The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Nanomedicines for cancer therapy: state-of-the-art and limitations to pre-clinical studies that hinder future developments
Open accessAbstract
The ability to efficiently deliver a drug or gene to a tumor site is dependent on a wide range of factors including circulation time, interactions with the mononuclear phagocyte system, extravasation from circulation at the tumor site, targeting strategy, release from the delivery vehicle, and uptake in cancer cells. Nanotechnology provides the possibility of creating delivery systems where the design constraints are decoupled, allowing new approaches for reducing the unwanted side effects of systemic delivery, increasing tumor accumulation, and improving efficacy. The physico-chemical properties of nanoparticle-based delivery platforms introduce additional complexity associated with pharmacokinetics, tumor accumulation, and biodistribution. To assess the impact of nanoparticle-based delivery systems, we first review the design strategies and pharmacokinetics of FDA-approved nanomedicines. Next we review nanomedicines under development, summarizing the range of nanoparticle platforms, strategies for targeting, and pharmacokinetics. We show how the lack of uniformity in preclinical trials prevents systematic comparison and hence limits advances in the field.
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Cites
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Cited by
Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine
Mattheolabakis, G., Milane, L., Singh, A., & Amiji, M. M. (2015) · Journal of Drug Targeting · doi:10.3109/1061186x.2015.1052072 · Cited by 597
Bridging Bio–Nano Science and Cancer Nanomedicine
Björnmalm, M., Thurecht, K. J., Michael, M., Scott, A. M., & Caruso, F. (2017) · ACS Nano · doi:10.1021/acsnano.7b04855 · Cited by 382
The “Sweet” Side of the Protein Corona: Effects of Glycosylation on Nanoparticle–Cell Interactions
Wan, S., Kelly, P. M., Mahon, E., Stöckmann, H., Rudd, P. M., Caruso, F., Dawson, K. A., Yan, Y., & Monopoli, M. P. (2015) · ACS Nano · doi:10.1021/nn506060q · Cited by 223
Oral lipid nanomedicines: Current status and future perspectives in cancer treatment
El Moukhtari, S. H., Rodríguez-Nogales, C., & Blanco-Prieto, M. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.004 · Cited by 70
Samani, R. K., Tavakoli, M. B., Maghsoudinia, F., Motaghi, H., Hejazi, S. H., & Mehrgardi, M. A. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105487 · Cited by 40
Metadata
- Authors
- Dawidczyk, C. M., Russell, L. M., & Searson, P. C.
- Venue
- Frontiers in Chemistry
- Publisher
- Frontiers Media SA
- Published
- 2014-08-25
- Volume
- 2
- Pages
- 69-69
- ISSN
- 2296-2646 (ISSN-L)
- OpenAlex
- W2038495811
- Cited by
- 164
- References
- 14
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Nanomedicines for cancer therapy: state-of-the-art and limitations to pre-clinical studies that hinder future developments. https://app.cochat.ai/papers/10.3389/fchem.2014.00069
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- Dawidczyk, C. M., Russell, L. M., & Searson, P. C. (2014). Nanomedicines for cancer therapy: state-of-the-art and limitations to pre-clinical studies that hinder future developments. Frontiers in Chemistry. https://doi.org/10.3389/fchem.2014.00069
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
