USP7 Is a Master Regulator of Genome Stability

Cites (274)

Items 201–272 of 272

1. Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies.
   Fountain, Michael D., Oleson, David S., Rech, Megan E., Segebrecht, Lara, Hunter, Jill V., McCarthy, John M., Lupo, Philip J., Holtgrewe, Manuel, Moran, Rocio, Rosenfeld, Jill A. et al. · 2019 · Genetics in Medicine
2. USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.
   Zlatanou, A, Sabbioneda, S, Miller, E S, Greenwalt, A, Aggathanggelou, A, Maurice, M M, Lehmann, A R, Stankovic, T, Reverdy, C, Colland, F et al. · 2016 · Oncogene
3. Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format.
   Tian, Xufan, Isamiddinova, Nigora S., Peroutka, Raymond J., Goldenberg, Seth J., Mattern, Michael R., Nicholson, Benjamin, Leach, Craig · 2011 · ASSAY and Drug Development Technologies
4. USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status.
   Agathanggelou, Angelo, Smith, Edward, Davies, Nicholas J., Kwok, Marwan, Zlatanou, Anastasia, Oldreive, Ceri E., Mao, Jingwen, Da Costa, David, Yadollahi, Sina, Perry, Tracey et al. · 2017 · Blood
5. Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7
   Roland Pfoh, Ira Kay Lacdao, Anna A. Georges, Adam Capar, Hong Xing Zheng, Lori Frappier, V. Saridakis · 2015 · PLoS Pathogens
6. Ring finger protein RNF169 antagonizes the ubiquitin-dependent signaling cascade at sites of DNA damage.
   Chen, Jie, Feng, Wanjuan, Jiang, Jun, Deng, Yiqun, Huen, Michael S.Y. · 2012 · Journal of Biological Chemistry
7. A role for USP7 in DNA replication.
   Jagannathan, Madhav, Nguyen, Tin, Gallo, David, Luthra, Niharika, Brown, Grant W., Saridakis, Vivian, Frappier, Lori · 2014 · Molecular and Cellular Biology
8. USP7 is a suppressor of PCNA ubiquitination and oxidative-stress-induced mutagenesis in human cells.
   Kashiwaba, Shu-ichiro, Kanao, Rie, Masuda, Yuji, Kusumoto-Matsuo, Rika, Hanaoka, Fumio, Masutani, Chikahide · 2015 · Cell Reports
9. Identification and structure-guided development of pyrimidinone based USP7 inhibitors
   O’Dowd, Colin R., Helm, Matthew D., Rountree, J. S. Shane, Flasz, Jakub T., Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R., Jordan, Linda, Barker, Oliver, Hughes, Caroline et al. · 2018 · ACS Medicinal Chemistry Letters
10. Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation
    Luna Yamaguchi, Atsuya Nishiyama, Toshinori Misaki, Yoshikazu Johmura, Jun Ueda, Kyohei Arita, Koji Nagao, Chikashi Obuse, Makoto Nakanishi · 2017 · Scientific Reports
11. DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.
    Sirano Dhe‐Paganon, Farisa Syeda, Lawrence Park · 2011 · PubMed
12. C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site
    Jianhong Ma, John D. Martin, Yu Xue, Leng A. Lor, Karen M. Kennedy-Wilson, Robert H. Sinnamon, Thau F. Ho, Guofeng Zhang, Benjamin K. Schwartz, Peter J. Tummino et al. · 2010 · Archives of Biochemistry and Biophysics
13. USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells.
    Zhang, Chao, Lu, Jing, Zhang, Quan-Wu, Zhao, Wei, Guo, Jia-Hui, Liu, Shan-Ling, Wu, Ying-Li, Jiang, Bin, Gao, Feng-Hou · 2016 · The International Journal of Biochemistry & Cell Biology
14. MCM-BP regulates unloading of the MCM2–7 helicase in late S phase
    Atsuya Nishiyama, Lori Frappier, Marcel Méchali · 2010 · Genes & Development
15. The role of UBL domains in ubiquitin-specific proteases
    Alex C. Faesen, Mark P.A. Luna‐Vargas, Titia K. Sixma · 2012 · Biochemical Society Transactions
16. USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia
    Shan, Huizhuang, Li, Xiangyun, Xiao, Xinhua, Dai, Yuting, Huang, Jinyan, Song, Junjun, Liu, Meng, Yang, Li, Lei, Hu, Tong, Yin et al. · 2018 · Signal Transduction and Targeted Therapy
17. USP7 and Daxx regulate mitosis progression and taxane sensitivity by affecting stability of Aurora-A kinase.
    Giovinazzi, S, Morozov, V M, Summers, M K, Reinhold, W C, Ishov, A M · 2013 · Cell Death & Differentiation
18. Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
    Choi, Jun-Hyuk, Lindsey-Boltz, Laura A., Sancar, Aziz · 2007 · Proceedings of the National Academy of Sciences
19. A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model.
    Becker, Kerstin, Marchenko, Natalia, Palacios, Gustavo, Moll, Ute M. · 2008 · Cell Cycle
20. Protein-linked Ubiquitin Chain Structure Restricts Activity of Deubiquitinating Enzymes
    Jonathan B. Schaefer, David O. Morgan · 2011 · Journal of Biological Chemistry
21. Genomic rearrangements induced by unscheduled DNA double strand breaks in somatic mammalian cells
    Ayeong So, Tangui Le Guen, Bernard S. López, Josée Guirouilh‐Barbat · 2017 · FEBS Journal
22. Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins
    Marie E. Morrow, Michael Thomas Morgan, Marcello Clerici, Kateřina Growková, Ming Yan, David Komander, Titia K. Sixma, Michal Šimíček, Cynthia Wolberger · 2018 · EMBO Reports
23. Post-translational modifications of PML: consequences and implications
    Xiwen Cheng, Hung‐Ying Kao · 2013 · Frontiers in Oncology
24. USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability.
    Qian, J, Pentz, K, Zhu, Q, Wang, Q, He, J, Srivastava, A K, Wani, A A · 2015 · Oncogene
25. DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
    Hernández-Pérez, S, Cabrera, E, Salido, E, Lim, M, Reid, L, Lakhani, S R, Khanna, K K, Saunus, J M, Freire, R · 2017 · Oncogene
26. Dual-utility NLS drives RNF169-dependent DNA damage responses
    Liwei An, Yiyang Jiang, Howin H. W. Ng, Ellen P.S. Man, Jie Chen, US Khoo, Qingguo Gong, Michael S.Y. Huen · 2017 · Proceedings of the National Academy of Sciences
27. The USP7 inhibitor P5091 induces cell death in ovarian cancers with different p53 status.
    Wang, Mengying, Zhang, Yayun, Wang, Taishu, Zhang, Jinrui, Zhou, Zhu, Sun, Yan, Wang, Shanshan, Shi, Yulin, Luan, Xuelin, Zhang, Yingqiu et al. · 2017 · Cellular Physiology and Biochemistry
28. The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies.
    Sarkari, Feroz, Wang, Xueqi, Nguyen, Tin, Frappier, Lori · 2011 · PLoS ONE
29. DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
    Fengshan Liang, Adam S. Miller, Simonne Longerich, Caroline Tang, David G. Maranon, Elizabeth A. Williamson, Robert Hromas, Claudia Wiese, Gary M. Kupfer, Patrick Sung · 2019 · Nature Communications
30. ABRO1 suppresses tumourigenesis and regulates the DNA damage response by stabilizing p53
    Jianhong Zhang, Mengmeng Cao, Jiahong Dong, Chang‐Yan Li, Wang‐Xiang Xu, Yi‐Qun Zhan, Xiaohui Wang, Miao Yu, Chang‐Hui Ge, Zhiqiang Ge et al. · 2014 · Nature Communications
31. HAUSP , a novel deubiquitinase for Rb – MDM 2 the critical regulator
    Seemana Bhattacharya, Mrinal K. Ghosh · 2014 · FEBS Journal
32. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation.
    Jung, Yong-Sam, Qian, Yingjuan, Chen, Xinbin · 2012 · DNA Repair
33. Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role
    Robbert Q. Kim, Willem J. van Dijk, Titia K. Sixma · 2016 · Journal of Structural Biology
34. Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks
    Donna R. Whelan, Wei Ting C. Lee, Yandong Yin, Dylan M. Ofri, Keria Bermudez‐Hernandez, Sarah Keegan, David Fenyö, Eli Rothenberg · 2018 · Nature Communications
35. TSPYL5 depletion induces specific death of ALT cells through USP7-dependent proteasomal degradation of POT1.
    Episkopou, Harikleia, Diman, Aurélie, Claude, Eloïse, Viceconte, Nikenza, Decottignies, Anabelle · 2019 · Molecular Cell
36. Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7.
    Sarkari, Feroz, La Delfa, Anthony, Arrowsmith, Cheryl H., Frappier, Lori, Sheng, Yi, Saridakis, Vivian · 2010 · Journal of Molecular Biology
37. USP7 enforces heterochromatinization of p53 target promoters by protecting SUV39H1 from MDM2-mediated degradation.
    Mungamuri, Sathish Kumar, Qiao, Rui F., Yao, Shen, Manfredi, James J., Gu, Wei, Aaronson, Stuart A. · 2016 · Cell Reports
38. USP7 is a novel deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis.
    Peng, Yuchong, Liu, Youhong, Gao, Yingxue, Yuan, Bowen, Qi, Xuli, Fu, Yuxin, Zhu, Qianling, Cao, Tuoyu, Zhang, Songwei, Yin, Linglong et al. · 2019 · Journal of Experimental & Clinical Cancer Research
39. Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells
    Lerner, Leticia K., Francisco, Guilherme, Soltys, Daniela T., Rocha, Clarissa R.R., Quinet, Annabel, Vessoni, Alexandre T., Castro, Ligia P., David, Taynah I.P., Bustos, Silvina O., Strauss, Bryan E. et al. · 2017 · Nucleic Acids Research
40. The G2/M Regulator Histone Demethylase PHF8 Is Targeted for Degradation by the Anaphase-Promoting Complex Containing CDC20
    Hui-Jun Lim, Nevena V. Dimova, Meng-Kwang Marcus Tan, Frederic D. Sigoillot, Randall W. King, Yang Shi · 2013 · Molecular and Cellular Biology
41. p53-mediated heterochromatin reorganization regulates its cell fate decisions.
    Mungamuri, Sathish Kumar, Benson, Erica Kay, Wang, Shaomeng, Gu, Wei, Lee, Sam W, Aaronson, Stuart A · 2012 · Nature Structural & Molecular Biology
42. Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity
    Young Mi Oh, Soon Ji Yoo, Jae Hong Seol · 2007 · Biochemical and Biophysical Research Communications
43. Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.
    Wei, Xi, Wu, Shaofang, Song, Tanjing, Chen, Lihong, Gao, Ming, Borcherds, Wade, Daughdrill, Gary W., Chen, Jiandong · 2016 · Proceedings of the National Academy of Sciences
44. BRCA1 contributes to transcription-coupled repair of DNA damage through polyubiquitination and degradation of Cockayne syndrome B protein.
    Wei, Leizhen, Lan, Li, Yasui, Akira, Tanaka, Kiyoji, Saijo, Masafumi, Matsuzawa, Ayako, Kashiwagi, Risa, Maseki, Emiko, Hu, Yiheng, Parvin, Jeffrey D. et al. · 2011 · Cancer Science
45. Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors
    Peng Li, Hong-Min Liu · 2020 · European Journal of Medicinal Chemistry
46. Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
    Wei Zhang, Jingxin Zhang, Chenzhou Xu, Shiqing Zhang, Saiyan Bian, Feng Jiang, Wenkai Ni, Lishuai Qu, Cuihua Lu, Runzhou Ni et al. · 2020 · Cancer Cell International
47. An Intramolecular Interaction of UHRF1 Reveals Dual Control for Its Histone Association
    Linfeng Gao, Xiao-Feng Tan, Shen Zhang, Tianchen Wu, Zhimin Zhang, Hui‐wang Ai, Jikui Song · 2018 · Structure
48. BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.
    Biswas, Kajal, Philip, Subha, Yadav, Aditya, Martin, Betty K., Burkett, Sandra, Singh, Vaibhav, Babbar, Anav, North, Susan Lynn, Chang, Suhwan, Sharan, Shyam K. · 2018 · Nature Communications
49. Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity.
    Kim, Robbert Q., Geurink, Paul P., Mulder, Monique P. C., Fish, Alexander, Ekkebus, Reggy, El Oualid, Farid, van Dijk, Willem J., van Dalen, Duco, Ovaa, Huib, van Ingen, Hugo et al. · 2019 · Nature Communications
50. Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair
    Mitsuru Higa, Xue Zhang, Kiyoji Tanaka, Masafumi Saijo · 2016 · Journal of Biological Chemistry
51. Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity
    Jing Ruan, Dirk Schlüter, Xu Wang · 2020 · Journal of Neuroinflammation
52. USP7 regulates the stability and function of HLTF through deubiquitination.
    Qing, Peng, Han, Lu, Bin, Liu, Yan, Lu, Ping, Wen Xue · 2011 · Journal of Cellular Biochemistry
53. USP7 protects genomic stability by regulating Bub3.
    Giovinazzi, Serena, Sirleto, Pietro, Aksenova, Vasilisa, Morozov, Viacheslav M., Zori, Roberto, Reinhold, William C., Ishov, Alexander M. · 2014 · Oncotarget
54. UVSSA and USP7: New players regulating transcription-coupled nucleotide excision repair in human cells
    Sarasin, Alain · 2012 · Genome Medicine
55. Cyanopyrrolidine inhibitors of ubiquitin specific protease 7 mediate desulfhydration of the active-site cysteine.
    Bashore, Charlene, Jaishankar, Priyadarshini, Skelton, Nicholas J., Fuhrmann, Jakob, Hearn, Brian R., Liu, Peter S., Renslo, Adam R., Dueber, Erin C. · 2020 · ACS Chemical Biology
56. Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation
    Ayşegül Özen, Lionel Rougé, Charlene Bashore, Brian R. Hearn, Nicholas J. Skelton, Erin C. Dueber · 2017 · Structure
57. HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP
    Seemana Bhattacharya, Mrinal K. Ghosh · 2015 · Cellular Oncology
58. POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length
    Mengyuan Xu, Janna Kiselar, Tawna L. Whited, Wilnelly M. Hernandez-Sanchez, Derek J. Taylor · 2019 · Proceedings of the National Academy of Sciences
59. Phosphorylation of Daxx by ATM contributes to DNA damage-induced p53 activation.
    Tang, Jun, Agrawal, Trisha, Cheng, Qian, Qu, Like, Brewer, Michael D., Chen, Jiandong, Yang, Xiaolu · 2013 · PLoS ONE
60. The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7
    Ivo Zemp, Joachim Lingner · 2014 · Journal of Biological Chemistry
61. Control of DNA Replication Initiation by Ubiquitin
    Esperanza Hernández-Carralero, Elisa Cabrera, Ignacio Alonso‐de Vega, Santiago Hernández-Pérez, Veronique A. J. Smits, Raimundo Freire · 2018 · Cells
62. Independent functions of DNMT1 and USP7 at replication foci
    Olya Yarychkivska, Omid Tavana, Wei Jun Gu, Timothy H. Bestor · 2018 · Epigenetics & Chromatin
63. The potential utility of geminin as a predictive biomarker in breast cancer.
    Sundara Rajan, Sreekumar, Hanby, Andrew M., Horgan, Kieran, Thygesen, Helene H., Speirs, Valerie · 2014 · Breast Cancer Research and Treatment
64. Rethinking origin licensing
    Stephen P. Bell · 2017 · eLife
65. USP7 deubiquitinates and stabilizes SIRT1.
    Song, Nan, Cao, Cheng, Tian, Shanshan, Long, Meijing, Liu, Ling · 2020 · The Anatomical Record
66. USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage
    Qianzheng Zhu, Nan Ding, Shengcai Wei, Ping Li, Gulzar Wani, Jinshan He, Altaf A. Wani · 2019 · Cell Cycle
67. Separase: a conserved protease separating more than just sisters
    Karen E. ROSS, Orna Cohen‐Fix · 2002 · Trends in Cell Biology
68. Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates.
    Masuda, Yuji, Kanao, Rie, Kawai, Hidehiko, Kukimoto, Iwao, Masutani, Chikahide · 2019 · Journal of Biological Chemistry
69. Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4
    Tin Nguyen, Madhav Jagannathan, Kathy Shire, Lori Frappier · 2012 · PLoS ONE
70. Cyclin A is a reliable proliferation marker in endometrial cancer cell lines.
    Horie, Kayo, Yamamoto, Hayate, Karube, Kouhei, Takebayashi, Kai, Yoshino, Hironori, Yoshioka, Haruhiko, Watanabe, Jun · 2019 · Oncology Letters
71. Targeting deubiquitinases in CLL.
    Sampath, Deepa · 2017 · Blood
72. Damaged replication forks tolerate USP7 to maintain genome stability
    Anastasia Zlatanou, Grant S. Stewart · 2015 · Molecular & Cellular Oncology