The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering
Open accessAbstract
Endothelial to mesenchymal transition (EndMT) is a complex biological process that gives rise to cells with multipotent potential. EndMT is essential for the formation of the cardiovascular system during embryonic development. Emerging results link EndMT to the postnatal onset and progression of fibrotic diseases and cancer. Moreover, recent reports have emphasized the potential for EndMT in tissue engineering and regenerative applications by regulating the differentiation status of cells. Transforming growth factor β (TGF-β) engages in many important physiological processes and is a potent inducer of EndMT. In this review, we first summarize the mechanisms of the TGF-β signaling pathway as it relates to EndMT. Thereafter, we discuss the pivotal role of TGF-β-induced EndMT in the development of cardiovascular diseases, fibrosis, and cancer, as well as the potential application of TGF-β-induced EndMT in tissue engineering.
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Citations
Cites
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BackgroundSpecificity, versatility, and control of TGF-β family signaling
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BackgroundBmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
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EndMT contributes to the onset and progression of cerebral cavernous malformations
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Cited by
TGF‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
Budi, E. H., Schaub, J. R., Decaris, M., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 292
TGF-β as A Master Regulator of Aging-Associated Tissue Fibrosis
Ren, L.-L., Miao, H., Wang, Y.-N., Liu, F., Li, P., & Zhao, Y.-Y. (2023) · Aging and disease · doi:10.14336/ad.2023.0222 · Cited by 139
Li, H., Henty-Ridilla, J. L., Bernstein, A. M., Ganapathy, P. S., & Herberg, S. (2022) · Current Eye Research · doi:10.1080/02713683.2022.2071943 · Cited by 29
Future prospects in the tissue engineering of heart valves: a focus on the role of stem cells
Albert, B. J., & Butcher, J. T. (2023) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2023.2214313 · Cited by 8
Metadata
- Authors
- Ma, J., Sanchez-Duffhues, G., Goumans, M.-J., & ten Dijke, P.
- Venue
- Frontiers in Cell and Developmental Biology
- Publisher
- Frontiers Media SA
- Published
- 2020-04-21
- Volume
- 8
- Pages
- 260-260
- ISSN
- 2296-634X (ISSN-L)
- OpenAlex
- W3020412742
- Cited by
- 244
- References
- 15
- FWCI
- 9.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ma, J., Sanchez-Duffhues, G., Goumans, M.-J., & ten Dijke, P. (2020). TGF-β-Induced Endothelial to Mesenchymal Transition in Disease and Tissue Engineering. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2020.00260
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
