The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation
Open accessAbstract
This review describes the role of bone cells and their surrounding matrix in maintaining bone strength through the process of bone remodelling. Subsequently, this work focusses on how bone formation is guided by mechanical forces and fluid shear stress in particular. It has been demonstrated that mechanical stimulation is an important regulator of bone metabolism. Shear stress generated by interstitial fluid flow in the lacunar-canalicular network influences maintenance and healing of bone tissue. Fluid flow is primarily caused by compressive loading of bone as a result of physical activity. Changes in loading, e.g. due to extended periods of bed rest or microgravity in space are associated with altered bone remodelling and formation in vivo. In vitro, it has been reported that bone cells respond to fluid shear stress by releasing osteogenic signalling factors such as nitric oxide and prostaglandins. This work focusses on the application of in vitro models to study the effects of fluid flow on bone cell signalling, collagen deposition and matrix mineralization. Particular attention is given to in vitro set-ups which allow long-term cell culture and the application of low fluid shear stress. In addition, this review explores what mechanisms influence the orientation of collagen fibres which determine the anisotropic properties of bone. A better understanding of these mechanisms could facilitate the design of improved tissue-engineered bone implants or more effective bone disease models.
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Cites
Osteoclast differentiation and activation
Boyle, W. J., Simonet, W. S., & Lacey, D. L. (2003) · Nature · doi:10.1038/nature01658 · Cited by 6,670
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,622
Caplan, A. I. (1991) · Journal of Orthopaedic Research · doi:10.1002/jor.1100090504 · Cited by 6,548
Scaffolds in tissue engineering bone and cartilage
Hutmacher, D. W. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00121-6 · Cited by 4,994
Myofibroblasts and mechano-regulation of connective tissue remodelling
Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
Ducy, P., Zhang, R., Geoffroy, V., Ridall, A. L., & Karsenty, G. (1997) · Cell · doi:10.1016/s0092-8674(00)80257-3 · Cited by 4,246
Flow-mediated endothelial mechanotransduction
Davies, P. F. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.519 · Cited by 2,802
Manolagas, S. C. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.2.0395 · Cited by 2,568
Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,336
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287
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Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models
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Bone-on-a-chip: Microfluidic technologies and microphysiologic models of bone tissue
Mansoorifar, A., Gordon, R., Bergan, R. C., & Bertassoni, L. E. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202006796 · Cited by 142
Wang, W., Wang, L., Zhang, B., Shang, S., Zhao, C., Zhang, W., Chen, J., Zhou, C., Zhou, H., & Feng, S. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149444 · Cited by 51
Dielectric and biodegradation properties of biodegradable nano-hydroxyapatite/starch bone scaffold
You, B. C., Meng, C. E., Mohd Nasir, N. F., Mohd Tarmizi, E. Z., Fhan, K. S., Kheng, E. S., Abdul Majid, M. S., & Mohd Jamir, M. R. (2022) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2022.04.014 · Cited by 44
Metadata
- Authors
- Wittkowske, C., Reilly, G. C., Lacroix, D., & Perrault, C. M.
- Venue
- Frontiers in Bioengineering and Biotechnology
- Publisher
- Frontiers Media SA
- Published
- 2016-11-15
- Volume
- 4
- Pages
- 87-87
- ISSN
- 2296-4185 (ISSN-L)
- OpenAlex
- W2556861557
- Cited by
- 293
- References
- 214
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wittkowske, C., Reilly, G. C., Lacroix, D., & Perrault, C. M. (2016). In Vitro Bone Cell Models: Impact of Fluid Shear Stress on Bone Formation. Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2016.00087
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
