Microbiome and skin biology
Open accessAbstract
Purpose of review: The skin is home to a diverse milieu of bacteria, fungi, viruses, bacteriophages, and archaeal communities. The application of culture-independent approaches has revolutionized the characterization of the skin microbiome and have revealed a previously underappreciated phylogenetic and functional granularity of skin-associated microbes in both health and disease states. Recent findings: The physiology of a given skin-niche drives the site-specific differences in bacterial phyla composition of healthy skin. Changes in the skin microbiome have consistently been associated with atopic dermatitis. In particular, Staphylococcus aureus overgrowth with concomitant decline in Staphylococcus epidermidis is a general feature associated with atopic dermatitis and is not restricted to eczematous lesions. Changes in fungal species are now also being described. Changes in the composition and metabolic activity of the gut microbiota are associated with skin health. Summary: We are now beginning to appreciate the intimate and intricate interactions between microbes and skin health. Multiple studies are currently focused on the manipulation of the skin or gut microbiome to explore their therapeutic potential in the prevention and treatment of skin inflammation.
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Intestinal flora disorders may be one of the reasons for the occurrence of AD.
“intestinal flora disorders may be one of the reasons for the occurrence of AD [95].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [95]
Compared with healthy controls, the level of Bifidobacterium in the intestinal tract of AD patients is lower.
“compared with the healthy control group, the level of Bifidobacterium in the intestinal tract of AD patients was lower”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [95]
The level of Bifidobacterium in the intestinal tract is negatively correlated with the severity of disease in AD patients.
“the level of Bifidobacterium in the intestinal tract was negatively correlated with the severity of disease in AD patients.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [95]
Changing of intestinal flora may be earlier than the development of AD.
“the changing of intestinal flora may be earlier than the development of AD.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [95]
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Research works printed but not linked: 4
- [1]1. Papers of particular interest, published within the annual period of review, (the last 18 months) have been highlighted as: * of special interest ** of outstanding
- [8]8. Review of the microbiome-related mechanisms that contribute to allergy and asthma. *
- [17]17. This review describes the recent insights into skin microbial communities, including their composition in health and disease.
- [24]24. This review describes the role of S. aureus on the skin of AD patients. **32
Cited by
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Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
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Update on the pathogenesis of atopic dermatitis.
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- Authors
- Lunjani, N., Hlela, C., & O’Mahony, L.
- Affiliations
- University of Cape Town (ZA)
- University College Cork (IE)
- Corresponding author
- O’Mahony, Liam
- Venue
- Current Opinion in Allergy & Clinical Immunology
- Published
- 2019-08
- Volume
- 19
- Issue
- 4
- Pages
- 328-333
- ISSN
- 1473-6322 (ISSN-L)
- 1528-4050
- OpenAlex
- W2945996466
- Cited by
- 93
- References
- 55
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 21 · 2023: 14 · 2022: 22 · 2021: 10 · 2020: 8 · 2019: 3
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Current Opinion in Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- skin microbiome, atopic dermatitis, Staphylococcus aureus, Staphylococcus epidermidis, gut microbiota, skin inflammation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Dermatitis, Atopic, Fungi, Humans, Mycoses, Phylogeny, Skin, Staphylococcal Infections, Staphylococcus aureus, Staphylococcus epidermidis, Microbiota
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