14 · see citing works
Rahmati, Z., Behzadipour, S., Schouten, A. C., Taghizadeh, G., & Firoozbakhsh, K. K. (2020) · BioMedical Engineering OnLine · doi:10.1186/s12938-020-00776-1 · Cited by 14 · see citing works
Bajracharya, R., & Ballard, J. W. O. (2018) · Fly · doi:10.1080/19336934.2018.1482139 · Cited by 13 · see citing works
Bliss, R. R., & Church, F. (2021) · Sports · doi:10.3390/sports9060072 · Cited by 13 · see citing works
Physical Exercise Interventions on Quality of Life in Parkinson Disease: A Network Meta-analysis
Lorenzo‐García, P., de Arenas‐Arroyo, S. N., Cavero‐Redondo, I., Guzmán‐Pavón, M. J., Priego-Jiménez, S., & Álvarez‐Bueno, C. (2022) · Neurology Report · doi:10.1097/npt.0000000000000414 · Cited by 12 · see citing works
Ferrari, A., Ginis, P., Nieuwboer, A., Greenlaw, R., Muddiman, A., & Chiari, L. (2016) · Lecture notes in computer science · doi:10.1007/978-3-319-39601-9_22 · Cited by 12 · see citing works
Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings
Archer, T., & Kostrzewa, R. M. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_409 · Cited by 11 · see citing works
Quality of life predicts rehabilitation prognosis in Parkinson's disease patients
Meng, D., Jin, Z., Chen, K., Yu, X., Wang, Y., Du, W., Wei, J., Xi, J., & Fang, B. (2022) · Brain and Behavior · doi:10.1002/brb3.2579 · Cited by 10 · see citing works
Han, T., Liu, Q., Hu, Y., Wang, Y., & Xue, K. (2023) · African Health Sciences · doi:10.4314/ahs.v23i2.67 · Cited by 10 · see citing works
Yuan, Z.-Y., Yang, J., Ma, X., Wang, Y.-Y., & Wang, M. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.239447 · Cited by 9 · see citing works
Paz, T. D. S. R., Guimarães, F. S., de Britto, V. L. S., & Corrêa, C. L. (2019) · Fisioterapia em Movimento · doi:10.1590/1980-5918.032.ao01 · Cited by 9 · see citing works
Qin, Y., Meng, D., Jin, Z., Du, W.-J., & Fang, B. (2024) · Journal of Neural Transmission · doi:10.1007/s00702-024-02745-7 · Cited by 8 · see citing works
Sherron, M. A., Stevenson, S. A., Browner, N., & Lewek, M. D. (2020) · Neurology Report · doi:10.1097/npt.0000000000000315 · Cited by 8 · see citing works
Group therapeutic singing improves clinical motor scores in persons with Parkinson’s disease
Stegemöller, E. L., Forsyth, E., Patel, B., & Elkouzi, A. (2022) · BMJ Neurology Open · doi:10.1136/bmjno-2022-000286 · Cited by 8 · see citing works
PARKIBIP Feedback Wearable Rehabilitation Device: Market Analysis and Enhancements
Pasker, V., Huerta, C., Sainz, S., Santos, D., & Símini, F. (2021) · IEEE International Symposium on Medical Measurements and Applications (MeMeA) · doi:10.1109/memea52024.2021.9478736 · Cited by 7 · see citing works
Caminiti, S. P., Gallo, S., Menegon, F., Naldi, A., Comi, C., & Tondo, G. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230616121213 · Cited by 7 · see citing works
Ren, H., Zhou, Y., Lv, Y., Liu, X., He, L., & Yu, L. (2025) · Brain Sciences · doi:10.3390/brainsci15080792 · Cited by 6 · see citing works
Zhou, C., Zhou, N., Zheng, Y., Si, H., Wang, Y., & Yin, J. (2024) · BMC Surgery · doi:10.1186/s12893-024-02486-0 · Cited by 6 · see citing works
Development of an Exercise‐Specific Parkinson's Disease Questionnaire: The PDQ‐Exercise
Morley, D., Dummett, S., Kelly, L., & Jenkinson, C. (2021) · Movement Disorders · doi:10.1002/mds.28644 · Cited by 6 · see citing works
Gilby, J., Kent, B., Lozano, R. K., & Marsden, J. F. (2025) · Systematic Reviews · doi:10.1186/s13643-025-02892-2 · Cited by 5 · see citing works
Breathing disorders in neurodegenerative diseases
Ghosh, S. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-323-91532-8.00008-2 · Cited by 5 · see citing works
Alcalá-Zúniga, D., Espinoza-Torres, E., Das, R. K., Vargas, M., Maldonado, O., Benavides, O. M., Manojkumar, A., Garza, R. D. L., Davila, N., Perez, I., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03951-w · Cited by 5 · see citing works
Moratelli, J., Lima, A. G., Alexandre, K. H., Fausto, D. Y., Haas, A. N., & Guimarães, A. C. D. A. (2024) · Sport Sciences for Health · doi:10.1007/s11332-024-01197-6 · Cited by 5 · see citing works
Kottaras, A., Lytras, D., Iakovidis, P., Chatziprodromidou, I. P., Myrogiannis, I. S., & Apostolou, T. S. (2022) · Critical Reviews in Physical and Rehabilitation Medicine · doi:10.1615/critrevphysrehabilmed.2022042416 · Cited by 5 · see citing works
Rigby, B. R., Davis, R. W., Avalos, M. A., Levine, N. A., Becker, K. A., & Nichols, D. L. (2018) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.2017-0200 · Cited by 5 · see citing works
Grillo, P., Martino, D. D., Calculli, A., Icco, R. D., Martinis, L., Bottinelli, R., Porcelli, S., Fazio, C., Comolli, D., Bighiani, F., et al. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107065 · Cited by 4 · see citing works
Andersen, J. K., & Chinta, S. J. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_8 · Cited by 4 · see citing works
Orcioli‐Silva, D., Vitório, R., Beretta, V. S., Oliveira, A. S., da Conceição, N. R., Nóbrega‐Sousa, P., dos Santos, P. C. R., Gobbi, L. T. B., & Barela, J. Â. (2025) · Clinical Neurophysiology · doi:10.1016/j.clinph.2025.2110755 · Cited by 3 · see citing works
Hu, W., Zhou, H., Zhu, W., Xie, S., Zeng, Y., & Wang, Z. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1381500 · Cited by 3 · see citing works
What does characterize exercise guidelines for Parkinson’s disease?
Barbieri, F. A., Kalva‐Filho, C. A., & Torriani‐Pasin, C. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01748-0 · Cited by 3 · see citing works
Ramos, L., Watson, J., Macalintal, R., & Ellis, C. E. (2024) · International journal of exercise science · doi:10.70252/ihkw5009 · Cited by 2 · see citing works
Capecci, M., Baldini, N., Andrenelli, E., Lambertucci, A., Bisoglio, P., Grugnetti, M., Hibel, M., & Ceravolo, M. G. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01035-7 · Cited by 2 · see citing works
How is dynamic balance during walking affected by PD?
Mancini, M., Nutt, J. G., & Horak, F. B. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813874-8.00006-4 · Cited by 2 · see citing works
Immediate Effects of High-Cadence Cycling on Core Outcomes in Individuals With Parkinson’s Disease
Miner, D. G., & Chui, K. K. (2023) · Journal of Aging and Physical Activity · doi:10.1123/japa.2022-0413 · Cited by 2 · see citing works
Abitteboul, Y., Bugat, M.-È. R., Naoures, H. L., Lassoued, S., Oustric, S., & Rivière, D. (2019) · Science & Sports · doi:10.1016/j.scispo.2019.10.003 · Cited by 2 · see citing works
Pechstein, A. E., Gollie, J. M., Keyser, R. E., & Guccione, A. A. (2022) · Neurology Report · doi:10.1097/npt.0000000000000423 · Cited by 2 · see citing works
Effects of Balance Training on Nonmotor Symptoms in Individuals With Parkinson Disease
Singh, G., Jain, T. K., Liu, W., Colgrove, Y., Pahwa, R., Lyon, K., & Sharma, N. K. (2020) · Topics in Geriatric Rehabilitation · doi:10.1097/tgr.0000000000000279 · Cited by 2 · see citing works
Ahmad, S. O., Stiles, D., Born, E., Scheffler, J., & Vogel, K. E. L. (2024) · Applied Sciences · doi:10.3390/app14167236 · Cited by 2 · see citing works
Effects of Gyroscope on Arm Swing and Gait in Healthy Volunteers
Şipal, M. S., Yalçın, E., & Karaduman, A. A. (2023) · Applied Bionics and Biomechanics · doi:10.1155/2023/6630913 · Cited by 1 · see citing works
A-posteriori error estimates for the finite element method. Technical report TR-581
Babuska, I. M., & Rheinboldt, W. C. (1977) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · Cited by 1 · see citing works
Pratique professionnelle en neurologie
Bonnechère, B., Guémann, M., Mesure, S., Pallot, A., Morichon, A., & André-Vert, J. (2015) · Kinésithérapie la Revue · doi:10.1016/j.kine.2015.07.007
Singh, G. (2016) · KU ScholarWorks (The University of Kansas)
zamani, T. M., Movahedi, A., & Ameri, E. A. (2019) · journal of ilam university of medical sciences · doi:10.29252/sjimu.26.6.143
Deepa, S., Suganthirababu, P., Alagesan, J., & Vijayaraghavan, R. (2021) · Annals of the Romanian Society for Cell Biology
Cervera-Ocaña, M. S., & González, Y. M. (2022) · Sport Sciences for Health · doi:10.1007/s11332-022-00937-w
Straube, A. M. (2018) · Springer eBooks · doi:10.1007/978-3-662-56539-1_5
Kharge, S. J., Kanase, S. B., & Adhikari, A. D. (2024) · doi:10.53555/kuey.v30i4.1834
Limb Speed Perception Accuracy in Neurodegenerative Disease
Brandmeir, C. L. (2024) · doi:10.33915/etd.12362
Yildirim, M. C., Ekici, H. S., Collins, J., Piasecki, J., Skelly, R., Gordon, A. L., & Phillips, B. E. (2024) · Translational Exercise Biomedicine · doi:10.1515/teb-2024-0031
Mayoral-Moreno, A., Santos, L. R., López, C. A. C., Denche-Zamorano, Á. M., Ramos‐Fuentes, M. I., & Adsuar, J. C. (2025) · Psychiatric Quarterly · doi:10.1007/s11126-025-10197-9
Qian, Y., Fu, X., Zhang, H., Yang, Y., & Wang, G. (2023) · Figshare · doi:10.6084/m9.figshare.24046125
Rahmati, Z., Behzadipour, S., Schouten, A. C., Taghizadeh, G., & Firoozbakhsh, K. K. (2020) · Figshare · doi:10.6084/m9.figshare.12285251
- Authors
- Lamotte, G., Rafferty, M. R., Prodoehl, J., Kohrt, W. M., Comella, C. L., Simuni, T., & Corcos, D. M.
- Affiliations
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Northwestern University (US)
- Midwestern University (US)
- University of Colorado Anschutz (US)
- Rush University Medical Center (US)
- ORCID
- Venue
- Journal of Parkinson s Disease
- Publisher
- SAGE Publications
- Published
- 2015-01-01
- Volume
- 5
- Issue
- 1
- Pages
- 21-41
- ISSN
- 1877-7171 (ISSN-L)
- 1877-718X
- OpenAlex
- W1496458617
- Cited by
- 98
- References
- 69
- Citations by year
- 2025: 7 · 2024: 14 · 2023: 10 · 2022: 12 · 2021: 7 · 2020: 13 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 7
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Locations
- Journal of Parkinson s Disease (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Balance, Gait, and Falls Prevention
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, endurance training, motor symptoms, non-motor symptoms, UPDRS motor score, gait, balance, cardiorespiratory fitness, VO2max, exercise prescription, quality of life
- MeSH terms
- Cardiovascular Physiological Phenomena, Postural Balance, Exercise Therapy, Gait, Humans, Neurophysiology, Parkinson Disease, Physical Endurance, Quality of Life, Respiration, Randomized Controlled Trials as Topic, Databases, Bibliographic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
