Melatonin Engineered Adipose-Derived Biomimetic Nanovesicles Regulate Mitochondrial Functions and Promote Myocardial Repair in Myocardial Infarction
Open accessAbstract
Myocardial infarction (MI), one type of ischemic heart disease, is a major cause of disability and mortality worldwide. Currently, extracellular vesicles (EVs) derived from adipose-derived stem cells (ADSC) have been proven to be a potentially promising therapeutic treatment for MI. However, the inconvenience of isolation, the low productivity, and the high cost of EVs greatly limits their application in clinic. In this study, we constructed novel biomimetic ADSC-derived nanovesicles (ADSC NVs) to achieve cell-free therapy for MI. Here, we firstly developed a novel Mel@NVs delivery system consisting of engineered ADSC NVs with melatonin (Mel). Then, the characterization and properties of Mel@NVs were performed. The effect of Mel@NVs on cellular oxidative stress and myocardial infarction repair was conducted. The results showed that Mel@NVs treatment under ischemia mimic condition reduced cell apoptosis from 42.59 ± 2.69% to 13.88 ± 1.77%. Moreover, this novel engineered Mel@NVs could ameliorate excessive ROS generation, promote microvessel formation, and attenuate cardiac fibrosis, which further alleviates mitochondrial dysfunction and finally enhance myocardial repair. Hence, the engineered NVs show a potential strategy for MI therapy.
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Mel@NVs could promote formation of microvessels and alleviate cardiac fibrosis, thereby restoring mitochondrial dysfunction for myocardial repair.
“Further reports showed the Mel@NVs could promote the formation of microvessels and alleviate cardiac fibrosis, thereby further restoring mitochondrial dysfunction for myocardial repair.”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [96]
Mel@NVs proved to be a potentially promising therapy for myocardial infarction.
“Mel@NVs proved to be a potentially promising therapy for myocardial infarction [96].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [96]
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- Authors
- Zhang, Y., Yang, N., Huang, X., Zhu, Y., Gao, S., Liu, Z., Cao, F., & Wang, Y.
- Affiliations
- Chinese PLA General Hospital (CN)
- Zhongda Hospital Southeast University (CN)
- Nankai University (CN)
- Corresponding author
- Cao, Feng
- Wang, Yabin
- Venue
- Frontiers in Cardiovascular Medicine
- Publisher
- Frontiers Media SA
- Published
- 2022-03-23
- Volume
- 9
- Pages
- 789203-789203
- ISSN
- 2297-055X (ISSN-L)
- PMC
- PMC8985816
- OpenAlex
- W4220734814
- Cited by
- 18
- References
- 54
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 4
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cardiovascular Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (2017MBD-008, 81530058, 81571841, 81970443, 2017TM-003, 91939303, 81570272, 81671731, 81820108019)
- General Hospital of People’s Liberation Army (2017TM-003, 91939303, 81820108019, 2017MBD-008)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- myocardial infarction, melatonin, adipose-derived stem cells, biomimetic nanovesicles, extracellular vesicles, cell-free therapy, mitochondrial dysfunction, oxidative stress, apoptosis, myocardial fibrosis, angiogenesis, myocardial repair, reactive oxygen species
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