An initial exploration of in vivo hair cortisol responses to a brief pain stressor: latency, localization and independence effects
Open accessAbstract
Cortisol is secreted by the central hypothalamo-pituitary-adrenal axis and affects many target organs and tissues, particularly in response to stressor demands and infection. Recent data reporting cortisol synthesis in hair follicles have shown the existence of a parallel "peripheral" HPA-axis. However, although there is evidence from in vitro studies and single-observation comparisons between groups that cortisol from hair follicles reflects endocrine changes associated with stressor demands, there are no reports to date of repeated measurements of in vivo cortisol responsivity in hair to transitory stressors. This issue was investigated with three males who underwent 1 min cold pressor test (CP). Cortisol response in hair to stressor demand appears to be (a) swift but transitory, (b) localized to the site of the demand and (c) independent of central HPA-axis activity.
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Hair follicles and follicular keratinocytes produce cortisol after stimulation with CRH and ACTH.
“On the other hand HF and follicular keratinocytes were found to produce cortisol after stimulation with CRH and ACTH [59, 68].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [68]
Hair follicle cortisol levels can change locally without central input.
“However, it was recently documented that indeed those levels can change locally without central input [68].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [68]
In vivo, hair follicles release cortisol into the hair shaft after local pain stimuli.
“Similarly, in vivo studies demonstrate that HF releases cortisol into the hair shaft after local pain stimuli [68].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [68]
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- Authors
- Sharpley, C., Kauter, K., & McFarlane, Jr.
- Venue
- Physiological Research
- Published
- 2009
- Volume
- 58
- Issue
- 5
- Pages
- 757-761
- ISSN
- 0862-8408 (ISSN-L)
- 1802-9973
- OpenAlex
- W2122210379
- Cited by
- 69
- References
- 29
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 10
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Physiological Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- RUNE (Research UNE) (submittedVersion)
- EPubDev Repository (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- hair cortisol, cold pressor test, stress response, hypothalamic-pituitary-adrenal axis, repeated measures
- MeSH terms
- Adult, Cold Temperature, Hair, Humans, Hydrocortisone, Male, Middle Aged, Saliva, Stress, Physiological, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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