Microbiome in the gut-skin axis in atopic dermatitis
Open accessAbstract
The microbiome is vital for immune system development and homeostasis. Changes in microbial composition and function, termed dysbiosis, in the skin and the gut have recently been linked to alterations in immune responses and to the development of skin diseases, such as atopic dermatitis (AD). In this review, we summarize the recent findings on the gut and skin microbiome, highlighting the roles of major commensals in modulating skin and systemic immunity in AD. Although our understanding of the gut-skin axis is only beginning, emerging evidence indicates that the gut and skin microbiome could be manipulated to treat AD.
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Dietary factors, particularly the Western diet, contribute to intestinal dysbiosis and AD by altering the intestinal microbial genes and inflammatory responses.
“Dietary factors, particularly the Western diet, contribute to intestinal dysbiosis and AD by altering the intestinal microbial genes and inflammatory responses.107”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [107]
In “Gut microbiome and AD” (page unavailable), the review says diet affects gut microbial composition and that gut dysbiosis and immune imbalance may contribute to AD. Its “Immunologic pathway” section also discusses differences in gut microbiome genes and host immune function. It does not identify the Western diet as a particular cause or establish the claimed causal chain from diet through microbial genes and inflammatory responses to AD. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThere is a bidirectional link between the skin and the gut.
“there have been many experiments demonstrating a bidirectional link between the skin and the gut”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [93]
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Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
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Myles, I. A., Castillo, C. R., Barbian, K. D., Kanakabandi, K., Virtaneva, K., Fitzmeyer, E., Paneru, M., Otaizo-Carrasquero, F., Myers, T. G., Markowitz, T. E., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz8631 · Cited by 139 · see citing works
Matrix Metalloproteinases on Skin Photoaging
Feng, C., Chen, X., Yin, X., Jiang, Y., & Zhao, C. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16558 · Cited by 112 · see citing works
Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66 · see citing works
Exosomes in chronic inflammatory skin diseases and skin tumors
Wang, W., Wu, C., & Jin, H. (2019) · Experimental Dermatology · doi:10.1111/exd.13857 · Cited by 59 · see citing works
Abdel-Mageed, H. M. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01642-z · Cited by 45 · see citing works
Prebiotics in atopic dermatitis prevention and management
Lee, Y. H., Verma, N. K., & Thanabalu, T. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104352 · Cited by 19 · see citing works
- Authors
- Lee, S.-Y., Lee, E., Park, Y. M., & Hong, S.-J.
- Affiliations
- Asan Medical Center (KR)
- Chonnam National University (KR)
- University of Ulsan (KR)
- Corresponding author
- Hong, Soo-Jong
- Venue
- Allergy, Asthma & Immunology Research
- Publisher
- XMLink
- Published
- 2018
- Volume
- 10
- Issue
- 4
- Pages
- 354
- ISSN
- 2092-7355 (ISSN-L)
- 2092-7363
- PMC
- PMC6021588
- OpenAlex
- W2789799903
- Cited by
- 326
- References
- 79
- Citations by year
- 2026: 35 · 2025: 58 · 2024: 47 · 2023: 37 · 2022: 50 · 2021: 42 · 2020: 34 · 2019: 19 · 2018: 3
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Allergy Asthma and Immunology Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF-2014R1A2A1A10050687)
- Ministry of Health and Welfare (HI14C2687)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- atopic dermatitis, gut-skin axis, skin microbiome, gut microbiota, dysbiosis, commensal bacteria, immunomodulation, skin immunity, systemic immunity, microbiota-based therapy
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